Nikoleta Parahuleva

Medical University Plovdiv · Department of Obstetrics and Gynecology

The widespread adoption of tattoos and permanent makeup across all social classes and age groups globally has led to an increase in reports of subsequent health problems. This article presents a systematic review aimed at investigating the potential health risks associated with body modifications (tattoos and permanent makeup), highlighting the nee...

To create a review of the published scientific literature on the benefits and potential perspectives of the use of 3D bio-printing in the field of pharmaceutics. This work was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting meta-analyses and systematic reviews. Th...

Background: The implementation of surfactant for respiratory syndrome approbates the therapy as a revolutionary method inintensive neonatal therapy and respiratory resuscitation. It is important to investigate the costs of this treatment. Objective: The aim of the study is to analyze the data by the application of the surfactant Curosurf to preterm...

Citation: Toshev A, Petkova-Gueorguieva E, Mihaylova A, Pavlova G, Parahuleva N, Balkanski S, Peikova L, Getova V, Madzharov V, Gueorguiev S (2024) Health Emergency Preparedness and Response Authority's (HERA) role in dealing with the monkeypox emergency in the European Union. Pharmacia 71: 1-6. https://doi. Abstract The current article examines an...

Recent studies show that hospitalized COVID-19 patients have an increased incidence of arrhythmia, especially atrial fibrillation (AF). This single-center study included 383 hospitalized patients with positive polymerase chain reaction tests for COVID-19 from March 2020 to April 2021. Patient characteristics were documented, and data were analyzed...

Endometrial cancer (EC) has been associated with an increased risk of cardiovascular disease, including atrial fibrillation (AF). We performed a prospective, case-controlled analysis among 310 Bulgarian women with new-onset, histologically confirmed EC, free of AF at the baseline survey, and women with normal (senile) endometrium/endometrial hyperp...

Thrombophilia, congenital or acquired, is a condition characterized by an increased tendency for thrombosis in circulation. Pregnant women with thrombophilia have a high risk of vascular thrombotic events during pregnancy and postpartum, as well as spontaneous fetal loss. Pregnancy predisposes to thrombotic events, especially in patients with a his...

Introduction: Thrombophilia is a rare medical problem that may be inherited or acquired. In pregnant women with thrombophilia, there is a high risk of vascular thrombotic incidents during pregnancy and postpartum as well as spontaneous loss of the fetus. Antithrombotic therapy should be included in the diagnosis. The use of anti-aggregates and low...

It is known that control of procedural pain in newborns is an ethical act and requires treatment. It includes homeopathic agents used in certain clinical conditions in neonatology. The purpose of this prospective study is to determine the effect of administration of the preparation of Arnica D30 to reduce the severity of procedural pain induced by...

Objective: Anti-Mullerian hormone (AMH) was highlighted as a valid marker of ovarian dysfunction inwomen with anovulatory polycystic ovarian syndrome (PCOS) and was linked with cardiovascularconditions. This study was designed to determine the circulating AMH levels in different phenotypes ofPCOS without additional risk factors for atherosclerosis...

Poland Syndrome is a rare condition evident at birth that includes a wide range of malformations of chest and arm. The exact cause of the syndrome is unknown, but genetic involvement and a vascular abnormality of the subclavian artery are suspected. We report two cases of right-sided Poland Syndrome with true dextrocardia, diagnosed in neonatal per...

Premature birth is a significant medical, social and economic problem worldwide. In the 21st Century in developed countries, this problem accounts for over two thirds of neonatal deaths. In Bulgaria, statistics show that 10-12% of all pregnancies end with premature birth. Despite the number of studies in this field and the efforts made by obstetric...

Premature birth is a serious medical, social and economic problem. Its consequences are multiple health complications leading to high neonatal mortality worldwide. Respiratory insufficiency and surfactant deficiency significantly increase the risk of developing Hyaline Membrane Disease (HMD) and other forms of Respiratory Distress (RDS). These are...

In recent years, the objectification and control of neonatal pain has caused many discussions. Given its early and late effects, researchers' efforts are aimed at minimizing the impact of maternal and child-related factors, with a possible effect on pain sensitivity in new-borns. Our aim is to study the influence of maternal factors (daily intake o...

Preterm birth is a medical and severe socioeconomic problem. It is the most common cause of neonatal mortality in developed countries represents 80% of all deaths worldwide in neonatology (over 1.1 million) and more than 30% of the same in Europe. In the United States as of 2010 over 12% of all births are preterm, where 30% increase is observed sin...

Premature birth is the most common cause of neonatal mortality in developed countries (5, 13, 15, 16). Over 80% of all cases of death in the world are result of neonatology premature birth (6, 29). The complications which are result of preterm birth are significant socioeconomic problem and the hyaline membrane disease (HMD) is in the leading place...

The aim of the following study is to present the current evidence of antenatal use of corticoids in premature birth. The benefits of antenatal use of corticosteroids after 34 week of gestation is still a process of discussion.

Premature birth (PB) occurs in 5% to 18% of births in the world. Children born prematurely are at increased risk of death, major neonatal complications, long-term adverse consequences for health and development. The cause of spontaneous preterm birth is often unknown, but it is believed that intrauterine infection is implicated in 40% of cases. The...

Clinical case: It is about a girl 17 years and 9 months,transported to OG Clinic at University Hospital "St. George" 10 days after a normal vaginal delivery, with complaints of fever and debilitating hip pain in left gluteal area. Streptococcus pyogenes was isolated as in the culture of lochial secretions, as well as in the tested blood culture. T...

Increasing number of studies during the last years reveal that steroid hormone vitamin D not only regulate calcium metabolism but it influences and other biological processes like glucose metabolism, neural function, cardio-vascular and reproductive systems. More and more clinical data suggests that normal plasma vitamin D levels are required for p...

Unlabelled: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and the leading cause of oligo/anovulatory infertility. The incidence of PCOS in the population is 5-10% depending on the phenotypic expression of the syndrome as use criteria for diagnosis Anti- Mullerian Hormone may be defined as a gly...

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder which deficiency of the platelet glycoprotein IIb - III a. The disorder usually manifests as severe mucocutaneus bleeding in the chaildhood, menstrual patterns in pubertal--adolescent years, rarely life-threatening. Pregnancy and delivery in patients with TG are very rare and are...

Objective: Atherosclerosis, as an inflammatory disease, is characterized by pathologically altered levels of cytokines. We investigated whether smoking and/or oral contraceptives (OCs) affect the CD40/CD40L plasma levels and expression in young females without other risk factors for atherosclerosis. Patients and methods: A case-control single-ce...

Unlabelled: Polycystic Ovary Syndrome is the most common endocrine disorder in women of reproductive age, whose final pathogenesis remains unclear. PCOS is a distinctive disorder of follicular growth leading to obstruction of the selection of the dominant follicle, and as a result--arrest at small antral follicles. Anti-Mullerian hormone (AMH) is...

Introduction: Contemporary data show that there is a link between insulin resistance and preeclampsia (PE) due to many common features. Material and methods: We examined 90 pregnant women at the clinic of Obstetrics and Gynecology at the University Hospital "St.George". 35 of them were preeclamptic and 55 normotensive. Glucose levels were measur...

Anti-Mullerian hormone (AMH) is a glycoprotein produced by the granulosa ovarian cells with respect to the regulation of the follicular growth and development. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disturbances affecting 6-7 of women in reproductive age. Women with PCOS exhibit a number of metabolic and endocrine dist...