Nikolaos Orfanos

Nikolaos Orfanos
National and Kapodistrian University of Athens | uoa · Division of Surgery V

M.D.

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12
Publications
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64
Citations

Publications

Publications (12)
Article
Objective: Apoptosis, measured via caspase activity, can be used to assess renal tissue damage in haemorrhagic shock. We investigated whether Triiodothyronine could attenuate apoptosis and protect against haemorrhagic shock-induced renal injury. Methods: Haemorrhagic shock was induced in swine until the mean arterial pressure (MAP) was 35-40 mmH...
Article
Aim of the study: To investigate the pulmonary oxidative stress and possible protective effect of N-Acetylcysteine (NAC) and Desferoxamine (DFX)in a porcine model subjected to hemorrhagic shock. Materials and methods: Twenty-one pigs were randomly allocated to Group-A (sham, n = 5), Group-B (fluid resuscitation, n = 8) and Group-C (fluid, NAC an...
Article
Purpose: The aim of this study is to assess the efficacy of the combination of N-acetylcysteine (NAC) and deferoxamine (DFO) in the resuscitation from hemorrhagic shock in a porcine model of bleeding during hepatectomy. Methods: Twenty-one pigs were divided randomly to three groups: Sham (S) group n=5, fluid (F) resuscitation group n=8 and fluid...
Article
Ischemia-reperfusion injury caused by severe hemorrhagic shock and subsequent resuscitation leads to deterioration of hepatic homeostasis and possibly to liver failure. The present study focuses on determining whether there is a different biological response to hemorrhagic shock by different sources of hemorrhage, hepatic hemorrhage (HH) versus per...
Article
Introduction: The aim of the present study was to evaluate the effect of triiodothyronine (T3) administration in a porcine model of hemorrhagic shock due to liver surgery, in terms of hemodynamic stability, acid-base status, and hepatic injury markers. Materials and methods: Hemorrhagic shock was induced in swine by left lobe liver resection and...
Article
The thyroid gland is mainly supplied by the superior and inferior thyroid arteries, with the latter being its principal arterial supply in adults. The inferior thyroid artery usually arises from the thyrocervical trunk, and less frequently from the subclavian artery. Rarely, it may originate from the vertebral artery or the common carotid artery. I...
Article
The liver is currently considered to be one of the first organs to be subjected to the hypoxic insult inflicted by hemorrhagic shock. The oxidative injury caused by resuscitation also targets the liver and can lead to malfunction and the eventual failure of this organ. Each of the various fluids, vasoactive drugs, and pharmacologic substances used...
Article
Lobular breast cancer in men is an extremely infrequent occurrence due to the lack of lobules and acini in the male breast. Such a rare case is described here. A 74-year-old patient presented with a sizeable lesion in the right breast, which proved to be a lobular carcinoma. Genetic studies excluded Klinefelter's syndrome, though revealing an inter...
Article
Full-text available
Desmoid tumors, characterized by aggressive local infiltration of surrounding tissues, are uncommon benign neoplasms with no metastatic potential, that occasionally may attain large size. We report a case of a 37-year-old woman with an abdominal wall desmoid tumor that appeared and grew rapidly during her pregnancy, diagnosed by trucut core biopsy....
Article
The objective of this study was to report an unusual case of gastric duplication in an 82-year-old female patient. The patient was treated immediately by Billroth I partial gastrectomy due to massive hematemesis. The surgical specimen was histopathologically examined. The histopathologic report confirmed the operative diagnosis of a gastric duplica...
Article
A 49-year-old woman with slightly increased serum calcium levels on random biochemical blood tests was found by Tc-99m MIBI scintigraphy to have a giant parathyroid adenoma with an atypical ultrasonographic image showing a homogenous mass with atypical vascularization. Surgical excision was carried out. The size of the adenoma did not correlate wit...

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