Nikola M Stojanovic

Nikola M Stojanovic
University of Niš | NIS · Department of Physiology

MD, PhD candidate

About

149
Publications
151,468
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1,072
Citations
Education
October 2009 - July 2015
Faculty of Medicine, University of Nis, Serbia
Field of study
  • Medicine

Publications

Publications (149)
Article
Full-text available
The aim of this study was to evaluate the usage prevalence of herbal products (HP) and to ascertain the identity, mode and adverse effects of plant taxa used in self-medication practice for anxiety, depression and insomnia in patients with non-psychotic disorders originating from southeastern Serbia. Also, we compared HP users and non-users on the...
Article
Lycopene is one of the most potent antioxidants among carotenoids due to its ability to quench singlet oxygen and react with free radicals to reduce DNA damage. Methotrexate is widely used in the treatment of several types of cancers and autoimmune diseases. One of the most common side effects of a high-dose of methotrexate is kidney injury. In thi...
Article
Despite being renowned for its volatiles, the data on the toxicity of the essential oil of lemon balm (Melissa officinalis L., Lamiaceae) is rather limited compared to its solvent/water-soluble extractibles. In this study, the aerial parts essential oil of M. officinalis, with over 130 constituents identified herein, 26 of which detected for the fi...
Article
Full-text available
Both oxidative and psychological (mental) stress are the likely culprits for several acute and chronic health disturbances, and adequate tests mimicking that are needed. Herein, in controlled laboratory surroundings, a PEBL (Psychology Experiment Building Language) test battery was used to evoke stress-related biological responses followed by track...
Conference Paper
Uvod: Anksiozni poremećaji (AP) obuhvataju veliku grupu entiteta koji se karakterišu perzistentnom anksioznošću visokog intenziteta koja je uzrokovana unutrašnjim konfliktima. Tokom pandemije Sars Cov-19 virusom primećen je globalni porast u incidence AP, ali i porast anksioznosti u zdravoj populaciji. Ciljevi: Cilj ove studije je da se ispita kako...
Article
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Inflammatory bowel diseases (IBM), such as Crohn's disease, and their common complications represent a global health challenge. Many pyrazole derivatives, such as the spasmolytic drug metamizole, have already found their place among the frequently used therapeutic agents. Alteration of the structure of established therapeutic drugs by introducing a...
Article
Immortelle (Helichrysum italicum, Asteraceae) essential oil has been widely used in alternative medicine to accelerate wound healing, as well as in cosmetic products to stimulate skin regeneration and to reduce the appearance of wrinkles. It is also considered a natural and safe culinary spice that could also be applied in the food industry as a pr...
Article
To complement the knowledge on the anti‐inflammatory activity of methyl and isopropyl N ‐methylanthranilates, two natural products with panacea‐like properties, we investigated their effects on thioglycolate‐elicited macrophages by evaluating macrophage ability to metabolize MTT, macrophage membrane function, and macrophage myeloperoxidase and phag...
Article
Full-text available
Ethnopharmacological relevance Besides psyche-related symptoms, patients with anxiety disorders can have a large number of somatic symptoms as well. Although the treatment of these disorders is mainly focused on resolving their mental component, one cannot neglect the need for the treatment of accompanying somatic symptoms. Melissa officinalis L. (...
Article
Aims The present study aimed to evaluate the protective action of thymol towards l-arginine-induced acute pancreatitis (AP) by studying the function of rat peritoneal immune cells. Main methods Rat peritoneal exudate cells (PECs), obtained 24 h after the injection of l-arginine (350 mg/100 g of b.w.), were evaluated for mitochondrial activity (MTT...
Article
Doxorubicin is an anticancer agent that is commonly used to treat a number of tumors and is associated with acute and chronic changes of the cardiovascular system. Ellagic acid has strong free radical scavenging capacity, neuroprotective and hepatoprotective effects, and is known to protect against changes occurring due to diabetes, cardiovascular...
Article
Oleuropein (OLE) is the main bioactive ingredient in the leaves of the olive plant Olea europaea L. (Oleaceae), which has proven beneficial due to the antiinflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral effects. This study aimed to investigate the antihypertensive and vasodilator potential of OLE by analyzing its acute effec...
Article
Structural elucidation of three new sesquiterpenoids, namely, (1Z,4E)-lepidoza-1(10),4-dien-14-ol (1), rel-(1(10)Z,4S,5E,7R)-germacra-1(10),6 diene-11,14-diol (2), and rel-(1(10)Z,4S,5E,7R)-humula-1(10),5-diene-7,14-diol (3), isolated from the liverwort Conocephalum conicum, was accomplished by a combination of extensive NMR experiments, 1H NMR sim...
Article
In this investigation, chromatographic separations of the diethyl ether extracts of two European annual Bupleurum taxa, B. praealtum and B. veronense, yielded nine new natural products, namely, a series of esters of stereoisomeric tetradeca-5,7,9,11-tetraen-1-ols (1–4 and 8), a tetra-unsaturated γ-tetradecalactone (5), a dibenzylbutyrolactone ligna...
Article
Full-text available
Social psychiatry emphasizes the inclusion of mentally ill persons in family and social life. The negative attitude towards them is still an obstacle for achieving the best treatment results and their optimal quality of life. Young educated people could be an important community factor in the fight against stigmatization of psychiatric patients. Th...
Article
In this work we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens, 4‐(alkylamino)‐3‐nitrocoumarins, as antianxiety agents, using a battery of in vivo experiments. Three chosen coumarin derivatives, differing in the substituent (sec‐butylamino, hexadecylamino, or benzylam...
Article
Full-text available
Background and objectives: A long-term therapeutic strategy in hypertensive patients equally depends on measured arterial blood pressure values and total determined cardiovascular risk. The aim of the adequate hypertensive patient treatment is both the reduction in arterial blood pressure and the reduction of all preexisting modifiable risk factors...
Article
Background: Besides numerous advantages and commodities offered by smartphones, there are obvious unhealthy effects. The global trend of an increase in the frequency of usage of smartphones, that is, prolonged screen time, is closely related to problematic smartphone use. The aim of our study was to measure the level of problematic smartphone use...
Article
Full-text available
Information on recurrent Clostridium difficile infections (rCDI) in children is rare and limited, especially community acquired (CA-CDI).This study was designed to identify risk factors for rCA-CDI in Serbian pediatric population. The study group included 71 children (aged from 1 to 14 years) with a first episode of CDI. Data were collected from 56...
Article
Since cisplatin-induced nephrotoxicity has very important clinical consequences, the purpose of this study was to determine the potential protective effect of aminoguanidine on the acute kidney injury caused by cisplatin. Experiments were done on 40 Wistar rats divided into four groups. The CIS group received cisplatin in a single dose of 8 mg/kg,...
Poster
Two volatile alkaloids, methyl (MA) and isopropyl N-methylanthranilates (IA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacological properties (antinociceptive, anti-inflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an ef...
Conference Paper
Full-text available
Lemon balm (Melissa officinalis) represents one of the most renowned plant species used for the treatment of different medical conditions, but it is predominantly used by patients suffering from central nervous system disorders. The gastrointestinal system function is liable to the influence of ingested substances, and this is especially true for i...
Conference Paper
Full-text available
Two volatile protoalkaloids, methyl N-methylanthranilate (MMA) and isopropyl N-methylanthranilate (IMA), identified in the essential oil of Mexican orange (Choisya ternata Kunth (Rutaceae)) [1] exhibited polypharmacological properties [2]. Recently, we investigated their organ- [2] and urinary-metabolite profiles [3]. Herein we report on the gender...
Conference Paper
Full-text available
The essential oil of immortelle, Helichrysum italicum (Asteraceae), has a long application for wound healing. Nowadays, it is one of the most popular essential oils in cosmetics as it may stimulate blood circulation and regeneration of the skin, and reduce the appearance of fine lines and wrinkles. However, several chemotypes of H. italicum, charac...
Conference Paper
Full-text available
The genus Pulicaria (Compositae) consists of ca. 100 species with a distribution from Europe to North Africa and Asia [1]. Although some of the flavonoids, sesquiterpenoids, and diterpenoids from Pulicaria species possess significant bioactivities, the genus is still poorly phytochemically and pharmacologically studied [1]. Analyses by GC and GC-MS...
Conference Paper
Full-text available
Acute pancreatic damage, such as the one following the application of a high dose of L-arginine, is frequently associated with gastric mucosa damage. Application of natural-based agents to prevent different illnesses, including gastric tissue damage, has found its way into the medicinal practice worldwide. Thymol is a monoterpenoid phenol with nume...
Conference Paper
Full-text available
Two volatile alkaloids, methyl (MA) and isopropyl N-methylanthranilates (IA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacological properties (antinociceptive, antiinflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an eff...
Conference Paper
Full-text available
Although for centuries essential oils are readily used to improve oral health, their efficacy and safety are not completely investigated. In the present study, we aimed to evaluate in vitro toxicity of Pinus spp. essential oils towards human gingival epithelial cells and gingival exudate anaerobic bacterial isolates. Three pine essential oils (Pinu...
Article
Full-text available
Background and objectives: Here we report a rare case of a pancreatic polypeptide-secreting tumour (PPoma) discovered by accident during an autopsy. These PPomas occur in less than 2% of all pancreatic neoplasms and are almost exclusively silent, i.e., they are non-functional. Symptoms arising from PPoma are due to its compression of surrounding ti...
Article
Full-text available
The currently used immunohistochemical approach in determining the estrogen receptor (ER) positivity of breast cancers (BCs) is inherently subjective and additionally limited by its semi-quantitative nature. The application of software in the analysis of digitized slide images may overcome some of these limitations. However, the utilization of such...
Article
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In this study, we aimed to evaluate whether the encapsulation of ellagic acid (EA) into nanoliposomes would improve its potential in preventing cyclophosphamide-induced liver damage. Stability and antioxidative potential of free and encapsulated EA were determined. Experimental study conducted in vivo included ten groups of rats treated with cyclop...
Article
Full-text available
Structural elucidation of a new triquinane sesquiterpenoid, presilphiperfolane-7α,8α-diol, 1a, isolated from Pulicaria vulgaris, was accomplished by combining solvent-induced removal of chemical shift degeneracy and computational (DFT-GIAO) prediction of NMR spectra with the analysis of 1H NMR splitting patterns. In addition to extensive NMR experi...
Article
Full-text available
Background and objectives: Gastric cancer (GC) is one of the deadliest malignancies, with the underlying pathophysiological mechanisms still not completely understood. In this study, we aimed to investigate the signal transducer and activator of transcription 3 (STAT3) moleculeconnection with the pathological features of GCs, and the expression of...
Conference Paper
Full-text available
In this study we aimed to evaluate effects of ellagic acid (EA) in preventing cyclophosphamide-induced liver damage. The protective effect of EA was determined based on serum liver function, liver tissue antioxidative capacities and oxidative tissue damage parameters. Also, tissue morphological changes following cyclophosphamide administration were...
Conference Paper
Full-text available
Oleuropein (OLE) is a glycosylated seco-iridoid-phenol, present in olive leaves and fruits, is believed to be one of the main carriers of Olea europaea medical properties which include anti-cancer, nephroprotective, cardioprotective, antineurodegenerative, etc. Madin-Darby canine kidney (MDCK) cells represent a good substitution model for human col...
Conference Paper
Full-text available
Quercetin is natural polyphenolic flavonoid present in high concentration in red wine cytoprotective effects, the aim of our study was to investigate the possible effect of quercetin on cisplatin-induced nephrotoxicity in rats. Experiments were done on twenty four male Wistar rats in 4 groups. The CIS group received a single dose of cisplatin (8 mg...
Article
Full-text available
Background and objectives: The objective of this study was to determine if the angular photogrammetric analysis of soft-tissue characteristics can determine similarities between parents and their offspring in the Serbian population. Materials and Methods: A total of 15 families (52 participants) met the participation criteria of this study and thei...
Article
Full-text available
We aimed to evaluate whether two methionine-related compounds, S-adenosylmethionine (SAM), and selenomethionine (SM), could lessen liver damage induced by regurgitated bile in a model of rat bile duct ligation (BDL). Hepatoprotective potentials of S-adenosylmethionine and selenomethionine were estimated based on the changes of serum liver damage pa...
Article
Two volatile alkaloids, methyl (MMA) and isopropyl N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacological properties (antinociceptive, anti-inflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an...
Article
Carvacrol (5-isopropyl-2-methylphenol) is a biologically active monoterpene phenol abundantly present in the essential oils of many Lamiaceae aromatic/ethnomedicinal plants. Herein, we aimed to evaluate the damaging effect of carvacrol to rat pancreatic tissue, but also to assess its possible ameliorative impact on pancreatic damage induced by L-ar...
Article
Acute kidney injury is a frequent disorder that can be mimicked by the application of different nephrotoxic agents, including carbon tetrachloride (CCl 4 ), where kidney injury marker-1 (KIM-1) has been recognized as a highly specific marker. Melatonin is one of the most powerful natural antioxidants and has numerous beneficial properties. We evalu...
Article
Introduction For hundreds of years honey and bee products have been used in diets and as a home remedies. In order to assess the prevalence of bee products usage in pediatric pulmonary patients, an anonymous survey of parents/guardians was conducted. Methods A cross-sectional study was performed in the pediatric pulmonology outpatients clinic usin...
Article
Full-text available
Background/Aim. A type of personality and negative emotional reactions could be important for clustering biological risk factors for a cardiovascular disease in patients with arterial hypertension (AH). This study investigated if the patients with AH and psychological characteristics of the Distressed Type of personality with elevated anxiety/depre...
Article
The toxicity of natural marine iodoarenes or their synthetic counterparts is widely unknown despite the fact that triiodothyronine and thyroxine are members of this class. In this work we aimed to expand such knowledge on iodinated marine natural products and tested an ascidian (Didemnum rubeum) metabolite, N-(3,5-diiodo-4-methoxyphenethyl)benzamid...
Article
Full-text available
The importance of metabolic syndrome (MetSy) lies in the fact that its components are proven risk factors for early blood vessel atherosclerosis and thrombosis.Aim of the paper: Our aim was to establish the prevalence of MetSy in patients with arterial hypertension (AH) and its impact on asymptomatic carotid atherosclerosis. The study involved 391...
Article
Full-text available
The purpose of our study was to determine the effects of co-treatment with vitamins C and E on gentamicin-induced nephrotoxicity and to quantify renal structural changes through morphometric analysis. Experiments were done on 24 Wistar rats divided into three groups of 8 animals each. The GM group animals were treated with gentamicin in the dose of...
Conference Paper
Full-text available
Thymol and carvacrol are two frequently abundant volatile monoterpene phenols found as constituents of different, widely used medicinal plants mainly belonging to the Lamiaceae family. The two compounds were previously proven to possess a large number of pharmacological/toxicological activities, including the nephroprotective activity. The present...
Conference Paper
Full-text available
The genus Pulicaria (tribe Inuleae of the Compositae family) consists of ca. 100 species with a distribution from Europe to North Africa and Asia, particularly around the Mediterranean [1]. A number of compounds from Pulicaria species (flavonoids, sesquiterpenoids, and diterpenoids) possess significant bioactivities, and they could be promising can...
Conference Paper
Full-text available
Oregano (Origanum vulgare L., Lamiaceae) is used for centuries as a culinary spice due to its food flavor enhancing properties and its specific aroma. Essential oil isolated from oregano is known to affect the function of the gastrointestinal system by causing stomach and throat smooth muscle relaxation. The present work aims to evaluate the potent...
Conference Paper
Full-text available
In Serbia and the surrounding countries, Acorus calamus L. (Acoraceae) rhizome decoction is frequently used for the treatment of different gastrointestinal disorders, especially gastric ulcers [1]. The rhizomes are rich in the essential oil, to which the rhizomes‟ bulk activity is assumed to be attributed to. Nowadays, a large number of patients is...
Conference Paper
Full-text available
Carvacrol (5-isopropyl-2-methylphenol) is a monoterpene present in the essential oils of many aromatic plants of the Lamiaceae family, including the genera Origanum, Thymus, Thymbra, and Satureja. Carvacrol is reported to have a variety of biological properties and its activity might partially be responsible for the activity of ethnomedicinal plant...
Article
Full-text available
Rat bile duct ligation (BDL) represents a useful method that mimics obstructive extrahepatic cholestasis which is known to be a frequent disorder in humans. Polyamines (putrescine, spermidine and spermine) are one of the key molecules regulating cell proliferation and differentiation. This work aimed to evaluate the potential beneficial properties...
Article
Full-text available
About a third of adults have sleep problems, while in the student population this number is much higher due to a specific lifestyle. It has been shown that the use of devices with light-emitting diode screens before sleep adversely affects sleep, sleeping and circadian rhythm in respondents. The aim of this study was to assess subjective sleep qual...
Article
Full-text available
Background/purpose: Tooth extraction is often followed by a number of different complications that demand additional treatment. In order to accelerate healing processes and decrease the complication occurrence various agents, growth factors, natural and synthetic antioxidants (e.g coenzyme Q10-CoQ10), are applied. Due to the partially known health-...
Article
Two novel β-diketones, 2,6,9-trimethyl-8-decene-3,5-dione (A) and 3,7,10-trimethyl-9-undecene-4,6-dione (B), were identified from the renowned medicinal plant Hypericum perforatum L. The structures of β-diketones A and B were corroborated by syntheses (4 steps starting from methyl acetoacetate, overall yields 30% and 23%, respectively). In solution...