Nihad Elsadig

National centre of neurological sciences-sudan ,Khartoum and Darfour univesity college · Stem cell lab

Introduction Meningioma is the second most common primary intracranial tumor of the central nervous system. in Sudan, meningioma is the most common primary brain tumor, among Sudanese patients, Surgical total excision of meningioma offers a better survival, however, Chemotherapy has largely been unsuccessful for meningioma treatment, and therefore,...

Perception of Medical Laboratory Students toward Professionalism at the University of Medical Sciences and Technology 2022

Effusions, characterized by abnormal fluid accumulations in body cavities, present difficulties in identifying the primary organs of metastatic tumors through cytopathologic investigation, particularly in cancer-related complications. This retrospective cross-sectional laboratory study aimed to investigate the role of thyroid transcription factor-1...

Background: Hypertensive disorders are a common complication of pregnancy that put women and their fetuses at disproportionate risk for further complications, as well as a lifelong sequela. This study aimed to measure the Methytetrahydrofolate Level (folate) among Sudanese women with hypertensive disorders of pregnancy Material and method: This was...

ARTICLE INFO ABSTRACT Background: Hypertensive disorders of pregnancy HDP are the second leading cause of global maternal mortality behind maternal hemorrhage and are a significant cause of short-and long-term maternal and fetal/offspring morbidity. This study aimed to measure the ferritin level among Sudanese women with hypertensive disorders of p...

Background: ischemic stroke is one of three types of strokes. It is caused by a blockage in an artery that supplies blood to the brain. If circulation isn’t restored quickly, brain damage can be permanent. This study was aimed to measure the protein c level among sudanese patients with the ischemic stroke. Material And Method: This was a case...

Background: Menopause is a natural stage in life and part of the aging process. it marks when a woman’s period stops as her ovaries stop producing eggs. Many changes take place in the physiological parameters some of which are known to enhance the risk of vascular-related diseases such as stroke and ischemic heart disease. This study aimed to estim...

Background: Stroke is a non-traumatic, focal vascular injury of the nervous system and typically results in permanent damage in the form of cerebral infarction or intracerebral hemorrhage and/ or subarachnoid hemorrhage. This study was aimed to measure the ferritin Level among Sudanese patients with the ischemic stroke. Material and method: This wa...

No diseases are known to result from the lack of expression of ABO blood group antigens, but the susceptibility to a number of diseases has been linked with a person's ABO phenotype. A cross sectional study conducted at research laboratory of Gharb El-Niel College from May to August 2022, to estimate the relation of ABO blood group on fibrinogen le...

Abstract: Background: One of four vaccinations, the AstraZeneca vaccine, was given conditional approval to prevent COVID-19. It has been licensed and approved for use in more than 170 nations, and as of late November 2021, about 1 billion doses had been given worldwide. In order to produce the SARS-CoV-2 spike protein, which triggers an immune res...

Background Recurrent pregnancy loss affects 1 to 5% of women trying to conceive, I t has a significant impact at individual and social level. Methodology case-control study conducted at the research laboratory of the national center of neurological sciences, Khartoum, Sudan. All patients attending Ibrahim Malik teaching hospital and diagnosed with...

background: Type 2 diabetes mellitus (T2DM) is a major public health problem that not only affects individual life quality, but also increases social economic burden. The pointed of this research to detect MTHFR gene polymorphisms in Sudanese patients with type 2 diabetes mellitus. Materials and Methods: This was case control study conducted at the...

Background: A COVID 19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome corona virus 2. Ad26.COV2.S (Johnson & Johnson) vaccine is adenovirus vector-based vaccine that targets the spike protein of the SARS-CoV-2 virus, when it enters the body it stimulates the immune response. Materials and method...

Background: A COVID-19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome corona virus 2. Ad26.COV2.S (Johnson & Johnson) vaccine is adenovirus vector-based vaccine that targets the spike protein of the SARS-CoV-2 virus, when it enters the body it stimulates the immune response. Materials and method...

Covid-19 pandemic has resulted in global health disaster and posed a great challenge to the suitable measures to contain the disease. The pathogenesis of the disease is still evolving. In the search for the pathogenesis of the virus, little attention has been made to the peripheral blood picture in Covid-19 patients. This study has focused on the m...

Background Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, also known as cerebral bleed, intraparenchymal bleed and hemorrhagic stroke. This study was designed to detect the possible present of factor II polymorphism (G20210A) among Sudanese patients with Intercereberal hemorrhage. Material and method This study...

Background: Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. Materials and methods: This was cross sectional study conducted at Baraah pediatric center, Khartoum, Sudan during the period from May 2022 to August 2022, to measure protein C level in Sudanese children...

Background Intracranial hemorrhage refers to any bleeding within the intracranial vault, including the brain parenchyma and surrounding meningeal spaces. In Sudan, there is no published data regarding factor V Leiden mutation. Therefore this study was designed to detect the possible present of factor V polymorphism (G1691A) among Sudanese patients...

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirusdisease 2019 (COVID-19) has rapidly evolved from an epidemic outbreak in Wuhan, China into a pandemic infecting more than one million individuals all over the world, where as billions of citizens are affected by measures of social distancing and the socioeco...

Background: Sepsis is the most common worldwide cause of death in infants and children. It was Known that coagulative and inflammatory parameters were involved in the host’s defense against sepsis resulted from severe infection and inflammation. Materials and Methods: This was cross sectional study conducted at Albraa pediatric center, Khartoum, Su...

Background: Recurrent spontaneous abortion is a health issue that occurs in about 1 — 5% of all women of reproductive age. Experimental evidence suggests that COX-2 plays an important part in blastocyst implantation but rarely is the role of COX-2 recognized in recurrent spontaneous abortions. Methods: This is a descriptive analytical case-contro...

Background: Vitamin D endocrine system was formally known as a key player in calcium and phosphatehomoeostasis and in regulation of bone remodelling. It is influences maternal and fetal cell differentiation and cell growth immune regulation, insulin secretion and anti-proliferative processes Methods: A case control study was conducted at the Nation...

Recurrent Spontaneous abortion (RSA) is defined as consecutive pregnancy loss before 20 weeks of gestation. This study aimed to detect p53 codon 72 polymorphisms among Sudanese women with recurrent spontaneous abortion. A case-control study was conducted at the national centre of neurological sciences, Khartoum, Sudan. All patients attending the ob...

Recurrent Pregnancy Loss (RPL) is recognized as the loss of a clinical pregnancy before 20 completed weeks of gestational age. This was a descriptive-analytical case-control study conducted at the research laboratory of the national centre of neurological sciences (NCNS), Khartoum, Sudan. The study aimed to detect factor XIII gene polymorphisms amo...

Background: Recurrent Spontaneous abortion (RSA) is defined as consecutive pregnancy loss before 20 weeks gestation and it has been attributed to either genetic, structural infective, endocrine, immune, or unexplained causes Material and methods This study was case – control study conducted at the Algophran medical laboratory, Khartoum, Sudan durin...

Background Ischemic stroke is known as rapidly progressing clinical feature of focal disturbance of cerebral function extending for more than 24 hours or leading to death, with no apparent cause other than vascular origin Material and methods This was a case control study conducted at the research laboratory of the national center of neurological...

Background: Miscarriage is that the commonest complication of pregnancy, defined as rate of pregnancy loss in women with a missed menstrual period and positive urine pregnancy and it is occurrence of three consecutive pregnancy losses during the primary trimester. Material and methods: This study was an analytical case – control study conducted at...

Abstract Background: Meningioma is the second most common primary intracranial tumor of the central nervous system, surgical total excision of meningioma offers a better survival to patients; however, a significant proportion of histological variant recur within 5 years despite complete excision. Chemotherapy is generally unsuccessful in treating m...

Background Hypertension is a prevalent situation in which the long term force of the blood against artery walls is high enough that it may be eventually cause health problems, like heart disease.

Background: Cerebral bleed, intraparenchymal bleed, and hemorrhagic stroke are all terms for intracerebral hemorrhage. It accounts for about 10% of all strokes. The prevalence of stroke among Sudanese people with diabetes was 2.5% in that country. A neuroprotective hormone called vitamin D receptor (VDR), also called the calcitriol receptor, contro...

Background: Recurrent spontaneous abortion (RSA) has traditionally been defined by two or more consec-utive pregnancy losses before 20 weeks’ gestation. RSA has been estimated to occur in approximately 1% of all couples. The World Health Organization (WHO) defines it as expulsion or extraction of an embryo or fetus weighting 500 g or less. Methods:...

Background: Recurrent spontaneous abortion (RSA) has traditionally been defined by two or more consecutive pregnancy losses before 20 weeks' gestation. RSA has been estimated to occur in approximately 1% of all couples. The World Health Organization (WHO) defines it as expulsion or extraction of an embryo or fetus weighting 500 g or less. Methods:...

Background: Aerobic exercise induces physiological stress on the body and brings changes in hematological parameters. This study aimed to determine the effect of playing football as an exercise on the total white blood cell count, absolute Neutrophil, lymphocyte and Platelet counts among Sudanese football players. Material and method: This was a de...

Background: Coagulation, also known as blood clotting, is the process by which blood convert from a liquid to a gel, forming a blood clot. It referred to haemostasis, the stopping of blood loss from a damaged vessel, followed by repair. Material and methods: This was cross sectional study conducted at the albawasla medical laboratory, Khartoum, Sud...

Background: Cisplatin is one of therapy used as anticancer activity in a variety of tumors. Among many chemotherapy drugs that are widely used for cancer, Cisplatin is one of the most compelling ones. Material and methods: This study was Analytical cross sectional study conducted at Taiba Cancer Center, Khartoum, Sudan, during the period July 2021...

Abstract: Meningioma is the most common primary brain tumor. In spite of the available surgical options and adjuvant treatment, tumor recurrence is still a challenge. Advances in molecular cell biology and genomic techniques have demonstrated in human brain tumors the existence of subpopulations of cells that functionally behave as tumor stem cell....

Background: Chronic myeloid leukemia (CML) is a malignancy of white blood cells, distinguished by the Philadelphia chromosome's presence. The biological profile of sufferers with CML at diagnosis is nevertheless missing in Africa, especially in Sudan. Therefore, the study pursued to measure the fibrinogen level among Sudanese patients diagnosed wit...

Preeclampsia is a serious disease, is one of a potentially fatal complication of pregnancy, it can lead to eclampsia and may result in maternal and neonatal mortality and morbidity.This is a case control study conducted at hematology lab in Omdurman maternity hospital and central lab in Ibrahim malik teaching Hospital, Khartoum Sudan. The study aim...

Major histocompatibility complex (MHC) is consisted of cluster of genes known as human leukocyte antigen HLA, these genes are committed to process and present antigens to T lymphocyte. Corona viruses, belonging to a genus of the corona viridae family, are enveloped viruses containing single stranded RNA 27-32 kb. This study was conducted to highlig...

Background: studies have shown a variety of diabetes mellitus related abnormalities in hemostasis and thrombosis. The diabetic condition contributes for initiation and progression of microvascular and macrovascular complication. Materials and Methods: during May 2012 to June 2012. The study included samples from type 2 diabetic patients diagnosed c...

Background: Gliomas are the most common brain neoplasms in adults, accounting for about

Gliomas are the most common brain neoplasms in adults, accounting for about 70% of primary neoplasms of the Central Nervous System (CNS). Adenomatous Polyposis Coli (APC) is a tumor suppressor protein and one of the key players of the Wnt signaling pathway. Epidermal Growth Factor Receptor (EGFR) is an ErbB receptor with tyrosine kinase activity. E...

Introduction: Mesenchymal stem cells (MSCs) were described as adherent cells with a fibroblast-like appearance, have a great capacity for self-renewal while maintaining their multipotency and differentiation into multiple tissues in vivo and in vitro. Methods: MSCs were isolated from cord blood of Sudanese donors using Ficoll-Hypaque gradient densi...

Contraceptives are intentional prevention of conception through the use of various devices sexual practices, chemicals, drugs or surgical procedures become a contraceptive if its purpose is to prevent a woman from becoming pregnant. This is a cross sectional study conducted at ALnow Hospital Khartoum, Sudan, the study aimed to estimate D.dimer leve...

Introduction: Mesenchymal stem cells (MSCs) were described as adherent cells with a fibroblast-like appearance, have a great capacity for self-renewal while maintaining their multipotency and differentiation into multiple tissues in vivo and in vitro. Methods: MSCs were isolated from cord blood of Sudanese donors using Ficoll-Hypaque gradient densi...

Myocardial infraction (AMI) is an irreversible myocardial injury and necrosis caused by serious and long-term ischemia. It is generally seen in middle aged men with high risk factors for coronary artery disease. Only 4% of patients with AMI are under 40 years of age. This was a cross sectional study conducted at AL SHAB hospital, Khartoum, Sudan, a...

Chronic myeloid leukaemia (CML) is a kind of cancer that affects the white blood cells and resort to progress slowly through many years. It’s occur at any age, but is most common in older (60-65 years) of age. This is a cross sectional study aimed to detect MTHFR gene polymorphism (C677T) among Sudanese patients diagnosed with Chronic Myeloid Leuka...

Abstract Adipose or fatty tissue is similar to bone marrow ontogenetically. Mesenchymal stem cells can be isolated from different types of adipose tissue depots in greater amount than other sources, making them especially suitable for use in regenerative medicine. Adipose tissue was taken from Sudanese donors; the SVF which contains MSCs was isolat...

Diabetes mellitus is a major health problem in the world. The total number of diabetic’s population is increasing every year. Currently used treatment of diabetes mellitus type 1 by controlling the blood sugar levels, doesn’t prevent complications which associate diabetes. The stem cell based therapy for diabetes aims to replace the diseased or los...

Background: Point mutations in MSH6 gene had been related to group of cancers called lynch syndrome which accounts for 3% to 5% of all colorectal cancers. Despite the excessively studied MSH6 mutations, the mechanism by which these mutations promote carcinogenesis remains controversial. Methods: MSH6 was investigated in dbSNP/NCBI in December 2015,...

Genetic epidemiological studies have suggested that several genetic variants increase the risk for hypertension. It is likely that a number of genes rather than a single gene account for the heritability of this complex disorder. However, the genetic analysis of hypertension produced complex, inconsistent and nonreproducible results, which makes it...