Nikos Mattheos

Nikos Mattheos
Chulalongkorn University · Faculty of Dentistry

DDS, MASc, PhD

About

150
Publications
62,474
Reads
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3,554
Citations
Additional affiliations
February 2020 - present
Karolinska Institutet
Position
  • Researcher
January 2020 - present
Chulalongkorn University
Position
  • Professor
January 2016 - July 2017
The University of Hong Kong
Position
  • Head of Faculty

Publications

Publications (150)
Article
Objectives: The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR). Materials & methods: 236 medically and periodontally healthy...
Article
Background: Computer-assisted implant surgery (CAIS) can facilitate accuracy of single implant placement, but little is known with regards to parallelism between multiple implants. Purpose: To compare the accuracy of position and parallelism of two implants, using static and dynamic CAIS systems. Materials and methods: Thirty patients received...
Article
Full-text available
Emerging evidence points towards significant interrelations between the condition of the peri-implant tissue and the implant-abutment-prosthesis complex. A new paradigm is essential, where the peri-implant tissues will be studied in close interrelation with the implant, abutment and prosthesis complex, under the presence of oral biofilm. The aim of...
Article
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Lateral Window sinus surgery, also known as Caldwell-Luc antrostomy is an operation aiming to approach structures of the sinus cavity through the anterior wall of the maxilla. It was introduced by George Caldwell (1893) and Henry Luc (1897) as an operation to remove irreversibly damaged mucosa of the maxillary sinus (1). In ENT and Maxillofacial Su...
Article
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Objective: The aim of this review was to investigate the evidence correlating the emergence profile (EP) and emergence angle (EA), peri-implant tissue height, implant neck design, abutment and/or prosthesis material, retention and connection types with risk of peri-implant mucositis and peri-implantitis. Methods: Seven focus questions were ident...
Article
This case report describes a novel approach combining orthodontic and implant digital treatment planning workflows to enable prosthetically driven implant placement before orthodontic treatment is performed or completed. The computer-assisted implant placement is performed using a static surgical guide based on the future positions of the teeth aft...
Article
Functional overload has long been suspected as a cause of complications and failures in implant dentistry, with, however, limited solid evidence in this direction. Damaging effects of excessive or adverse loading can be manifested on the peri-implant bone or on the mechanical implant components. Although theoretically possible, an objective definit...
Article
Full-text available
The aim of this study is to assess the stress distribution on the bone tissue and bone-implant interface of a customized anatomic root-analog dental implant (RAI) by means of finite element analysis (FEA) for different types of bone density. A mandibular right second premolar was selected from the CBCT database. A DICOM file was converted to an STL...
Article
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Computer Assisted Implant Surgery (CAIS), either as static or dynamic, is well documented to significantly improve the accuracy of implant placement. Whether the increased accuracy leads to corresponding improvement of clinical outcomes, has not yet been systematically investigated. The aim of this critical review was to investigate whether the us...
Article
The optimal implant position is a critical factor for long-term success in fully edentulous patients. Implants can be placed through conventional freehand, static computer-assisted implant surgery (CAIS), or dynamic CAIS protocols, but at present there is very limited clinical evidence on their accuracy in fully edentulous patients. This study was...
Article
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Purpose: 1) To investigate tissue features and interproximal contour of posterior implant supported single crowns (ISSC), which correlate with food impaction. 2) To evaluate the influence of food impaction on the health of the adjacent peri-implant tissue and patients' oral health related quality of life (OHRQoL). Materials and methods: Patients...
Article
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Computer Assisted Implant Surgery is increasingly popular, with almost every implant system racing to deliver the most reliable technology and protocols. Either as static or dynamic, CAIS promises unprecedented accuracy in implant placement and evidence now shows that it delivers. But is it just about accuracy? How reliable is this technology and...
Article
This systematic review was conducted to evaluate the available literature on the clinical outcomes of the use of autogenous tooth bone graft prepared chairside, and its current applications. A literature search was done to answer the focused questions "In partially edentulous patients, what are the alveolar ridge volumetric changes, histological fi...
Article
Objective: The effect of different deproteinized bovine bone mineral (DBBM) particle sizes on bone healing in maxillary sinus floor augmentation remains unclear. This study compared the newly formed tissue and angiogenesis-related bone healing after sinus floor augmentation using large or small DBBM particles. Materials and methods: Overall 32 p...
Article
Introduction As implant therapy is a widely applied treatment modality, general dentists are in the frontline of maintaining health in patients with implants. It is however unknown to what extent general dentists are competent and feel prepared to deliver maintenance of implants to patients. Objectives The aim of this study was to investigate the...
Article
Full-text available
Objective: To evaluate the influence of implant and prosthetic components on peri-implant tissue health. A further aim was to evaluate peri-implant soft-tissue changes following surgical peri-implantitis treatment. Materials and methods: Group discussions based on two systematic reviews (SR) and one critical review (CR) addressed (i) the influen...
Article
Background: Appropriate patients' perceptions as one of Patient Reported Outcome Measures (PROMs), are shown to be critical for the sustainable success of implant therapy, little is known however of how they prospectively evolve throughout the treatment process. Objective: This study aimed to prospectively assess patients' perceptions before and...
Article
Acemannan, a linear polysaccharide produced by Aloe vera, has been shown to have important biological effects promoting wound healing and tissue regeneration. The aim of this randomized clinical trial was to investigate the impact of acemannan in guided bone regeneration (GBR) with simultaneous implant placement. Twenty patients were randomly alloc...
Article
Objective The purpose of this study was to compare patient-reported outcomes and experiences (PROs and PREs) among three techniques of dental implant placement, including (a) conventional freehand, (b) dynamic, and (c) static computer-aided implant surgery (CAIS). Material and methods Ninety patients were randomly assigned to have dental implant p...
Article
Background: Different designs of surgical drilling systems have been developed for the purpose of static Computer-Assisted Implant Surgery (sCAIS), but there is at present little understanding of how design principles affect the accuracy of implant placement. Purpose: The aim of this in vitro study was to compare the accuracy of implant placemen...
Article
Purpose: To test the hypothesis that surface roughening and polishing of ceramics have no effect on their surface roughness and biofilm adhesion. Materials and methods: Feldspathic ceramic Vitablocks™ TriLuxe forte (VTF), lithium disilicate glass IPS e.max Press™ (IPS) and zirconia reinforced lithium silicate Vita Suprinity™ (VS) ceramic blocks...
Article
Full-text available
Purpose: To investigate the impact of different extents of misfit between a restoration and the supporting implant on veneer fractures in screw-retained implant-supported metal-ceramic fixed dental prostheses (FDPs). Materials and methods: A finite element analysis (FEA) model of a five-unit screw-retained metal-ceramic FDP supported by three im...
Article
Background: To compare the effects of icariin and teriparatide on the treatment of medication-related osteonecrosis of jaw (MRONJ using a rat model. Methods: 50 rats undergoing ovariectomy were randomly assigned to control group (n = 10) and MRONJ model group (n = 40). 0.2 mg/kg zoledronic acid and 2 mg/kg dexamethasone were injected into rats i...
Article
Background and objective: Peri-implantitis is a biofilm-mediated infectious disease that results in progressive loss of implant-supporting bone. As compared to its analogue periodontitis, peri-implantitis is generally known to be more aggressive, with comparatively rapid progression and less predictable treatment outcomes, especially when advanced...
Article
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Objective: To profile the salivary microbiomes of a Hong Kong Chinese cohort at a species-level resolution and determine species that discriminated clinically resolved periodontitis from periodontally healthy cases. Methods: Salivary microbiomes of 35 Hong Kong Chinese subjects’ under routine supportive dental care were analysed. All subjects had b...
Article
Data from cone beam computed tomography (CBCT) and optical scans (intraoral or model scanner) are required for computer-assisted implant surgery (CAIS). This study compared the accuracy of implant position when placed with CAIS guides produced by intraoral and extraoral (model) scanning. Forty-seven patients received 60 single implants by means of...
Article
Objective: The aims of this study were to evaluate and analyze the factors affecting patients' perceptions and satisfaction after receiving implant treatment. Material and methods: Questionnaires were mailed to 691 patients who had completed implant treatment for at least 6 months. The questionnaire consisted of 23 items, including demographic d...
Poster
Full-text available
Objectives: To analyze similarities in gene expression patterns of peri-implant soft tissue and experimental foreign body reaction. Methods: Publicly available microarray data of gene-expression (Affymetrix Rat Genome 230-2.0 Array) from normal rat peri-implant soft-tissue (GSE43744) and experimentally induced early foreign body reaction (FBR)...
Article
Aim: This randomized controlled clinical trial (RCT) aimed to compare the accuracy of implant positions between static computer-assisted implant surgery (CAIS) and freehand implant surgery in a single edentulous space. Materials and methods: Sites with single edentulous spaces and neighbouring natural teeth were randomized into static CAIS or fr...
Article
Full-text available
Aims: To explore molecular mechanisms that link periimplantitis and type 2 diabetes mellitus (T2DM) by bioinformatic analysis of publicly available experimental transcriptomic data. Materials and methods: Gene expression data from periimplantitis affected tissues were downloaded from the GEO database, integrated, differentially expressed genes (DE...
Article
Objectives The aim of this RCT was to compare the accuracy of implant placement between static and dynamic computer‐assisted implant surgery (CAIS) systems in single tooth space. Materials and methods A total of 60 patients in need of a single implant were randomly assigned to two CAIS groups (Static n = 30, Dynamic n = 30) and implants were place...
Article
Full-text available
The ability of spatial representation is one of the most important competences of an oral surgeon, but also a challenging competence to assess in educational settings. The aim of this pilot study was to investigate the impact of a hands‐on simulation practice on the development of the Dental Anatomy Spatial Representation Ability (DASRA) of recent...
Article
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Objectives: To perform an exploratory analysis of factors influencing annual rates of peri-implant marginal bone loss (RBL) calculated over different time-frames, at implants unaffected by peri-implantitis. Material and Methods: 154 implants from 86 patients were reviewed at 1.6-6.8 years after placement. Marginal bone levels (MBL) were assessed on...
Article
Objective To prospectively evaluate Patient Reported Outcome Measures (PROMs) and treatment outcomes of mandibular two‐implant retained overdentures (IOD) in an edentulous geriatric cohort with history of deficient Complete Dentures (CD). Materials and Methods 103 patients with deficient CD received new optimal CD. After a period of 3 months, 80 o...
Article
Full-text available
Background Massive Open Online Courses (MOOCs) have been often described as a major innovation Higher Education, but their application in the teaching of clinical disciplines is still very limited, while there is a lack of scientific evaluations in this domain. The aim of this study was to investigate learners’ behaviors and correlate patterns of S...
Article
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Objectives: The aim of this cross-sectional study was to explore the demographic and educational patterns related to the dentists' first implant dental experience. Material and methods: Participants of a Massive Open Online Course in implant dentistry who have placed and restored implants completed a 25-item online questionnaire investigating th...
Article
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Background and Objective: Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms towards hypothesis development, based on information discovery. To aim of this study was to explore potential Periodontitis-Rheum...
Article
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Objectives: The aim of Working Group 3 was to focus on three topics that were assessed using patient-reported outcome measures (PROMs). These topics included the following: (a) the aesthetics of tooth and implant-supported fixed dental prostheses focusing on partially edentulous patients, (b) a comparison of fixed and removable implant-retained pr...
Article
Full-text available
Objective The aim of this systematic review was to compare patient‐reported outcomes measures (PROMs) of implant‐supported fixed complete dentures (IFCDs) and overdentures (IODs). Material and methods PubMed, Cochrane Library, EMBASE, Scopus and Web of Science were searched, complemented by manual search. Studies published in English up to Novembe...
Article
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Objectives This retrospective study assessed radiographic bone changes and prevalence of peri‐implant inflammation around teeth and neighboring implants supporting a single‐unit fixed dental prosthesis (FDP), in relation to implant‐ positioning and characteristics. Material and Methods Patients with an implant‐supported FDP in function for at leas...
Article
Purpose: The aim of this pilot study was to investigate the morphological micro-features of 3 commercially available implant-abutment joints, using compatible and original prosthetic components and to explore the correlation between the micromorphology and potential functional complications. Methods: Three abutments (one original and two compati...
Conference Paper
Objectives: To determine salivary microbiome configurations and indicator taxa of a chronic periodontitis phenotype in cohorts from two different populations; Indian and Chinese. Methods: 51 Indian and 39 Hong Kong Chinese (HK) adults (30-65 years), under supportive dental care, were evaluated. Subjects had been treated for dental caries and perio...
Article
Statement of problem: Evidence for micromorphology and precision of fit of third-party prosthetic components compared with the original manufacturer's components is lacking. Purpose: The purpose of this in vitro pilot study was to evaluate the micromorphological differences among different commercial brands of zirconia, titanium, and gold abutme...
Article
Objective: This study was intended to investigate the effects of Icariin on the healing of tooth extraction sites under systemic administration of Zoledronic and Dexamethasone. Method: Thirty female rats underwent bilateral ovariectomy and were randomly assigned to 5 groups: SS group received weekly injection of saline while ZD, ZD+LICA, ZD+MICA...
Article
Full-text available
Objective: The advent of high-throughput sequencing and 'omic' technologies is facilitating an 'open-ended' understanding of the human microbial community and its interplay with health. This commentary aims to present key perspectives and summarize current evidence from metagenomic studies of salivary microbiota in relation to general health and s...
Article
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Purpose of Review Dental wear is an existing and increasing problem. This review aims to describe the prosthodontic principles as well as the current trends in materials and techniques for the rehabilitation of patients with worn dentition. Recent Findings The current literature includes a lot of information in relation to clinical and laboratory...
Article
Background: Resonance Frequency Analysis (RFA) is widely applied to assess implant stability, as expressed by Implant Stability Quotient (ISQ). However, the relation between ISQ value and the presence and extent of narrow marginal bone defects around implants has not been documented. Purpose: To investigate the potential of RFA devices to identi...
Article
Full-text available
Objective: To profile salivary microbiomes of an urban-living, healthy Indian cohort and explore associations with proinflammatory status. Methods: 51 clinically healthy Indian subjects' salivary microbiomes were analyzed using 16S rRNA Illumina MiSeq sequencing. Community distribution was compared with salivary data from the Human Microbiome Pr...
Article
Background: The aim of this study was to investigate the micromorphological differences among three commercially available titanium abutments on Straumann implants. Furthermore, the possible impact of functional loading on the micromorphology and potential complications was investigated with the use of in vitro testing. Material and methods: Thr...
Conference Paper
Objectives: To analyze via next-generation sequencing and microbiome-based clustering, how periodontal disease experience over 4 decades linked with subgingival plaque composition in a historical, well-studied Sri-Lankan tea worker cohort. Methods: Subgingival plaque was collected from 23 subjects with over 40-years clinical periodontal data and an...
Article
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Background The objective of this pilot study was to evaluate the effect of local application of low-magnitude high-frequency vibration (LMHFV) on the bone healing of rabbit calvarial defects that were augmented with different grafting materials and membranes. Methods Four calvarial defects were created in each of two New Zealand rabbits and filled...
Article
Objective: Technical complications such as veneer fractures are more common in implant-supported than tooth-supported restorations. The underlying causes have not been fully identified. The aim of this study was to evaluate whether misfit between the restoration and the implant may affect the risk of veneer fractures. Materials and methods: Twen...
Article
Full-text available
Objectives: This study aims to assess the educational value of YouTube patient testimonial videos in implant dentistry and qualitatively analyse the themes mentioned. Methods: Videos were sampled consecutively on YouTube, using the keywords "dental implant patients' testimonials experience," sorted "by relevance." Patient testimonials on dental...
Article
Objective: The purpose of this prospective clinical study was to determine whether reduced bone mineral density (BMD) is correlated with a higher risk for dental implant therapy in an elderly patient population. Material and methods: Seventy-nine patients recruited at the Prince Philip Dental Hospital were provided with 2-implant-supported mandi...
Article
Objectives: The aim of this study was to investigate the gene expression profile related to guided bone regeneration (GBR) at the early healing stage while using combinations of different biomaterials. Materials and methods: Cranial defects in 4 New Zealand rabbits were filled with A) biphasic calcium phosphate/experimental pericardium-derived c...
Article
Objectives: To compare patient-centered outcome assessments (POAs) over a 2-week period after five categories of dento-alveolar surgical procedures. Methods: A total of 339 patients in need of dento-alveolar surgical procedures such as simple tooth extraction (SE), transalveolar extraction (TE), straightforward implant placement (I), implant pla...
Article
Objective: While research in terms of patient-centered care in implant therapy is growing, few studies have investigated patients' initial perceptions prior to consultation with the implant dentist. The aim of this cross-sectional study was to capture patients' initial information level, perceptions, as well as expectations from the implant therap...
Article
Full-text available
Background: What patients expect to happen during treatment or benefit from the treatment might influence the subsequent factors such as treatment outcome, patient satisfaction, patient's cooperation as well as compliance. The aim of this systematic review is to assess th