Nikolaos Spantideas

• Trust Grade Doctor at Royal National Throat Nose and Ear Hospital

Aim: Hemiplegic migraine (HM) is a rare and debilitating neurological condition with a strong genetic basis. Sequencing technologies have improved the diagnosis and our knowledge of the molecular pathophysiology of HM. Aim of this review is to update the current literature. Methods and material : We searched PubMed and Scopus databases for peer-rev...

Background and Objectives: The relationship between migraine and tension-type headache (TTH) with Parkinson's disease (PD) is controversial, while a common pathophysiological link remains obscure. The aim of this systematic review is to investigate the association between PD, migraine and TTH. Materials and Methods: Following PRISMA, we searched ME...

Objective With the outbreak of COVID-19 in December 2019 fears were expressed for a possible twindemic in the coming flu seasons. Fortunately, this was not the case for the 2019-2020 and 2020-2021 flu seasons as flu showed very low historical rates during these periods. The objective of our study was to look at the existing flu data for the 2019-20...

Στόχος: To προσωπικό υγειονομικής περίθαλψης υποχρεούται να φορά μάσκα προσώπου κατά τη διάρκεια της πανδη- μίας COVID-19, αλλά δεδομένα με παρενέργειες της παρατεταμένης χρήσης είναι λιγοστά. Στόχος μας ήταν να εξετάσουμε τη συσχέτιση της χρήσης μάσκας με την σοβαρότητα της κεφαλαλγίας σε επαγγελματίες υγείας σε υγειονομικό κέντρο. Υλικό και Μέθοδ...

Objective To investigate the possible association between salivary CRP, IL-1β, and IL-6 levels, depression/anxiety and migraine, and tension type headache (TTH) in saliva of these patients. Method A longitudinal prospective study was conducted on 30 migraineurs, 30 TTH patients, and 30 age-matched healthy controls. Anxiety and depression were meas...

The use of levodopa for treatment of Parkinson’s disease is a well-established clinical practice. Data about the true incidence and severity of cutaneous complications associated with the use of levodopa are largely lacking. Aim of this review was to evaluate the quality of evidence referring to the skin disorders caused by levodopa treatment for P...

BACKGROUND: To give, if possible, an answer in the long-standing debate of the efficacy of proton pump inhibitors (PPIs) in treating laryngopharyngeal reflux (LPR) through published systematic reviews and meta-analyses. METHOD: PubMed, Cochrane Library, and EMBASE were searched from 1984, the year the term LPR first appeared in the literature, unt...

Background The aim of this study was to review the clinical data on the effectiveness of the pharmacotherapy of HIV-associated neurocognitive disorders (HANDs). Methods A literature search of PubMed was performed (from January 1996 to October 2018) using the terms: ‘HIV-associated neurocognitive disorders’, ‘HIV-associated dementia’, ‘mild neuroco...

Fig1_supplementary – Supplemental material for Optimal treatment of HIV-associated neurocognitive disorders: myths and reality. A critical review

Background: Allergies are among the most common chronic conditions worldwide affecting 10%-30% of adult individuals and 40% of children. Phonation can be affected by different allergic conditions in various ways. The role of allergy in phonation has been under-researched and poorly understood and the respective literature is poor. Several studies...

Stress is considered to be the most common factor reported to trigger headaches in children and adolescents. Although tension-type headache and migraine are the two most common types of headache in children and adolescents, they are often untreated, ignoring their stressful background. Since stress-induced alterations of the stress system are invol...

Perioperative hyperglycemia is very common among critically ill patients with or without diabetes mellitus (DM). Perioperative elevated levels of blood glucose (BG) have been linked with increases in morbidity, infections, anastomotic failure, autoimmune dysfunction, and raised mortality and prolongation of hospitalization. A variety of different a...

From 2009, the global economic crisis not only deepened poverty but also led to adverse health effects. Headaches which concerns between 1 and 3 % of total emergency departments (ED) visits are challenging for diagnosis and treatment due to significant psychological and socioeconomic consequences. Although people were less likely to visit outpatien...

Stress is considered to be the most common factor reported to trigger headaches in children and adolescents. Although tension-type headache and migraine are the two most common types of headache in children and adolescents, they are often untreated, ignoring their stressful background. We provide a narrative review of the available evidence for hea...

Although stress is a common trigger of stress-type headache, stress management programs are less studied in children and adolescents. Our goal is to evaluate the effectiveness of a stress management and health promotion program in adolescents with tension-type headache.

Headache is an almost universal symptom of significant individual and socio-economic cost for children and adolescents. However, there are few studies on the impact of the current economic crisis on health. The purpose of the review is to relate the headache to children and adolescents with socio-economic status in the context of the modern economi...

Suicide represents a significant global public health and social concern, and theirs rates have been increased in patients with migraine. Immigrant and ethno-cultural minorities face mental health challenges associated with psychiatric behaviours, however, data on others health effects are lacking. Our aim was to investigate a link between migraine...

Hypothyroidism often coexists with primary headaches especially migraine. However, temporal relationship is generally unknown between headache and hypothyroidism. This is the first longitudinal cohort study to determine whether the incidence of hypothyroidism was increased in patients with preexisting headache disorders after adjusting for covariat...

Suicide represents a significant global public health and social concern, and suicide rates have been increased in patients with migraine. Immigrant and ethno-cultural minorities face mental health challenges associated with suicide behaviours,however, data on pain-associated suicidality are lacking. Our aim was to investigate a potential link betw...

: Vasculitis of the peripheral nervous system (PNS) occurs rarely either in the context of systemic vasculitis or isolated (non-systemic vasculitic neuropathy- NSVN). This is the first large prospective study which aims to investigated the clinical, and pathological features of both systemic and nonsystemic vasculitic neuropathy in order to establi...

Central nervous system (CNS) vasculitides are a heterogeneous group of disorders characterized by an inflammatory cell infiltration and necrosis of blood vessel walls in the brain, spinal cord, and the meninges. The CNS complications are likely to be fatal without judicious use of immunosuppression; thus, early diagnosis may prevent from damage and...

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) was previously considered a rare, early-onset recessive form of small-vessel disease (SVD) caused by biallelic mutations in the serine protease gene HTRA1 with subsequent loss of its activity. However, very recently, there is growing interest of re...

Aims and method To identify correlates between burnout and job stress of care staff at Leros PIKPA Asylum. Forty-nine asylum employees were assessed by Maslach's Burnout Inventory, a sociodemographic questionnaire, the Perceived Stress Scale and the Job Content Questionnaire. Results Emotional exhaustion is related negatively to social support (P =...

Background: Voice problems are the most common and most annoying local side effect of inhaled corticosteroids (ICS), affecting not only patients' treatment compliance but also their quality of life. The literature is very poor regarding prevalence, mechanism, prevention, and management of voice problems attributed to ICS use and especially for the...

Background and aims Population-based data regarding the prevalence of gastroesophageal reflux disease (GERD) in Greece are very poor. This study estimated the prevalence of GERD symptoms and their risk factors in the Greek adult population. Methods A self-administered questionnaire was answered by a randomly selected population of 340 subjects. Th...

Very few neurological research is published regarding health effects of global economic crisis. Our aim was to assess the impact of economic recession on frequency and severity of headaches. We also tested if depression, anxiety and experiences associated with crisis, such as unemployment, were reflected in headaches. This is a retrospective observ...

There is growing evidence that headaches are connected to melatonin secretion. Our aim was to assess the potential effectiveness of melatonin for primary headache prevention. Forty-nine patients (37 with migraine and 12 with chronic tension-type headache, TTH) were prescribed oral melatonin, 4 mg, 30 minutes before bedtime for six months. Forty-one...

Background: To assess the prevalence of laryngopharyngeal reflux (LPR) in the Greek general population and its risk factors. Methods: Questionnaire based epidemiological, adult participants' survey. The Reflux Symptom Index (RSI) was used for the assessment of LPR prevalence. The RSI questionnaire was completed by 340 (183 male and 157 female) r...

Vasculitides comprise a heterogeneous group of autoimmune disorders, occurring as primary or secondary to a broad variety of systemic infectious, malignant or connective tissue diseases. The latter occur more often but their pathogenic mechanisms have not been fully established. Frequent and varied central and peripheral nervous system complication...

Poster presentation in the 1st Congress of European Academy of Neurology

Background/aims: Α growing body of research shows pineal hormone melatonin as possible candidate for primary headache prevention. Methods/Materials: We performed an open-label single arm study at the outpatient Headache Clinic at the Korgialenio Benakio Hospital of Athens. Forty nine patients (37 with migraine and 12 with tension-type headache) rec...

To assess the prevalence of voice disorders in the general Greek population and in patients with laryngopharyngeal reflux (LPR) with the use of the reflux symptom index (RSI). Prospective epidemiological adult participant survey. General Greek population. The validated Greek version of the RSI was used to assess the prevalence of voice disorders in...

Quality of life and symptoms improvement after 6 months treatment with Roflumilast 500 μg daily in a large Greek COPD cohorthort Introduction Chronic obstructive pulmonary disease (COPD) is a major public health problem of high and increasing prevalence and is a leading cause of mortality and morbidity[1]. The disease is classified in four stages...

A 56-year-old man initially presented with a 6-month duration of a continuous, diffuse headache of mild to moderate and sometimes of severe intensity. A CT of the brain was normal. Neurological examination was normal, including absence of symptoms and signs of meningismus. During the last 2 months, an intermittent eye pain, redness, and gradual los...

Chronic Tension-Type Headache management with Emotional Freedom Τechnique Bougea A, Spandideas N, Thomaides Th , Stamboulis E, Kararizou E, Chroussos G*, Darviri C* Objective: To evaluate the short-term effects of the emotional freedom technique (EFT) in the managemanet of patients with chronic tension-type headache (TTH). Μethods: Thirty-five...

To evaluate the short-term effects of the emotional freedom technique (EFT) on tension-type headache (TTH) sufferers. We used a parallel-group design, with participants randomly assigned to the emotional freedom intervention (n = 19) or a control arm (standard care n = 16). The study was conducted at the outpatient Headache Clinic at the Korgialeni...