Nikolay KuleminScientific Research Institute of Physical-Chemical Medicine | SRI PCM · Department of Molecular Biology and Genetics
Nikolay Kulemin
PhD in Bioinformatics
About
54
Publications
23,467
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1,289
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Introduction
Additional affiliations
September 2014 - May 2015
Independent Researcher
Position
- Researcher
September 2011 - June 2012
September 2011 - present
Publications
Publications (54)
About 7% of all cancer deaths are caused by pancreatic cancer (PCa). PCa is known for its lowest survival rates among all oncological diseases and heterogenic molecular profile. Enormous amount of genetic changes, including somatic mutations, exceeds the limits of routine clinical genetic laboratory tests and further stagnates the development of pe...
Fuchs' endothelial corneal dystrophy is a socially significant hereditary disease. More than a half of cases in the European population are caused by the increased number of trinucleotude repeats in the TCF4 gene. The study was aimed to develop and test the approach of dividing patients into groups based on the chip-based genotyping and genome-wide...
Díaz, J, Álvarez Herms, J, Castañeda, A, Larruskain, J, Ramírez de la Piscina, X, Borisov, OV, Semenova, EA, Kostryukova, ES, Kulemin, NA, Andryushchenko, ON, Larin, AK, Andryushchenko, LB, Generozov, EV, Ahmetov, II, and Odriozola, A. The GALNTL6 gene rs558129 polymorphism is associated with power performance. J Strength Cond Res XX(X): 000-000, 2...
Purpose:
To replicate previous genome-wide association study identified sprint-related polymorphisms in 3 different cohorts of top-level sprinters and to further validate the obtained results in functional studies.
Methods:
A total of 240 Japanese, 290 Russians, and 593 Brazilians were evaluated in a case-control approach. Of these, 267 were top...
Background
The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate the association of common single-nucleotide polymorphisms (SNPs) with endurance athlete status in a large cohort of...
Whole genome sequencing (WGS) has great potential to explore all possible DNA variants associated with physical performance, psychological traits and health conditions of athletes. Here we present, for the first time, annotation of genomic variants of elite athletes, based on the WGS of 20 Tatar male wrestlers. The maximum number of high-quality va...
The MGISEQ-2000 developed by MGI Tech Co. Ltd. (a subsidiary of the BGI Group) is a new competitor of such next-generation sequencing platforms as NovaSeq and HiSeq (Illumina). Its sequencing principle is based on the DNB and the cPAS technologies, which were also used in the previous version of the BGISEQ-500 device. However, the reagents for MGIS...
PurposeIron is an important component of the oxygen-binding proteins and may be critical to optimal athletic performance. Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino acid replacement, in the HFE is associated with elevated iron indexes and may give some advantage in endurance-oriented s...
The present study investigated the genetic architecture of muscle fibers composition by means of the genome-wide association study and polygenic score modeling. Hundred thousands of single genetic variants and aggregated signal from multiple genetic variants were tested for an association with a proportion of the type I muscle fibers. We found seve...
Studies of suicide genetics can be divided into 3 periods: 1) period of classical methods of behavioral genetics; 2) candidate genes association studies, and 3) genome-wide association studies. The majority of studies using candidate genes strategy has been dedicated to main neurotransmitter systems (serotonine, catecholamines, GABA, excitatory ami...
Background: The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate the association of common single-nucleotide polymorphisms (SNPs) with endurance athlete status in a large cohort of...
Muscle strength is a highly heritable trait. So far, 196 single nucleotide polymorphisms (SNPs) associated with handgrip strength have been identified in 3 genome-wide association studies. The aim of our study was to validate the association of 35 SNPs with strength of elite Russian weightlifters and replicate the study in Polish weightlifters. Gen...
Pickering, C, Suraci, B, Semenova, EA, Boulygina, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Leońska-Duniec, A, Pająk, B, Chycki, J, Moska, W, Lulińska-Kuklik, E, Dornowski, M, Maszczyk, A, Bradley, B, Kana-ah, A, Cięszczyk, P, Generozov, E...
Background
MGISEQ-2000 developed by MGI Tech Co. Ltd. (a subsidiary of the BGI Group) is a new competitor of such next-generation sequencing platforms as NovaSeq and HiSeq (Illumina). Its sequencing principle is based on the DNB and cPAS technologies, which were also used in the previous version of the BGISEQ-500 device. However, the reagents for M...
Guilherme, JPLF, Egorova, ES, Semenova, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Ospanova, EA, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Govorun, VM, Generozov, EV, Ahmetov, II, and Lancha Junior, AH. The A-allele of the FTO gene rs9939609 polymorphism is associated with decrease...
Biochemical properties of muscle tissue are linked to a specific muscle fibers type. Predominance of slow-twitch muscle fibers predispose to more efficient
endurance performance while fast-twitch fibers are crucial for sprinting activity. Since the composition of muscle fibers is known to be influenced by heredity up to 45% (Simoneau & Bouchard, 19...
We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene (AGTR2) rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of t...
Muscle fibers composition is determined by the specific genetic characteristics to a large extent and it is connected with various physical traits of athletes. Establishment of genetic markers for sport prediction is an important task of great scientific and practical importance. We aimed to create a relevant model for prediction of the athlete mus...
Marmite is a popular food eaten around the world, to which individuals have commonly considered themselves either “lovers” or “haters”. We aimed to determine whether this food preference has a genetic basis. We performed a genome-wide association study (GWAS) for Marmite taste preference using genotype and questionnaire data from a cohort of 261 he...
Introduction: Genetic risk modelling using simulated datasets demonstrated to be a useful method having predictive ability comparable with empirical data. The outcome of such modelling is measured as area under the receiver-operating characteristic curve (AUC) and is ultimately defined by simulation and prediction parameters. We aimed to check whet...
The definition of DNA and RNA G-quadruplexes (G4s) has recently been broadened to include structures with certain defects: bulges, G-vacancies or mismatches. Despite the striking progress in computational methods for assessing G4 folding propensity, predicting G4s with defects remains problematic, reflecting the enhanced sequential diversity of the...
Scientific Reports 5 : Article number: 17319 10.1038/srep17319 ; published online: 30 November 2015 ; updated: 29 March 2016 The original version of this Article contained a typographical error in the spelling of the author Mikhail A. Livshits, which was incorrectly given as Mikhail A.
There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance at...
Regional association plot of the index SNP—rs921665.
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Regional association plot of the index SNP—rs7650685.
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Regional association plot of the index SNP—rs2910756.
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Regional association plot of the index SNP—rs16906888.
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Regional association plot of the index SNP—rs9355947.
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Regional association plot of the index SNP—rs17690338.
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Regional association plot of the index SNP—rs9580890.
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Quantile-Quantile plot of observed vs expected—log 10 p values for genome-wide data from Japanese athletes and controls.
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Regional association plot of the index SNP—rs6548153.
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Regional association plot of the index SNP—rs2761291.
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Regional association plot of the index SNP—rs2361506.
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Regional association plot of the index SNP—rs6959675.
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Supporting Information Text.
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Distribution of GENATHLETE VO2max of the 315 Elite Endurance Athletes.
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Regional association plot of the index SNP—rs10007111.
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Regional association plot of the index SNP—rs558129.
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Regional association plot of the index SNP—rs11975386.
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Regional association plot of the index SNP—rs4541108.
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Regional association plot of the index SNP—rs10874242.
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Regional association plot of the index SNP—rs12047209.
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Regional association plot of the index SNP—rs3780169.
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Regional association plot of the index SNP—rs2694093.
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The Discovery Phase: The GENATHLETE Cohort.
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Exosomes, small (40-100 nm) extracellular membranous vesicles, attract enormous research interest because they are carriers of disease markers and a prospective delivery system for therapeutic agents. Differential centrifugation, the prevalent method of exosome isolation, frequently produces dissimilar and improper results because of the faulty pra...
To investigate the association between multiple single-nucleotide polymorphisms (SNPs), aerobic performance and elite endurance athlete status in Russians. By using GWAS approach, we examined the association between 1,140,419 SNPs and relative maximal oxygen consumption rate (VO2max) in 80 international-level Russian endurance athletes (46 males an...
Exercise-induced oxidative stress is a state that primarily occurs in athletes involved in high-intensity sports when pro-oxidants overwhelm the antioxidant defense system to oxidize proteins, lipids, and nucleic acids. During exercise, oxidative stress is linked to muscle metabolism and muscle damage, because exercise increases free radical produc...
New Findings
What is the central question of this study?
Variations in genes are considered to be molecular determinants maintaining the expression of the slow or fast myosin heavy chains of adult skeletal muscle. The role of polymorphisms of candidate genes involved in skeletal muscle development, energy homeostasis and thyroid and calcium metabol...
The effect of cucurbit[7]uril (Cb7) on the photonics of 3,3′-diethylthiazolinocarbocyanine iodide (Car) in water was studied by spectrofluorimetry, ns-laser kinetic spectroscopy, and quantum chemistry. The formation of an inclusion complex of Car with Cb7 was established, and the binding constant and composition of the Car@Cb7 (1 : 2) complex were...