Nikolett Varró

Semmelweis University | SOTE

Carnosine and homocarnosine have long been known to be important constituents of the human metabolome, performing pH- and redox homeostasis-related roles. These are the most important imidazole-containing ‘small’ chemical entities in biological media. In this work these dipeptides were studied by 1H NMR-pH titration under near-physiological conditi...

Intrinsically disordered proteins (IDPs) play important roles in disease pathologies; however, their lack of defined stable 3D structures make traditional drug design strategies typically less effective against these targets. Based on promising results of targeted covalent inhibitors (TCIs) on challenging targets, we have developed a covalent desig...

Foldamers are non-natural oligomers that mimic the structural behaviour of natural peptides, proteins and nucleotides by folding into a well-defined 3D conformation in solution. Since their first description about two decades ago, numerous studies have been undertaken dealing with the design, synthesis, characterization and application of foldamers...

In the present publication, multiwalled carbon nanotubes (MWCNT) coated with SiO2–MgO nanoparticles were successfully fabricated via sol–gel method to facilitate their incorporation into polymer matrices. Magnesium acetate tetrahydrate and tetraethyl orthosilicate were used as precursors. The coated MWCNTs were characterized by transmission electro...