Nicolò Dossi

Nicolò Dossi
University of Udine | UNIUD · Department of Food Sciences

About

65
Publications
6,982
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1,525
Citations
Citations since 2016
29 Research Items
1027 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (65)
Article
Full-text available
Cow’s milk allergy is one of the most common food allergies in children with a prevalence of around 2.5%. Milk contains several allergens; the main ones are caseins and β-lactoglobulin (β-LG). At regulatory level, β-LG is not explicitly named, but milk is included in the list of substances or products causing allergies or intolerances. Hence, the p...
Article
A low-cost portable analytical device, suitable for performing reflectance measurements on paper supports is proposed. It consists of a simple module consisting of a matrix of six types of photodiodes (six channels) with maximum sensitivity at six different wavelengths in the visible region. The device was used in combination with paper-based analy...
Article
A screen printed electrode modified for gas phase measurements is used for analyzing the ethanol content in alcoholic drinks. It consists in the application of a paper crown, soaked with the room temperature ionic liquid (RTIL) 1‐butyl‐3‐methylimidazolium hydrogen sulfate, upon a screen printed cell contacting the outer edge of the gold disc workin...
Article
Full-text available
Nanomaterials can be used to modify electrodes and improve the conductivity and the performance of electrochemical sensors. Among various nanomaterials, gold-based nanostructures have been used as an anchoring platform for the functionalization of biosensor surfaces. One of the main advantages of using gold for the modification of electrodes is its...
Article
Full-text available
Paper has been widely employed as cheap material for the development of a great number of sensors such as pregnancy tests, strips to measure blood sugar, and COVID-19 rapid tests. The need for new low-cost analytical devices is growing, and consequently the use of these platforms will be extended to different assays, both for the final consumer and...
Article
This investigation was carried out with the aim of verifying whether transmittance detection modes on soaked paper, which is a simple and attractive determination approach for microfluidic paper-based analytical devices, can be improved by using deep eutectic solvents (DESs) as suitable media for minimizing reflection and refraction phenomena affec...
Article
Full-text available
Deep Eutectic Solvents (DESs) are a new class of solvents characterized by a remarkable decrease in melting point compared to those of the starting components. The eutectic mixtures can be simply prepared by mixing a Hydrogen Bond Acceptor (HBA) with a Hydrogen Bond Donor (HBD) at a temperature of about 80 • C. They have found applications in diffe...
Article
Malondialdehyde (MDA) is a mutagenic secondary product of the peroxidation of polyunsaturated fatty acids, often used as a target for the food oxidation state, whose determination is frequently performed by its slow reaction with thiobarbituric acid (TBA), dissolved in acidified aqueous-ethanol medium, to produce a pink colored MDA-TBA adduct. In t...
Article
This investigation was carried out with the aim of stressing that technologically-advanced systems can be prototyped and produced by using 3D printing and inexpensive electronic modules. In particular, open-source technologies are opening new exciting possibilities also in the area of chemical analysis, thus making possible the assembly of customiz...
Article
Enzyme-linked immunosorbent assays are currently the most popular methods to quantify gluten in foods. Unfortunately, the antibodies used as specific receptors in such methods are not compatible with the usual solvents for the extraction of gluten proteins. In consequence, commercial tests require a high dilution of the sample after the extraction,...
Article
We describe here a convenient assembly for screen printed carbon electrodes (SPCE) suitable for enabling analyses in gaseous samples which are of course lacking in supporting electrolytes. This assembly consists of a circular crown of filter paper, soaked in a RTIL or a DES, placed upon a disposable screen printed carbon cell, so as to contact the...
Article
A rapid and user‐friendly approach is here presented for assembling smart and versatile platforms for simultaneous electrochemical and spectrophotometric measurements. They consist of an optically transparent pencil‐drawn electrochemical cell, including reference, counter and working carbon electrodes, assembled on flexible PVC supports, exploiting...
Article
The cyclic voltammetric behaviour of propionaldehyde (PA) and hexanaldehyde (HA), in 1-butyl-3-methylimidazolium bis(trifluoromethyl-sulfonyl) imide ([BMIM][NTF2]), 1-butyl-3-methylimidazolium hydrogen sulphate ([BMIM][HSO4]) and 1-butyl-3-methylimidazolium hydroxide ([BMIM][OH]) was investigated at a platinum microelectrode. A clear oxidation proc...
Article
A simple, effective and low-cost technique is here presented for assembling flexible and robust electrochemical devices on transparent PVC supports, using ordinary tools, all installed on a commercial desktop digitally controlled plotter/cutter. Small diamond burs were first set up to rough precise and well defined patterns on the surface of smooth...
Article
Hydrophobic deep eutectic solvents (DESs) have been recently introduced and acknowledged to offer remarkable advantages over the common organic solvents, thanks to their biodegradability, low toxicity and low cost. In the present paper a first study of the electrochemical properties and extraction capabilities of a prototypical hydrophobic DES, bas...
Article
Here we show the feasibility of using deep eutectic solvents as a faster way of selecting aptamers targeting poorly water-soluble species. This unexplored concept is illustrated for gluten proteins. In this way, detection of gluten based on aptamers can be performed directly in the extraction media with improved detectability. We envision deep impl...
Article
Herein, we show the feasibility of using deep eutectic solvents as a faster way of selecting aptamers targeting poorly water‐soluble species. This unexplored concept is illustrated for gluten proteins. In this way, aptamer‐based gluten detection can be performed directly in the extraction media with improved detectability. We envision deep implicat...
Article
A simple and sensitive device is presented based on the use of pencil-drawn paper based electrochemical detector placed at the end of a cotton thread fluidic channel in wall-jet configuration. This innovative and fast responding electroanalytical system can be adopted for both single and dual electrode electrochemical detection, this last achieved...
Article
The communication reports on the electrocatalytic properties exhibited by five Cu alloys (Cu-Zn, Cu-Sn, Cu-Ni, Cu-Zn-Ni, Cu-Al) and of pure Cu, Ni and Al in the reduction or oxidation of a number of representative species. A prototypical strong oxidising agent, namely hydrogen peroxide, and some of the most important oxidisable species, namely meth...
Article
Full-text available
A simple, reliable and low-cost fabrication method is here proposed for assembling paper-based electrochemical devices using a commercial desktop digitally controlled plotter/cutter, together with ordinary writing tools. Permanent markers (tips of 1 mm) were used to create effective hydrophobic barriers on paper, while micro-mechanical pencils (mou...
Article
Full-text available
Gluten analysis is still affected by the lack of an efficient and universal extraction solvent for gliadin, i.e., the prolamine fraction of gluten which is the analytical target used to quantify gluten in food. In this investigation, the possibility of adopting pure choline chloride deep eutectic solvents (ChCl-DESs) as gliadin extraction media was...
Article
Glassy carbon electrodes have been successfully employed for the determination, by differential pulse voltammetry, of Mn(II) ions dissolved in aqueous solutions. In particular, a simple and fast procedure also suitable for on-line or at-line process control has been developed. Statistical analysis of the results obtained reveals that the procedure...
Article
In the present article the development of a paper-based amperometric sensor for the determination of glucose and of the total carbohydrates is described. The motivation of the study lies in the necessity of novel low cost and fast methods for the determination of sugars in foodstuff; the commonly used procedures, in fact, often suffer from inaccura...
Article
A simple, sensitive and fast responding device is described for the discrimination of hydrophilic ortho-diphenols, whose presence in abundant enough amounts is typical for extra virgin olive oils (EVOOs), from hydrophilic mono-phenols instead present in almost all vegetable oils. It consists of a dual electrode detector pencil-drawn at the end of a...
Poster
We present here an approach for the rapid, simple and cheap detection of gliadin in food, employing carboxyl functionalized multi-walled carbon nanotubes (MWCNTs) screen printed electrodes (SPE). The aptamer used is 5’-amino modified gli4 (5’-CAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC-3’)1. Exploiting the carboxylic acid residues present on MWCNTs, ap...
Poster
We present here an approach for the rapid, simple and cheap detection of gliadin in food, employing carboxyl functionalized multi-walled carbon nanotubes (MWCNTs) screen printed electrodes (SPE). The aptamer used is 5’-amino modified gli4 (5’-CAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC-3’)1. Exploiting the carboxylic acid residues present on MWCNTs, ap...
Article
A simple electrochemical microprobe (EMP) is proposed for the detection of analytes in gaseous atmospheres. The EMP consists of two platinum fibres of 25 and 300 μm in diameter encased into a theta glass pipette to form an electrochemical cell in a two-electrode configuration. Ion conductivity between the two electrodes is ensured by a thin film of...
Article
The anodic oxidation of species possessing potentially oxidisable functionalities has been studied on a non conventional electrode system based on a Ti substrate partially coated by electrodeposited Au nanoparticles. The results show that the electrocatalytic behaviour of the Au nanoparticles, in the frame of such a bimetallic system, is very diffe...
Article
The determination of strong oxidizing species is of outmost importance in a number of practical applications. However, the currently available analytical tools should be improved in terms of reliability, automation, and costs. With this respect amperometric techniques are particularly promising candidates; nevertheless, the performance of conventio...
Article
The possibility of adopting deep eutectic solvents (DESs) instead of room temperature ionic liquids (RTILs) in membrane-free electrochemical gas probes was estimated by first evaluating the performance of ethaline as electrochemical medium. This very easily prepared DES was chosen as prototype since it displays high conductivity and fairly modest v...
Article
The growing demand for low cost and easy to use analytical devices requires the development of reliable and rapid deposition strategies suitable for changing easily planned designs and applicable to a wide range of materials for assembling conductive tracks and sensitive elements. Further important challenges to be pursued are the possibility of us...
Article
This paper describes for the first time the fabrication of pencil drawn electrodes (PDE) on paper platforms for capacitively coupled contactless conductivity detection (C(4) D) on electrophoresis microchips. PDE-C(4) D devices were attached on PMMA electrophoresis chips and used for detection of K(+) and Na(+) in human tear samples. PDE-C(4) D devi...
Article
We propose here simple electrochemical cells assembled with electrodes pencil drawn on paper for conducting one-spot tests enabling olive oil to be easily distinguished from other vegetable oils. They consist of small circular pads of hydrophilic paper defined by hydrophobic barriers, these last printed by using custom-designed rubber stamps, where...
Article
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and hexane (10:1.5 w/w) onto chromatographic paper using...
Article
We propose here a quick and easy procedure for preparing pencil leads doped with Ag and AgCl suitable for the reproducible and easy drawing on paper or other porous supports of carbon based Ag/AgCl conductive lines for the use as reference electrodes. They were prepared by careful electrodeposition of silver and silver chloride on carbon powder (co...
Article
A gas sensors based on a room temperature ionic liquid (RTIL) supported on paper is proposed as amperometric sniffer for monitoring volatile amines (VAs) released from fish samples, in order to gain indication of their state of turning spoiled. It was used as a paper electrochemical detector (PED) for a flow injection system in which controlled hea...
Article
A simple strategy is here described for assembling graphite-based pencil leads doped with electrode modifiers suitable for drawing electrochemical devices on porous materials such as paper in a very reproducible and easy way. They were prepared by mixing controlled amounts of the chosen modifier with different quantities of carbon powder (conductiv...
Article
AbstractA simple method is described to discriminate between analytes comigrating under on‐plate separation conditions, whose electrochemical behavior displays different reversible characters. It is based on the use of dual electrode detectors pencil‐drawn at the end of paper‐based fluidic channels defined by hydrophobic barriers. Simultaneous dete...
Article
A simple procedure for preparing inexpensive paper-based three-electrode electrochemical cells is here described. They consist of small circular pads of hydrophilic paper defined by hydrophobic barriers printed on paper with wax-based ink. The back face of these pads is insulated by thermally laminating a polyethylene layer and working, reference a...
Article
An array of quartz crystals coated with different room-temperature ionic liquids (RTILs) is proposed for the analysis of flavors by quartz crystal microbalance (QCM) measurements. Seven RTILs were adopted as sensing layers, all containing imidazolium or phosphonium cations, differing from one another in the length and branching of alkyl groups, and...
Article
Full-text available
This communication describes a simple and cost-effective method for fabricating glass microchannels by wet chemical etching using masks made by xurography in vinyl adhesive films. Analytical performance of microfluidic devices fabricated using the new approach was evaluated by microchip electrophoresis coupled to capacitively coupled contactless co...
Article
A prototype of a fast-response task-specific amperometric gas sensor based on paper-supported room-temperature ionic liquids (RTILs) is proposed here for improved analysis of volatile acid species. It consists of a small filter paper foil soaked with a RTIL mixture containing an ionic liquid whose anion (acetate) displays a basic character, upon wh...
Article
A conveniently assembled membrane-free amperometric sensor is proposed for the detection of oxygen in gaseous atmospheres which exploits some profitable properties of room temperature ionic liquids (RTILs), such as their high electrical conductivity, negligible vapour pressure and good thermal stability. The advantages offered by this type of mediu...
Article
AbstractA conveniently assembled, sensitive and fast‐responding membrane free amperometric sensor is described for the detection of nitrogen oxides in gaseous atmospheres which exploits some profitable properties of room temperature ionic liquids (RTILs), such as high electrical conductivity, negligible vapor pressure and good thermal stability. It...
Article
Full-text available
A sensitive and fast-responding membrane-free amperometric gas sensor is described, consisting of a small filter paper foil soaked with a room temperature ionic liquid (RTIL), upon which three electrodes are screen printed with carbon ink, using a suitable mask. It takes advantage of the high electrical conductivity and negligible vapour pressure o...
Article
Full-text available
The use of a mixed-valent ruthenium oxide/hexacyanoruthenate polymeric film electrochemically deposited onto glassy carbon electrodes is proposed here for the detection of biogenic amines and their amino acid precursors, following their separation by microchip capillary electrophoresis. The ability of this ruthenium coating to electrocatalyze the o...
Article
Based on preliminary voltammetric investigations at unmodified and modified electrodes in aqueous solutions buffered at different pHs, a profitable thin layer dual-electrode detector was developed for the selective and simultaneous determination of ascorbic acid (AA) and hydrogen peroxide present in the same samples. It consists of a small thicknes...
Article
A simple hydrodynamic injection method is proposed here for microchip CE coupled to electrochemical detection. It is based on the use of a precise syringe pump to push the sample into the microfluidic circuit, accompanied by the application of a secondary electric field to the injection channel, soon after the end of the injection step. In such a w...
Article
A porous gold electrode supported on one face of an ion-exchange membrane, acting as a solid polymer electrolyte (SPE), is proposed as an amperometric sniffer for monitoring the aldehyde content in the headspace in equilibrium with lipid samples, in order to gain indication of their state of turning rancid It was used as a detector for a flow injec...
Article
A sensitive and fast responding electrochemical sensor is described for the determination of free and total sulphur dioxide in wines and grape juices which prevents interferences coming from ethanol and other natural components. It consists of a cell provided with a porous gold working electrode supported on one face of an ion-exchange membrane, ac...
Article
A method based on microchip electrophoresis with electrochemical detection has been developed for the simultaneous determination at trace levels of the main small-chain aldehydes (formaldehyde, acetaldehyde and 2-propenal) present in the atmosphere. Sampling was performed by forcing atmospheres through silica-gel cartridges coated with 2,4-dinitrop...
Article
Full-text available
A linear sweep voltammetric (LSV) approach is proposed for achieving rapid information on metal release from tinned containers into preserved vegetables. Chopped tomato and pea preserves were chosen as prototypes for acid and nearly neutral canned food, respectively. Metal release in these vegetables tinned into both bare and lacquered containers w...
Article
Full-text available
An improved single step microwave digestion procedure is described for providing the fast and easy exhaustive mineralisation of biological samples concomitantly with the quantitative conversion of any type of selenium compounds into Se(IV). In such a way, digested samples are directly suitable for the subsequent Se analysis at trace and ultratrace...
Article
This article describes an effective microchip protocol based on electrophoretic-separation and electrochemical detection for highly sensitive and rapid measurements of nitrate ester explosives, including ethylene glycol dinitrate (EGDN), pentaerythritol tetranitrate (PETN), propylene glycol dinitrate (PGDN) and glyceryl trinitrate (nitroglycerin, N...
Article
A method, based on microchip electrophoresis with electrochemical detection, has been developed for the simultaneous determination of light aliphatic aldehydes (acetaldehyde, propionaldehyde, butyraldehyde and hexylaldehyde) derivatized with 2,4-dinitrophenylhydrazine (DNPH). Optimal conditions for the derivatization reaction, providing recoveries...
Article
Full-text available
A method based on microchip electrophoresis with electrochemical (EC) detection has been developed for the simultaneous determination of Yellow AB, Red 2G, Sunset Yellow, New Coccine, and Amaranth which are azo-dyes frequently added to foodstuffs. Factors affecting both separation and detection processes were examined and optimized, with best perfo...
Article
A conveniently assembled probe is here proposed for the electrochemical detection of the phenol index (total volatile phenols) in wastewaters, which exploits some advantageous properties of ionic liquids (ILs), such as their negligible vapor pressure, good electrical conductivity and ability to dissolve a wide range of organic and inorganic compoun...
Article
An in-channel configuration for amperometric detection has been adopted in capillary electrophoresis performed in photolithographically microfabricated chips. This electrode alignment, compared with the more conventional end-channel configuration, led to a better peak resolution and a higher sensitivity, because it involves no gap between the chann...
Article
Full-text available
Based on preliminary voltammetric investigations at both Pt and Au electrodes in aqueous solutions buffered at different pH values in the range 0–10, two possible profitable triple-pulse amperometric approaches were developed for determining simultaneously peroxyacetic acid (PAA) and hydrogen peroxide present in the same samples. At both surfaces a...
Article
Full-text available
A reverse-phase HPLC method for the simultaneous determination of the main artificial sweeteners, preservatives and dyes present in soft drinks is proposed. It involves the use of a 10 μm LiChrosorb RP18 column and a binary eluent consisting of aqueous 0.1 M phosphate buffer (pH 4.0) added with methanol, according to a suitable gradient elution pro...
Article
A piezoelectric immunosensor is described which consists of a gold filmed quartz crystal, whose surface is modified with a thin Nafion layer entrapping known amounts of the specific antibody. This layer was applied by droplet evaporation on the gold surface of a mixture prepared by mixing a stock ethanol solution of Nafion with a stock antibody sus...

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