Nikki Van Bel

Nikki Van Bel
KWR Water Research Institute · Microbial Water Quality and Health

MSc. PhD.

About

14
Publications
1,284
Reads
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172
Citations
Citations since 2016
7 Research Items
142 Citations
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025
Additional affiliations
October 2010 - January 2015
University of Amsterdam
Position
  • PhD Student

Publications

Publications (14)
Article
Aeromonas is included in the Dutch Drinking Water Decree as an indicator for elevated microbial regrowth in non-chlorinated drinking water distribution systems (DWDS). The temporal and spatial diversity of Aeromonas species in ten DWDS and their planktonic growth characteristics for different carbon sources was investigated. Genotyping of the gyrB...
Article
Full-text available
Biological treatment processes have the potential to remove organic micropollutants (OMPs) during water treatment. The OMP removal capacity of conventional drinking water treatment processes such as rapid sand filters (RSFs), however, has not been studied in detail. We investigated OMP removal and transformation product (TP) formation in seven full...
Article
Full-text available
To ensure delivery of microbiologically safe drinking water, the physical integrity of the distribution system is an important control measure. During repair works or an incident the drinking water pipe is open and microbiologically contaminated water or soil may enter. Before taking the pipe back into service it must be cleaned. The efficacy of fl...
Article
Full-text available
Vrijwel alle drinkwaterbedrijven hebben ambities voor een klimaatneutrale bedrijfsvoering. Een aantal drinkwaterbedrijven probeert met opwekking van duurzame energie hun CO2-voetafdruk te verlagen. Een bijzondere manier van energieopwekking is de levering van thermische energie uit drinkwater, kortweg TED. Toepassing van TED moet een positieve mili...
Article
Full-text available
Background HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LEDGF interaction during integration, the major impact...
Article
Een groot deel van de wereld heeft geen toegang tot microbiologisch veilig drinkwater. Maar ook in landen met veilig drinkwater moeten we alert zijn op ziekteverwekkende virussen en bacteriën in water als dat wordt gebruikt voor recreatie, landbouw of als bron voor drinkwater. Naast de bekende microbiologische bedreigingen zijn er ook nieuwe bedrei...
Article
Full-text available
The 5' leader of the HIV-1 RNA genome encodes signals that control various steps in the replication cycle, including the dimerization initiation signal (DIS) that triggers RNA dimerization. The DIS folds a hairpin structure with a palindromic sequence in the loop that allows RNA dimerization via intermolecular kissing-loop (KL) base pairing. The KL...
Article
The 5' leader region of the HIV-1 RNA contains the major 5' splice site (ss) that is used in the production of all spliced viral RNAs. This splice-donor (SD) region can fold a stem-loop structure. We demonstrate that whereas stabilization of this SD hairpin reduces splicing efficiency, destabilization increases splicing. Both stabilization and dest...
Article
Full-text available
The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN inhibitors (ALLINIs). Although designed to interfere with the IN-LEDGF/p75 interaction to block HIV...
Article
Full-text available
The 5' untranslated leader region of the human immunodeficiency virus type 1 (HIV-1) RNA genome is a strongly conserved sequence that encodes several regulatory motifs important for viral replication. Most of these motifs are exposed as hairpin structures, including the dimerization initiation signal (DIS), the major splice donor site (SD) and the...
Article
Herpesviruses escape elimination by cytotoxic T lymphocytes through specific interference with the antigen-presenting function of MHC class I (MHC I) molecules. The transporter associated with antigen processing (TAP) forms a bottleneck in the MHC I antigen presentation pathway. The fact that multiple viruses, especially herpesviruses, encode molec...

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