Nicolò Schifano

Nicolò Schifano
San Raffaele Scientific Institute | OSR · Dipartimento di Urologia

Doctor of Medicine

About

165
Publications
4,357
Reads
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209
Citations
Citations since 2017
165 Research Items
209 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Introduction
Skills and Expertise

Publications

Publications (165)
Article
Full-text available
Hyaluronic acid (HA) is a glycosaminoglycan widely utilised in different fields of medicine. We aimed to provide a comprehensive overview of the scientific evidence on the use of HA in andrology. A review of the literature to identify pertinent studies concerning the use of HA in andrology was carried out on the Medline, EMBASE, and the Cochrane da...
Article
Full-text available
Objectives To investigate which infertile men with semen parameters above WHO reference limits at first semen analysis deserve a second semen test. Materials and methods Data from 1358 consecutive infertile men were analysed. Patients underwent two consecutive semen analyses at the same laboratory. Descriptive statistics and logistic regression mo...
Article
Background: Recurrent pregnancy loss (RPL) and unexplained infertility are the current indications to test sperm DNA fragmentation (SDF) according to the EAU Guidelines on sexual and reproductive health. Objective: To identify a novel and better performing model to diagnose primary infertile men presenting with altered SDF and to outlie its pred...
Article
Background: Peyronie's disease (PD) has a huge impact on patients' physical and psychological wellbeing. Objectives: To investigate whether patients' age has an impact on PD symptomatic burden at first presentation. Materials & methods: Data from 129 consecutive heterosexual patients seeking first medical attention for PD at a single andrologi...
Article
Full-text available
Recreational drug intake may be associated with a range of medical untoward consequences, including male infertility. However, as the related evidence is still limited, the main outcome of this review is to provide a better understanding of the existence of any association between recreational drug misuse and male fertility levels’ decline. Whilst...
Chapter
Radical prostatectomy (RP) represents the treatment of choice to manage clinically-localized prostate cancer (PCa). However, the risk of postoperative functional side effects including urinary incontinence (UI) and erectile dysfunction (ED) remains non-negligible. The pathophysiology of post-RP ED primarily involves three factors which almost inevi...
Article
Objectives Patients with low urinary tract symptoms (LUTS) frequently complain some sexual dysfunction and sometimes even episodes of bothersome urinary incontinence (UI). We aimed to assess the relationship between UI (as measured with the ICIQ-UI-SF), and sexual disfunction (as measured with the IIEF), in men presenting with LUTS at a tertiary-re...
Article
Objectives The Masturbation Erection Index (MEI) has been recently validated in the setting of men presenting with erectile dysfunction (ED). We sought to analyze the correlation between MEI and the International Index for Erectile Function (IIEF) in a cross-sectional study in men with ED. Methods Data of 87 men presenting for ED at a tertiary ref...
Article
Objectives Erectile dysfunction (ED) has been demonstrated to be reasonably prevalent among young men (≤40 yr). We aimed to i) assess changes in patterns of reported ED in men ≤ 40 yr and ii) compare the sociodemographic and clinical characteristics of ED men ≤ 40 yr vs. > 40 yr of age over a 8-yr period at a single academic centre. Methods 1179 p...
Article
Objectives The Masturbation Erection Index (MEI) has been recently validated in the setting of men presenting with erectile dysfunction (ED). We sought to analyze the correlation between MEI and the International Index for Erectile Function (IIEF) in a cross-sectional study in men with ED. Methods Data of 87 men presenting for ED at a tertiary ref...
Article
Objectives High estrogens levels have been associated with higher rates of heart attacks, strokes, and prostate cancer. Moreover, hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the impact of hyperestrogenism on sexual functioning in the real-life setting. Methods Data from 481 men seeking first medical help f...
Article
Objectives The ASCVD (Atherosclerotic Cardiovascular Disease) risk score is a validated and standardised algorithm predicting the individual 10-year risk of developing acute cardiovascular events (CVs). Patients with erectile dysfunction (ED) are at greater risk of CVs; we aimed to i) apply the ASCVD score at a homogenous cohort of men undergoing d...
Article
Objectives Laser enucleation of the prostate is associated with an invariable risk of retrograde ejaculation which could affect patient’ sexual life with negative impact on orgasmic function (OF). We investigated OF outcomes after Holmium Laser Enucleation of the Prostate (HoLEP) in patients consecutively treated at a single center. Methods The Ex...
Article
Objectives Surgery remains the most effective treatment for Peyronie Disease (PD), despite different conservative therapies have been suggested. However, surgical procedures are associated with a non-negligible risk of complications and failures. We investigated patients’ willingness of being operated for PD. Methods Data were prospectively collec...
Article
Objectives Testosterone therapy (TT) is commonly prescribed in men with androgen deficiency. TT has several common side effects. Moreover, the effect of TT on serum prostate specific antigen (PSA) levels has been a matter of debate over the last decade. We aimed to investigate the effect of TT on PSA and haematocrit levels in a cohort of men with a...
Article
Objectives Patients with low urinary tract symptoms (LUTS) frequently complain some sexual dysfunction and sometimes even episodes of bothersome urinary incontinence (UI). We aimed to assess the relationship between UI (as measured with the ICIQ-UI-SF), and sexual disfunction (as measured with the IIEF), in men presenting with LUTS at a tertiary-re...
Article
Objectives High estrogens levels have been associated with higher rates of heart attacks, strokes, and prostate cancer. Moreover, hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the impact of hyperestrogenism on sexual functioning in the real-life setting. Methods Data from 481 men seeking first medical help f...
Article
Objectives To investigate whether patients’ age has an impact in terms of Peyronie's disease (PD) clinical characteristics at presentation. Methods Data from a group of 110 consecutive patients aged >18 and <70 years with PD and seeking first andrological attention, with a complete clinical assessment and who completed the IIEF-15 and PDQ question...
Article
Objectives Testosterone therapy (TT) is commonly prescribed in men with androgen deficiency. TT has several common side effects. Moreover, the effect of TT on serum prostate specific antigen (PSA) levels has been a matter of debate over the last decade. We aimed to investigate the effect of TT on PSA and haematocrit levels in a cohort of men with a...
Article
Objectives To investigate whether patients’ age has an impact in terms of Peyronie's disease (PD) clinical characteristics at presentation. Methods Data from a group of 110 consecutive patients aged >18 and <70 years with PD and seeking first andrological attention, with a complete clinical assessment and who completed the IIEF-15 and PDQ question...
Article
Context The outcomes and morbidity following treatment for persistent or varicocele recurrence remain controversial. Objective To conduct a systematic review relating to the outcomes following treatment (any surgical or radiological) for varicocele persistence/recurrence. Evidence acquisition A systematic review was conducted in accordance with t...
Article
Penile prosthesis implantation continues to represent a reliable solution to address erectile dysfunction when oral medications fail, are not tolerated or are contraindicated, and most typically is associated with excellent satisfaction rates and durable results. Despite the dramatic improvements in the prostheses’ design, in the surgical instrumen...
Article
Purpose: Overall, male factor infertility (MFI) accounts for up to 50% of etiologies of couple's infertility, with almost 30% of MFI cases being idiopathic in nature. Idiopathic MFI does not support a tailored treatment work-up in clinical practice. To investigate rates of and characteristics of men presenting for idiopathic versus unexplained pri...
Article
Full-text available
Purpose To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. Methods Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional h...
Article
Background: Penile prosthesis implantation has been associated with overall good functional outcomes. Of relevance, some patients reported higher level of satisfaction and quality of life. Aim: We investigated the profile of the patients who may benefit the most from penile prosthesis implantation. Materials and methods: Data from a national m...
Article
Background: Alfa-fetoprotein (AFP) is a serum glycoprotein highly produced during fetal development. While AFP synthesis drops dramatically after birth, AFP production only persists or returns under specific pathological condition OBJECTIVE: : We sought to investigate the rate of and the potential meaning of high AFP serum levels in men seeking fi...
Article
Context The benefits and harms of varicocele treatment versus observation in adult infertile males are still controversial. Objective To systematically pool the evidence on outcomes of varicocele treatment (any surgical or radiological) versus observation in adult infertile men. Evidence acquisition A systematic review and meta-analysis was condu...
Article
Full-text available
The aim of this study is to describe the outcomes for a modified glans-resurfacing technique for benign and malignant penile conditions in which the uninvolved glans corona is preserved in order to maintain glans erogenous sensation. A total of 13 patients underwent coronal-sparing glans resurfacing (CSGR), with follow-up every 3 months for ≥2 year...
Article
Background: Erectile dysfunction aetiology (ED) has been historically identified as organic, psychogenic, and mixed. Objectives: To stratify and compare a cohort of patients seeking medical help for ED for the first time according to the newly proposed binary classification of the EAU guidelines: "primary organic" versus "primary psychogenic"....
Article
Full-text available
Background: In 2021, the World Health Organization (WHO) has provided the latest update on processing and evaluating semen analysis. Objectives: To assess (i) the rate of discordance in semen parameters categorization across three different WHO reference values (namely WHO21, 2010 and 1999) and (ii) the clinical differences among discordant seme...
Article
Full-text available
A range of drugs have a direct role in triggering ischaemic priapism. We aimed at identifying: a) which medications are associated with most priapism-reports; and, b) within these medications, comparing their potential to elicit priapism through a disproportionality analysis. The FDA Adverse Event Reporting System (FAERS) database was queried to id...
Article
Full-text available
A limited number of studies have described patients on finasteride showing findings which were consistent with Peyronie’s disease (PD). We aimed to detect a pharmacovigilance signal of possible association between finasteride and PD-related clinical features. The Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database was...
Article
Introduction The routine use of dynamic duplex ultrasound of the penis (DDUP) to detect vasculogenic erectile dysfunction (V-ED) has been questioned because of a related patient’ discomfort and costs issues. Objective to investigate clinical factors which could guide the physician in selecting candidates for DDUP in routine practice. Methods Data...
Article
Introduction High serum estrogens levels have been associated with higher rates of heart attacks, strokes, and prostate cancer. Moreover, hyperestrogenism is believed to be harmful to male sexuality. Objectives We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical atte...
Article
Introduction Peyronie's disease is a benign condition involving the tunica albuginea of the corpora cavernosa of the penis. Objectives To investigate whether patients’ age has an impact in terms of Peyronie's disease (PD) clinical characteristics at presentation. Methods Data from a group of 110 consecutive patients aged >18 and <70 years with PD...
Article
Introduction The Sexual and Reproductive Health guidelines of the European Association of Urology (EAU) suggest stratifying patients complaining of haemospermia into low versus high-risk categories for treatable aetiologies. Objective To validate EAU guidelines in a homogeneous cohort of men with haemospermia and to identify a novel and better per...
Article
Introduction Patients with low urinary tract symptoms (LUTS) frequently complain some sexual dysfunction and sometimes even episodes of bothersome urinary incontinence (UI). Objective We aimed to assess the relationship between UI (as measured with the ICIQ-UI-SF), and sexual disfunction (as measured with the IIEF), in men presenting with LUTS at...
Article
Introduction There is a current lack of effective conservative treatments for Peyronie Disease (PD). Surgery represents an effective treatment, despite being associated with bothering complications, including erectile dysfunction (ED). Objective We investigated patients wish of being operated for PD at a single center. Methods Data were prospecti...
Article
Introduction Erectile dysfunction (ED) is defined according to three different aetiological groups: organic, psychogenic and mixed. As most cases have mixed aetiology, EAU guidelines suggests using the terms "primary organic" or "primary psychogenic". Objectives We aimed to stratify a homogenous cohort of patients seeking medical help for ED for t...
Article
Introduction The interrelationship between male sexual desire and erectile dysfunction (ED) has been variously investigated. Objectives We aimed to investigate the prevalence of and the predictors of unrecognized low sexual desire (LSD) in a cohort of men seeking medical help for new onset ED in the real-life setting. Methods Data from 1509 men s...
Article
The term scrotoplasty embraces several techniques which aim to restore a normal scrotal appearance and function. We provide here a quick reference tool to allow the urologist to select the appropriate surgical strategy among the several available options. A comprehensive research was carried out on MEDLINE/PubMed to identify relevant studies concer...
Article
Full-text available
We investigated changes in patterns of reported male SDs at a single academic centre over a 10-year time frame. Comprehensive data of 2013 patients consecutively assessed for the first time by a single Sexual Medicine expert between 2006 and 2019 has been analysed. All patients were assessed with a thorough sexual and medical history. Primary reaso...
Article
Study question Current scientific guidelines do not clearly suggest which patients would benefit the most from a sperm DNA fragmentation (SDF) test. Summary answer We aimed to investigate potential predictive factors for altered SDF in a homogenous cohort of white-European men presenting for primary couple’s infertility. What is known already Hig...
Article
Study question We aimed to investigate the association between air pollutants levels and semen parameters in a cohort of white-European men seeking medical attention for couple’s infertility. Summary answer We found that Pm10, Pm 2.5, and NO2 levels were negatively associated with sperm morphology. What is known already Air pollutants levels have...
Article
Study question We investigated the prevalence of kidney function impairment in a homogeneous cohort of white-European primary infertile men. Summary answer Mild kidney function impairment characteristics were found in 9% of asymptomatic and unaware patients presenting for primary infertility investigation. What is known already Infertile men have...