Niklas Domdei

Carl Zeiss Vision International GmbH · Advanced Development

Previous studies showed an impact of the light spectrum on ocular growth. It is unclear whether the eye reacts to the light chromaticity or to the defocus induced by the longitudinal chromatic aberration (LCA). This study investigated the influence of narrow-band aberration-free light on axial length as an indicator for eye growth. Using a laser-in...

The small physical depression of the human retina, the fovea, is the retinal locus of prime visual resolution, achieved by a peaking topography of the light-sensitive cone photoreceptor outer segments1, 2, 3 and a post-receptor wiring scheme preserving high-density sampling.⁴,⁵ Humans dynamically direct their gaze such that the retinal images of ob...

Purpose: The cellular topography of the human foveola, the central 1° diameter of the fovea, is strikingly non-uniform, with a steep increase of cone photoreceptor density and outer segment (OS) length toward its center. Here, we assessed to what extent the specific cellular organization of the foveola of an individual is reflected in visual sensit...

The small physical depression of the human retina, termed fovea, is the functional center of human vision, providing an acute sense of visual space and color, but it is yet unclear if the exact arrangement of the few thousand photoreceptors at the foveal center is relevant for visual behavior. By employing adaptive optics in vivo imaging and micro-...

The spatial and spectral topography of the cone mosaic set the limits for detection and discrimination of chromatic sinewave gratings. Here, we sought to compare the spatial characteristics of mechanisms mediating hue perception against those mediating chromatic detection in individuals with known spectral topography and with optical aberrations re...

Multi-wavelength ophthalmic imaging and stimulation of photoreceptor cells require consideration of chromatic dispersion of the eye, manifesting in longitudinal and transverse chromatic aberrations. Contemporary image-based techniques to measure and correct transverse chromatic aberration (TCA) and the resulting transverse chromatic offset (TCO) in...

Multi-wavelength ophthalmic imaging and stimulation of photoreceptor cells requires consideration of chromatic dispersion of the eye, manifesting in longitudinal and transverse chromatic aberrations. Current image-based techniques to measure and correct transverse chromatic aberration (TCA) and the resulting transverse chromatic offset (TCO) in an...

Due to the enormous dynamic range of human photoreceptors in response to light, studying their visual function in the intact retina challenges the stimulation hardware, specifically with regard to the displayable luminance contrast. The adaptive optics scanning laser ophthalmoscope (AOSLO) is an optical platform that focuses light to extremely smal...

Purpose: To determine the minimal optical coherence tomography B-scan density for reliable detection of intraretinal and subretinal fluid. Methods: Spectral domain optical coherence tomography raster scanning (Spectralis; Heidelberg Engineering, Heidelberg, Germany) using a scan field of 20° × 20° of 97 B-scans with an interscan distance (ISD) o...

The use of adaptive optics in ophthalmoscopy is a breakthrough technological achievement. With AO ophthalmoscopes, the microscopic retinal structure can be visualised non-invasively and on a cellular level, allowing for cellular scale imaging of the retinal nerve fibre layer, the smallest retinal capillaries, rod and cone photoreceptors, and the re...

During the last 25 years ophthalmic imaging has undergone a revolution. This review gives an overview of the possibilities of adaptive optics (AO) for ophthalmic imaging technologies and their development and illustrates that the role of ophthalmic imaging changed from the documentation of obvious abnormalities to the detection of microscopic yet s...

Even during fixation, our eyes are constantly in motion, creating an ever-changing signal in each photoreceptor. Neuronal processes can exploit such transient signals to serve spatial vision, but it is not known how our finest visual acuity—one that we use for deciphering small letters or identifying distant faces and objects—is maintained when con...

Equipping an ophthalmoscope with adaptive optics (AO) offers access to the living human retina with unprecedented spatial resolution. With AO, cellular structures such as the nerve fiber layer, the microvasculature of the smallest retinal capillaries, rod and cone photoreceptors and the mosaic of the retinal pigment epithelium are directly observab...

Purpose: To investigate the potential of optical coherence tomography (OCT) angiography to detect and quantify the neovascular network in exudative AMD. Methods: Treatment-naïve eyes that were diagnosed with exudative AMD were prospectively examined by OCT angiography (OCT-A). The extent of the neovascular network was measured by three independe...