Nina Christiansen

University of Leipzig · Department of Pediatric Oncology

We recently identified Galectin-1 (Gal-1), a β-galactoside-binding lectin, as a novel immune regulator in neuroblastoma (NB). Here, we characterized the tolerogenic function of Gal-1 within the CD8+ T cell compartment and further evaluated its relevance as an antigen for effective DNA vaccination against NB in a mouse model. NB cells with Gal-1 kno...

Congenital plasminogen (Plg) deficiency leads to the development of ligneous membranes on mucosal surfaces. Here, we report our experience with local and intravenous fresh frozen plasma (FFP). We retrospectively reviewed medical files of 17 patients and their eight first-degree relatives. Conjunctivitis was the main complaint. Thirteen patients wer...

Objective: Type I plasminogen deficiency (Plgdef) is an uncommon chronic inflammation of mucous membranes. Gingival enlargements usually proceed with progressive periodontal destruction and tooth-loss. Plasmin(ogen)-independent enzymatic mechanisms for fibrin clearance have already been discussed in the literature. Our primary objective was to ver...

Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks anti-tumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extra-cranial solid childhood tumor, is not known. Here, we demonstrate for the first time a prognostic relev...

Reliable diagnostic strategies for individuals with cancer demand practical methods for highly sensitive and specific detection of tumor cells. Amplification of genomic regions that include putative oncogenes is common in tumor cells of various types. Genomic array platforms offer the opportunity to identify and precisely map amplified genomic regi...

Zusammenfassung Zu den in der pädiatrischen Onkologie wesentlichen höhergradigen gliomatösen Tumoren zählen das anaplastische Astrozytom, das maligne Hirnstammgliom sowie das Glioblastom. Trotz derzeitiger multimodaler Therapie, bestehend aus Tumorresektion, Bestrahlung und zytostatischer Therapie, ist die Prognose der betroffenen Kinder schlecht....

Purpose: We compared the expression of the insulin receptor-related receptor (IRR) in primary human neuroblastomas with other biological and clinical parameters and the impact of its expression on prognostic outcome. Experimental Design: We studied 49 neuroblastomas of different clinical stages and histological subtypes for (a) IRR, insulin-like gr...

We compared the expression of the insulin receptor-related receptor (IRR) in primary human neuroblastomas with other biological and clinical parameters and the impact of its expression on prognostic outcome. We studied 49 neuroblastomas of different clinical stages and histological subtypes for (a) IRR, insulin-like growth factor 1 receptor (IGF-1R...

RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases betwe...

Neuroblastoma tumors are characterized by aberrations of chromosome 1. Rapid detection of these chromosomal aberrations at diagnosis could give important clues to outcome and therapy. We attempted to detect numerical and structural aberrations of chromosome 1 not only by classical metaphase cytogenetics but also by interphase cytogenetics in order...

http://deepblue.lib.umich.edu/bitstream/handle/2027.42/47534/432_2005_Article_BF01625409.pdf

12 primary neuroblastomas (NB) of different maturation stages, 2 ganglioneuromas (GN), and 2 neuroblastoma cell lines were analysed for RNA expression of the protooncogene N-myc and the gene encoding the nerve growth factor receptor (NGF-r) by Northern-blots, RNA-dot-blots and for receptor presence by immunohistological procedures. In 4 tumors with...

Chromosome deletion at the short arm of one chromosome 1 (1p32)—the most common aberration in neuroblastoma cells—was found to be combined with the generation of a homogeneously staining region at this specific site in a newly established neuroblastoma cell line (GI-LI-N) from a stage IV neuroblastoma. By in situ hybridization this homogeneously st...

Eine Kopplung eines Homöobox Gens, Xi-X, von 15 cM mit den platyspezifischen Pigmentzellloci (PSPL) bzw. dem Tu-Komplex im Xiphophorus Melanom-Modell konnte gefunden werden. Ein Xi-X Transkript von 1,5 kb charakterisiert die Zellen der Grundfärbung (Mikromelanophoren, Xanthophoren) und die undifferenzierten Zellstadien. Ein anderes Transkript von 2...

Thesis (M.S.D.)--Indiana University School of Dentistry. Vita. Includes abstract (1 leaf). Available also on microfilm, No. 33. Includes bibliographical references (leaves 103-106).