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Publications
Publications (77)
An investigation of six species of Silene (Caryophyllaceae) cultivated in Baikal District isolated 22 flavonoids, including new C,O-glycosylflavones 1–5. The structures of 1–5 were established using UV and NMR spectroscopy and mass spectrometry as genkwanin 6-C-(2′′-O-β-D-glucopyranosyl)-β-D-glycopyranoside-4′-O-β-D-glucopyranoside (sileneside H, 1...
Studies of three species of Dryas (D. sumneviczii Serg., D. octopetala L., D. oxyodonta Juz., Rosaceae), growing in Baikal District led to the isolation of 19 flavonoids, including seven new flavonol glycosides. UV and NMR spectroscopic and mass spectrometric data characterized the new flavonoids as 8-methoxykaempferol 3-O-α-L-arabinopyranoside (dr...
Green waste from Cucurbitaceae agriculture is a common but underutilised resource. in this study, we performed targeted HPLC-PDA-MS profiling to analyse the flavonoid composition of Cucumis africanus L.f., Cucumis anguria L., Cucumis dipsaceus Ehrenb. ex Spach, Cucumis melo L., Cucumis sagittatus Wawra & peyr., Echinocystis lobata (michx.) torr. &...
Род Polygala Tourn. ex L. представлен в Сибири тремя видами, включая два малоизученных вида – P. hybrida DC. (син. P. comosa subsp. comosa, P. comosa var. hybrida (DC.) Petelin) и P. sibirica L., корни которых используются в восточной медицине. Хроматографическое разделение компонентов корней P. hydrida привело к выделению 21 вещества, идентифициро...
Four new flavonoids, isovitexin 4′-O-(2′′′-O-β-D-glucopyranosyl)-β-D-glucopyranoside (cucumoside H), isovitexin 4′-O-(6′′′-O-β-D-glucopyranosyl)-β-D-glucopyranoside (cucumoside I), isovitexin 4′-O-(6′′′-O-βD-glucopyranosyl)-β-D-glucopyranoside-2′′-O-(6′′′′-O-p-coumaroyl)-β-D-glucopyranoside (cucumoside J),
and isovitexin 4′-O-(6′′′-O-β-D-glucopyran...
Monoamine oxidase (MAO) inhibitors are effective therapeutic agents for the treatment of neuro-degenerative diseases, and natural flavonoids found in the species Agastache belong to them. In the present study, six new acylated flavone-O-glycosides were isolated from A. foeniculum and identified using UV, NMR spectroscopy, and mass spectrometry as a...
Seven new acylated C,O-glycosylflavones were isolated from leaves of Cucumis sativus L. (Cucurbitaceae) variety Gele Tros. The new compounds were isovitexin 4′-O-glucoside-2′′-O-(6′′′′-O-caffeyl)-glucoside (cucumoside A), isovitexin 4′-O-glucoside-2′′-O-(2′′′′-O-caffeyl)-glucoside (cucumoside B), isovitexin 4′-O-(2′′′-O-caffeyl)-glucoside-2′′-O-glu...
Dryas oxyodonta Yuz. is a perennial evergreen shrub from the Rosaceae family. D. oxyodonta thrives in subalpine and subarctic regions, as well as in highlands spanning from Central Asia to Siberia and Mongolia. Owing to a lack of information on its chemical composition, we conducted qualitative and quantitative chromatographic analyses on extracts...
The composition of phenolic compounds from Scutellaria titovii Juz. and S. catharinae Juz. (Lamiaceae) growing in Kazakhstan was studied for the first time. A total of 26 known compounds and two new O-glycosylflavones (1 and 2) were detected. The new flavonoids were elucidated as 5,7,2′-trihydroxy-6-methoxyflavone 7,2′-di-O-β-D-glucuronopyranoside...
Gentianopsis is a small gentianaceous genus with a known ethnopharmacological focus as hepatoprotectors containing two underestimated species that are scientifically unexplored: Gentianopsis komarovii (Grossh.) Toyok., which is typical of the Far East, and Gentianopsis stricta (Klotzsch) Ikonn., which is grown in Central Asia. Application of the HP...
A perennial plant Nepeta multifida L. (syn. Schizonepeta multifida (L.) Briq.) is one of the most common species of the Lamiaceae family growing in Eastern Siberia and used in traditional oriental medicine. The chemical composition of N. multifida has not been sufficiently studied. Chromatographic separation of phenolic compounds of N. multifida le...
The biological potential of plant objects depends on the active compounds they contain [...]
Cucumber is an important agricultural crop that is cultivated under greenhouse conditions. Cucumber cultivation generates substantial quantities of green waste that require proper disposal. The lack of data on the chemical composition of cucumber greens and their biological activity emphasizes the necessity for research on useful products resulting...
A study of phenolic compounds from four species of the genus Prunella (P. grandiflora, P. laciniata, P. vulgaris, and P. vulgaris subsp. asiatica) led to the isolation of 18 compounds, including the new flavonoid 1. UV and NMR spectroscopic and mass spectrometric data established that 1 was quercetin 3-O-(4′′-O-β-D-xylopyranosyl-6′′-O-α-L-rhamnopyr...
Nine compounds including two new flavonoids that were identified using UV and NMR spectroscopy and mass spectrometry as apigenin 6-C-(4-hydroxy-1-ethylbenzene)-8-C-(2′′′-O-β-D-glucopyranosyl)-β-D-glucopyranoside (cucumerin C, 1) and apigenin 6-C-(2′′′-O-β-D-glucopyranosyl)-β-D-glucopyranoside- 8-C-(4-hydroxy-1-ethylbenzene) (cucumerin D, 2) were is...
Lipid metabolism disorders are a large group of diseases for the treatment of which various strategies are used, including the use of pancreatic lipase inhibitors that reduce the intake and adsorption of lipids. This study was the first that shows that agricultural wastes of cucumber (Cucumis sativus) can be a source of the effective lipase inhibit...
Lipid metabolism disorders are a large group of diseases for the treatment of which various strategies are used including the use of pancreatic lipase inhibitors reduced the intake and adsorption of lipids. This study was the first shown that agricultural wastes of cucumber (Cucumis sativus) can be a source of the effective lipase inhibitors. As a...
α-Glucosidase inhibitors are essential in the treatment of diabetes mellitus. Plant-derived drugs are promising sources of new compounds with glucosidase-inhibiting ability. The Geum aleppicum Jacq. and Sibbaldianthe bifurca (L.) Kurtto & T.Erikss. herbs are used in many traditional medical systems to treat diabetes. In this study, metabolites of t...
The basic strategy for the treatment of diabetes mellitus is the control of postprandial glucose levels; therefore, pancreatic α-amylase, which hydrolyzes complex carbohydrates, is an important enzymatic target for scientific research. In the present study, an aqueous extract and its ethyl acetate fraction (EAF) from the seeds of Rhaponticum uniflo...
Two North bluebells, Mertonian stylosa and M. serrulata, are plants used in the traditional medicine of the Buryats as wound healing and antitumor remedies. Both mertensias have been used by local healers as substitutes for the rare Tibetan raw material Cynoglossum amabile. The lack of information on the chemical composition of M. stylosa and M. se...
Owing to progressive aging in the population, there is an increase in patients with cognitive impairment. For the prevention of dementia, the use of plant remedies is relevant. Of particular interest is Klasea centauroides (L.) Cass. (Serratula centauroides L., Asteraceae), which has significant natural reserves, contains a wide range of biological...
The basic strategy for the treatment of diabetes mellitus is the control of postprandial glucose levels, and therefore pancreatic α-amylase that hydrolyzes complex carbohydrates is an important enzymatic target for the scientific research. In the present study, an aqueous extract and its ethyl acetate fraction (EAF) from the seeds of Rhaponticum un...
Marigold (Calendula), an important asteraceous genus, has a history of many centuries of therapeutic use in traditional and officinal medicines all over the world. The scientific study of Calendula metabolites was initiated at the end of the 18th century and has been successfully performed for more than a century. The result is an investigation of...
Phenolic compounds of Urtica cannabina L. (cannabis nettle; family Urticaceae), a widespread Asian species of Russia, are poorly studied. In the present study, for the first time, a chromatographic analysis of U. cannabina growing in Eastern Siberia was realized together with isolation of flavonoids and hydroxycinnamates and study of the biological...
Polysaccharide constituents from the aerial part of three species of Gentiana (Gentianaceae) growing in Azerbaijan were characterized for the first time. Neutral and acidic polymers and water-soluble polyphenol-polysaccharide conjugates containing fragments of phenolic acids and possessing antiradical activity were observed in G. asclepiadea L., G....
Dracocephalum botryoides Steven and Dracocephalum austriacum L. are unexplored species of the Dracocephalum genus (Lamiaceae family) with a distribution in the Caucasus, where they are used in folk medicine and local cuisine. There are no data on the chemical composition of these Dracocephalum species. In this study, the application of a liquid chr...
A perennial plant Nepeta multifida L. (syn. Schizonepeta multifida (L.) Briq.) is one of the most common species of the Lamiaceae family growing in Eastern Siberia and used in traditional oriental medicine. The chemical composition of N. multifida has not been sufficiently studied. Chromatographic separation of phenolic compounds of N. multifida le...
Roots of Nepeta multifida L. (Schizonepeta multifida (L.) Briq.; Lamiaceae) contained 15 observed compounds including two new rosmarinic acid glycosides 1 and 2. UV and NMR spectroscopy and mass spectrometry showed that the new compounds were rosmarinic acid 3,3′-di-O-methyl ether 4′-O-β-D-glucopyranoside (nepetamultin C, 1) and rosmarinic acid 3′-...
In the course of the ongoing chemical study of species of Silene genus, S. repens Patrin as a common species of the genus, was selected as the object of this study. Using high-performance liquid chromatography with photodiode array detection and electrospray ionization triple quadrupole mass spectrometric detection (HPLC-PDA-ESI-tQ-MS), the presenc...
Rubus matsumuranus H. Lev. & Vaniot, a famous Siberian shrub of the Rosaceae family, is used in the folk medicine of nomads (Buryats, Yakuts, Soyots, and Mongols) as a remedy for the treatment of diseases of the respiratory and hepatobiliary systems. The lack of scientific information on R. matsumuranus leaves contributed to the investigation of th...
The present work realized the chemical study of Silene sibirica (L.) Pers. (Caryophyllaceae) high-performance liquid chromatography with diode array and mass spectrometric detection (electrospray ionization) (HPLC-DAD-ESI-MS). As a result, 25 compounds were found, including nine ecdysteroids and sixteen flavonoids. Ecdysteroids components were pode...
Chromatographic separation of extracts from the aerial parts of three Silene species (Caryophyllaceae) isolated 26 flavonoids including the four new C,O-glycosylflavones acacetin-6-C-(2″-O-β-D-glucopyranosyl)-β-D-glucopyranoside-7-O-β-D-glucopyranoside (sileneside D, 1) from S. jeniseensis Willd., apigenin-6-C-(2″-O-β-D-glucopyranosyl)-β-D-glucopyr...
Functional beverages constitute the rapidly increasing part of the functional food section and represent an area with a wide range of products including herbal-based beverages. We carried out screening investigations of the extracts of 85 Rosaceous tea plants. Among the extracts analyzed Agrimonia asiatica herb extract demonstrated the highest inhi...
The aim of the present work was to estimate the choleretic effect of dry extracts derived from Carthamus tinctotius L., Calendula officinalis L. and Tagetes erecta L.
Materials and methods: The experiments were carried out on white male rats weighing 180–230 g. The extracts in a single dose were introduced into the duodenum of the rats at the doses...
Serratula centauroides L. is a plant species of the Asteraceae family common in Cisbaiklia and containing phytoecdysteroids. As a result of chromatographic separation of the aerial part of S. centauroides growing in Buryatia Republic, nine compounds were isolated and identified based on UV, NMR and mass spectrometry data. The presence of six compou...
The members of Gentiana genus are widely distributed in the Caucasus region where they are used as phytoremedies, but they still have not been studied for their chemical composition and bioactivity. High-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection (HPLC-DAD-ESI-QQQ-MS) was used to investigate...
Chemical research of Silene genus focused on the study of terpene compounds including ecdysteroids and triterpenoids, to the detriment of other classes of compounds. One of these poorly estimated groups of substances is flavonoids, namely C-/O-glycosyl flavones, widely represented within the family Caryophyllaceae. Early studies revealed the presen...
Two new ellagic acid glycosides were isolated from Punica granatum L. (Lythraceae) pericarps and identified using UV and NMR spectroscopy and mass spectrometry as 1,6′-di-O-ellagoylgentiobiose (granatoside A, 1) and 1,6-di-O-ellagoyl-β-D-glucopyranose (granatoside B, 2). Compounds 1 and 2 exhibited α-glucosidase inhibitory activity.
Fringed sagewort (Artemisia frigida Willd., Compositae family) is a well-known medicinal plant in Asian medical systems. Fifty-nine hydroxycinnamates and flavonoids have been found in A. frigida herbs of Siberian origin by high-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection (HPLC-DAD-ESI-QQQ-MS)...
With obesity, the consumption of phenolic-enriched food additives as a part of traditional nutrition avoids the negative implications of eating high-calorie products. This study investigated the new herbal food additive, Phlojodicarpus sibiricus roots and herb, ubiquitously used in Siberia as a spice. Chromatographic techniques such as HPLC-DAD-ESI...
Leaves of Rhaponticum uniflorum (L.) DC. (Asteraceae) afforded 46 compounds including seven new flavonoids that were identified using UV, IR, and NMR spectroscopy and mass spectrometry as 6-hydroxyluteolin-7-O-(2′-O-caffeoyl)-β-D-glucopyranoside (rhaunoside A, 1), 6-hydroxyluteolin-7-O-(6″-O-cinnamoyl)-β-D-glucopyranoside (rhaunoside B, 2), 6-hydro...
Spiraea L. belongs to a genus of deciduous-leaved shrubs in the Rosaceae family that is abundant in Eastern Siberia. The study of six species of Spiraea growing in the Baikal region revealed that they were characterized with high content of phenolic compounds and their extracts demonstrated an inhibitory effect on α-amylase. It was established usin...
A method for the rapid quantitative analysis of 20-hydroxyecdysone in plants was developed using the microcolumn reversed-phase HPLC with UV detection (246 nm) on the ProntoSIL-120-5-C18 column (2×75 mm) and the gradient eluent system LiClO4/HClO4-acetonitrile. The chromatographic stage of the analysis was 5 minutes long, which made it possible to...
The phenolic compounds of Inonotus rheades (Pers.) Bondartsev and Singer (Hymenochaetaceae), a typical xylotrophic basidiomycete, and accumulation of styrylpyrones in mycelium under the influence of light of different wavelengths were investigated. Six styrylpyrones (cis- and trans-hispidin, cis- and trans-bisnoryangonin, and phellinins A1 and A2)...
Artemisia genus of Asteraceae family is a source of medicinal plants known worldwide and used as ethnopharmacological remedies for the treatment of diabetes in Northern Asia (Siberia). The aim of this study was to determine the phenolic profile of 12 Siberian Artemisia species (A. anethifolia, A. commutata, A. desertorum, A. integrifolia, A. latifo...
Rhaponticum uniflorum (L.) DC. is a plant species of the Asteraceae family, widely used in traditional medicine in the Easteren Asia. Currently R. uniflorum is a subject of scientific interest of the chemists, biologists, pharmacologists, and others. This review includes scientific data from 1991 to 2017. The investigation of the chemodiversity of...
Serratula centauroides L. is a plant species of Asteraceae family widespread in Cisbaiklia and containing phytoecdysteroids. As a result of chromatographic separation of the aerial part of S. centauroides growing in Buryatia Republic nine compounds were isolated and identified based on UV, NMR and mass spectrometry data. The presence of six compoun...
A reverse-phase microcolumn HPLC method with UV detection (330 nm) was developed for quantitative analysis of flavonoids of Matricaria chamomilla flowers using a ProntoSIL-120-5-C18 AQ column (60 mm × 1 mm × 5 μm), gradient elution system 0.2 M LiClO4/0.006 M HClO4–acetonitrile and cosmosiin as a reference compound. Optimal conditions for the hydro...
The influence of climatic factors, e.g., low temperature, on the phytochemical composition and bioactivity of the arctic plant Dracocephalum palmatum Steph. ax Willd. (palmate dragonhead), a traditional food and medical herb of Northern Siberia, was investigated. D. palmatum seedlings were grown in a greenhouse experiment at normal (20 °C, NT) and...
A new acylated quercetin glycoside and 36 known compounds were isolated from flowering runners of Spiraea salicifolia L. (Rosaceae). The structures of the new glycoside quercetin-3-O-[6″-(4‴-hydroxy-2‴-methylenebutyroyl)]-β-D-glucopyranoside (spireasalicin, 1) and the 36 known compounds were elucidated using UV, IR, and NMR spectroscopy and mass sp...
A new coumarin glycoside, neoisobaisseoside, was isolated from the flowers of Calendula officinalis L. (Asteraceae), together with three known compounds identified as isobaisseoside, haploperoside A and haploperoside D. The structure of neoisobaisseoside was characterized as 6,7-dihydroxycoumarin-7-О-(2′-О-α-L-rhamnopyranosyl)-β-D-glycopyranoside o...
Spiraea L. is a genus of deciduous shrubs of Rosaceae family widespread on the territory of Eastern Siberia. As a result of the study of six Spiraea species growing on the Baikal region, it was shown that they characterized by a high content of phenolic compounds and their extracts had an inhibitory effect on α-amylase. The use of correlation analy...
Serratula L. and Klasea Cass. are two systematically related genera of Asteraceae family containing phytoecdysteroids, a group of natural terpene compounds with various biological activity. Beginning from the 1970s, 76 phytoecdysteroids were isolated and identified in 13 species of Serratula and 5 species of Klasea. This review presented informatio...
Marigold (Calendula officinalis L.) is one of the most common and widespread plants used medicinally all over the world. The present study aimed to evaluate the anti-acetylcholinesterase activity of marigold flowers, detect the compounds responsible and perform chemical analysis of marigold commercial products. Analysis of 23 varieties of C. offici...
Naturally existing α-glucosidase inhibitors from traditional herbal medicines have attracted considerable interest to treat type 2 diabetes mellitus (DM). The present study aimed to evaluate the anti-α-glucosidase activity of extracts from marsh cinquefoil (Comarum palustre L.), their hypoglycaemic action and detection of the responsible compounds....
In recent years, the increased popularity of functional beverages such as herbal teas and decoctions has led to the search for new sources of raw materials that provide appropriate taste and functionality to consumers. The objective of this study was to investigate the nutritional, phytochemical profiles and bioactivities of possible functional bev...
Two new acylated apigenin glucosides that were identified as apigenin-7-O-(4″-malonyl)-β-Dglucopyranoside (1) and apigenin-7-O-(4″-malonyl-6′′-acetyl)- β-D-glucopyranoside (2) were isolated from edge flowers of Matricaria chamomilla [Chamomilla recutita], variety Podmoskovnaya. The effects of stomach and intestinal juices and cellular microflora on...
The new flavonoid gnaphaloside C, which was identified based on UV, MS, and NMR spectral data as spinacetin-7-O-(6″-O-caffeoyl)-β-D-glucopyranoside, and 24 known compounds including for the first time from this species quercetagetrin, quercetagetin-7-O-(6″-O-caffeoyl)glucoside, patulitrin, tinctoside, and spinacetin-7-O-glucoside were isolated from...
As a result of the wide distribution of herbal teas the data on nutritional characterisation, chemical profile and biological activity of these products are required. The decoctions of Gentiana algida, G. decumbens, G. macrophylla and G. triflora herb teas were nutritionally characterized with respect to their macronutrients, demonstrating the pred...
Some Gentiana species have been used by the nomadic people of Siberia as bitter teas or appetizers to eliminate digestive disorders (dyspepsia, heartburn, nausea, etc.). We studied the most frequently used gentians: Gentiana algida, G. decumbens, G. macrophylla and G. triflora. The aim of the present study was to evaluate the phytochemical features...
Chebulic ellagitannins (ChET) are plant-derived polyphenols containing chebulic acid subunits, possessing a wide spectrum of biological activities that might contribute to health benefits in humans. The herbal formulation Padma Hepaten containing ChETs as the main phenolics, is used as a hepatoprotective remedy. In the present study, an in vitro dy...
A new compound 1 and 19 known ones were isolated from Zingiber officinale Roscoe (Zingiberaceae) rhizomes. The structure of 1 was determined as 3-hydroxy-1-(4'-hydroxy-3'-methoxyphenyl)-octadeca-1,3-dien-5-one (1-dehydro-[14]-gingerdione) based on spectral data. The biological activity of several pure compounds was investigated. It was found that [...
Two new compounds that were identified as mucic acid 2,5-di-O-gallate (1) and mucic acid 2,5-di-O-gallate 1,4-lactone (2) and 14 known compounds, including for the first time in a plant 3,4,6-tri-O-galloyl-D-glucose, were identified by a phytochemical investigation of Phyllanthus emblica (Phyllanthaceae) fruit. Compounds 1 and 2 exhibited pronounce...
A chemical study of Potentilla anserina L. herb (Rosaceae) of Siberian origin led to the isolation of 17 compounds. Three ellagitannins—potentillin, agrimonic acid A and B—are reported for the first time in this species. With a view to rapid quantitative analysis, a new method was developed for simultaneous determination of major phenolic compounds...
Flavonoids are a class of natural phenolic compounds that show antioxidant properties. Besides the known mechanisms of action of flavonoids (binding/inactivation of free radicals and other reactive oxygen species) that determine this effect, an important factor is their ability to bind transition metal ions. In this paper, we used a HPLC method wit...
Four new flavonoids that were identified using chemical transformations and UV, MS, PMR, and 13C NMR spectroscopy were isolated from flower heads of Calendula officinalis (Asteraceae). The compounds were quercetin 3-O-(4″-α-L-rhamnopyranosyl)-β-D-glucopyranoside (calendoside I), quercetin 3-O-(3″-α-L-rhamnopyranosyl)-β-D-glucopyranoside (calendosid...
A new phenylpropanoid that was identified as 1,5-di-O-isoferuloylquinic acid (1) and 17 known compounds including 1,5-di-O-feruloylquinic acid (2), which was obtained for the first time from a plant and was synthesized previously, were isolated from pollen of Calendula officinalis. Compounds 1 and 2 were the dominant phenolic compounds from pollen...
An ethanolic extract and its ethyl acetate-soluble fraction from leaves of Calendula officinalis L. (Asteraceae) were found to show an inhibitory effect on amylase. From the crude extract fractions, one new phenolic acid glucoside, 6'-O-vanilloyl- β -D-glucopyranose, was isolated, together with twenty-four known compounds including five phenolic ac...
A total of 39 known compounds and two new flavonoid glycosides that were identified as isorhamnetin-3-O-(2''-acetyl)-beta-D-glucopyranoside and isorhamnetin-3-O-(2'',6''-diacetyl)- beta-D-glucopyranoside were isolated from florets of Calendula officinalis (Asteraceae). The distribution of phenolic compounds in morphological groups of C. officinalis...
