Niklaus F Friederich

Niklaus F Friederich
University of Basel | UNIBAS · CMBE

MD, Professor of Orthop. Surgery (Univ. of Basel)

About

212
Publications
33,773
Reads
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4,200
Citations
Additional affiliations
July 2015 - present
Universitätsspital Basel
Position
  • Consultant
April 1998 - March 2013
Kantonsspital Baselland Bruderholz
Position
  • Head of Department

Publications

Publications (212)
Article
Full-text available
Significance: The highest absorption peaks of the main components of bone are in the mid-infrared region, making Er:YAG and CO2 lasers the most efficient lasers for cutting bone. Yet, studies of deep bone ablation in minimally invasive settings are very limited, as finding suitable materials for coupling high-power laser light with low attenuation...
Article
Full-text available
The microsecond Er:YAG pulsed laser with a wavelength of λ = 2.94 μm has been widely used in the medical field, particularly for ablating dental tissues. Since bone and dental tissues have similar compositions, consisting of mineralized and rigid structures, the Er:YAG laser represents a promising tool for laserosteotomy applications. In this study...
Article
Full-text available
Objective: Developing robotic tools that introduce substantial changes in the surgical workflow is challenging because quantitative requirements are missing. Experiments on cadavers can provide valuable information to derive workspace requirements, tool size, and surgical workflow. This work aimed to quantify the volume inside the knee joint avail...
Article
Full-text available
Die Implantation von Knieendoprothesen gehört zu den weltweit häufigsten Routineeingriffen in der Orthopädie und Unfallchirurgie. Die Eingriffsraten variieren geographisch erheblich, wozu möglicherweise bisher nicht standardisierte Indikationskriterien beitragen. Ziel dieser Leitlinie war die Festlegung von Mindestanforderungen (Hauptkriterien), we...
Article
Full-text available
Background and Objectives Knee osteoarthritis (OA) is a significant public health burden. Rates of total knee arthroplasty (TKA) in OA vary substantially between geographical regions, most likely due to the lack of standardised indication criteria. We set out to define indication criteria for the German healthcare system for TKA in patients with kn...
Conference Paper
The aim of the present study is to investigate the effect of laser pulse duration on ablation efficiency of hard bones. The bones were ablated using a microsecond pulsed Er-YAG laser. The laser wavelength was 2.94 μm and the repetition rate was 10Hz. Three samples of porcine femur were used and several areas were ablated with a fixed pulse energy o...
Article
Traditionen werden in der Chirurgie von älteren Kollegen an die junge Medizinergeneration weitergegeben. Häufig sind diese Überlieferungen eher Mythen als Fakten und entsprechen meist einer Level-4-Evidenz. Im Review von Husted et al. 2014 [11] werden einige Traditionen und Mythen im Zusammenhang mit der Knie-Endoprothetik auf ihren wissenschaftlic...
Article
Full-text available
Cartilage matrix is a composite of discrete, but interacting suprastructures, i.e. cartilage fibers with microfibrillar or network-like aggregates and penetrating extrafibrillar proteoglycan matrix. The biomechanical function of the proteoglycan matrix and the collagen fibers are to absorb compressive and tensional loads, respectively. Here, we are...
Data
TEM image of immunogold labelled collagen fibril extracted from healthy human articular cartilage after treatment with hyaluronidase and trypsin. Representative example of a collagen II labelling. Bar = 100 nm. (TIF)
Data
Analysis of enzyme treatment on human AC and bovine tendon. (TIF)
Article
Full-text available
Metal debris from metal-on-metal (MoM) total hip arthroplasties (THA) has been suspected to cause periprosthetic heterotopic ossifications (HO). We determined the influence of disseminated cobalt, chromium and molybdenum on the development of HO. Native blood samples from patients with 86 high-carbon and 16 low-carbon Co 28 Cr 6 Mo articulations we...
Chapter
Auch wenn das Konzept der Viergelenkskette angesichts der in den letzten Jahrzehnten herausgearbeiteten Komplexität der Spannungsänderungen in einzelnen Bandanteilen altmodisch erscheint, so ist es auch nach mehr als 30 Jahren noch ein hilfreiches Werkzeug, um die Bewegungsabläufe im Kniegelenk besser nachvollziehen zu können. Insbesondere haben di...
Book
Dieses Buch setzt Standards im Verständnis von Biomechanik und ligamentären Rekonstruktionstechniken des wohl kompliziertesten Gelenks des menschlichen Körpers. Von der funktionellen Anatomie zur optimalen Therapie, das war der Grundgedanke, den Prof. Werner Müller seinem 1982 erschienenen Buch „Das Knie – Form, Funktion und ligamentäre Wiederherst...
Chapter
Die erste Auflage dieses Buches verfasste Herr Prof. Werner Müller – sie erschien 1982 und war ein Bestseller! Herr Prof. Michael Jagodzinski und Prof. Niklaus Friedrich haben sich in Zusammenarbeit mit dem ehemaligen Autor an die Arbeit gemacht, um dieses alte Meisterwerk ergänzt durch die neuen Erkenntnisse aus Wissenschaft, Forschung und Medizin...
Chapter
In diesem Kapitel steht die Rotation des Kniegelenks im Fokus der Betrachtung. Hierbei werden Physiologie und Pathophysiologie der freien und aktiven Rotation ebenso beleuchtet wie Besonderheiten der patello-femoralen Anatomie und ihrer Auswirkung auf die Rotation. Ein weiterer Abschnitt befasst sich mit der Varus-Flexion-IR und Valgus-Flexion-AR....
Article
Trochleoplasty and reconstruction of the medial patellofemoral ligament (MPFL) are among the most commonly performed surgical treatments in patients with patellofemoral instability. The primary purpose of the study was to perform a systematic literature review on trochleoplasty in the treatment of patients with patellofemoral instability. The secon...
Article
Full-text available
BACKGROUND: The introduction of a standardized SPECT/CT algorithm including a localization scheme, which allows accurate identification of specific patterns and thresholds of SPECT/CT tracer uptake, could lead to a better understanding of the bone remodeling and specific failure modes of unicondylar knee arthroplasty (UKA). The purpose of the prese...
Article
Purpose The purpose of this study was to analyse the long-term outcome of patients treated for combined posterior cruciate ligament (PCL) and posterolateral corner injuries by combined PCL reconstruction and popliteus bypass according to Mueller or refixation of the popliteus tendon. Methods Sixteen patients treated by combined PCL reconstructio...
Article
Die Zahl der sportlich aktiven Menschen ist in den letzten Jahren stark angestiegen. Wir untersuchten 101 Patienten nach Hüft-Totalprothese. Die Patienten wurden in Abhängigkeit von ihrer sportlichen Aktivität in drei Gruppen unterteilt. Die klinische und radiologische Evaluation erfolgte mittels Fragebögen und standardisierten Röntgenuntersuchung....
Article
To test meniscal mechanical properties such as the dynamic modulus of elasticity E* and the loss angle δ at two loading frequencies ω at different locations of the menisci and compare it to E* and δ of hyaline cartilage in indentation mode with spherical indenters. On nine pairs of human menisci, the dynamic E*-modulus and loss angle δ (as a measur...
Chapter
A thorough knowledge of the anatomy and biomechanics of the knee joint is the key factor for performing surgical procedures successfully. The following seven basic principles should be kept in mind: Think before you cut! Respect the patient`s anatomy – split layers in line with fibres. Do not make dissections in the subcutaneous layer; go down to t...
Article
Based on this double-blind, placebo-controlled study, ibandronate has no beneficial effect on clinical and radiological outcome in patients with spontaneous osteonecrosis of the knee over and above anti-inflammatory medication. Observational studies suggest beneficial effects of bisphosphonates in spontaneous osteonecrosis (ON) of the knee. We inve...
Article
Full-text available
Purpose The current study investigates whether patella height and tilt or leg alignment influence the intensity values as well as the distribution pattern of single photon emission computerized tomography/computerized tomography (SPECT/CT) tracer uptake in the patellofemoral joint. Methods 99mTc-HDP-SPECT/CT and radiographs of consecutive 84 kne...
Article
Full-text available
Osteoporotic fragility fractures of the femoral neck are the most common type of fractures in the elderly and are associated with a high mortality. Most frequently these fractures are due to falls but spontaneous onset has also been described. In these patients the insufficient quantity and quality of the osteoporotic bone finally leads to the deve...
Article
Full-text available
Introduction: Achondroplasia is the most common reason for disproportionate short stature. Normally, orthopedic limb lengthening procedures must be discussed in the course of this genetic disorder and have been successful in numerous achondroplastic patients in the past. In some cases, the disease may lead to leg length differences with need for s...
Article
Not much is known about biologic reactions at ACL graft insertion sites. SPECT/CT is a hybrid imaging modality, which combines a 3D single photon emission computed tomography and a conventional computerized tomography. It allows accurate anatomical localization of metabolic tracer activity and allows therefore the correlation of surgical factors su...
Article
SPECT/CT could be used to evaluate the in vivo loading pattern of the patellofemoral joint before and after realignment surgery. The purpose of this study is to investigate, whether the patella position (height and tilt) influences the intensity values as well as the distribution pattern of SPECT/CT tracer uptake in the patellofemoral joint. 99mTc-...
Article
Trochleoplasty and reconstruction of the medial patellofemoral ligament (MPFL) are the most commonly used surgical treatment in patients with patellofemoral instability. Although there is an increasing number of publications dealing with treatment of patellofemoral instability, the clinical evidence about outcomes and in particular the question whe...
Data
This video is related to a case report previously published in KSSTA. Combined gracilis tendon autograft reconstruction and discus repair of a chronic anterior-superior sternoclavicular joint dislocation. Friedrich L, Afifi FK, Skarvan J, Friederich NF, Hirschmann MT. Knee Surg Sports Traumatol Arthrosc. 2012 Oct;20(10):1978-82. Epub 2011 Dec 30.....
Article
The electromyographic (EMG) signal is known to show large intra-subject and inter-subject variability. Adaptation to, and preparation for, the heel-strike event have been hypothesized to be major sources of EMG variability in walking. The aim of this study was to assess these hypotheses using a principal component analysis (PCA). Two waveform shape...
Article
This study investigates if the mechanical/anatomical alignment influences the intensity values as well as the distribution pattern of SPECT/CT tracer uptake. Eighty-five knees (mean age 48 ± 16) undergoing 99mTc-HDP-SPECT/CT due to pain were prospectively included. SPECT/CTs were analyzed using a previously validated localization method. The maximu...
Article
Full-text available
Purpose Patient-based and psychological factors do influence outcome in patients undergoing total knee arthroplasty (TKA). The purpose was to investigate if preoperative psychological factors influence the subjective and objective outcomes 6 weeks, 4 months and 1 year after TKA. Our hypothesis was that there is a significant influence of psychologi...
Conference Paper
PURPOSE/AIM The purpose of this exhibit is to present diagnostic guidelines by showing typical cases for the use of SPECT/CT in patients with pain after total hip arthroplasty. CONTENT ORGANIZATION 1. Presentation of diagnostic guidelines, imaging protocol and SPECT/CT imaging analysis - Detailed description of SPECT/CT imaging protocol - SPECT im...
Conference Paper
PURPOSE/AIM SPECT/CT has been increasingly recognized as a promising new diagnostic imaging modality. We intend to define the optimal indication for patients after knee surgery and describe how to perform and analyse a SPECT/CT including mechanical measurements, 3D volumetric quantification and thresholding method and tracer uptake analysis. CONTE...
Article
Full-text available
Reconstruction of the anterior cruciate ligament (ACL) is one of the most frequently performed procedures in orthopaedics.1 Although most of the patients show a satisfactory outcome reflecting stable and pain free knees, some complain about persistent or recurrent instability or pain after ACL reconstruction.2 The state-of-the-art diagnostic follow...
Article
Full-text available
Purpose: SPECT/CT is a hybrid imaging modality, which combines a 3D scintigraphy (SPECT) and a conventional computerised tomography (CT). SPECT/CT allows accurate anatomical localisation of metabolic tracer activity. It allows the correlation of surgical factors such as tunnel position and orientation with mechanical alignment, clinical outcome an...
Article
Full-text available
Purpose: The purpose of this study was to identify predictive factors for the occurrence of complications in a consecutive series of patients who underwent step-cut tibial tubercle osteotomy (TTO) and subsequent screw refixation in primary total knee arthroplasty (TKA). Methods: Using standardised conventional radiographs, critical parameters in...
Article
Full-text available
Purpose The purpose of the study was to evaluate the clinical and radiological outcomes after medial/lateral collagen meniscus substitution (CMI) at 12 months postoperatively. Methods Sixty-seven patients (m:f = 47:20, mean age 36 ± 10 years) underwent arthroscopic CMI after previous subtotal medial (n = 55) or lateral meniscectomy (n = 12) due to...
Article
Full-text available
Purpose: The purpose of this study was to introduce a novel standardized algorithm using SPECT/CT, which promises the potential combined assessment of the biology of the joint in particular the bone-graft-fixation complex and the 3D tunnel placement in patients after ACL reconstruction. Its clinical application and inter- and intra-observer reliab...
Article
Full-text available
The single-incision anterior cruciate ligament (ACL) reconstruction evidently has its shortcomings. In an attempt to improve the biomechanical but also the biological state of the knees after an ACL-reconstruction, double, even triple-bundle reconstructions have been popularised recently. As a positive side effect, details concerning ACL-insertion...
Article
Full-text available
Purpose: The primary purpose of our study was to analyse the long-term outcome of patients treated for anterior cruciate ligament (ACL) tears by anatomical single-bundle ACL reconstruction with patellar tendon autograft. The secondary purpose was to identify predictive factors for good outcome and occurrence of osteoarthritis. Methods: Sixty-thr...
Article
Full-text available
A case of an 18-year-old gardener who sustained an anterior–superior dislocation of the sternoclavicular joint while playing handball and falling on his right shoulder is presented. Non-surgical treatment failed, and the patient could willingly dislocate the right clavicle while abduction and external rotation of the arm. This painful condition was...
Article
Full-text available
Ultrasound-navigated cementless total hip arthroplasty (THA) was performed in 10 consecutive patients with primary osteoarthritis of the hip between August 2008 and October 2009 (M:F, 6:4; median age, 61 years; age range, 30-86 years). The pelvic orientation was defined by preoperative digitization and registration of bony landmarks. Cup inclinatio...
Article
Orthopaedic implants and osteosynthesis materials are increasingly being used. Complications include mainly physical-mechanical problems and infections. Uncommonly, an allergic reaction towards an alloy metal or a bone cement component has been implicated. Potential bone cement allergens include acrylates, benzoyl peroxide, N,N-dimethyl-p-toluidine...
Article
Full-text available
With the cases described, we strive to introduce single photon emission computerized tomography in combination with conventional computer tomography (SPECT/CT) to shoulder surgeons, illustrate the possible clinical value it may offer as new diagnostic radiologic modality, and discuss its limitations. SPECT/CT may facilitate the establishment of dia...
Article
Integrated hybrid single photon emission computerized tomography (SPECT)/computer tomography (CT) is a promising new diagnostic imaging modality for orthopedic patients. A high diagnostic yield is available from combining the detection of abnormal bone metabolism with SPECT, to the precise anatomical detail available in high resolution CT. With thi...
Article
Full-text available
In focal repair of joint cartilage and meniscus, initial stiffness and strength of repairs are generally much less than surrounding tissue. This increases early failure potential. Secure primary fixation of the repair material is also a problem. Acrylamide polymer double-network (DN) hydrogels are candidate-improved repair materials. DN gels have e...
Article
Meniscal tears often occur in association with anterior cruciate ligament (ACL) lesions or in chronically lax knees. It is also known that meniscal repairs are less likely to heal in ACL-deficient knees. To test the effect of different knee joint motion and loading conditions on the gapping behavior of longitudinal posterior horn meniscal tears in...
Article
Full-text available
Patellofemoral disorders are common conditions seen in a knee clinic but can present a great diagnostic challenge to the orthopaedic surgeon. Combined single photon emission computerised tomography with conventional computer tomography (SPECT/CT) provides the clinician with precise anatomical and physiological information of the patellofemoral join...
Article
We studied the intra- and interobserver reliability of measurements of the position of the components after total knee replacement (TKR) using a combination of radiographs and axial two-dimensional (2D) and three-dimensional (3D) reconstructed CT images to identify which method is best for this purpose. A total of 30 knees after primary TKR were as...
Article
Full-text available
One major concern in the treatment of ACL lesions in children and adolescents with open physes is the risk of iatrogenic damage to the physes and a possibly resulting growth disturbance. The primary purpose of this article is to describe our technique of a transphyseal ACL reconstruction using quadriceps tendon-bone autograft in children and adoles...
Article
Full-text available
The purpose of our study was to evaluate the clinical value of hybrid SPECT/CT for the assessment of patients with painful total knee arthroplasty (TKA). Twenty-three painful knees in patients following primary TKA were assessed using Tc-99m-HDP-SPECT/CT. Rotational, sagittal and coronal position of the TKA was assessed on 3D-CT reconstructions. Th...
Article
Full-text available
Arthroplasty is a well-established routine elective surgical procedure in orthopaedics. To a great extent, diagnosis, treatment and post-operative rehabilitation in these patients is standardised. In a busy clinic, surgeons from time to time tend to focus their attention on common causes of joint pain, but it may lead them to overlook sinister but...
Article
We have recently demonstrated that indentation-type atomic force microscopy (IT-AFM) is capable of detecting early onset osteoarthritis (OA) (Stolz, 2009). This study was based on biopsies, using a desk-top commercial atomic force microscope (AFM). However, cartilage analysis in the knee joints needs to be non-destructive to avoid new seeding point...
Article
Full-text available
Excessive varus and valgus stress forces during arthroscopy might exceed minimal compressive strength of cancellous bone. In extreme cases, this could lead to post-arthroscopic osteonecrosis. It was our purpose to measure the valgus and varus stress forces during arthroscopy and draw conclusions on the development of osteonecrosis. On 24 consecutiv...
Article
Full-text available
The pathological changes in osteoarthritis-a degenerative joint disease prevalent among older people-start at the molecular scale and spread to the higher levels of the architecture of articular cartilage to cause progressive and irreversible structural and functional damage. At present, there are no treatments to cure or attenuate the degradation...