Nina Schumacher

• Doctor at Universitätsklinikum Schleswig - Holstein

Detlef Zillikens, MD, director and chair of the Department of Dermatology at the University of Lübeck, Lübeck, Germany, died in September 2022, aged only 64. He dedicated his professional life to autoimmune blistering diseases (AIBDs) and built his department into one of the world’s leading centers for these diseases. Herein, his professional life...

Importance Immunoglobulin A (IgA) epidermolysis bullosa acquisita (EBA) is an autoimmune skin blistering disease with IgA autoantibodies directed against type VII collagen. There is debate whether it should be considered part of the clinical spectrum of linear IgA bullous dermatosis (LABD) or a separate disease entity. Objective This cohort study...

Background European guidelines propose a 0.5 mg/kg/day dose of oral prednisone as initial treatment of bullous pemphigoid (BP). We assessed the safety and efficacy of this regimen depending on BP extent, and patients’general condition. Methods In a prospective international study, we consecutively included all patients diagnosed with BP. Patients...

Blisters and erosions of skin and mucous membranes are key features of the clinically heterogeneous group of autoimmune bullous diseases (AIBDs). These can be divided into pemphigoid diseases with autoantibodies against structural proteins of the dermal-epidermal junction, pemphigus diseases with autoantibodies against desmosomal proteins, and derm...

Zusammenfassung Die Ursprünge der Lübecker Universitäts-Hautklinik reichen in die 30er-Jahre des letzten Jahrhunderts zurück. Die Klinik hat in den letzten Jahrzehnten eine konsequente bauliche und inhaltliche Weiterentwicklung erfahren und verfügt heute über 85 Betten auf 2 Stationen und in einer Tagesklinik. Ein modernes Weiterbildungsprogramm, d...

Zusammenfassung Die Dermatomyositis ist eine chronisch-inflammatorische Erkrankung mit charakteristischen Hautveränderungen und unterschiedlich stark ausgeprägter Myopathie. Einige Patienten zeigen zwar typische Hauteffloreszenzen, präsentieren sich jedoch zunächst ohne erkennbare (amyopathisch) oder mit geringer (hypomyopathisch) klinischer und la...

The Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity-Score (ABSIS) scores have been proposed to provide an objective measure of pemphigus activity. These scores have been evaluated only on already treated patients mainly with mild to moderate activity. The objective was to assess the interrater reliability of ABSIS...

Introduction Deux scores de sévérité du pemphigus, l’ABSIS et le PDAI ont été récemment proposés afin de grader la sévérité au moment du diagnostic et faciliter le suivi des patients. Le but de cette étude a été d’étudier la corrélation de ces scores entre eux et avec d’autres marqueurs de sévérité : score de sévérité global (PGA), DLQI et taux d’A...

Introduction L’ABSIS et le PDAI ont ete proposes comme scores d’evaluation de la severite des lesions cutanees et muqueuses pemphigus. Leur interet depend de la reproductibilite entre differents observateurs, pour comparer des populations de malades entre differentes etudes. Notre objectif a ete d’etudier la concordance des scores ABSIS et PDAI ent...

A 69-year-old male was transferred to our department by helicopter on a Sunday morning from the intensive care burn unit of another university hospital. In this unit, he had been treated for 3 days including a radical debridement of unattached skin. Before, he had been admitted in a dermatology department of another university hospital for exacerba...

Beim Antiphospholipidsyndrom treten neben Thrombosen der tiefen Gefäße auch Hautmanifestationen wie Raynaud-Symptomatik, akrale Nekrosen, Petechien, Livedo racemosa, subkutane Knoten und Ulcera crurum auf. Wir berichten über einen 72-jährigen Patienten mit rasch größenprogredientem, schmerzlosem Ulcus cruris. Der Patient war bei bekanntem Vorhoffli...

Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and leg ulcers. A 72-year-old man presented with a rapidly progressing leg ulcer. He was already on anticoagulation with warfarin due to atrial fibrillati...

  It has been previously shown in a relatively small group of patients that a combination of immunoadsorption (IA) and rituximab with daily use of high-dose oral corticosteroids and azathioprine/mycophenolate mofetil may induce a rapid and durable remission in severe, treatment-resistant pemphigus. To achieve a more rapid reduction of serum autoant...

To optimize immunosuppressive treatment in individual transplant patients, functional measurements of the effects of tacrolimus (FK 506) are of clinical importance. Previous investigations have demonstrated the occurrence of tacrolimus-resistant production of interleukin-2 (IL-2) in vitro, which may explain in part why rejection episodes are still...

The quantitative analysis of cyclosporin A (CsA) effects might be helpful for optimizing immunosuppressive treatment after allogeneic organ transplantation in individual patients, as rejection can occur despite the existence of CsA blood levels within therapeutic ranges. Previous investigations found that costimulation of the CD28 pathway generally...

Because cyclosporin A (CsA) and glucocorticoids inhibit the production of interleukin-2 (IL-2) and other cytokines, quantitative analysis of cytokine mRNA might constitute a pharmacodynamic measure for immunosuppressive drug effects. We investigated whether immunosuppressive drugs influence cytokine mRNA expression kinetics during T-cell costimulat...