Nikos Mattheos

Nikos Mattheos
Chulalongkorn University · Faculty of Dentistry

DDS, MASc, PhD

About

186
Publications
100,677
Reads
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5,126
Citations
Additional affiliations
February 2020 - present
Karolinska Institutet
Position
  • Researcher
January 2020 - present
Chulalongkorn University
Position
  • Professor
January 2016 - July 2017
The University of Hong Kong
Position
  • Associate Dean

Publications

Publications (186)
Article
Full-text available
Emerging evidence points towards significant interrelations between the condition of the peri-implant tissue and the implant-abutment-prosthesis complex. A new paradigm is essential, where the peri-implant tissues will be studied in close interrelation with the implant, abutment and prosthesis complex, under the presence of oral biofilm. The aim of...
Article
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Objective: The aim of this review was to investigate the evidence correlating the emergence profile (EP) and emergence angle (EA), peri-implant tissue height, implant neck design, abutment and/or prosthesis material, retention and connection types with risk of peri-implant mucositis and peri-implantitis. Methods: Seven focus questions were ident...
Article
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Computer Assisted Implant Surgery (CAIS), either as static or dynamic, is well documented to significantly improve the accuracy of implant placement. Whether the increased accuracy leads to corresponding improvement of clinical outcomes, has not yet been systematically investigated. The aim of this critical review was to investigate whether the us...
Article
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Objectives: The aim of this study was to investigate the association of the Mucosal Emergence Angle (MEA) with peri-implant tissue mucositis. Material and methods: Forty-seven patients with 103 posterior bone level implants underwent clinical and radiographic examination. Three-dimensional data from Cone Bean Computer Tomography and Optica Scan...
Article
Current research has identified features of the prosthetic design with potential to significantly impact the long-term health of peri-implant tissues, while the choice of prosthetic components is also shown to be critical in an effort to reduce long-term complications of implant therapy. Overcontouring of the prosthesis emergence profile has been a...
Article
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Aim To (i) evaluate structured postgraduate part‐time programs in periodontology, including those addressing peri‐implant diseases, among members of the European Federation of Periodontology (EFP), (ii) the impact of the 2018 classification scheme and EFP clinical practice guidelines and (iii) propose a framework for periodontal vocational educatio...
Article
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Aim To assess the influence of the emergence angle on marginal bone loss (MBL) and supracrestal soft tissue around dental implants. Materials and Methods In six mongrel dogs, the mandibular premolars and molars were extracted. After 3 months of healing, four dental implants were placed in each hemimandible. The implants were randomly allocated to...
Article
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Background Osseointegrated dental implants are widely established as a first-choice treatment for the replacement of missing teeth. Clinical outcomes are however often compromised by short or longer-term biological complications and pathologies. Nanoparticle-coated materials represent a very active research area with the potential to enhance clinic...
Article
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Background/purpose: Computer-assisted implant surgery (CAIS) is increasingly performed to reduce deviations in implant position. Dynamic CAIS or navigation systems provide instant display of implant drilling instruments and patient positions directly on the computer monitor. Augmented reality (AR) technology allows operators to visualize real-time...
Article
Objective Computer‐assisted implant surgery (CAIS) has been introduced as a tool to aid in reaching a more accurate implant position. The aim of this network meta‐analysis was to compare all the available CAIS techniques and obtain collective evidence on the method that offers the highest accuracy compared to freehand implant placement. Materials...
Article
Objective: The use of extracted teeth has been introduced as an option for bone grafting. However, the current method requires special machines and solutions, posingsignificant time and cost. The aim of this study was to evaluate the clinical performance of autogenous raw tooth particles (RTP), a grafting material made from aground tooth using basi...
Article
Background/Purpose: The increasing importance of computer assisted implant surgery (CAIS) in the practice of implant dentistry calls for adequate education and training of clinicians. However, limited evidence exists to support optimal educational strategies and best practices. This study aimed to investigate the effectiveness of distributed traini...
Article
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Background/purpose: Many designs of static computer-assisted implant surgery (sCAIS) are available for clinician to achieve proper implant position. However, there were not any studies that approached the design alone to evaluate whether sleeve-in-sleeve or sleeve-on-drill design provided most accuracy implant position. The purpose of this study wa...
Article
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Objectives The primary aim of this cross‐sectional study was to investigate the association between prosthesis design and peri‐implant mucosa dimensions and morphology. The secondary aim was to investigate associations between mucosal dimensions and the presence of mucositis. Materials and Methods Forty‐seven patients with 103 posterior bone level...
Article
In this study, hydroxyapatite (HAp) was synthesized from natural biowaste materials, specifically mussel shells, and combined with chitosan (CS) and gentamicin sulfate antibiotic (GA) using an in-situ method. The resulting composite material, designated HAp/CS-GA, has its physicochemical and structural properties characterized by Fourier transform...
Article
Objectives To assess navigation accuracy for complete‐arch implant placement with immediate loading of digitally prefabricated provisional. Materials and Methods Consecutive edentulous and terminal dentition patients requiring at least one complete‐arch FDP were treated between December 2020 and January 2022. Accuracy was evaluated by superimposin...
Article
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The purpose of this review was to summarize the evidence with regard to behavioral and psychosocial assessment of the periodontitis patient, the candidate for implant therapy, and the peri‐implantitis patient. Periodontitis has an adverse effect on quality of life and its treatment can lead to significant improvements experienced by the patient. Th...
Article
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Objective Cyanoacrylate tissue adhesive has been presented as an alternative to sutures and several studies have compared them. The objective of this meta-analysis was to evaluate the effect of cyanoacrylate tissue adhesive on postoperative pain and swelling, following mandibular third molar surgery. Materials and Methods Database search was condu...
Article
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This mapping review highlights the need for a new paradigm in the understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on the relationship between biofilm, inflammation, and bone biology. The close interactions between immune and bone cells are discussed, wi...
Article
Aims The aim of this randomized controlled clinical trial was to compare the gene expression, micro‐CT, histomorphometrical analysis between biphasic calcium phosphate (BCP) of 70/30 ratio and deproteinized bovine bone mineral (DBBM) in sinus augmentation. Materials and Methods Twenty‐four patients in need for sinus floor augmentation through late...
Article
Evidence-based implant dentistry (EBID) is part of the ITIʼs DNA and its philosophy, and it is clearly reflected in our Purpose, Mission, and Value statements. It is one of our key differentiators and reassures dentists and ultimately patients that we strive for excellence in everything we do. The aim of this position paper is to define EBID and o...
Article
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Peri-implantitis, a prevalent complication in dental implant therapy, poses a significant threat to long-term implant success. The identification of reliable biomarkers for the early detection and monitoring of peri-implantitis is crucial for timely intervention and improved treatment outcomes. Salivary and peri-implant sulcular fluid (PISF) biomar...
Article
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Objective This scoping review aimed to (1) critically evaluate the outcomes measures used to assess the accuracy of implant placement with Computer Assisted Implant Surgery (CAIS) and (2) review the evidence supporting the efficient implementation of CAIS in training and education of clinicians. Methods A scoping literature review was conducted ai...
Article
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Introduction The aim of this study was to assess the students' experience with education during the COVID‐19 pandemic, as well as to investigate their views moving forward after resumption of face‐to‐face education. Materials and Methods A questionnaire was administered to dental students in clinical dental education at seven dental schools. The q...
Article
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Objectives Although studies have revealed that dentists’ mental health was initially affected by the COVID-19 pandemic, there are no reports on how this notion has evolved during the pandemic years. The aim of this study therefore was to compare Thai dentists’ stress prevalence and levels due to the pandemic over a three period of the pandemic, 202...
Article
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Objectives The aim of Working Group 4 was to address patient benefits associated with implant dentistry. Focused questions on (a) dental patient‐reported outcomes (dPROs), (b) improvement in orofacial function, and (c) preservation of orofacial tissues in partially and fully edentulous patients following provision of implant‐retained/supported dent...
Article
Objective: To compare the accuracy of implant position, using a combination of static and dynamic computer-assisted implant surgery (CAIS), with either static, dynamic, or freehand implant placement, in fully edentulous arches. Materials and Methods: Twenty-one patients with a total of 88 fixtures were in- cluded. Implants were divided equally int...
Article
Objectives: This systematic review aimed to evaluate the current evidence on the effectiveness of autogenous dentin block graft prepared chairside for alveolar ridge augmentation and compare its clinical outcomes to the main available grafting materials and techniques. Materials and methods: Three databases were screened, including prospective c...
Article
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Purpose The Allogenic Demineralized Dentin Matrix (Allo-DDM) has been introduced as a new grafting material, and several investigations were conducted, showing its efficacy in bone augmentation. The objective of this systematic review was to evaluate the available literature on the Allo-DDM, revealing its clinical performance when used for implant...
Article
Background: Hemostatic agents are used to control bleeding after tooth extraction and have been compared with conventional measures (that is, sutures or gauze pressure) in several studies. The objective of this systematic review was to evaluate the benefits of topical hemostatic agents for controlling bleeding after tooth extractions, especially i...
Article
Aims: The aim of this randomized, double- blind, clinical trial was to compare the sta-bility of the horizontal dimensions (facial bone thickness) of augmented bone using biphasic calcium phosphate (BCP) with hydroxyapatite/β- tricalcium phosphate ratio of either 60/40 or 70/30. Materials and Methods: Sixty dental implants placed with contour augm...
Article
Bone regeneration is currently one of the most widely researched topics in regenerative medicine. Several bone-grafting materials have been introduced and compared. However, the limitations of the currently available grafts have led researchers to investigate new materials to be used. In contrast, the periosteum performs endogenous bone regeneratio...
Article
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Objectives: Recent research has suggested the contour of the prosthesis and the vertical height of the peri‐implant mucosa as important parameters that can influence the long term health and stability of the peri‐implant tissue. In particular, overcontouring of the prosthesis has been correlated with an increased risk for peri‐implantitis, while re...
Article
Background: Dynamic Computer Assisted Implant Surgery (CAIS) systems have beenshown to improve accuracy of implant placement, thus training in the use of suchsystems is becoming increasingly important. There is a scarcity of research on how to implement dynamic CAIS training in the settings of postgraduate universityeducation. Purpose: To determine...
Article
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Computer Assisted Implant Surgery has helped us increase accuracy of implant placement and empower a new era of immediacy, even in cases of complex surgeries. Although most modern systems of guided surgery or implant navigation can reduce deviation to less than a millimetre, the legendary “zero miss” remains elusive. At the same time, we star...
Article
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This study aimed to investigate the effect of the lack of keratinized mucosa on the risk of peri-implantitis, while also accounting for possible confounding factors. A literature search was conducted in PubMed and Scopus, including human studies that assessed the presence and width of keratinized mucosa in relation to the occurrence of peri-implant...
Article
Objective: To compare implant accuracy of combined static and dynamic (SD) computer assisted implant surgery (CAIS) with static (S), dynamic (D) CAIS and freehand surgery (FH) for single implant placement. Materials and methods: 120 patients were randomized into four groups. Implants were placed using both stereolithographic surgical guide and d...
Article
This case report describes a novel approach combining orthodontic and implant digital treatment planning workflows to enable prosthetically driven implant placement before orthodontic treatment is performed or completed. The computer-assisted implant placement is performed using a static surgical guide based on the future positions of the teeth aft...
Article
Functional overload has long been suspected as a cause of complications and failures in implant dentistry, with, however, limited solid evidence in this direction. Damaging effects of excessive or adverse loading can be manifested on the peri-implant bone or on the mechanical implant components. Although theoretically possible, an objective definit...
Article
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The aim of this study is to assess the stress distribution on the bone tissue and bone-implant interface of a customized anatomic root-analog dental implant (RAI) by means of finite element analysis (FEA) for different types of bone density. A mandibular right second premolar was selected from the CBCT database. A DICOM file was converted to an STL...
Article
The optimal implant position is a critical factor for long-term success in fully edentulous patients. Implants can be placed through conventional freehand, static computer-assisted implant surgery (CAIS), or dynamic CAIS protocols, but at present there is very limited clinical evidence on their accuracy in fully edentulous patients. This study was...
Article
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Purpose: 1) To investigate tissue features and interproximal contour of posterior implant supported single crowns (ISSC), which correlate with food impaction. 2) To evaluate the influence of food impaction on the health of the adjacent peri-implant tissue and patients' oral health related quality of life (OHRQoL). Materials and methods: Patients...
Article
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Computer Assisted Implant Surgery is increasingly popular, with almost every implant system racing to deliver the most reliable technology and protocols. Either as static or dynamic, CAIS promises unprecedented accuracy in implant placement and evidence now shows that it delivers. But is it just about accuracy? How reliable is this technology and...
Article
This systematic review was conducted to evaluate the available literature on the clinical outcomes of the use of autogenous tooth bone graft prepared chairside, and its current applications. A literature search was done to answer the focused questions "In partially edentulous patients, what are the alveolar ridge volumetric changes, histological fi...
Article
Objective: The effect of different deproteinized bovine bone mineral (DBBM) particle sizes on bone healing in maxillary sinus floor augmentation remains unclear. This study compared the newly formed tissue and angiogenesis-related bone healing after sinus floor augmentation using large or small DBBM particles. Materials and methods: Overall 32 p...
Article
Introduction As implant therapy is a widely applied treatment modality, general dentists are in the frontline of maintaining health in patients with implants. It is however unknown to what extent general dentists are competent and feel prepared to deliver maintenance of implants to patients. Objectives The aim of this study was to investigate the...
Article
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Objective: To evaluate the influence of implant and prosthetic components on peri-implant tissue health. A further aim was to evaluate peri-implant soft-tissue changes following surgical peri-implantitis treatment. Materials and methods: Group discussions based on two systematic reviews (SR) and one critical review (CR) addressed (i) the influen...
Article
Background: Appropriate patients' perceptions as one of Patient Reported Outcome Measures (PROMs), are shown to be critical for the sustainable success of implant therapy, little is known however of how they prospectively evolve throughout the treatment process. Objective: This study aimed to prospectively assess patients' perceptions before and...
Article
Acemannan, a linear polysaccharide produced by Aloe vera, has been shown to have important biological effects promoting wound healing and tissue regeneration. The aim of this randomized clinical trial was to investigate the impact of acemannan in guided bone regeneration (GBR) with simultaneous implant placement. Twenty patients were randomly alloc...
Article
Objective The purpose of this study was to compare patient-reported outcomes and experiences (PROs and PREs) among three techniques of dental implant placement, including (a) conventional freehand, (b) dynamic, and (c) static computer-aided implant surgery (CAIS). Material and methods Ninety patients were randomly assigned to have dental implant p...
Article
Background: Different designs of surgical drilling systems have been developed for the purpose of static Computer-Assisted Implant Surgery (sCAIS), but there is at present little understanding of how design principles affect the accuracy of implant placement. Purpose: The aim of this in vitro study was to compare the accuracy of implant placemen...
Article
Full-text available
Lateral Window sinus surgery, also known as Caldwell-Luc antrostomy is an operation aiming to approach structures of the sinus cavity through the anterior wall of the maxilla. It was introduced by George Caldwell (1893) and Henry Luc (1897) as an operation to remove irreversibly damaged mucosa of the maxillary sinus (1). In ENT and Maxillofacial Su...
Article
Background: Computer-assisted implant surgery (CAIS) can facilitate accuracy of single implant placement, but little is known with regards to parallelism between multiple implants. Purpose: To compare the accuracy of position and parallelism of two implants, using static and dynamic CAIS systems. Materials and methods: Thirty patients received...
Article
Purpose: To test the hypothesis that surface roughening and polishing of ceramics have no effect on their surface roughness and biofilm adhesion. Materials and methods: Feldspathic ceramic Vitablocks™ TriLuxe forte (VTF), lithium disilicate glass IPS e.max Press™ (IPS) and zirconia reinforced lithium silicate Vita Suprinity™ (VS) ceramic blocks...
Article
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Purpose: To investigate the impact of different extents of misfit between a restoration and the supporting implant on veneer fractures in screw-retained implant-supported metal-ceramic fixed dental prostheses (FDPs). Materials and methods: A finite element analysis (FEA) model of a five-unit screw-retained metal-ceramic FDP supported by three im...
Article
Background: To compare the effects of icariin and teriparatide on the treatment of medication-related osteonecrosis of jaw (MRONJ using a rat model. Methods: 50 rats undergoing ovariectomy were randomly assigned to control group (n = 10) and MRONJ model group (n = 40). 0.2 mg/kg zoledronic acid and 2 mg/kg dexamethasone were injected into rats i...
Article
Objectives: The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR). Materials & methods: 236 medically and periodontally healthy...
Article
Background and objective: Peri-implantitis is a biofilm-mediated infectious disease that results in progressive loss of implant-supporting bone. As compared to its analogue periodontitis, peri-implantitis is generally known to be more aggressive, with comparatively rapid progression and less predictable treatment outcomes, especially when advanced...
Article
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Objective: To profile the salivary microbiomes of a Hong Kong Chinese cohort at a species-level resolution and determine species that discriminated clinically resolved periodontitis from periodontally healthy cases. Methods: Salivary microbiomes of 35 Hong Kong Chinese subjects' under routine supportive dental care were analyzed. All subjects had b...
Article
Data from cone beam computed tomography (CBCT) and optical scans (intraoral or model scanner) are required for computer-assisted implant surgery (CAIS). This study compared the accuracy of implant position when placed with CAIS guides produced by intraoral and extraoral (model) scanning. Forty-seven patients received 60 single implants by means of...
Article
Objective: The aims of this study were to evaluate and analyze the factors affecting patients' perceptions and satisfaction after receiving implant treatment. Material and methods: Questionnaires were mailed to 691 patients who had completed implant treatment for at least 6 months. The questionnaire consisted of 23 items, including demographic d...
Poster
Objectives: To analyze similarities in gene expression patterns of peri-implant soft tissue and experimental foreign body reaction. Methods: Publicly available microarray data of gene-expression (Affymetrix Rat Genome 230-2.0 Array) from normal rat peri-implant soft-tissue (GSE43744) and experimentally induced early foreign body reaction (FBR)...
Article
Aim: This randomized controlled clinical trial (RCT) aimed to compare the accuracy of implant positions between static computer-assisted implant surgery (CAIS) and freehand implant surgery in a single edentulous space. Materials and methods: Sites with single edentulous spaces and neighbouring natural teeth were randomized into static CAIS or fr...
Article
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Aims: To explore molecular mechanisms that link periimplantitis and type 2 diabetes mellitus (T2DM) by bioinformatic analysis of publicly available experimental transcriptomic data. Materials and methods: Gene expression data from periimplantitis affected tissues were downloaded from the GEO database, integrated, differentially expressed genes (DE...
Article
Objectives The aim of this RCT was to compare the accuracy of implant placement between static and dynamic computer‐assisted implant surgery (CAIS) systems in single tooth space. Materials and methods A total of 60 patients in need of a single implant were randomly assigned to two CAIS groups (Static n = 30, Dynamic n = 30) and implants were place...
Article
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The ability of spatial representation is one of the most important competences of an oral surgeon, but also a challenging competence to assess in educational settings. The aim of this pilot study was to investigate the impact of a hands‐on simulation practice on the development of the Dental Anatomy Spatial Representation Ability (DASRA) of recent...
Article
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Objectives: To perform an exploratory analysis of factors influencing annual rates of peri-implant marginal bone loss (RBL) calculated over different time-frames, at implants unaffected by peri-implantitis. Material and Methods: 154 implants from 86 patients were reviewed at 1.6-6.8 years after placement. Marginal bone levels (MBL) were assessed on...
Article
Objective To prospectively evaluate Patient Reported Outcome Measures (PROMs) and treatment outcomes of mandibular two‐implant retained overdentures (IOD) in an edentulous geriatric cohort with history of deficient Complete Dentures (CD). Materials and Methods 103 patients with deficient CD received new optimal CD. After a period of 3 months, 80 o...
Article
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Background Massive Open Online Courses (MOOCs) have been often described as a major innovation Higher Education, but their application in the teaching of clinical disciplines is still very limited, while there is a lack of scientific evaluations in this domain. The aim of this study was to investigate learners’ behaviors and correlate patterns of S...
Article
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Objectives: The aim of this cross-sectional study was to explore the demographic and educational patterns related to the dentists' first implant dental experience. Material and methods: Participants of a Massive Open Online Course in implant dentistry who have placed and restored implants completed a 25-item online questionnaire investigating th...
Article
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Background and Objective: Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms towards hypothesis development, based on information discovery. To aim of this study was to explore potential Periodontitis-Rheum...