Nimisha Singh

University of Burgundy | UB · Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB)

Because of their unique photophysical properties and superior sensitivity, the optically active nanoparticles are extensively applied in the field of sensing, biosensing and bioimaging. Over the past few years, the polymeric nanoparticles (PNPs) have emerged as a novel, optically active nanomaterial because of their high and tunable fluorescence qu...

Nanomaterials have a huge potential in the research fields from nanomedicine to medical devices. However, surface modifications of nanoparticles (NPs) and thus of their physicochemical properties failed to predict their biological behavior. This requires investigating the “missing link” at the nano-bio interface. Protein corona (PC), the set of pro...

Multifunctional iron oxide magnetic nanoparticles, among them nanorods, were prepared with a mussel-inspired polydopamine (pDA) surface coating agent for cancer therapeutics. Taurine, a free sulfur-containing ß amino acid, was grafted on the pDA at the iron oxide nanoparticle surface to enhance its biocompatibility and targeted delivery action. Dox...

Different blood groups of ABO system have specific antigen which bestows them with different biochemical properties and hence they can show different hemolytic activity. In this report, hemolytic activity of thiol-functionalized Fe3O4-Au nanoparticles were studied in presence and absence of doxorubicin and the effect of various thiol coatings were...

Glutathione (GSH) coated gold‑iron oxide core shell nanoparticles (GS-Au-Fe 3 O 4 ) were prepared by coating glutathione shell on nanoparticles to reduce the dose dependent behaviour of anticancer drug, doxorubicin (DOX). The resultant nanoparticles were characterized using XPS, FTIR, HR-TEM with STEM profile to analyze the GSH shell over the surfa...

Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone of pDA enhances the binding efficiency of various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in the cytoplasm, was immobilized on the pDA-IONP surface. It serve...

A novel mechanism was developed to study the interaction of mussel inspired polydopamine surfaces with bovine serum albumin using cyclic voltammetry and electrochemical Impedance spectroscopy supplemented with XPS, IR, UV and Atomic Force microscopy. The polydopamine surfaces reveal different mechanism that gives a new insight in understanding the...

Inorganic sulphidenanoparticles (NPs) were prepared by wrapping the magnetic iron oxide NPs with thin shell (5 nm) of zinc sulphide. The as prepared NPs show maximum mercury removal capacity of 98–99% under ambient conditions from tap, ground and polluted river water without any pre-treatment. The magnetic nanoparticlesinteract with toxic mercuric...

The morphology and physiochemical properties of polydopamine is not totally inherent and undergo changes with reaction conditions like choice of solvent used for polymerization. The polymerisation of dopamine to polydopamine carried out in different solvents like sodium hydroxide, sodium bicarbonate, PBS and Tris reveals exceptionally different mor...

Nitric oxide releasing superparamagnetic (Fe3O4-Au@NTHP) nanoparticles were synthesized by conjugation of human biomarker of nitric oxide, N-nitrosothioproline with iron oxide-gold (Fe3O4-Au) core shell nanoparticles. The structure and morphology of the prepared nanoparticles were confirmed by ATR-FTIR, HR-TEM, EDAX, XPS, DLS and VSM measurements....

Inspired by the biochemical reaction of of L-4-Thiazolidinecarboxylic acid (thioproline, TCA) with nitric oxide in human body, a novel method was developed to quantify the NO2⁻ in biological matrix at very high sensitivity and selectivity. The developed assay has added advantage over traditional Griess reagent and can be employed for the clinical a...

Gastrointestinal (GI) tract has a unique mechanism for nitric oxide (NO) capture in the form of N-nitrosamines. N-Nitrosamines are formed by the reaction between thioproline (THP) and NO under the acidic conditions prevalent in the stomach. The nitrosamines thus formed are excreted in the urine and act as an important biomarker for human NO concent...