Nihat Mert

Nihat Mert
Yuzuncu Yil University · Department of Biochemistry

Prof.Dr .DMV

About

156
Publications
9,179
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,155
Citations

Publications

Publications (156)
Article
Context: Diabetes is a metabolic disorder related to blood insulin deficiency and high glucose level. Cinnamaldehyde is an important component of cinnamon and has an effect on blood glucose. Objective: It was aimed to investigate the the effect of cinnamaldehyde on the liver glutathione (GSH), glucose-6-phosphate dehidrogenase (G6PD) activity, b...
Article
Full-text available
The aim of the study was to compare some mineral substances and total antioxidant and totaloxidan levels of healthy Morkaraman and Norduz sheep breeds in the same age and care conditions. A total of 20 animals, 10 from each sheep breed, were included in the study. Serum total oxidant status (TOS) and total antioxidant status (TAS) were determined b...
Article
Background: In this study, the effects of White Muscle Disease (WMD) on certain blood parameters, MDA and GSH levels in liver and thyroid tissues and the thyroid hormones were investigated in sheep. Methods: Sixteen lambs (8 with WMD, 8 controls) of similar age, 3 to 50 days old, selected from the same region were used in the study. Blood samples w...
Article
Full-text available
In this study, it was aimed to investigate the effect of evening primrose oil (EPO) on some biochemical parameters on nephrotoxicity induced by gentamicin (GM) in rats. The rats used in the study were randomly divided into 4 groups each consisting of 8 rats. The control group, EPO group, GM group and GM+ EPO group. The blood samples were taken 24 h...
Article
We studied the potential application of a zigzag and an armchair AlN nanotube (AlNNT) as an anode material for the Mg-ion batteries (MIBs) using B3LYP-gCP-D3/6-31G* model chemistry. The Mg²⁺ adsorption energy on the zigzag or armchair AlNNTs is −217.2 or −234.9 kcal/mol, but the Mg atom interaction is much weaker and the adsorption energy is −10.5...
Article
We investigated the structure, stability and chemical properties of novel singlet (s) and triplet (t) Hammick carbenes with different fused aromatic rings, at (U)B3LYP/6‐311+G*, (U)M06-2X/6‐311+G*, (U)B3LYP/AUG-cc-pVTZ and (U)M06-2X/AUG-cc-pVTZ levels of theory. It is observed that: (1) All singlet and triplet structures appear as minima on their e...
Article
Full-text available
N-Aryl sulfonamides belong to a highly important class of organosulfur compounds which are found in a number of FDA-approved drugs such as dofetilide, dronedarone, ibutilide, sotalol, sulfadiazine, sulfamethizole, vemurafenib, and many more. There is therefore continuing interest in the development of novel and convenient protocols for the preparat...
Article
Burn is a systemic injury affecting the entire organism according to its etiology and severity. The aim of this study was to investigate plasma AOPP levels before and after treatment of second- and third-degree thermal burn patients and determine the changes in this parameter, and also, to find out the relationship between AOPP level and hospitaliz...
Article
Full-text available
The objectivity of this study was to investigate some blood minerals and parameters in Honamli goats reared under semi-intensive conditions. 90 goats (2-4 ages) in different three herds kept under similar manage mental conditions were chosen as research materials in Teke Border of Antalya Province. Serum Ca 6.786±0.206 mg/dL, P 4.094±0.173 mg/dL, C...
Article
The effect of evening primrose oil on adiponectin level and some biochemical parameters in model of fructose-induced metabolic syndrome were investigated. The rats were divided into 4 groups: control, evening primrose oil, fructose, fructose + evening primrose oil. Body weight, daily feed and water consumptions and systolic blood pressures of anima...
Article
Ferulic acid is a kind of phenolic compound that can be found in various fruits and vegetables. This study aims to investigate the effect of ferulic acid on nephrotoxicity induced by gentamicin (GM). In this study, rats were separated into 4 groups such that each containing 8 randomly selected rats: Control group, Ferulic Acid (FA) group, Gentamici...
Article
Full-text available
Esterification of N-hydroxyimides to corresponding active esters (N-hydroxyimide esters) is one of the most important organic transformations not only for their importance as versatile intermediates for amides and esters but also their use as coupling partners in various C-S, C-C and C-N coupling reactions. Therefore, there is continuing interest i...
Article
Full-text available
Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies distinguished by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. Extracts of the V. album leaves was reported to exert a beneficial effect to alleviate the symptoms of diabetes in local medicines. The aim of present investigation is to evaluat...
Article
Full-text available
Background Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI), nitric oxide (NO), zinc (Zn), copper (Cu) levels, paraoxonase (PON1), arylesterase (ARES) activities, and biochemical changes were studied on sheep with cystic echinococcosis. Methods The materials were taken from 2–3 yr old sheep slaughtered in...
Article
Fucoidan is a sulfate polysaccharide extracted from brown algae. Fucoidan has various pharmacological properties, such as anti-tumor, anti-mutagenic, anti-inflammatory, antiviral, antioxidant, anti-fibrogenic activity and anti-complementary activities Objective: This study was aimed to explore the effect of fucoidan on biochemical parameters (ALT,...
Article
Full-text available
This study aims to investigate the protective effects of kefir against myocardial infarction induced by isoproterenol (ISO). The rats were randomly divided into 4 groups, each group consisting of 8 rats. The control group, the kefir group (5 mL/kg/d kefir administered to rats as intra-gastric gavage for 60 d), the ISO group (100 mg/kg ISO was admin...
Article
Full-text available
In this study, serum amylase activity and structural changes of the pancreatic tissue in rats under the effects of grape seed extract were investigated. Thirty-two female Wistar albino rats were divided into 4 groups. First one was the control group. The second group was the streptozotocin (STZ)-induced diabetes mellitus (DM) group (45 mg/kg), whil...
Article
Full-text available
Fucoidan is a polysaccharide with high viscosity and mucilage, which contains significant proportion of sulphate ester group and L-fucose. It is present in intercellular spaces of brown algae. This study aimed to investigate the effect of fucoidan on some biochemical parameters and kidney tissues in nephrotoxicity induced by GM in rats. The rats us...
Article
Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – a...
Article
Full-text available
Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – a...
Article
In this study, the effects of Grape Seed Extract (GSE) on glucose, enzymatic activities of elastase and collagenase, and certain biochemical parameters, were investigated. 32 female Wistar albino rats were used in the process. The subjects were randomly divided into 4 groups (control, diabetic (DM), GSE, DM+GSE). A single dose of saline was injecte...
Article
Full-text available
Fucoidan is a sulfate polysaccharide extracted from brown algae. Fucoidan has various pharmacological properties, such as anti-tumor, anti-mutagenic, anti-inflammatory, antiviral, antioxidant, anti-fibrogenic activity and anti-complementary activities Objective: This study was aimed to explore the effect of fucoidan on biochemical parameters (ALT,...
Article
Full-text available
Introduction Radiation therapy (RT) is a major treatment modality, and the central nervous system is a dose-limiting organ in clinical RT. This experimental study aims to present the evaluation of the neuroprotective effects of erythropoietin (EPO) against oxidant injury following brain irradiation in rats. Material and methods Forty Wistar rats w...
Article
Full-text available
The aim of this study was to evaluate the effects of forced molting using biochemical parameters and histopathological findings in laying hens. 36 Hyline W36 strain laying hens, 90 weeks old were chosen for this research. Eight of these chickens were randomly selected and placed in a cage as the control group before the molting program began. All t...
Article
Full-text available
Stomach cancer is one of the most observed in Van and surroundings. Dietary source of Vitamin D are hepfull to survive from cancer with low mortality rates. There are so many reports on the association between nitrate intake from food and gastric cancer risk and also nitrate intake from water. The blood samples were taken patients with stomach canc...
Article
Full-text available
The ingestion of excessive amounts of the fluoride ion (F) may cause chronic fluorosis with abnormalities in many organs and systems including, in addition to dental and skeletal fluorosis, impaired renal function. The aim of the present study was to investigate renal function and the levels of advanced oxidation protein products (AOPP) as oxidativ...
Article
Full-text available
Objective: It was aimed to compare the some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid levels in patients with stomach cancer before and after chemotherapy to the healthy controls. Material and Methods: Forty-eight patients with stomach adenocarcinoma and 20 healthy controls, totally 68 subjects were used. Blood sa...
Article
Leptin hormone is produced by fat cells and is believed to coordinate the control of body weight. This study was conducted to determine the levels of leptin, triglyceride, cholesterol, VLDL, LDL, HDL and glucose in serum apart from the body weight of animals, and to find out the correlations between them. Four breeds of sheep (Karakul; semi-fat tai...
Article
The aim of this study was to evaluate the vitamin levels of ram seminal plasma and the relationship between vitamins and spermatological characteristics. For this aim, nine 3-5 year old rams of Norduz, Karakas and Ile-de-France x Akkaraman (G1) genotypes were provided. Sperm of each ram was collected once per month from June to October of the year...
Article
Full-text available
The ingestion of excessive amounts of the fluoride ion (F) may cause chronic fluorosis with abnormalities in many organs and systems including, in addition to dental and skeletal fluorosis, impaired renal function. The aim of the present study was to investigate renal function and the levels of advanced oxidation protein products (AOPP) as oxidativ...
Research
Ascorbic Acid and Heat Stress in Laying Hens
Article
Full-text available
ZET Leptin, son zamanlarda keşfedilen ve önemi giderek artan metabolik bir hormondur. Leptinin esas salınım yeri ve etkisi yağ dokusu olarak bilinse de, yapılan son çalışmalar leptinin ve leptin reseptörlerinin vücudun diğer organlarında da üretildiğini kanıtlamaktadır. Leptin metabolik etkilerinin çoğunu merkezi sinir sisteminde ve periferik dokul...
Article
There are so many stressors, like heat, effects the egg production in laying hens. Experiment was conducted in a poultry farm inBursa. 1730Hy-Line W77 layer aged 40 weeks assigned to caging unit were used as research materials. Hens were divided into six groups and had different amount of ascorbate supplementation; 0, 50, 100, 150, 200 and 250 mg k...
Article
Full-text available
The aim of this study was to evaluate serum lipoprotein and tissue antioxidant levels of sheep with and without fluorosis living in a volcanic area of Turkey. Fifteen Akkaraman sheep with fluorosis in the Ağri region north of Lake Van and 10 Akkaraman sheep without fluorosis in the Van region just south of Lake Van in the eastern part of Turkey wer...
Article
In this dissertation, the effect of the widely used pepper gas (oleoresin capsicum, OC) derived from the cayenne pepper was studied in the blood gases, electrolytes and some biochemical parameters on the rats with different dosages and periods. In the pre-dosage phase, 12 of 47 Wistar albino rats were used as the live material. Commercially availab...
Article
Full-text available
This study was carried out on nine 3-5-year-old rams of different species: four Norduz, two Karakas, and three Ile de France × Akkaraman rams. Sperm of each ram was collected by means of an artificial vagina once per month from June to October 2007. In each case, the sperm volume, pH, viscosity, mass activity, motility, concentration, abnormal sper...
Article
Bleomycin (BLM) is a chemotherapeutic agent against different carcinomas, one dose of which causes dependent pulmonary fibrosis. The present study was taken up in order to measure the retinyl ester, alpha-tocopherol and cholecalciferol (vitamin D(3)) level in lung tissue in the rats following BLM-induced fibrosis. Fourteen rats were randomly divide...
Article
Full-text available
The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, α- and δ-tocopherol, and vitamin D3) in sheep naturally infected with Babesia ovis. The investigation included 30 infected and 10 control sheep. Serum α-tocopherol levels were signifi...
Article
Full-text available
The serum levels of copper, zinc, iron, manganese, nickel, cadmium, cobalt, sodium, potassium, calcium, and magnesium were determined in seven different breeds of dogs: Pointer, Poodle, Setter, Labrador Retriever, Golden Retriever, German Shepherd, and Mallinois. Only slight variations were found among the different breeds, and the results presente...
Article
Full-text available
The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blo...
Article
Full-text available
ZET Bu çalışma, Babesia ovis ile doğal olarak enfekte olan koyunlarda serum folik asit düzeylerinin araştırılması ve tedavi sonrasında nasıl etkilendiklerinin saptanması amacıyla yapıldı. Klinik ve parazitolojik olarak babesiosis tanısı konulan 30 adet koyun hasta grubunu, 10 adet sağlıklı koyun da kontrol grubunu oluşturdu. Hasta koyunlar, antipro...
Article
The aim of this study was to assess the effects of natural distomatosis infections on sheep liver malondialdehyde (MDA) concentration, activities of enzymatic antioxidants (glutathione peroxidase (GPx), superoxide dismutase (Cu, Zn-SOD), catalase (CAT)) and concentrations of non-enzymatic antioxidants (reduced glutathione (GSH), vitamin C, and beta...
Article
Full-text available
This study was performed to investigate the serum levels of vitamins in yearling rams with growth failure. A total of 70 yearling rams of Akkaraman breed, 50 of which were classified as growth-failure with an average body weight of 37.30 ± 1.1 kg (test) and the remaining 20 were classified as normal with an average body weight of 67.80 ± 2.2 kg (co...
Article
The study was undertaken to investigate the influence of alpha-tocopherol (vitamin E) on malondialdehyde (MDA) and glutathione (GSH) levels and catalase (CAT) activity in lung of rats with bleomycin-induced pulmonary fibrosis (PF). Fourteen Wistar-albino rats were randomly divided into two groups of seven animals each. The first group was treated i...
Article
Full-text available
The aim of this study was to determine the serum concentrations of total and lipid-bound sialic acid in sheep naturally infected with Babesia ovis before and after treatment. Thirty diseased sheep and ten control animals were used. Babesia infection was confirmed with Giemsa's staining of blood smears. Compared to the control animals (1.351 +/- 0.1...
Article
Full-text available
This study was designed to demonstrate the effects of 900-MHz electromagnetic field (EMF) emitted from cellular phone on brain tissue and also blood malondialdehyde (MDA), glutathione (GSH), retinol (vitamin A), vitamin D(3) and tocopherol (vitamin E) levels, and catalase (CAT) enzyme activity of guinea pigs. Fourteen male guinea pigs, weighing 500...
Article
Full-text available
The serum concentrations of copper, zinc, iron, and cobalt and copper/zinc ratio were investigated in horses infected with equine herpesvirus-1 (EHV-1). Nine horses were naturally infected with the virus and nine healthy horses served as controls. The concentrations of copper, zinc, iron, and cobalt were determined spectrophotometrically in the blo...
Article
This study was designed to examine the effects of vitamin E on the levels of Zn, Mn, Cu, Fe, and carbonic anhydrase in rats with bleomycin-induced pulmonary fibrosis. Twenty-one male Wistar albino rats were randomly divided into three groups: bleomycin alone, bleomycin+vitamin E, and saline alone (control group). The bleomycin group was given 7.5 m...
Article
Measles is a highly contagious viral disease of childhood associated with serious complications and significant morbidity and mortality. In the present study, antioxidant and oxidant status was investigated in children with measles. Our aim was to evaluate the possible changes in non-enzymatic antioxidant levels and their relationship to the oxidat...
Article
Full-text available
Values obtained from the gentamicin - included renal failure in rats and control group were compared statistically. Significant increases were observed in the oci urn urea (P < 0.001), creatinine (P < 0.01), MDA (P < 0.001), and significant decreases were seen in the GSH, GPx SOD and Vitamin E values (P < 0.001).
Article
Full-text available
Serum levels of T-3, T-4, and TSH hormones, some elements, and glucose with regard to their involvement for growth retardation in yearling rams were investigated. A total of 70 yearling rams of the Akkaraman breed, 50 of which were classified with a retarded growth, and the remaining 20 were classified as normal, were included in the study. Serum t...
Article
Full-text available
This study was conducted to evaluate the effects of combined deficiencies of Se and vitamin E on catalase activity in order to investigate the possible interactions between Se, α-tocopherol, and catalase in lambs with white muscle disease (WMD). Ten healthy and fifteen WMD affected lambs of the Akkaraman breed were used. Serum α-tocopherol and Se l...
Article
Full-text available
To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator of oxidative stress) and nonenzymic antioxidants in children with acute hepatitis A. Whole blood MDA and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin E and vitamin C levels...
Article
The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was treated intratracheally with bleomy...
Article
Full-text available
Brucellosis is a zoonotic disease that is encountered in sheep rather frequently. In this study, 100 sheep diagnosed with brucellosis that had aborts and 40 healthy sheep were used as materials. Analyses for Cu, Zn, Fe, Cr, Ca, Mg, and K were performed with the atomic absorption spectrophotometric method on blood collected from vena jugularis of al...
Article
Full-text available
: This study was designed to investigate the serum copper (Cu), zinc (Zn), manganese (Mn), and magnesium (Mg) status in a group of subjects with chronic fluorosis. Fifteen subjects diagnosed with fluorosis who live near Van, Turkey in the fluoride-polluted volcanic Tendurek Mountain region (altitude ca. 2000 m) were randomly selected to represent t...
Article
The aim of the present study was to investigate whether altered serum total sialic acid (TSA), lipid-associated sialic acid (LSA), copper (Cu), manganese (Mn), zinc (Zn), chromium (Cr), iron (Fe), and magnesium (Mg) levels had an interactive connection with diabetes and also whether they were correlated with each other in diabetic patients. Two stu...