Niels Ter Huurne

• Radboud University Medical Centre (Radboudumc)

Rationale Trust is a key component of social interactions. In order to assess the trustworthiness of others, people rely on both information learned from previous encounters, as well as on implicit biases associated with specific facial features. Objective Here, we investigated the role of catecholamine (dopamine and noradrenaline) transmission on...

A balance has to be struck between supporting distractor-resistant representations in working memory and allowing those representations to be updated. Catecholamine, particularly dopamine, transmission has been proposed to modulate the balance between the stability and flexibility of working memory representations. However, it is unclear whether dr...

Neuronal oscillations support cognitive processing. Modern views suggest that neuronal oscillations do not only reflect coordinated activity in spatially distributed networks, but also that there is interaction between the oscillations at different frequencies. For example, invasive recordings in animals and humans have found that the amplitude of...

LZP did not modulate alpha-phase to beta-low gamma amplitude coupling during WM delay. (A) Delayed match to sample WM task. Participants had to keep fixations while covertly attend to the cued visual hemifield to encode the target items. The task consisted to compare the cued items, compare them with a probe and decide whether they matched or not....

Time-frequency representations (TFR) of induced power locked to the peaks of the alpha oscillations during rest. (A) Grand mean TFRs from left and right hemisphere MEG axial gradiometers [for white sensors in (E)] time-locked to the alpha peaks (t = 0 s) under placebo session during EO. TFRs were calculated for each single trial and then averaged....

LZP did not significantly change CFD during EC. (A) Grand mean topographic representation of the CFD (8–12 Hz; 20–45 Hz) for the different drug conditions. White sensors were significantly modulated by LZP in Figure 1. The color code indicates the normalized Ψ~ weighted average of the CFD slope (Ψ = Ψ~/std(Ψ~)). (B) Grand mean normalized CFD index...

LZP did not change CFD during WM delay. (A) Grand mean topographic representation of alpha-beta CFD (16–22 Hz) during WM delay for each drug separately. Color code indicates the normalized Ψ~ weighted average of the CFD slope [Ψ = Ψ~/std(Ψ~); color scale same as in (B)]. (B) Grand mean normalized CFD index taken over the occipital sensors of intere...

LZP modulations in the alpha (8–12 Hz) and beta (15–30 Hz) bands during rest. (A) Grand mean topographic representation of alpha power during EO (left) and EC (right). Color code represents relative power changes with respect to the mean of the power spectrum (5–40 Hz). The rows reflect the drug levels: Placebo, 0.5 and 1.5 mg LZP. Sensors marked i...

Beta-low gamma peak-triggered average during rest. (A) Grand mean of event-related fields locked to the beta-low gamma (20–45 Hz) peaks. MEG axial gradiometers from left and right hemispheres [marked white in (B)] during EO for all drug sessions. Vertical dashed lines at ± 0.05 s indicates the lower limit of the bandpass filter used for peak detect...

LZP did not modulate bicoherence values during WM delay. (A) Grand mean topographic representation of alpha–alpha (8–12 Hz; 8–12 Hz; left) and alpha–beta coupling (8–12 Hz; 18–22 Hz; right) during WM delay (0.5–1.5 s). Color code represents magnitude-squared bicoherence. Note that the topographic plots have different scale. The strongest bicoherenc...

Neuronal oscillations support cognitive processing. Modern views suggest that neuronal oscillations do not only reflect coordinated activity in spatially distributed networks, but also that there is interaction between the oscillations at different frequencies. For example, invasive recordings in animals and humans have found that the amplitude of...

Objective: This study aimed to characterize alpha modulations in children with ADHD in relation to their attentional performance. Methods: The posterior alpha activity (8-12 Hz) was measured in 30 typically developing children and 30 children with ADHD aged 7-10 years, using EEG while they performed a visuospatial covert attention task. We focused...

Rationale Methylphenidate, the most common treatment of attention deficit hyperactivity disorder (ADHD), is increasingly used by healthy individuals as a “smart drug” to enhance cognitive abilities like attention. A key feature of (selective) attention is the ability to ignore irrelevant but salient information in the environment (distractors). Alt...

The evidence for a functionally inhibitory role of alpha oscillations is growing stronger, mostly derived from studies in healthy adults investigating spatial attention. It remains unexplored if the modulation of alpha band oscillations plays a similar functional role in typically developing children. The aim of this study was to characterize alpha...

Impressive in vitro research in rodents and computational modeling has uncovered the core mechanisms responsible for generating neuronal oscillations. In particular, GABAergic interneurons play a crucial role for synchronizing neural populations. Do these mechanistic principles apply to human oscillations associated with function? To address this,...

Increased use of stimulant medication, such as methylphenidate, by healthy college students has raised questions about its cognitive enhancing effects. Methylphenidate acts by increasing extracellular catecholamine levels and is generally accepted to remediate cognitive and reward deficits in patients with attention deficit hyperactivity disorder....

Background: Attention-deficit/hyperactivity disorder (ADHD) is characterized by problems in directing and sustaining attention. Recent findings suggest that alpha oscillations (8-12 Hz) are crucially involved in gating information between brain regions when allocating attention. The current study investigates whether aberrant modulation of alpha o...

The perceptual pattern in autism has been related to either a specific localized processing deficit or a pathway-independent, complexity-specific anomaly. We examined auditory perception in autism using an auditory disembedding task that required spectral and temporal integration. 23 children with high-functioning-autism and 23 matched controls par...

The role of oscillatory alpha activity (8-13 Hz) in cognitive processing remains an open question. It has been debated whether alpha activity plays a direct role in the neuronal processing required for a given task or whether it reflects idling and/or functional inhibition. Recent electroencephalography (EEG) studies have demonstrated that alpha ac...