Niels Wedderkopp

Niels Wedderkopp
University of Southern Denmark | SDU · Speciality in Clinical Pharmacology

Professor, MD, Ph.D.

About

271
Publications
85,150
Reads
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16,597
Citations
Education
September 1983 - January 1991
University of Southern Denmark
Field of study
  • Medicine, Pubic Health

Publications

Publications (271)
Article
Full-text available
OBJECTIVE Anterior cervical discectomy and fusion (ACDF) is often described as the gold standard surgical technique for cervical spondylotic radiculopathy. Although outcomes are considered favorable, there is little prognostic evidence to guide patient selection for ACDF. This study aimed to 1) describe the 24-month postoperative trajectories of ar...
Article
Study design: A method development and validation study. Objectives: The purpose of this study was to develop and test a method for step detection using accelerometer data in patients with lumbar spinal stenosis. There are two objectives: (1) to describe a method for step detection from accelerations measured at the wrist, hip, lower back, thigh...
Article
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This retrospective study of prospectively collected data aimed to identify unique pain and disability trajectories in patients following lumbar discectomy surgery. Patients of this study population presented chiefly with lumbar radiculopathy and underwent discectomy surgery from thirteen sites enrolled in the CSORN registry. Outcome variables of in...
Preprint
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Objectives (1) To develop reference values for health-related fitness European children and adolescents aged 6–18 years that are the foundation for the web-based, open-access and multi-language fitness platform (FitBack); (2) To provide comparisons across European countries. Methods This study builds on a previous large fitness reference study in...
Article
Context: There is a rise in overweight and obesity among children and adolescents with type 1 diabetes (T1D) in parallel with the rise in the metabolic syndrome (MetS) among children and adolescents. Objective: The aim of the study was to describe the prevalence and characteristics of MetS in children and adolescents with T1D compared to their h...
Article
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We investigated the longitudinal associations between physical activity (PA), lumbar multifidus morphology, and impactful low back pain (LBP) in young people. Nine-year-old children were recruited from 25 primary schools and followed up at age 13, 16, and 21 years. We measured PA with accelerometers at age 9, 13, and 16; quantified patterns of lumb...
Article
The adipokines adiponectin and leptin play key roles in human metabolic regulation and have gained great attention as biomarkers for various metabolic pathologies. Though, pediatric reference values are few and needed. This study aims to establish age- and sex-specific adipokine reference percentiles based on healthy Danish school children. Further...
Article
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This study aimed to investigate the trajectories of spinal pain frequency from 6 to 17 years of age and describe the prevalence and frequency of spinal pain and related diagnoses in children following different pain trajectories. First through fifth-grade students from 13 primary schools were followed for 5.5 years. Occurrences of spinal pain were...
Article
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Background Reverse total shoulder arthroplasty was originally designed for older patients with rotator cuff arthropathy and produces good results. The main objective of this retrospective study was to compare the patients younger than 65 years v s . the older patients in terms of the complications of reverse total shoulder arthroplasty and the func...
Article
Limited research exists on the relationship between changes in physical activity levels and injury in children. This study investigated the prognostic relationship between changes in activity measured with the acute:chronic workload ratio (ACWR) and injury in children. We used data from the Childhood Health, Activity, and Motor Performance School S...
Conference Paper
Background Shoulder rotation strength deficit measured at one time-point during preseason has been investigated as a risk factor for shoulder problems in sports with conflicting results. However, athletes face changes in physical demands and accumulative training exposure during a season, which likely influence their rotation strength over this per...
Article
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Our aim was to assess the association between changes in active travel to school and changes in different intensities of physical activity (i.e. moderate - MPA and vigorous - VPA) and time spent sedentary (SED) among adolescents and assess the moderating effect of children’s sex, age and weight status. Data from six cohort studies in the Internatio...
Article
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Physical activity (PA) is critical to improving health factors such as weight, adiposity, and aerobic fitness. However, children who meet PA guideline recommendations demonstrate developmental differences in health-related outcomes. To investigate prospective associations between PA behaviour (overall PA and PA intensity) and trajectories of health...
Article
Background and objective: Motor performance during childhood and adolescence is recognized as a relevant determinant of present and future health, but its effects on back pain (BP) remain unclear. In this systematic review, we aimed to identify the association between motor performance and BP in children and adolescents. Databases and data treatm...
Article
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We examined the influence of using different epoch lengths on the classification accuracy of laboratory-controlled sedentary behaviour (SB), and free-living total time and time spent in bouts of SB and moderate-to-vigorous physical activity (MVPA), in children and adolescents. We used two studies including accelerometer-derived data of: 1) controll...
Article
Objectives We aimed to determine the use of injury prevention exercises and injury prevention exercise programs in Danish youth handball and investigate coach and player experiences, beliefs and attitudes of injury and their prevention. Design A mixed-methods design consisting of cross-sectional quantitative surveys and qualitative interviews. Me...
Article
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Objective To investigate the effectiveness of conservative non-pharmacologic therapies on pain-related, physical capacity, and physical activity outcomes in patients with degenerative lumbar spinal stenosis (LSS). Data Sources Systematic search of MEDLINE, EMBASE, CENTRAL, and PsycINFO from inception to November 4, 2019 without language restrictio...
Article
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From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
Article
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From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
Article
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Objective Pain is the principal symptom in knee osteoarthritis (OA). Current non-operative treatment options have only moderate effects and often patients experience persistent pain or side-effects. Novel advances in the field of cryoneurolysis applies low temperatures to disrupt nerve signaling at the painful area, providing pain relief. The prima...
Article
Purpose Bone turnover markers (BTM) are gaining ground in clinical practice but to fully use their potential there is a need for establishing valid reference intervals (RI). Consequently, the purpose of the study was to establish general RI as well as suggested clinical RI for Carboxy-terminal Cross-Linked Telopeptide of Type I Collagen (β-CTX), Pr...
Article
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It remains unclear whether the provision of additional physical activity in school improves academic outcomes. We conducted a secondary analysis of the Childhood Health, Activity, and Motor Performance School Study Denmark (CHAMPS-study DK), a natural experiment based on a trebling of curricular physical education, to investigate whether children r...
Article
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Objectives To determine if subpopulations of students benefit equally from school-based physical activity interventions in terms of cardiorespiratory fitness and physical activity. To examine if physical activity intensity mediates improvements in cardiorespiratory fitness. Design Pooled analysis of individual participant data from controlled tria...
Article
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Background: Chiropractic technique systems ('prescriptive' techniques) might be interpreted as helpful guidelines. However, 'prescriptive' techniques, such as Functional Neurology (FN), Sacro-Occipital Technique, and Applied Kinesiology are more concerned with the 'technical' diagnosis than the condition and its symptoms and, thus, seem to provide...
Article
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Objectives Describe the trajectories of body mass index (BMI), waist circumference, and aerobic fitness in children and identify different outcomes of guideline-recommended physical activity (PA) in a subset of active children.Methods We recruited students from 10 public primary schools and obtained repeated measures of BMI, waist circumference, an...
Article
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There is solid evidence for an association between physical activity and metabolic health outcomes in children and youth, but for methodological reasons most studies describe the intensity spectrum using only a few summary measures. We aimed to determine the multivariate physical activity intensity signature associated with metabolic health in a la...
Article
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Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled ana...
Preprint
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Background: Limited research exists on the association between increased physical activity and injury in children. Objective: To assess how well different variations of the acute:chronic workload ratio (ACWR) predict injury in children. Methods: We conducted a prospective cohort study using data from 1670 Danish schoolchildren measured over 5.5 yea...
Article
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Background The relationship between motor performance and back pain in children and adolescents remains unclear. This article describes the protocol for a systematic review to summarize the knowledge about the association between motor performance, such as agility, flexibility, balance, strength, muscle endurance, and cardiorespiratory fitness, and...
Article
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Background: Adolescents' health-related behavior varies from weekday to weekend. Only few studies, however, have examined to which degree such variation will affect markers of cardiometabolic health. Therefore, the primary aim of this study is to examine if markers of cardiometabolic health differ between different days of the week in adolescents....
Article
Background perfluoroalkylated substances (PFAS) are highly persistent chemicals that are able to alter the human metabolism – potentially via disruption of cell signaling pathways mediated by adipokines. Both adiponectin and leptin are influenced by and exert influence on energy storage and energy expenditure, wherefore associations between PFAS an...
Preprint
Researchers often use model-based multiple imputation to handle missing at random data to minimize bias while making the best use of all available data. However, there are sometimes constraints within the data that make model-based imputation difficult and may result in implausible values. In these contexts, we explore the advantages of employing a...
Article
Objective: To investigate change in shoulder rotation strength from preseason to midseason during a competitive season in youth elite handball players without shoulder problems. Design: Prospective cohort study. Methods: Players (n = 292, 45% female, 14-18 years of age) without shoulder problems from Danish youth elite handball clubs were asse...
Article
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Study design: Longitudinal analysis of prospectively collected data. Objective: Investigate potential predictors of poor outcome following surgery for degenerative lumbar spinal stenosis (LSS). Summary of background data: LSS is the most common reason for an older person to undergo spinal surgery, yet little information is available to inform...
Article
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High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world³ and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein...
Article
Objective To examine the associations of changes in physical activity and sedentary-patterns with changes in cardiometabolic outcomes from childhood to adolescence. Study design Youth from the International Children's Accelerometry Database (n=1,088; 55% girls), aged 8-13 years and followed for ∼4 years, were used in this analysis. Hip-mounted acc...
Article
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High quality sports injury research can facilitate sports injury prevention and treatment. There is scope to improve how our field applies best practice methods—methods matter (greatly!). The 1st METHODS MATTER Meeting, held in January 2019 in Copenhagen, Denmark, was the forum for an international group of researchers with expertise in research me...
Article
Synopsis: High-quality sports injury research can facilitate sports injury prevention and treatment. There is scope to improve how our field applies best-practice methods-methods matter (greatly!). The first METHODS MATTER meeting, held in January 2019 in Copenhagen, Denmark, was the forum for an international group of researchers with expertise i...
Article
Full-text available
Background: Levels of physical activity and variation in physical activity and sedentary time by place and person in European children and adolescents are largely unknown. The objective of the study was to assess the variations in objectively measured physical activity and sedentary time in children and adolescents across Europe. Methods: Six da...
Article
Study design: Registry based repeated-measures psychometric validation of the Danish Oswestry Disability Index (ODI) OBJECTIVE.: The goal was to use classical and modern psychometric validation methods to assess the measurement properties and the minimally clinical important difference (MCID) of the ODI in a Danish cohort of patients with chronic...
Article
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Background: Spinal manipulation (SM) has been shown to have an effect on the pressure pain threshold (PPT) in asymptomatic subjects, but SM has never been compared in studies on this topic to a validated sham procedure. We investigated the effect of SM on the PPT when measured i) in the area of intervention and ii) in an area remote from the inter...
Article
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Background: Lipophilic compounds such as polychlorinated biphenyls (PCBs) are primarily stored in adipose tissue, but exercise-induced lipolysis is able to release PCBs from the adipose tissue into the circulation. The plasma concentration, distribution and metabolism of PCBs can thus vary much among individuals due to inter-human variations in li...
Article
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Evidence suggests that motor performance in children is declining globally. We tested whether participation in organized sport is associated with motor performance, and estimate the effect of 30 months participation in organized sport on motor performance. Study participants were 1067 primary school students, enrolled in the Danish Childhood Health...
Article
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Background While there is a broad spectrum of practice within chiropractic two sub-types can be identified, those who focus on musculoskeletal problems and those who treat also non-musculoskeletal problems. The latter group may adhere to the old conservative ‘subluxation’ model. The main goal of this study is to determine if chiropractic students w...
Article
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Background Taking the natural course of recurrent and fluctuating low back pain (LBP) seen in longitudinal studies of adults into consideration, the aetiology and development of LBP in children and adolescents also needs to be reflected in a long-term course. Therefore, a systematic critical literature review was undertaken to assess the natural co...
Article
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Background: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorou...
Article
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Background: In children, spinal pain is transitory for most, but up to 20% experience recurrent and bothersome complaints. It is generally acknowledged that interventions may be more effective for subgroups of those affected with low back pain. In this secondary analysis of data from a randomized clinical trial, we tested whether five indicators o...
Article
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Objective Identify patient subgroups defined by trajectories of pain and disability following surgery for degenerative lumbar spinal stenosis, and investigate the construct validity of the subgroups by evaluating for meaningful differences in clinical outcomes. Methods We recruited patients with degenerative lumbar spinal stenosis from 13 surgical...
Article
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Purpose To examine the prospective associations between spinal pain exposures and risk factors for cardiovascular disease in children and explore the mediating role of health-related physical activity. Methods Students were recruited from ten public primary schools. Each week from November 2008 to October 2010, parents reported spinal pain occurre...
Article
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
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Background: School-based physical education (PE) and organised leisure-time sports participation (LTSP) represent important physical activity opportunities for children. We examined the preventive effect of increased PE as well as LTSP on overweight and obesity (OW/OB) in school children. Methods: Longitudinal data from children attending 10 pri...
Article
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Aim: We evaluated the effect that increasing physical education lessons from 1.5 to 4.5 hours per week for five years had on the body mass index (BMI) and waist circumferences of children aged 5-11 years at inclusion. Methods: From 2008-2013, six intervention schools in Svendborg, Denmark, delivered 4.5 hours of physical education lessons per we...
Article
BACKGROUND CONTEXT On average, patients experience important reductions in pain and disability following surgery for degenerative lumbar spinal stenosis (LSS). However, variability in the postoperative course of symptoms suggests many patients do not fit the average symptom trajectory. PURPOSE To identify patient subgroups defined by trajectories...
Article
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Purpose To examine the prospective associations of pubertal development and linear growth with spinal pain frequency and duration in children. Methods We recruited students from 10 public primary schools. Over 42 months, pubertal development was assessed four times and categorized according to Tanner stages 1–5, and height was measured on seven oc...
Article
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Objectives: The aim of this study was to determine the prevalence of tinnitus and/or hyperacusis in Danish children aged 10 to 16 years, and to assess associations between tinnitus or hyperacusis and other relevant factors. Design: A cross-sectional study based on a previously established child cohort. A total of 501 children were enrolled in th...
Article
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Objective: To evaluate whether psychomotor therapy (PMT) in combination with usual care active exercise (AE) rehabilitation for the shoulder is superior to merely AE. Design: The trial was a single-center, stratified (by corticosteroid injection [yes or no]), randomized, and controlled superiority trial. Setting: Shoulder unit of the orthopedi...
Article
Full-text available
Background: Spinal manipulation (SM) has been shown in a systematic review to have a statistically significant effect on the pressure pain threshold (PPT) in asymptomatic subjects, when SM is compared to a sham intervention. The magnitude and duration of this effect is unclear. Objectives: To determine the effect-size of SM in asymptomatic subje...