Nicole Eva Neef

Nicole Eva Neef
Universitätsmedizin Göttingen · Deptartment of Diagnostic and Interventional Neuroradiology

PhD

About

68
Publications
15,857
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977
Citations
Citations since 2017
44 Research Items
839 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
Additional affiliations
February 2013 - present
Max Planck Institute for Human Cognitive and Brain Sciences
Position
  • PostDoc Position
June 2007 - December 2014
Universitätsmedizin Göttingen
Position
  • PostDoc Position

Publications

Publications (68)
Article
Inferior frontal cortex pars opercularis (IFCop) features a distinct cerebral dominance and vast functional heterogeneity. Left and right IFCop are implicated in developmental stuttering. Weak left IFCop connections and divergent connectivity of hyperactive right IFCop regions have been related to impeded speech. Here, we reanalyzed diffusion magne...
Article
Full-text available
Persistent stuttering is a prevalent neurodevelopmental speech disorder, which presents with involuntary speech blocks, sound and syllable repetitions, and sound prolongations. Affected individuals often struggle with negative feelings, elevated anxiety, and low self-esteem. Neuroimaging studies frequently link persistent stuttering with cortical a...
Article
Full-text available
Objective The neurophysiological dynamics of the occurrence of a stuttering event are largely unknown. This sensor-level EEG study investigated whether already the intention to speak alters the formation of the speech production network in stuttering. Methods We studied alpha (8-13 Hz), low beta (15-25 Hz) and high beta (25-30 Hz) power modulation...
Article
Fluency-shaping enhances the speech fluency of persons who stutter, yet underlying conditions and neuroplasticity-related mechanisms are largely unknown. While speech production-related brain activity in stuttering is well studied, it is unclear whether therapy repairs networks of altered sensorimotor integration, imprecise neural timing and sequen...
Article
Full-text available
Background: Brain metastases are particularly common in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with NSCLC showing a less aggressive clinical course and lower chemo- and radio sensitivity compared to SCLC. Early adequate therapy is highly desirable and depends on a reliable classification of tumor type....
Article
Full-text available
Purpose Childhood onset speech fluency disorder (stuttering) is possibly related to dopaminergic dysfunction. Mesencephalic hyperechogenicity (ME) detected by transcranial ultrasound (TCS) might be seen as an indirect marker of dopaminergic dysfunction. We here determined whether adults who stutter since childhood (AWS) show ME. Methods We perform...
Article
Full-text available
Recent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white matter deficit in the ventral laryngeal motor cortex, intensive fluency shaping intervention modulated the functional con...
Preprint
Full-text available
Background: Brain metastases are particularly common in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with NSCLC showing a more aggressive clinical course and lower chemo- and radio sensitivity compared to SCLC. Early adequate therapy is highly desirable and depends on a reliable classification of tumor type. T...
Article
For children who stutter (CWS), there is good evidence of the benefits of treatment for pre-school age, but an evidence gap for elementary school age. Here we report on the effectiveness of a fluency shaping treatment for 6- to 9-year-old children. The main treatment component is the reinforcement of soft voice onsets. An intensive in-patient group...
Article
Full-text available
Literacy acquisition is impaired in children with developmental dyslexia resulting in lifelong struggle to read and spell. Proper diagnosis is usually late and commonly achieved after structured schooling started, which causes delayed interventions. Legascreen set out to develop a preclinical screening to identify children at risk of developmental...
Preprint
Full-text available
Recent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white matter deficit in the ventral laryngeal motor cortex, intensive fluency shaping intervention modulated the functional con...
Preprint
Full-text available
Developmental stuttering is a fluency disorder with anomalies in the neural speech motor system. Fluent speech requires multifunctional network formations. Currently, it is unclear which functional domain is targeted by speech fluency interventions. Here, we tested the impact of fluency-shaping on resting-state fMRI connectivity of the speech plann...
Article
Full-text available
Developmental dyslexia, a severe deficit in literacy learning, is a neurodevelopmental learning disorder. Yet, it is not clear whether existing neurobiological accounts of dyslexia capture potential predispositions of the deficit or consequences of reduced reading experience. Here, we longitudinally followed 32 children from preliterate to school a...
Article
Full-text available
Persistent developmental stuttering (PDS) disrupts speech fluency in about 1% of adults. Although many models of speech production assume an intact sensory feedback from the speech organs to the brain, very little is actually known about the integrity of their sensory representation in PDS. Here, we studied somatosensory evoked potentials (SEPs) in...
Article
Children lay the foundation for later academic achievement by acquiring core mathematical abilities in the first school years. Neural reorganization processes associated with individual differences in early mathematical learning, however, are still poorly understood. To fill this research gap, we followed a sample of 5-6-year-old children longitudi...
Article
Full-text available
Objectives Persistent developmental stuttering is a speech fluency disorder defined by its symptoms, where the underlying neurophysiological causes remain uncertain. This study examined the underlying neurophysiological mechanisms of the speech planning process, using facilitation in the motor cortex during speech preparation as an analogue. Metho...
Data
Individual stuttering demographics–Group was used for the main analyses. Percentage of stuttering was used for the supplementary analyses. (DOCX)
Data
Model Summary for Experiment 2 –Additional statistical information pertaining to Table 3 in the text. (DOCX)
Data
Appendix (to Table 6)–Specific statistical analysis of the comparison between experiments 1 and 3. The constant (M = 0.617, SED = 0.133, p < .001) and pre-speech interval (M = 2.295, SED = 0.356, p < .001) were significantly smaller than in the first experiment, while group (M = -0.302, SED = 0.126, p = .0167) and the group-interval interaction (M...
Data
Model Summary for Experiment 3 –Additional statistical information pertaining to Table 4 in the text. (DOCX)
Data
Model Summary for Experiment 2 –Additional statistical information pertaining to Table 8 in the text. (DOCX)
Data
Appendix (to Table 10A–10D)–Significance of reaction time with pulse condition and trial. As a side note, one significant value was unexpected–the correlation between State and Trial in the first experiment. This implies that there were more late stimulation states in the later trials, on average. However, due to the random order of presentation an...
Data
Model Summary for Experiment 1 –Additional statistical information pertaining to Table 2 in the text. (DOCX)
Data
Model Summary for Experiment 1 –Additional statistical information pertaining to Table 7 in the text. (DOCX)
Data
Model Summary for Experiment 3 –Additional statistical information pertaining to Table 9 in the text. (DOCX)
Data
Appendix (to Table 5)–Specific statistical analysis of the comparison between experiments 1 and 2. The constant (M = 0.711, SED = 0.117, p < .001), pre-speech interval (M = 0.980, SED = 0.306, p < .01) and group (M = -0.305, SED = 0.113, p < .01) were all lower than in the immediate condition, even after Bonferroni correction (sig. p < 0.0125). The...
Article
Introduction Persistent developmental stuttering (PDS) disrupts speech fluency in about 1% of adults, predominantly males. Its etiology remains unclear. PDS shares clinical characteristics with focal, task specific dystonias. Both disorders are associated with excessive activity in muscles not needed to perform a desired movement. Both disorders ar...
Preprint
Full-text available
Previous studies helped unraveling the functional architecture of the human cerebral cortex. However, a comprehensive functional segregation of right lateral prefrontal cortex is missing. Here, we delineated cortical clusters in right area 44 and 45 based on their task-constrained whole-brain activation patterns across neuroimaging experiments obta...
Article
Full-text available
Previous studies helped unraveling the functional architecture of the human cerebral cortex. However, a comprehensive functional segregation of right lateral prefrontal cortex is missing. Here, we delineated cortical clusters in right area 44 and 45 based on their task-constrained whole-brain activation patterns across neuroimaging experiments obta...
Article
Full-text available
Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performe...
Article
Full-text available
A neuronal sign of persistent developmental stuttering is the magnified coactivation of right frontal brain regions during speech production. Whether and how stuttering severity relates to the connection strength of these hyperactive right frontal areas to other brain areas is an open question. Scrutinizing such brain-behaviour and structure-functi...
Article
Full-text available
Background Dyslexia is a specific learning disorder affecting reading and spelling abilities. Its prevalence is ~5% in German‐speaking individuals. Although the etiology of dyslexia largely remains to be determined, comprehensive evidence supports deficient phonological processing as a major contributing factor. An important prerequisite for phonol...
Article
Objectives This study examined underlying neurophysiological mechanisms of developmental stuttering – facilitation in the motor cortex during speech preparation served as analogue to the speech planning process. Methods Transcranial Magnetic Stimulation pulses induced Motor Evoked Potentials (MEPs), recorded from the tongue. 18 Adults Who Stutter...
Article
Full-text available
Purpose: Neuroimaging studies in persistent developmental stuttering repeatedly report altered basal ganglia functions. Together with thalamus and cerebellum, these structures mediate sensorimotor functions and thus represent a plausible link between stuttering and neuroanatomy. However, stuttering is a complex, multifactorial disorder. Besides sen...
Article
Full-text available
Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory br...
Article
Full-text available
Objective: Precise temporal coding of speech plays a pivotal role in sound processing throughout the central auditory system, which, in turn, influences literacy acquisition. The current study tests whether an electrophysiological measure of this precision predicts literacy skills. Methods: Complex auditory brainstem responses were analysed from...
Article
Full-text available
Area 44 is a cytoarchitectonically distinct portion of Broca's region. Parallel and overlapping large-scale networks couple with this region thereby orchestrating heterogeneous language, cognitive and motor functions. In the context of stuttering, area 44 frequently comes into focus because structural and physiological irregularities affect develop...
Article
Background: Recent studies suggest that neurobiological anomalies are already detectable in pre-school children with a family history of developmental dyslexia (DD). However, there is a lack of longitudinal studies showing a direct link between those differences at a preliterate age and the subsequent literacy difficulties seen in school. It is al...
Article
View largeDownload slide Deficient cortical plasticity in dyslexia may be genetically predetermined. Skeide et al. show that NRSN1 (neurensin 1)-associated patterns of grey matter volume in the ‘visual word form area’ distinguish individuals with dyslexia from controls at preschool ages. Detecting these differences could support early diagnosis an...
Article
Full-text available
Dyslexia is a severe disorder in the acquisition of reading and writing. Several studies investigated the role of genetics for reading, writing and spelling ability in the general population. However, many of the identified SNPs were not analysed in case-control cohorts. Here, we investigated SNPs previously linked to reading or spelling ability in...
Article
Full-text available
Neuroimaging and transcranial magnetic stimulation provide insights into the neuronal mechanisms underlying speech disfluencies in chronic persistent stuttering. In the present paper, the goal is not to provide an exhaustive review of existing literature, but rather to highlight robust findings. We, therefore, conducted a meta-analysis of diffusion...
Article
Sir, We thank Indra Kraft and colleagues (2015) for their insightful letter commenting on our recent report in Brain . We agree with the authors in their assessment that, while longitudinal studies are invaluable for disentangling cause and effect in neurodevelopmental disorders, such studies are unfortunately rare because of many practical diffic...
Article
Full-text available
The precise excitability regulation of neuronal circuits in the primary motor cortex is central to the successful and fluent production of speech. Our question was whether the involuntary execution of undesirable movements, e.g. stuttering, is linked to an insufficient excitability tuning of neural populations in the orofacial region of the primary...
Article
Question: Does the current direction influence the effect of intermittent theta burst stimulation (iTBS) on human motor cortex excitability? Methods: We stimulated the dominant hand representation of the motor cortex in 15 healthy subjects, using “unidirectional biphasic” pulses with an M-ratio (i.e, degree of monophasicity) of 0.2, generated by a...
Article
Full-text available
Transcranial Magnetic Stimulation (TMS) is a promising technology for both neurology and psychiatry. Positive treatment outcome has been reported, for instance in double blind, multi-center studies on depression. Nonetheless, the application of TMS towards studying and treating brain disorders is still limited by inter-subject variability and lack...
Conference Paper
Full-text available
Sound signals in our environment are often a superposition from many sources. A broad network of primary auditory as well as associative, attention-related brain areas is at work to analyze the auditory scene and to extract acoustic objects from the sounds impinging on our ears. A previous fMRI-study by Teki et al. (2011) reported that an automatic...
Article
Introduction Persistent developmental stuttering (PDS) is a speech fluency disorder that affects 1% of the population, predominantly males. Its etiology is unclear and likely multifactoral, with contributions from intrinsic factors pertaining to brain anatomy and neurophysiology, particularly abnormal right-hemispheric lateralization of blood flow...
Article
Full-text available
In individuals who stutter (IWS), speech fluency can be enhanced by altered auditory feedback, although it has adverse effects in control speakers. This indicates abnormalities in the auditory feedback loop in stuttering. Current motor control theories on stuttering propose an impaired processing of internal forward models that might be related to...
Article
In adults who do not stutter (AWNS), the control of hand movement timing is assumed to be lateralized to the left dorsolateral premotor cortex (PMd). In adults who stutter (AWS), the network of speech motor control is abnormally shifted to the right hemisphere. Motor impairments in AWS are not restricted to speech, but extend to non-speech orofacia...
Article
We aimed at detecting neurophysiological changes, in the primary motor tongue representation in adults with persistent stuttering. Using transcranial magnetic stimulation in 12 patients and 14 controls, we examined motor threshold, motor-evoked potential (MEP) input-output curve, short-term intracortical inhibition (SICI) and intracortical facilita...
Article
The previous decade has shed light on the neuro-anatomical correlates of persistent developmental stuttering (PDS). Initially, PET and more recently, functional MRI, were used to examine brain function in PDS. Diffusion Tensor Imaging (DTI) enables us to explore particularly the white matter in vivo. Previous DTI studies provided evidence for a dis...
Article
Imaging studies suggest a right hemispheric (pre)motor overactivity in patients with persistent developmental stuttering (PDS). The interhemispheric inhibition (IHI) studied with transcranial magnetic stimulation is an established measure of the interplay between right and left motor areas. We assessed IHI in 15 young male adults with PDS and 15 ag...

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