Nikoletta Jedlinszki

Nikoletta Jedlinszki
University of Szeged · Department of Pharmacognosy

About

30
Publications
12,632
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381
Citations
Additional affiliations
September 2011 - present
University of Szeged
Position
  • Research Assistant

Publications

Publications (30)
Article
The aim of this study was to prove whether Ginkgo biloba food supplements on the European market comply with pharmaceutical quality, and whether their composition satisfies the European Pharmacopoeia criteria. Medicinal products containing a standardised Ginkgo leaf extract are used for the improvement of cognitive impairment and quality of life in...
Article
Mutagenic and teratogenic pyrrolizidine alkaloids (PAs) have been identified in several plant species. The industrially most important PA-containing plant is Symphytum officinale (common comfrey). The application of its root is restricted in several countries due to its PA content. In medicines, the daily alkaloid quantity and duration of treatment...
Article
Background: . Silybum marianum (milk thistle) or its active flavonolignan complex, silymarin is widely used in the treatment of liver diseases of toxic and viral origin, and also in Wilson's disease to prevent chronic liver impairment. Purpose: Based on the available data it is probable that milk thistle-based preparations include copper in signifi...
Article
Background: Caffeine and L-theanine are pharmacologically important constituents of tea, especially due to their effects on the central nervous system. The effects of these two compounds are opposite: While caffeine is a well-known stimulant, theanine has a relaxing effect. Tea processing may influence the caffeine and theanine content of tea leav...
Article
Silybum marianum (milk thistle) has been used for centuries as a herbal medicine for the treatment of liver diseases. Its purified active fraction, silymarin, is applied in treatment of liver diseases of toxic and viral origin in the modern therapy. The plant and its products are applied in the treatment of patients suffering from Wilson's disease...
Poster
Full-text available
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0035-1565834 Products containing the standardized Ginkgo biloba L. (Ginkgoaceae) leaves extract, EGb 761, are used for the “improvement of cognitive impairment and of quality of life in mild dementia” (EMA-HMPC). The herbal drug Ginkgonis folium is used for the treatment of periph...
Article
In the last three decades more than 350 different hepatotoxic pyrrolizidine alkaloids (PAs) have been identified in several plant species. The application of Symphiti radix is restricted in several countries due to its PA content. In medicines, the daily alkaloid quantity and duration of treatment is limited even in case of topical application. Due...
Article
Full-text available
The radish-like hypocotyls of Maca (Lepidium meyenii Walp., Brassicaceae) are widely consumed as common vegetable in the Andean highlands. It is considered as healthy food, rich in carbohydrates and protein, a herbal medicine with a general invigorating reputation and fertility and sexual performance enhancer. The latter is the most popular contemp...
Article
Full-text available
The aim of the present work was to develop and validate an HPLC-MS/MS method for the determination of a major pyrrolizidine alkaloid of comfrey (lycopsamine) in aqueous samples as a basis for the development of a method for the determination of absorption of lycopsamine by human skin. A linear calibration curve was established in the range of 1.32-...
Article
Two new 2,2-dimethyl-chromene derivatives and the new pentaisovaleryl sucrose were isolated from the roots of Artemisia asiatica together with the known 1-(5-acetyl-2,4-dihydroxy-phenyl)-3-methyl-butan-1-one, 6-hydroxytremetone and (E)-coniferyl aldehyde. The structures of the compounds were elucidated by extensive 1D (1H, 13C and JMOD) and 2D (1H-...
Article
The neuronal and smooth muscle effects of a methanol extract prepared from the air-dried flowering aerial parts of Sideritis montana L. (SME) was tested in vitro on Guinea-pig ileum. The chemical composition of the investigated extract was analysed by HPLC-MS, and chrysoeriol, chlorogenic acid and caffeic acid were detected as main constituents. Th...
Article
Full-text available
The popular South African herbal tea, honeybush, is made from several Cyclopia species (family: Fabaceae), amongst them Cyclopia genistoides. Phytoestrogenic potential of C. genistoides. has been recently reported, however bioactivity-guided isolation of compounds with estrogenic activity has not yet been performed. A transgenic plant system, Arabi...
Article
Full-text available
Two new arylbenzofuran-type neolignans, 1″-dehydroegonol 3″-methyl ether (1) and egonol 3″-methyl ether (2), and four known lignan derivatives, namely, helioxanthin (3), (7E)-7,8-dehydroheliobuphthalmin (4), heliobuphthalmin (5), and 7-acetoxyhinokinin (6), were isolated from a chloroform-soluble partition of the methanol extract of the fresh roots...
Article
Chelidonium majus or greater celandine is spread throughout the world, and it is a very common and frequent component of modern phytotherapy. Although C. majus contains alkaloids with remarkable physiological effect, moreover, safety pharmacology properties of this plant are not widely clarified, medications prepared from this plant are often used...
Article
Full-text available
Alkamides are one of the most important constituents of lipophilic extracts of Echinacea angustifolia roots. These compounds play an important role in the versatile pharmacological actions of this plant. The present study aimed to compare the concentrations of isomeric dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (DTAI) in brain and periepi...
Article
The MeOH extract of the aerial parts of Artemisia asiatica significantly inhibited the xanthine oxidase (XO) induced uric acid production. Flavonoids were isolated from the active extract and identified as eupatilin (1), hispidulin (2), jaceosidin (3), cirsilineol (4), 5,7,4',5'-tetrahydroxy-6,3'-dimethoxyflavone (5), 6- methoxytricin (6) and chrys...
Article
Full-text available
l-Theanine, an amino acid occurring in the leaves of the tea plant (Camellia sinensis) possesses several beneficial pharmacologic effects. Its effects on the central nervous system are most widely studied, in addition, other activities (potential anticancer, cardiovascular) also stress the significance of this compound. However, analytical methods...
Article
Full-text available
The leaves of Morus alba L. have a long history in Traditional Chinese Medicine and also became valued by the ethnopharmacology of many other cultures. The worldwide known antidiabetic use of the drug has been suggested to arise from a complex combination effect of various constituents. Moreover, the drug is also a potential antihyperuricemic agent...
Article
The synthesis, structure elucidation and the complete (1) H and (13) C signal assignment of a series of dioxolane derivatives of 20-hydroxyecdysone, synthesized as novel modulators of multidrug resistance, are presented. The structures and NMR signal assignment were established by comprehensive one-dimensional and two-dimensional NMR spectroscopy s...
Article
Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were determined by means of LC-MS, 1D and 2D NMR spectr...
Article
Full-text available
Phenothiazines when exposed to white light or to UV radiation undergo a variety of reactions that result in degradation of parental compound and formation of new species. This process is slow and may be sped up with exposure to high energy light such as that produced by a laser. Varying concentrations of Chlorpromazine Hydrochloride (CPZ) (2-20 mg/...
Article
An assessment of the accuracy and precision of collinear multi-pulse laser induced breakdown spectrometry (MP-LIBS) analysis of soldering tin samples for their lead and tin content was performed. Quantitative results from inductively coupled plasma (ICP) atomic emission spectrometry carried out on dissolved samples were used as reference. For this...
Article
A detailed study of the relevant analytical figures of merit for time- and spatially integrated multi-pulse laser induced breakdown spectroscopy (MP-LIBS) was performed. Laser bursts containing up to 6, ns-range duration collinear pulses, separated by 20–40μs interpulse gaps were used in the experiments, and the effect of the number of pulses withi...
Article
Full-text available
Multi-pulse laser-induced breakdown spectroscopy (LIBS) in the collinear pulse configuration with time-integrating detection was performed on metallic samples in ambient air in an effort to clarify the contributing processes responsible for the signal enhancement observed in comparison with single-pulse excitation. Complementary experiments were al...
Article
A group of researchers respond to comments from a number of authors on one of their research papers. They state that they appreciate criticism from other authors, as such comments help them to improve their method, along with its analytical capability. They also state that they agree with most of the comments of the authors, as they help in improvi...
Article
Multi-pulse laser induced breakdown spectroscopy (LIBS), in combination with the generalized linear correlation calibration method (GLCM), was applied to the quantitative analysis (fineness determination) of quaternary gold alloys. Accuracy and precision on the order of a few thousandths (‰) was achieved. The analytical performance is directly comp...

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