Nihal Büyükuslu

Menopoz, ovaryum aktivitesinin yitirilmesi sonucunda menstrüasyonun kalıcı olarak sonlanmasıdır. Menopozdaki kadınlarda obezitenin görülme sıklığındaki artışlar önemli halk sağlığı endişelerini doğurmaktadır. Metabolik sendrom; kardiyovasküler hastalık ve tip 2 diyabet geliştirme riskini artıran hipertansiyon, dislipidemi, insülin direnci, obezite...

The addition of herbs to the diet is one of the methods for the treatment of obesity. It is aimed to examine the extracts of chamomile to use in the treatment of obesity, against high-fat diet. In this study, 6-8 weeks old fifteen female Sprague-Dawley rats were used. Five of the rats separated randomly for the control group and fed with a standard...

There are various studies showing that oral supplements are shortening or facilitating effects on this process. Therefore, this study investigates the use of edible oils as supplements in the wound healing process. Of the 7 groups (control, Hypericum perforatum extracts in olive oil, olive, sesame, fish, black seed, sunflower), each has 8 Wistar Al...

Polyamines are short-chain, basic biogenic amines that are essential for cell growth and reproduction. This study was conducted to examine the effects of maternal polyamine intake on growth and serum lipid levels in first generation rat offspring. Female Sprague-Dawley rats (n=35) of 8 weeks old were used in the study. Rats were divided into five g...

We aimed to assess the effects of omega fatty acids on time depending on responses of satiety hormones. Sixty adult rats were randomly divided into 4 groups; linoleic acid (LA), α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) groups. For each fatty acid, the dose of 400 mg/kg was applied by oral gavage. Blood samp...

Polyamines play an important role in the maintenance of intestinal permeability. Therefore we aimed to determine the effects of probiotics and omega 3 fatty acids on serum polyamine levels in colitis. Fifty BALB/c mice were randomly grouped as normal, colitis with no treatment applied, colitis treated by probiotics (VSL#3), colitis treated by omega...

Frailty syndrome is one of the most important problems of the aging population. Various pathophysiological factors constitute the pathophysiology of the syndrome, including dysregulation of inflammatory processes, oxidative stress, mitochondrial dysfunction, and cellular aging. Sociodemographic characteristics, psychological conditions, nutritional...

Adolescence is an important period in which the muscular and skeletal systems develop rapidly, special nutritional habits arise and nutritional requirements increase. Factors affecting bone health are of greater importance in this period. The bone cycle, balanced production and destruction of bone, continues throughout life. The highest level of bo...

Amaç: Çalışma kordon kanı yağ asitleri üzerine gebelikte beslenmenin etkisini değerlendimek amacıyla planlanmış ve yürütülmüştür. Gereç ve Yöntemler: Son trimesterin başında olan 33 gebeye ilişkin demografik özellikler ile antropometrik ölçümler önceden hazırlanmış bir anket formu kullanırak alınmış, 24 saatlik besin tüketimleri kaydedilmiştir. Kor...

GİRİŞ: Putresin (Put), spermidin (Spd) ve spermin (Spm), tüm canlı organizmalarda bulunan kısa zincirli ve bazik yapıdaki doğal poliaminlerdir. Hücre büyümesi ve çoğalması dahil birçok fonksiyona sahiptirler. Katyonik yapılarından dolayı serumda bulunan lipoproteinlerin yüzeyindeki anyonik fosfolipidlerle bağlanarak etkileşime girerler. Poliamin me...

Background: Early detection of breast cancer is a key to the success of breast cancer management. Serum proteome analysis using Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (SELDI-TOF-MS) generates useful information that can be utilized to describe exclusive prognostic and diagnostic biomarkers. Objective: This stu...

Breast cancer (BC) is the most frequently diagnosed cancer that affects women worldwide. Early detection of BC is important to improve survival rates and decrease mortality. The aim of the present study was to investigate serum biomarkers using surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to distingui...

Breast milk is the first source of omega-3 fatty acids (FA) for infants. We hypothesized that maternal omega-3 FAs supplementation affects the FA composition of breast milk. Thirtysix women received 950 mg omega-3 polyunsaturated (PUFA) supplementation per day for 9 months from 22-24 weeks of pregnancy until the 6 months of lactation and 26 women w...

The natural polyamines, putrescine, spermidine and spermine are distributed widely in all cells including adipocytes. They are involved in several physiological processes involving gene expression and cell proliferation. The body pool of polyamines is maintained by endogenous biosynthesis, intestinal microorganisms and the diet. A correlation betwe...

Objectives: Maternal intake of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) has positive effects on fetal development and pregnancy outcomes. Leptin plays an important role in placental transportion of LC-PUFAs. In this study, we aimed to evaluate the effects of maternal n-3 LC-PUFAs intake on anthropometric parameters of mother and newbor...

Omega-3 fatty acids (n-3 FA), specifically DHA, are associated with fetal growth and development. We aimed to determine the levels of DHA and EPA in cord serum after n-3 FA supplementation during the last trimester of pregnancy. Among 55 women, 23 were administered daily one capsule of n-3 FA supplement, involving DHA/EPA in a ratio of 1/1.3. Twent...

Human milk is the ideal food for all newborns and infants. It involves macro nutrients and functional compounds for growth and development. The composition of breast milk differs between preterm and term milk. Polyamines are essential for cell proliferation and differentiation. In addition to their de novo polyamine synthesis, cells can take up pol...

Polyamines are most abundant polycationic natural amines and involved in several physiological processes. They can be supplied by the endogenous synthesis inside the cell or by the intake from exogenous sources. The polyamine content of cells is regulated by biosynthesis, degradation, uptake and excretion. The benefits of dietary polyamines can be...

Putrescine, spermidine and spermine are the most abundant polycationic natural amines found in nearly all organisms. They are involved in regulation of gene expression, translation, cell proliferation and differentiation. They can be supplied by the endogenous synthesis inside the cell or by the intake from exogenous sources. There is a growing bod...

Under a magnetic field the activities of superoxide dismutase (SOD) in vitro and in vivo and accompanying activities of catalase activity in vivo were investigated in soybean roots. In plant cells a magnetic field creates a stress condition as other environmental stress factors do. To respond to the stress conditions, the occurred reactive oxygen s...

The effects of magnetic field on superoxide dismutase activity were investigated. All living systems are affected by magnetic field and electromagnetic field in a way of their response systems. Since magnetic field has an impact on biochemical reactions that involve more than one unpaired electron, in our study SOD activity, one of the enzyme respo...

Background: The ubiquitous multimeric RNA polymerases contain two large, conserved subunits, of which the beta subunit has been implicated in all three stages of transcription. We have previously described a genetic system involving random, PCR-mediated mutagenesis of the region of rpoB encoding the C-terminal 116 amino acids of the beta subunit o...

Background: The multimeric DNA-dependent RNA polymerases are widespread throughout nature. The RNA polymerase of Escherichia coli, which is the most well characterized, consists of a holoenzyme with subunit stoichiometry of alpha2betabeta'sigma. The beta subunit is conserved and has been implicated in all stages of transcription. The extreme C-ter...

We report the fine mapping of 55 of our 95 amber mutations in the beta gene of Escherichia coli RNA polymerase by virtue of the unique MaeI restriction sites created by this subset of nonsense mutations (i.e. CTAG, where the amber codon is underlined). [The full data are reported in Supplementary Publication SUP 50181 (12 pages), which has been dep...

We report the fine mapping of 55 of our 95 amber mutations in the β gene of Escherichia coli RNA polymerase by virtue of the unique MaeI restriction sites created by this subset of nonsense mutations (i.e. CTAG, where the amber codon is underlined). [The full data are reported in Supplementary Publication SUP 50181 (12 pages), which has been deposi...

The DNA-dependent RNA polymerases are widespread throughout nature. E. coli RNA polymerase, one of the most well characterized polymerase, consists of two major forms, core enzyme with subunit stoichiometry of 2' and holoenzyme which contains an additional  subunit to core enzyme. E. coli RNA polymerase plays a central role in transcription. Wh...

Thesis (Ph. D.)--University of Nottingham, 1996.