Nicolette J Wierdsma

Nicolette J Wierdsma
Amsterdam University Medical Center | VUmc · Nutrition and Dietetics

PhD, RD

About

84
Publications
30,933
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2,388
Citations
Citations since 2017
33 Research Items
1670 Citations
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20172018201920202021202220230100200300400
20172018201920202021202220230100200300400

Publications

Publications (84)
Article
Full-text available
Background: The nutritional problems of patients who are hospitalised for COVID-19 are becoming increasingly clear. However, a large group of patients have never been hospitalised and also seem to experience persistent nutritional problems. The present study describes the nutritional status, risk of sarcopenia and nutrition-related complaints of p...
Article
Background and aim Pancreatic enzymes are often prescribed in clinical practice to treat complaints of maldigestion and malabsorption after esophagectomy for cancer, but knowledge regarding the effect of this treatment on malabsorption related complaints is lacking. Aim of this study is to evaluate the presence of malabsorption related complaints a...
Article
Introduction: the ESPEN guideline offers a multidisciplinary focus on clinical nutrition in inflammatory bowel disease (IBD). Methodology: the guideline is based on a extensive systematic review of the literature, but relies on expert opinion when objective data are lacking or inconclusive. The conclusions and 64 recommendations have been subjec...
Article
Complaints of maldigestion, malabsorption, and unintended weight loss after esophagectomy are often attributed to an impaired exocrine pancreatic function. This review systematically summarizes all literature reporting on the presence of exocrine pancreatic insufficiency (EPI) after esophagectomy and the effect of treatment with pancreatic enzymes...
Article
Full-text available
Purpose of review: Serum or plasma citrulline levels are used as biomarker for a broad spectrum of intestinal functions. During high-dose chemotherapy, citrulline levels are decreased due to mucositis, a common side effect of chemotherapy. This may decrease intestinal function and result in diarrhea. In this review, most recent studies investigati...
Article
Full-text available
Background and aims Patients with COVID-19 infection presents with a broad clinical spectrum of symptoms and complications. As a consequence nutritional requirements are not met, resulting in weight- and muscle loss, and malnutrition. The aim of the present study is to delineate nutritional complaints, the (course of the) nutritional status and ris...
Article
Complaints of maldigestion, malabsorption, and unintended weight loss after esophagectomy are often attributed to an impaired exocrine pancreatic function. This review systematically summarizes all literature reporting on the presence of exocrine pancreatic insufficiency (EPI) after esophagectomy and the effect of treatment with pancreatic enzymes...
Article
Full-text available
Background The incidence of inflammatory bowel disease [IBD] is rising worldwide and no cure is available. Many patients require surgery and they often present with nutritional deficiencies. Although randomised controlled trials of dietary therapy are lacking, expert IBD centres have long-established interdisciplinary care, including tailored nutri...
Article
Full-text available
The present guideline is the first of a new series of "practical guidelines" based on more detailed scientific guidelines produced by ESPEN during the last few years. The guidelines have been shortened and now include flow charts that connect the individual recommendations to logical care pathways and allow rapid navigation through the guideline. T...
Article
Full-text available
Background and aims: The incidence of inflammatory bowel disease (IBD) is rising worldwide and no cure is available. Many patients require surgery and they often present with nutritional deficiencies. Although randomized controlled trials of dietary therapy are lacking, expert IBD centres have long established interdisciplinary care, including tai...
Book
Full-text available
The Dietetic Pocket Guide has two editions: The version on adults (2017) and the paediatric version (2019). The Dietetic Pocket Guides are is designed to help dietitians working in all care settings and with all patient groups to complete a full dietetic assessment and diagnosis. These guides contain a wealth of relevant information, tests and cri...
Article
Full-text available
The Publisher regrets that this article is an accidental duplication of an article that has already been published in <YCLNU, 38/3 (2019) 1485-1485, http://dx.doi.org/<10.1016/j.clnu.2019.03.004>. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-bus...
Article
Background & aims: Exocrine pancreatic function is affected in patients with locally advanced pancreatic cancer (LAPC), clinically leading to steatorrhea. It is unknown whether maldigestion and malabsorption can also be attributed to impaired intestinal enterocyte function. In this exploratory study enterocyte function was assessed in patients wit...
Article
Full-text available
Background/objectives: Muscle mass is a key determinant of nutritional status and associated with outcomes in several patient groups. Computed tomography (CT) analysis is increasingly used to assess skeletal muscle area (SMA), skeletal muscle index (SMI) and muscle radiation attenuation (MRA). However, interpretation of these muscle parameters is...
Poster
Muscle mass is a key determinant of nutritional status and associated with outcomes in several patient groups. Computed Tomography (CT) analysis is increasingly used to assess skeletal muscle area (SMA), skeletal muscle index (SMI) and muscle radiation attenuation (MRA). However, interpretation is difficult since values in a healthy population are...
Article
Full-text available
Background and Aim To provide a comprehensive quantitative assessment of nutritional status, digestion and absorption, and quality of life (QoL) in patients with locally advanced pancreatic cancer (LAPC). Methods Sixteen patients with LAPC were prospectively assessed for weight loss (WL), body mass index (BMI), fat-free mass index (FFMI), handgrip...
Article
Full-text available
Although the current doctrine of IBD pathogenesis proposes an interaction between environmental factors with gut microbiota in genetically-susceptible individuals, dietary exposures have attracted recent interest and are, at least in part, likely to explain the rapid rise in disease incidence and prevalence. The D-ECCO working group along with othe...
Book
Full-text available
see www.dieteticocketguide.com The Dietetic Pocket Guide adults is designed to help dietitians working in all care settings and with all patient groups to complete a full dietetic assessment and diagnosis. This guide contains a wealth of relevant information, tests and criteria in 10 chapters that cover nutritional status, energy- and protein requ...
Article
Full-text available
Low skeletal muscle area (SMA) and muscle radiation attenuation (MRA) have been associated with poor prognosis in various patient populations. Both non-contrast and contrast CT scans are used to determine SMA and MRA. The effect of the use of a contrast agent on SMA and MRA is unknown. Therefore, we investigated agreement between these two scan opt...
Article
Full-text available
Background Assessment of a quantifiable small intestinal function test is cumbersome. Fasting citrulline concentrations have been proposed as a measure of enterocyte function and elaborated into a citrulline generation test (CGT), which is applicable only when glutamine is administered orally. CGT is an oral test, limiting its use, for example, in...
Method
Full-text available
Bomb calorimetry as a method to assess intestinal absorption capacity
Article
Background: The role of diet in IBD has recently attracted substantial interest by the scientific community and dietary influences are likely to explain the rapid rise in disease epidemiology. Methods: The D-ECCO working group along with other ECCO experts reviewed the evidence looking at the role of diet and nutritional therapy in the onset, perpe...
Article
If the gut works, enteral nutrition is the preferred route of feeding during recovery from allogeneic hematopoietic stem cell transplantation. Yet, patients with gastrointestinal GvHD (GI-GvHD) with intolerance for enteral nutrition and progressive weight loss often require parenteral nutrition.
Article
Full-text available
Introduction: The ESPEN guideline presents a multidisciplinary focus on clinical nutrition in inflammatory bowel disease (IBD). Methodology: The guideline is based on extensive systematic review of the literature, but relies on expert opinion when objective data were lacking or inconclusive. The conclusions and 64 recommendations have been subje...
Poster
Low skeletal muscle area (SMA) and mean muscle attenuation (MMA) have been associated with poor prognosis in various patient populations. To determine SMA and MMA, both non-contrast and contrast CT scans are used. The effect of the use of a contrast agent on SMA and MMA is unknown. Therefore, we investigated agreement between these two scan options...
Article
Full-text available
Background: Refractory coeliac disease type II (RCDII) frequently transforms into an enteropathy-associated T-cell lymphoma (EATL) and therefore requires intensive treatment. Current evaluated treatment strategies for RCDII include cladribine (2-CdA) and autologous stem cell transplantation (auSCT). Objective: The purpose of this study was to ev...
Article
Full-text available
Gastroenterology (GE) used to be considered a subspecialty of internal medicine. Today, GE is generally recognized as a wide-ranging specialty incorporating capacities, such as hepatology, oncology and interventional endoscopy, necessitating GE-expert differentiation. Although the European Board of Gastroenterology and Hepatology has defined specif...
Article
Full-text available
Background & Aims: Refractory celiac disease type II (RCDII) and EATL (Enteropathy Associated T-cell Lymphoma) are (pre)malignant complications of celiac disease (CD). Data on malnutrition and intestinal absorption is lacking in these patients. Therefore, the aim of the study is to comprehensively assess nutritional status and intestinal absorption...
Chapter
Full-text available
Het onvermogen tot relaxatie van de onderste slokdarmsfincter door degeneratie van de ganglioncellen in de plexus van Auerbach. Patiënten hebben voedselpassageklachten, aanvankelijk vaak voor vloeibaar voedsel in het bijzonder, hetgeen uiteindelijk gepaard gaat met gewichtsverlies.
Chapter
In het eerste deel van dit hoofdstuk worden de ziektebeelden op het gebied van maag-, darm- en leverziekten op een beknopte, heldere wijze behandeld door vakexperts en een apotheker. De volgorde van de paragrafen is alfabetisch. In het tweede deel volgt een bespreking van de belangrijkste verschijnselen/ klachten in de gastro-enterologie, die bij v...
Article
Full-text available
Malabsorption, weight loss and vitamin/mineral-deficiencies characterize classical celiac disease (CD). This study aimed to assess the nutritional and vitamin/mineral status of current "early diagnosed" untreated adult CD-patients in the Netherlands. Newly diagnosed adult CD-patients were included (n = 80, 42.8 ± 15.1 years) and a comparable sample...
Article
Full-text available
A gluten-free diet (GFD) is recommended for all patients with coeliac disease (CD). The spectrum of gluten-related disorders in the early 1980s was simple: CD and dermatitis herpetiformis. In the last few years, wheat allergy, gluten ataxia and noncoeliac gluten sensitivity have become new gluten-related topics. Adherence to GFDs in CD is limited a...
Article
Background Intestinal absorption capacity is considered to be the best method for assessing overall digestive intestinal function. Earlier reference values for intestinal function in healthy Dutch adults were based on a study that was conducted in an inpatient metabolic unit setting in a relatively small series. The present study aimed to readdress...
Chapter
De belangrijkste wens van vrijwel iedereen is om zijn of haar leven zo zelfstandig mogelijk en naar eigen opvattingen en voorkeuren in te richten. Een redelijke tot goede gezondheid is daarvoor een van de basisvoorwaarden.
Chapter
In dit hoofdstuk worden diverse frequent en minder frequent voorkomende dikkedarmaandoeningen behandeld, waarbij met name wordt ingegaan op de prevalentie, etiologie, pathologie, klinische verschijnselen en diagnostiek. Voorts wordt een korte beschrijving van de behandeling en de dieetbehandeling gegeven. Allereerst worden veranderingen in de passa...
Chapter
In dit hoofdstuk wordt ingegaan op diverse frequent en minder frequent voorkomende dunne-darmaandoeningen, waarbij aandacht besteed wordt aan de prevalentie, pathologie, etiologie, klinische verschijnselen en diagnostiek. Verder wordt er een korte beschrijving gegeven van de behandeling en de dieetbehandeling. De volgende aandoeningen komen aan de...
Article
Full-text available
An important complication of allo-SCT is GVHD, which commonly affects the skin, liver and digestive tract. Clinical symptoms of GVHD of the digestive tract (GVHD-DT) include excessive diarrhoea, abdominal pain and cramps, nausea and vomiting, gastrointestinal bleeding, dysphagia, and weight loss. Treatment is complicated and regarding nutritional s...
Article
Full-text available
Malabsorption, which is frequently underdiagnosed in critically ill patients, is clinically relevant with regard to nutritional balance and nutritional management. We aimed to validate the diagnostic accuracy of fecal weight as a biomarker for fecal loss and additionally to assess fecal macronutrient contents and intestinal absorption capacity in I...
Article
Full-text available
Small intestinal function in critically ill patients should ideally be assessed in order to determine the preferred feeding route, timing, and composition of enteral nutrition. Additionally, evaluation of small bowel function may lead to new insights aimed to maintain enterocyte integrity. Critically ill patients are likely to have impaired enteroc...
Article
Full-text available
Objective: Intestinal microbiota is important in health and disease. The aim of this study was to evaluate the effect of fructo-oligosaccharides (FOS) and fibre-enriched tube feeding on quality of life and intestinal microbiota (faecal Bifidobacteria). Material and methods: Nineteen out of 59 home-living, tube-feeding-dependent, adult patients a...
Poster
SURVEY ON NUTRITIONAL CARE IN PATIENTS WITH GRAFT-VERSUS-HOST DISEASE OF THE TRACTUS DIGESTIVUS AFTER ALLOGENEIC STEM CELL TRANSPLANTATION IN THE NETHERLANDS
Article
The amino acid citrulline is mainly produced by enterocytes from conversion of glutamine. As fasting plasma citrulline proved disappointing as a biomarker for enterocyte dysfunction in clinical practice, we propose a citrulline generation test (CGT) to assess enterocyte function. To assess the feasibility of a CGT in healthy subjects and patients w...
Article
Our aim was to explore the diagnostic value of fasting citrulline concentrations to detect decreased intestinal energy absorption in patients with recently diagnosed celiac disease (CeD), refractory celiac disease (RCeD), and short bowel syndrome (SBS). Decreased intestinal energy absorption is regarded a marker of intestinal failure. Fasting plasm...
Article
Full-text available
Early enteral nutrition and tailored supply of nutrients have become standard in most of the intensive care units (ICU). So far little attention has been given to losses of energy in the stools. The purpose of this explorative study was to evaluate the energy losses of patients with loose stools, necessitating the use of a feces-collector device in...
Article
This article describes the characteristics of patients identified as malnourished using the Short Nutritional Assessment Questionnaire (SNAQ) in terms of health status (quality of life, functional capacity, and body composition) and care complexity. We expected that by using the quick and easy SNAQ method of screening on malnutrition, inferences co...
Article
Two adult patients, men aged 43 and 45 years, with Crohn's disease, complicated by high-output small-bowel-stomy and short-bowel syndrome due to several intestinal resections, presented with extreme weight loss. Although both patients followed a high-calorie diet combining solid foods and enteral nutrition by nasogastric tube, containing 16,000 kJ...
Article
Full-text available
For the early detection and treatment of malnourished hospital patients no valid screening instrument for the Dutch language exists. Calculation of percentage weight loss and body mass index (BMI) by the nurse at admission to the hospital appeared to be not feasible. Therefore, the short, nutritional assessment questionnaire (SNAQ), was developed....
Article
Full-text available
In 2001, the Dutch Dietetic Association conducted a national screening on malnutrition. The goal of this screening was to determine the prevalence of disease-related malnutrition in The Netherlands in all fields of medical care and to investigate the involvement of the dietitian in the treatment of malnutrition. Eight thousand five hundred and twen...

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