Ningfei Li

Ningfei Li

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47
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Introduction
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Publications

Publications (47)
Article
Full-text available
Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson's disease (PD), first bidirectional BCI implants for adaptive deep brain stimulation (DBS) are now available. Brain signal decoding can extend the clinical utility of adaptive DBS but the impact of neural source, computat...
Article
Introduction: Neurocircuits are involved in the motor, cognitive, and affective dysfunctions of multiple brain disorders. Functional segregation into these domains has been widely defined on a fronto-cortical basis. However, despite considerable interaction, these functional domains remain partitioned to some extent at (sub)thalamic levels (1). To...
Article
Introduction: Tremor is defined as an involuntary, rhythmic oscillatory movement of a body part and represents one of the most common symptoms in movement disorders, existing across several diseases. Particularly, in advanced states of tremor-related diseases such as Parkinson’s disease (PD) and Essential tremor syndrome (ET), response to pharmacot...
Article
Full-text available
Dystonia is a debilitating disease with few treatment options. One effective option is deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of isolated dystonia have been targeted with a common approach to the posterior third of the nucleus, large-scale investigations regarding optimal stimulation sites and po...
Article
Full-text available
Objectives Up to 40% of patients with idiopathic generalised epilepsy (IGE) are drug resistant and potentially could benefit from intracranial neuromodulation of the seizure circuit. We present outcomes following 2 years of thalamic-responsive neurostimulation for IGE. Methods Four patients with pharmacoresistant epilepsy underwent RNS System impl...
Article
Full-text available
Deep Brain Stimulation (DBS) is an efficacious treatment option for an increasing range of brain disorders. To enhance our knowledge about the mechanisms of action of DBS and to probe novel targets, basic research in animal models with DBS is an essential research base. Beyond nonhuman primate, pig, and mouse models, the rat is a widely used animal...
Chapter
In this chapter, we will give an overview of important imaging concepts in the field of DBS before going into details in the subsequent chapters. We begin by motivating why imaging in the context of DBS is crucial and which additional scientific questions we can ask if we are able to create meaningful models of DBS. We then discuss several strategi...
Preprint
Full-text available
Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS allow to pre-select a set of potentially optimal stimulation parameters. If efficacious, they could further carry insight into the mechanism of action of DBS and foster the development of more efficient stimulation approac...
Article
Full-text available
The subthalamic nucleus and internal pallidum are main target sites for deep brain stimulation in Parkinson’s disease. Multiple trials that investigated subthalamic versus pallidal stimulation were unable to settle on a definitive optimal target between the two. One reason could be that the effect is mediated via a common functional network. To tes...
Preprint
Full-text available
Dystonia is a debilitating disease with few conservative treatment options but many types of isolated dystonia can be effectively treated using deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of isolated dystonia have been targeted with a common approach to the posterior third of the nucleus, large-scale...
Article
Full-text available
Obsessive-compulsive disorder is among the most disabling psychiatric disorders. Although deep brain stimulation is considered an effective treatment, its use in clinical practice is not fully established. This is, at least in part, due to ambiguity about the best suited target and insufficient knowledge about underlying mechanisms. Recent advances...
Preprint
Full-text available
Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson’s disease (PD), first bidirectional BCI implants for adaptive deep brain stimulation (DBS) are now available. To elevate the therapeutic potential of BCI with machine learning, further research is required to characterize...
Article
Full-text available
Background: Multiple deep brain stimulation (DBS) targets have been proposed for treating intractable obsessive-compulsive disorder (OCD). Here, we investigated whether stimulation effects of different target sites would be mediated by one common or several segregated functional brain networks. Methods: Seeding from active electrodes of four patien...
Preprint
Full-text available
The subthalamic nucleus and internal pallidum are main target sites for deep brain stimulation in Parkinson's disease. Multiple trials that investigated subthalamic versus pallidal stimulation were unable to settle on a definitive optimal target between the two. One reason could be that the effect is mediated via a common network. To test this hypo...
Chapter
Full-text available
In this chapter, we will give an overview about important imaging concepts in the field of DBS before going into details in subsequent chapters. We begin by motivating why imaging in context of DBS is crucial and which additional scientific questions we can ask if we are able to create meaningful models of DBS. We then discuss several strategies th...
Cover Page
Full-text available
Structural connectivity between individual STN-DBS sites and the rest of the brain based on patient-specific connectivity (blue) and normative connectome (orange). A coronal plane of the 7T MRI ex vivo human brain template (Edlow et al., 2019) is shown. The yellow sphere represents the VTA.
Cover Page
Full-text available
Cover Image: DBS contacts of 51 PD patients visualized as point clouds and colored by clinical improvement using Lead group. A 7T 100-μm T1 scan (Edlow et al., 2019) serves as background and anatomical structures are informed by the Ultra-high field atlas for DBS planning (Wang et al., 2018).
Article
Full-text available
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, a number of studies have employed normative atlases of the human connectome. To da...
Article
Full-text available
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, a number of studies have employed normative atlases of the human connectome. To da...
Article
Full-text available
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different targets may modulate the same neural network responsible for clinical improvement. We analyzed data from four cohorts of patients (N = 50) that underwent DBS to the anterior limb of the internal capsule (ALIC...
Cover Page
Full-text available
A computer reconstruction summarizing data from patients with deep brain stimulation of the subthalamic nucleus (orange) for Parkinson disease, showing fiber tracts, identified by diffusion tensor imaging, that were associated with stimulation sites that improved (red) or worsened (blue) depressive symptoms. For details see Irmen et al., pp. 962–97...
Article
Full-text available
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders and is under investigation for treatment of a growing number of other brain diseases. It has been shown that exact electrode placement crucially affects the efficacy of DBS and this should be considered when investigating novel indications or DBS targets. To meas...
Article
Full-text available
Objective Subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's Disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non‐motor DBS effects is not well characterized. By focusing on the affective domain, we systematically investigate the impact o...
Preprint
Full-text available
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, most studies have employed normative atlases of the human connectome. To date, it...
Article
Full-text available
Background and importance: At least 25% of patients with idiopathic generalized epilepsy do not obtain adequate seizure control with medication. This report describes the first use of responsive neurostimulation (RNS), bilaterally targeting the centromedian/ventrolateral (CM/VL) region in a patient with drug-refractory Jeavons syndrome (eyelid myo...
Preprint
Full-text available
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders and is investigated to treat a growing number of other brain disorders. It has been shown that DBS effects are highly dependent on exact electrode placement, which is especially important when probing novel indications or stereotactic targets. Thus, considering p...
Article
Full-text available
Neuroimaging has seen a paradigm shift away from a formal description of local activity patterns towards studying distributed brain networks. The recently defined framework of the 'human connectome' enables global analysis of parts of the brain and their interconnections. Deep brain stimulation (DBS) is an invasive therapy for patients with severe...
Article
Full-text available
Objective: To investigate whether functional sweetspots of deep brain stimulation (DBS) in the subthalamic nucleus (STN) can predict motor improvement in PD patients. Methods: Stimulation effects of 449 DBS settings in 21 PD patients were clinically and quantitatively assessed through standardized monopolar reviews and mapped into standard space...
Preprint
Full-text available
Objective Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s Disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non-motor DBS effects is not well characterized. By focusing on the affective domain, we systematically investigate the impact o...
Preprint
Full-text available
Multiple surgical targets have been proposed for treating obsessive-compulsive disorder (OCD) with Deep brain stimulation (DBS). However, different targets may lie along the same fiber bundle, which could be responsible for clinical improvement. Here we analyzed data from two cohorts of OCD patients that underwent DBS to either the anterior limb of...
Preprint
Full-text available
Neuroimaging has seen a paradigm shift from a formal description of local activity patterns toward studying distributed brain networks. The recently defined framework of the 'human connectome' allows to globally analyse parts of the brain and their interconnections. Deep brain stimulation (DBS) is an invasive therapy for patients with severe moveme...
Article
Full-text available
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders and a growing number of other indications are investigated in clinical trials. To ensure optimal treatment outcome, exact electrode placement is required. Moreover, to analyze the relationship between electrode location and clinical results, a precise recon...
Article
Full-text available
Nonlinear registration of individual brain MRI scans to standard brain templates is common practice in neu- roimaging and multiple registration algorithms have been developed and refined over the last 20 years. How- ever, little has been done to quantitatively compare the available algorithms and much of that work has ex- clusively focused on corti...
Article
Objective 1. To evaluate and optimize commonly used nonlinear deformation algorithms when applied to human brain MRI. 2. To evaluate and optimize accuracy of automated atlas-based segmentation of the two most commonly used target regions for deep brain stimulation (DBS), the nucleus subthalamicus (STN) and the internal part of the globus pallidus (...
Preprint
Full-text available
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders and a growing number of other indications are investigated in clinical trials. To ensure optimal treatment outcome, exact electrode placement is required. Moreover, to analyze the relationship between electrode location and clinical results, a precise recon...
Poster
Full-text available
1. First, we identified two nonlinear deformation algorithms (SPM Segment and ANTs SyN) that perform superiorly to other commonly used algorithms in the field. We then further optimized their performance resulting in a more precise alignment of subcortical structures. 2. The results of atlas-based segmentations are similar to inter-rater results ma...
Article
Objective: This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency. Methods: Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson...
Article
Objective: The benefit of deep brain stimulation (DBS) for Parkinson's disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients remains unknown. Here, we identify the structural and functional connectivity profile of effective DBS to the...
Article
Three-dimensional atlases of subcortical brain structures are valuable tools to reference anatomy in neuroscience and neurology. For instance, they can be used to study the position and shape of the three most common deep brain stimulation (DBS) targets, the sub-thalamic nucleus (STN), internal part of the pallidum (GPi) and ventral intermediate nu...
Poster
Full-text available
BACKGROUND The benefit of deep brain stimulation (DBS) for Parkinson’s disease (PD) may depend on connectivity between the stimulation site and other brain regions, but which regions and whether connectivity can predict outcome in patients remains unknown. Here, we identify the structural and functional connectivity profile of effective DBS to the...
Conference Paper
Full-text available
Pairwise clustering methods are able to handle relational data, in which a set of objects is described via a matrix of pairwise (dis)similarities. Using the framework of source coding, it has been shown that pairwise clustering can be considered as entropy maximization problem under the constraint of keeping the distortion at a small value. This ca...
Chapter
Human head modeling is the foremost research topic of the multi-modal fusion for medical information in brain function research Human head modeling is the foremost research topic of the multi-modal fusion for medical information in brain function research based on EEG/fMRI. Finding an effective way to construct the geometric model of human head is...

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Projects

Projects (3)
Project
Work on a book about connectomic deep brain stimulation for Academic Press. https://www.elsevier.com/books/connectomic-deep-brain-stimulation/horn/978-0-12-821861-7
Project
To provide group connectivity datasets in standardized stereotactic (ICBM/MNI) space defining average structural and functional connectivity of the brain in health and disease.
Project
Continuous development of a toolbox aimed at precisely localizing deep brain stimulation electrodes based on postoperative data. Toolbox website here: www.lead-dbs.org / www.leadsuite.io / www.lead-connectome.org