Nicole Stone

Nicole Stone
The University of Sheffield | Sheffield · Sheffield Institute for Translational Neuroscience (SITraN)

Biomedical Sciences BSc 1st class

About

9
Publications
12,317
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
556
Citations
Citations since 2016
9 Research Items
554 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
BBSRC iCase Doctoral Training Partnership. University of Nottingham Research areas: Neurodegeneration, ischaemic stroke pathophysiology, the blood- brain barrier. Therapeutic effects of phytocannabinoids; neuroprotection and preservation of barrier integrity.
Additional affiliations
September 2016 - September 2020
University of Nottingham
Position
  • PhD Student
Description
  • Researching the blood brain barrier (BBB) and neuroprotective properties of phytocannabinoids

Publications

Publications (9)
Article
The blood brain barrier (BBB) is central to the neurovascular unit (NVU) where it creates a semi-permeable barrier between neuronal tissue and the vascular networks that feed the brain. In neurodegenerative conditions and ischaemic stroke, the BBB becomes compromised and as a result its permeability increases. This not only exacerbates neuronal dam...
Article
Full-text available
Background and Objectives: Preclinical studies have shown cannabidiol is protective in models of ischemic stroke. Based on results from our recent systematic review, we investigated the effects of two promising neuroprotective phytocannabinoids, cannabigerol (CBG) and cannabidivarin (CBDV), on cells of the blood-brain barrier (BBB), namely human br...
Article
Full-text available
Embase and Pubmed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, aside from cannabidiol and Δ9‐tetrahydrocannabinol, including Δ9‐tetrahydrocannabinolic acid (Δ9‐THCA), Δ9‐tetrahydrocannabivarin (Δ9‐THCV), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabichromene (CBC), cannabichrom...
Article
Full-text available
Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of cannabidiol in a variety of med...
Article
Full-text available
Structural alterations and breakdown of the blood brain barrier (BBB) is often a primary or secondary consequence of disease, resulting in brain oedema and the transport of unwanted substances into the brain. It is critical that effective in vitro models are developed to model the in vivo environment to aid in clinically relevant research, especial...
Article
Full-text available
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to collate published data in this area. Methods: A systematic search of PubMed and EMBASE (including MEDLINE...
Article
Full-text available
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to investigate whether activities other than running can increase circulating eCBs. Nine healthy female...
Article
Full-text available
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids. Endocannabinoids are lipid signalling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to investigate whether activities other than running can increase circulating endocannabinoids. 9...

Questions

Questions (2)
Question
I'm looking to measure axon length post-stroke in vitro, are there any good image analysis tools that anyone could recommend for this? Cheers!
Question
I am currently researching staining techniques for corning collagen coated transwell inserts (6.5mm). Does anyone know of any protocol that outlines how to stain inserts with H&E? Any information would be appreciated! 

Network

Cited By

Projects

Projects (2)