Nikolay Atanasov Yanev

Nikolay Atanasov Yanev
Medical University of Sofia · Department of Pulmonary Diseases

Doctor of Medicine

About

49
Publications
1,889
Reads
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40
Citations
Citations since 2016
35 Research Items
39 Citations
201620172018201920202021202202468101214
201620172018201920202021202202468101214
201620172018201920202021202202468101214
201620172018201920202021202202468101214
Introduction
Nikolay Atanasov Yanev currently works at the Department of Pulmonary Diseases, Medical University of Sofia. Nikolay does research in Interventional Pulmonology and Respiratory Medicine.
Additional affiliations
August 2018 - present
Medical University of Sofia
Position
  • Professor (Assistant)
August 2018 - present
Medical University of Sofia
Position
  • Professor (Assistant)
June 2012 - January 2017
Medical University of Pleven
Position
  • Professor (Assistant)
Education
June 2011 - October 2015
Medical University of Pleven
Field of study
  • Pulmonary diseases; COPD
September 2004 - September 2010
Medical University of Pleven
Field of study
  • Medicine

Publications

Publications (49)
Article
Full-text available
(1) Background: A number of studies have demonstrated the connection between develop- ing or exacerbating chronic respiratory diseases in adults and children. However, still, few studies focus on reducing exacerbations via immunomodulation. (2) Methods: In this pilot study, a total of 25 pediatric and adult patients with bronchial asthma (BA) and c...
Article
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Background: Each year, approximately two million adolescents and young adults in the world become infected with tuberculosis (TB). The problem is that the classification of the disease includes children in the age group 0-14 years and young adults aged 15 and over. The present study aims to analyze and compare the epidemiology and clinical present...
Article
Full-text available
Introduction: Diaphragmatic dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). This study aimed to assess the prognostic significance of impaired diaphragmatic movement at rest and after exercise. Methods: This was a prospective study of patients with stable COPD. Diaphragmatic movements were examined at rest an...
Article
Full-text available
Introduction The Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy report provides guidance on effective management of chronic obstructive pulmonary disease (COPD) according to local healthcare systems. However, COPD is a heterogenous disease and certain aspects, including prevalence, disease–time course and phenotype distribut...
Article
Full-text available
Introduction and importance Thyroid cancer is the most common endocrine malignancy, while primary paraganglioma of the thyroid gland (TP) is an unusual tumour and in rare cases, this disease tends to mimic thyroid cancer. They are rare extra-adrenal neuroendocrine tumours originating from the neural crest, and are found almost exclusively in the he...
Article
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Immunoglobulin G4-related disease (IgG4-RD) is a lymphoproliferative disease which is described almost exclusively in adults. There are only a few pediatric patients who have been observed with this disorder. Here, we describe a rare case of IgG4-RD in a 17-year-old girl with a single manifestation—tracheal stenosis without previous intubation or o...
Article
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Background In recent years, there has been a revolution in the genomic profiling and molecular typing of lung cancer. A key oncogene is the epidermal growth factor receptor (EGFR). The gold standard for determining EGFR mutation status is tissue biopsy, where a histological specimen is taken by a bronchoscopic or surgical method (transbronchial bio...
Article
Full-text available
Background In recent years, there has been a revolution in the genomic profiling and molecular typing of lung cancer. A key oncogene is the epidermal growth factor receptor (EGFR). The gold standard for determining EGFR mutation status is tissue biopsy, where a histological specimen is taken by a bronchoscopic or surgical method (transbronchial bio...
Article
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Objectives: Obtaining qualitative, sufficient material for the diagnosis of malignancies in cases with normal endoscopic findings in patients with suspected lung cancer and hilar and mediastinal lymphadenopathy is challenging. Materials and methods: Endobronchial ultrasound (EBUS) was used to control a transbronchial needle biopsy (ТBNA) for the fi...
Article
Background Understanding the risk factors for exacerbations of COPD may help provide a more personalised approach to exacerbation prevention. Method Observational, prospective, international, multicentre study aimed at identifying risk factors for exacerbations of COPD. Clinical variables, lung function and CAT scores were collected at baseline. I...
Article
Full-text available
Surgical interventions for corrosive stricture of the esophagus are extremely difficult and technically challenging. In this manuscript, we present a patient with esophagectomy due to perforation of a corrosive stricture of the esophagus that underwent malignant transformation and subsequent perforation of a giant duodenal stress ulcus, which occur...
Article
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Introduction: Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations. Methods: Cross-sectional, multicentre study performed in four centres in Spain, Italy, Bulgaria, and Slo...
Article
Introduction Granulomatosis with polyangiitis is rare but severe necrotizing vasculitis. Disseminated and limited forms are distinguished. The latter are characterized by only upper respiratory tract and/or lung and/ or glomerulonephritis. The lung involvement is confirmed with fibrobronchoscopy. Aim The aim of the study is to present the bronchos...
Article
Introduction Present medical care for the children with cystic fibrosis (CF) improves the quality and the duration of life, although digestive and respiratory dysfunction, chronic infections, progressive lung destruction and growth retardation leads to premature death. Our aim is to review the morbidity and mortality in patients with CF in Central...
Article
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Aspergillus is a fungus which could cause a number of infectious and allergic diseases especially in immunocompromised patients. We report a case of 15-year-old boy with a small post- pneumonic cavity formation in the 3rd segment of the right lung. After conventional intravenous antibiotic treatment the X-ray changes were still persisting. The boy...
Article
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Background: At present, there is little information in Bulgaria regarding the rate and stability of frequent-exacerbation phenotype in COPD patients. Aim: To study the rate and stability of frequent-exacerbation phenotype in COPD patients. Materials and methods: We followed up 465 COPD patients for exacerbations over a 3-year period. Exacerbations...
Article
Full-text available
In recent years, there has been a revolution in genomic profiling and molecular typing of lung carcinoma. Full genomic profiling is recommended forassessment of optimal personalized therapy. The epidermal growth factor receptor (EGFR) is a key oncogene for targeted therapy. A gold standard for determining EGFR mutation status is histological specim...
Article
Full-text available
Background: Autofluorescence bronchoscopy (AFB) allows a more sensitive approach to the diagnosis of premalignant and malignant endobronchial lesions than white light bronchoscopy (WLB) can do. Aim: To assess the autofluorescence bronchoscopy and white light bronchoscopy in diagnosing malignant endobronchial lesions. Materials and methods: The desi...
Article
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As part of a retrospective study on bronchoscopies performed at the Clinic of Pneumonology and Phthisiatry of the University Hospital - Pleven by autofluorescence bronchoscopy we found 3 cases diagnosed with carcinoma in situ. They were treated in different ways - endobronchial electrocoagulation, extraction by forceps biopsy and open surgery, but...
Article
Full-text available
Background: Environmental pollution can be one of the main risk factors for acute exacerbations of chronic obstructive pulmonary disease (COPD). Aim: To study the relationship between air pollution, outdoor temperature and exacerbations of COPD. Materials and methods: COPD patients (n=1432) were followed up for one year. The levels of particul...
Article
Full-text available
The study aimed to assess the inhalation technique of patients with bronchial asthma/chronic obstructive pulmonary disease (COPD) via an objective method and to evaluate the effect of training in patients with incorrect technique. Тhe inhalation technique of 120 patients with obstructive pulmonary disease was tested. The patients were divided into...
Article
Background: Studies showed good correlation between CAT score and mortality in COPD patients. Aim: To study the relationship between CAT score, mortality and exacerbations in COPD patients who require LTOT. Methods: Patients with severe hypoxemia with indications for LTOT were followed up for three years with assessment of symptoms, hospitalization...
Article
Topic: There is not enough data in Bulgaria about the influence of air pollution and outdoor temperature on the frequency of acute exacerbations of COPD (AECOPD). Aim: To study the relationship between the levels of air pollutants and outdoor temperature and frequency of AECOPD. Methods: To observe the frequency of AECOPD we followed 477 hospitaliz...
Article
Introduction Correct inhalation technique is essential part of obstructive pulmonary diseases treatment. Aims To test patients' inhalation technique, to determine most common mistakes during inhalation and to find out factors, which affect the inhalation technique. Methods The inhalation technique of 94 patients with obstructive pulmonary disease (...
Article
Background: Indications for LTOT in patients with moderate hypoxemia (MH) are controversial. Aim: To characterize and compare patients with MH versus patients with severe hypoxemia (SH) with or without access to LTOT. Methods: Patients were added to a registry and were followed up for three years. Main aspects of follow up were mortality, rate of h...
Article
Introduction: GOLD 2014 recommendations categorise COPD patients in four groups, which differ significantly in clinical characteristics and outcomes. Aim: This follow-up study attempted to determine the distribution and stability of GOLD 2014 revision groups in three consecutive years 2012, 2013 and 2014. Methods: A total of 262 (210 male and 52 fe...
Article
Background: The control of asthma is important to maintain normal activity. One of the key points in good asthma control is the management of exacerbations. Aim: To characterize asthmatic patients with and without exacerbations (E). Methods: Specially designed questionnaire was used to evaluate asthma patients from around 37 medical practices acros...
Article
There are COPD patients who are rehospitalised due to recurring COPD exacerbations. Aim: To characterize COPD patients who were rehospitalised due to acute exacerbations of COPD(AECOPD). Methods: We followed retrospectively 544 patients for hospitalization for AECOPD for one year. Information about age, FEV1, CRP, WBC, fibrinogen, comorbidities and...
Article
Introduction: Some of the patients with long-term bronchial asthma present with irreversible airflow limitation (FEO1/FVC< 0.7) on their routine pulmonary function tests. Aims: To analyse outpatients with asthma and FEO1/FVC< 0.7 looking for characteristics that could be easily applied in clinical practice. Methods: Four hundred and forty nine pati...
Article
Introduction: The GOLD 2014 assessment predicts future exacerbations and mortality risk, separating patients into high symptom groups (B, D) and high risk groups (C, D). Aim: Our aim was to investigate hospitalisations, exacerbations and mortality in a 3 year prospective study in outpatients with COPD. Material and Methods: A total of 262 (210 male...
Article
Background: Many studies examine the cost effectiveness of care provided for COPD patients receiving long-term oxygen treatment (LTOT). Aim: The aim of our study was to evaluate the costs for hospital treatment of exacerbations in COPD patients requiring LTOT which is not reimbursed in Bulgaria. Methods: Patients with COPD and indications for LTOT...
Article
Background: The revision of GOLD in 2011 and its updates suggested a more complex approach for the COPD severity evaluation and management. Objectives: To evaluate COPD severity and management in Bulgaria using data from pulmonary specialists (PS) from all over the country. Methods and Material: We applied a specially designed questionnaire to eval...
Article
Objectives To investigate serum zinc concentrations in pediatric patients with cystic fibrosis (CF). Methods 33 children with CF were included in the patient group of the study. They were divided into two sub-groups according to the severity of the clinical manifestation of the malabsorption syndrome. The control group of the study consisted of 28...
Article
Full-text available
Purpose: The clinical aspects of antibiotic resistance (ABR) of patients in ambulatory practice with chronic obstructive pulmonary disease (COPD) are not investigated thoroughly. The aim of the present study is to find the most frequent respiratory pathogens of ambulatory COPD patients and to evaluate the resistance of their isolates to tested anti...
Article
Full-text available
Data concerning the prevalence of AAT deficiency in general population or respiratory patients in CEE countries are limited or non-existent. The overwhelming majority of individuals with AAT deficiency remains undiagnosed. We present data from the CEE A1AT Network established in 2013. DBS samples were collected in 2013 from 866 COPD patients in Po...
Article
Introduction The latest GOLD 2011 recommendations provide an opportunity for a more patient oriented therapeutic approach. Aim This prospective 1-year, follow-up study attempted to determine the direct cost and the cost of associated comorbidities derived from the management of COPD patients hospitalized for an exacerbation. Methods A total of...

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