Nihal Aydogan

Nihal Aydogan
Hacettepe University · Department of Chemical Engineering and Bioengineering Division

PhD

About

42
Publications
2,477
Reads
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746
Citations
Citations since 2017
11 Research Items
343 Citations
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
Additional affiliations
June 2001 - December 2012
Hacettepe University
January 1997 - March 2001
University of Wisconsin–Madison
Position
  • PhD Student

Publications

Publications (42)
Article
Nematic liquid crystal (LC) droplets have been widely used for the detection of molecular species. We investigate the response of micrometer sized nematic LC droplets against the adsorption of nanoparticles from aqueous media. We synthesized ∼100 nm-in-diameter silica nanoparticles and modified their surfaces to mediate either planar or homeotropic...
Article
An anionic and amphiphilic molecule, AQua (AQ-NH-(CH2)10COOH; where AQ is anthraquinone), which has two stimuli responsive functional-groups, can form self-assembled interfacial aggregates at the air-water interface and, their morphologies can be controlled by changing the subphase conditions such as the pH of the subphase. These interfacial morpho...
Article
Oral administration of the drugs is considered as one of the most convenient and comfortable routes. However, an effective oral delivery of insulin still remains a challenging and elusive goal, due to bioavailability problem. The aim of our work is to develop a pH sensitive polymeric system for the oral delivery of insulin based on a poly (ϵ‐caprol...
Article
The biophysical interaction between the nanoparticles (NPs) and biological interfaces is vitally important due to the increasing usage of NPs in biomedical and pharmaceutical applications such as drug delivery. Several different approaches or ligands can be utilized including surfactants for the surface decoration of NPs. We used two custom-made, p...
Article
Recently, nanomaterial-based adhesives have arised as alternatives to be used in the industrial field or to provide the next generation of biomedical adhesives with their enhanced mechanical properties and adhesion strengths. In this work, we developed a method for achieving adhesion between two PDMA (Poly dimethylacrylamide) hydrogel surfaces by u...
Article
Lungs are critical organs that are continuously exposed to exogeneous matter. The presence of the mucus layer helps to protect them via its adhesive structure and filtering mechanisms. Mucus also acts as a strong barrier against the drugs and nanocarriers in drug delivery. In this study, solid lipid nanoparticles (SLNs), at different sizes and surf...
Article
Stimuli-responsive liquid marbles can serve as reservoirs for encapsulating and carrying different materials, which could be used on demand for several applications. Here, enhanced spreading behavior of catanionic mixtures with magnetic liquid marbles were combined and a new approach to the phase separation, actuation and manipulation of liquids th...
Article
Organic‐inorganic hybrid nanotubes are highly functional and interesting materials. However, their formation generally requires reducing agents, high temperatures, special procedures, organic solvents etc. Here, using a simple concept based on engineering and materials design, we fabricated stimuli‐responsive lipid‐gold hybrid nanotubes. Self‐assem...
Article
Microcapsules (MCs), prepared using colloidal particles as shell material for assembly, are a drug-delivery system offering several advantages such as increased drug encapsulation efficiency, higher surface area, modifiable structure, and multi-functionality. Nano-in-micro ibuprofen (IBU) MCs were prepared using the layer-by-layer method for use as...
Article
Effective and efficient spreading of drug formulations on the pulmonary mucosal layer is key to successful delivery of therapeutics through the lungs. Pulmonary mucus layer, which covers the airway surface, acts as a barrier against therapeutic agents, especially in the case of chronic lung diseases due to increased thickness and viscosity of mucus...
Article
Magnetic nanocomposites (Fe3O4-MPTMS-PLGA) were synthesized by single oil emulsion method and characterized by transmission electron microscopy (TEM), X-Ray diffraction (XRD), and vibrating sample magnetometer (VSM). Particle size of nanocomposites was between 117 nm and 246 nm. High performance liquid chromatography (HPLC) was used to investigate...
Article
There are several approaches available for the synthesis of nanoparticles below 20 nm, which is also the critical size for superparamagnetic iron oxide nanoparticles (SPIONs). In this study, we aimed to determine optimum synthesis conditions for SPIONs via a co-precipitation method as well as demonstrate the effect of each parameter on the size, mo...
Article
Solid lipid nanoparticles (SLN), a promising drug delivery vehicle, offer an alternative system to traditional colloidal carriers. In our study 12 new SLN formulations were fabricated via the “microemulsion (ME) method”, each leading to a different SLN size and composition. This method is a relatively easy technique and involves biocompatible condi...
Article
Lipid nanotubes are the preferred structures for many applications, especially biological ones, and thus have attracted much interest recently. However, there is still a significant need for developing more lipid nanotubes that are reversibly controllable to improve their functionality and usability. Here, we presented a two-way reversible morpholo...
Article
Lipid nanotubes (LNTs) are one of the most advantageous structures for drug delivery and targeting. LNTs formed by a specially designed molecule called AQUA (AQ-NH-(CH2)10COOH (AQ: anthraquinone group) is used for drug delivery, and doxorubicin (DOX) is the drug selected. DOX and AQUA have some similarities in their molecular structures, so a signi...
Article
Full-text available
Magnetic nanoparticles are considered as the ideal substrate to selectively isolate target molecules or organisms from sample solutions in a wide variety of applications including bioassays, bioimaging and environmental chemistry. The broad array of these applications in fields requires the accurate magnetic characterization of nanoparticles for a...
Article
Serum proteins, especially fibrinogen, inactivate the lung surfactant mixture by adsorbing quickly and irreversibly to the alveolar air/aqueous interface. As a consequence of the inactivation, the surfactant becomes dysfunctional, and respiration cannot be maintained properly. Preventing the adsorption of surface active serum proteins to the air/wa...
Article
Boron contamination is an environmentally serious problem especially due to its hazards on plants. In this work, newly synthesized poly (vinyl amino-N, N′-bis-propane diol) (GPVA) is presented as an excellent chelating polymer for boron removal. Boron concentration could be reduced from 10 ppm down to 0.4 ppm via total recycle Polymer Enhanced Ultr...
Article
In this study, a copolymer, poly (vinyl amino-N, N′-bis-propane diol-co-DADMAC) (GPVA-co-DADMAC) was synthesized in three comonomer ratios (2%, 5% and 10%) and efficiently exploited for boron removal via polymer enhanced ultrafiltration (PEUF). Boron concentration could be reduced from 10 ppm down to 0.8 ppm by the employment of novel copolymer in...
Article
Surface structure of nanoparticles (NPs) has considerable effect on their usability and efficiency in a wide variety of applications such as electronics, photonics, catalysis, chemical sensing, and drug-delivery systems, etc. This turns the surface modification of nanoparticles into a quite important and intriguing issue. Therefore, being able to d...
Article
Self-assembled lipid nanotubes arouse lots of interest due to their exceptional properties such as very simple production procedures, large variety of applications and high biocompatibility. In this study, the new eccentric but simple molecule, AQua (AQ-NH-(CH(2))(10)COOH; where AQ is anthraquinone), which integrates redox-active and pH sensitive c...
Article
The interfacial behavior of the newly designed Fluorocarbon Hydrocarbon Cationic Lipid (FHCL or CH(3)(CH(2))(17)N(+)(C(2)H(5))(2)(CH(2))(3)(CF(2))(7)CF(3)I(-)) and its mixtures with a phospholipid (DPPC, Dipalmitoylphosphatidylcholine) at different mole fractions were investigated. This new molecule was synthesized to mimic the selected properties...
Article
Two selective functional polychelatogens, namely hydroxyethylaminoglycerol functioned poly(glycidylmethacrylate (PNS) and Poly(4-Vinyl-1,3-dioxalan-2-one-co-vinyl acetate) (COP) were synthesized and utilized in polymer-enhanced ultrafiltration (PEUF) to remove boron from the aqueous solution. The effect of operating parameters on boron retention wa...
Article
A very sensitive and highly specific heterogeneous immunoassay system, based on surface-enhanced Raman scattering (SERS) and gold nanoparticles, was developed for the detection of bacteria and other pathogens. Two different types of gold nanoparticles (citrate-stabilized gold nanosphere and hexadecyltrimethylammonium bromide (CTAB)-stabilized gold...
Article
Fractional separation of industrially important heavy metals (cadmium, nickel, zinc) from binary and ternary metal mixtures by continuous mode polymer enhanced ultrafiltration was studied. Polyethyleneimine (PEI) was used as a complexation polymer. Effects of pH and ionic strength on process efficiency were investigated. To gain insight about the c...
Article
The hydrophobic core of the multicompartment micelles consists of incompatible and clearly separated distinct subdomains which make them different from the classical micelles. Owing to these properties multicompartment micelles have a great potential to be used as solubilization agents and carriers for a wide variety of applications where it is imp...
Article
This paper reports the surface and bulk properties of a newly designed redox active hybrid surfactant Fc(CH2)11N+(C2H5)2(CH2)2(CF2)5CF3 I- or FcFHUB, where Fc is ferrocene. This new surfactant displays strong surface tension lowering ability (31 mN/m) and low critical micelle concentration (0.03 mM in 100 mM Li2SO4). The minimum area per surfactant...
Article
As foaming appears as a problem in chemical and fermentation processes that inhibits reactor performance, the eminence of a novel fluorocarbon-hydrocarbon unsymmetrical bolaform (FHUB: OH(CH2)11N+(C2H4)2(CH2)2(CF2)5CF3 I-) surfactant as an antifoaming agent as well as a foam-reducing agent was investigated and compared with other surfactants and a...
Article
We report the interfacial properties of a new fluorocarbon-hydrocarbon hybrid surfactant [OH(CH 2) 11N +(C 2H 4) 2(CH 2) 2(CF 2) 5CF 3 I -, or FHUB], which has a fluorocarbon chain as well as a w-hydroxyalkyl chain. This new hybrid surfactant has properties that are different than classical hydrocarbon- and fluorocarbon-containing surfactants. This...
Article
We report the interfacial properties of a new fluorocarbon−hydrocarbon hybrid surfactant [OH(CH2)11N+(C2H4)2(CH2)2(CF2)5CF3 I-, or FHUB], which has a fluorocarbon chain as well as a ω-hydroxyalkyl chain. This new hybrid surfactant has properties that are different than classical hydrocarbon- and fluorocarbon-containing surfactants. This difference...
Article
We report the effect of electrolyte concentration on the surface and bulk solution properties of a redox-active ferrocenyl surfactant, Fc(CH2)11SO3-Na+, where Fc is ferrocene. Electrochemical oxidation of the electrically neutral Fc moiety to the ferrocenium cation reversibly transforms the anionic surfactant (Fc(CH2)11SO3-) into a zwitterionic spe...
Article
The paper reports an investigation of the surface behavior of N,N-dimethylferrocenylmethylundecyl ammonium bromide, Br−Fc(CH2)N+(CH3)2(CH2)10CH3, where Fc is ferrocene, by employing a simple molecular thermodynamic model and by comparing the predictions of the model to experimental measurements. Whereas a past study (Colloids Surfaces A: Physicoche...
Article
We report the results of a combined experimental and theoretical investigation of the equilibrium interfacial properties of unsymmetrical bolaform surfactants that possess one ionic and one nonionic head group. By synthesizing the surfactant (11-hydroxyundecyl)trimethylammonium bromide (HTAB) and by performing measurements of the equilibrium surfac...
Article
We report the synthesis and aqueous solution properties of a novel redox-active surfactant, Fc(CH2)11SO3-Na+, where Fc is ferrocene. Electrochemical oxidation of Fc to the ferrocenium cation (Fc+) reversibly transforms the anionic surfactant (Fc(CH2)11SO3-) into a zwitterionic species (Fc+(CH2)11SO3-). When dissolved at concentrations between 0.15...
Article
We report the development of a molecular-thermodynamic model for Gibbs monolayers formed from the redox-active surfactant (11-ferrocenylundecyl)trimethylammonium bromide (II+), or oxidized II+ (II2+), at the surfaces of aqueous solutions. This model provides an account of past experimental measurements (Gallardo, B. S.; Metcalfe, K. L.; Abbott, N....
Article
Due to the complexity of fermentation mixtures, separation of solutes and secondary substrates has a special importance. Membrane processes such as nanofiltration may offer good alternatives for the separation of fermentation products or recovery of substrates. For an efficient separation, the membrane type and operating parameters such as feed flo...
Article
In continuous ethanol fermentation processes, which include product removal and recovery steps, to limit the concentration of secondary products, a bleed stream may be used. This stream contains several small molecular weight organic fermentation products and substrate sugars. To recover sugars and to minimize the amount of waste, the bleed stream...

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