Nicole Leite Galvão-Coelho

Nicole Leite Galvão-Coelho
Universidade Federal do Rio Grande do Norte | IIP · Department of Physiology and Behavior

About

32
Publications
9,517
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Introduction
Associate professor of Department of physiology and behavior of Federal University of Rio Grande do Norte (UFRN), Natal-RN, Brazil. Professor and researcher of Graduate Program of Psychobiology (UFRN), Coordinator of the Laboratory of Hormonal Measures of UFRN, member of the National Institute of Science and Technology in Translational Medicine, Brazil. Bachelor in Biology by UFRN. PhD in Psychobiology by UFRN, in the Behavioral Endocrinology area. Currently occupation area; Study of the Physiological, Cognitive and Behavioral Changes Induced by Chronic Stress and Associated Psychopathologies, with emphasis on Major Depression, using Animal Models of Nonhuman Primates and Patients. Modulation of Anxiety in the Treatment of in vitro Fertilization.
Additional affiliations
August 2009 - March 2019
Universidade Federal do Rio Grande do Norte
Position
  • Professor (Associate)

Publications

Publications (32)
Article
Purpose of review: Despite advances in treatment modalities for mood disorders over recent decades, further therapeutic options are still required. Increased research is occurring, with the pursuit of psychedelic-based pharmacotherapies for a range of mood disorders and other conditions. Recent findings: Serotonergic psychedelics have been found...
Article
Introduction Emerging evidence suggests that psychedelic compounds, including the Amazonian botanical decoction ayahuasca, may provide clinical benefit in the treatment of alcohol or other drug use disorders. This study investigates associations between ayahuasca consumption in naturalistic settings and current alcohol and other drug use. Methods...
Article
Full-text available
Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies showed that they are mainly monogamous, live in rela...
Article
Full-text available
Rationale Major depressive disorder is one of the leading global causes of disability, for which the classic serotonergic psychedelics have recently reemerged as a potential therapeutic treatment option. Objective We present the first meta-analytic review evaluating the clinical effects of classic serotonergic psychedelics vs placebo for mood stat...
Article
Full-text available
Husbandry procedures may cause behavioral and physiological changes to animals living in captivity. However, an individual´s reaction is not uniform and may be related to different coping strategies. In this study, we analyzed whether and how 12 adult captive capuchin monkeys (Sapajus libidinosus) varying in four personality axes (‘Feeding’, ‘Socia...
Article
Full-text available
In this study, we tested the hypothesis that individual differences in behavioural profiles correlate to differences in stress-related behaviours and hormonal levels in captive brown capuchin monkeys (Sapajus libidinosus). Based on a sample of 25 animals, 143 h of behavioural data collection and 518 faecal samples, principal component analyses indi...
Article
Full-text available
Background: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. P...
Article
Full-text available
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. T...
Article
Full-text available
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal mod...
Preprint
Recent open label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. In order to further test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients...
Article
Critical periods of plasticity (CPPs) are defined by intervals of postnatal brain development wherein neuronal circuits are most susceptible to environmental influences. The CPP of the prefrontal cortex (PFC), which controls executive functions, extends up to early adulthood and, like other cortical areas, reflects the maturation of perineuronal ne...
Article
Full-text available
Phenotypic sex differences in primates are associated with body differentiation during the early stages of life, expressed in both physiological and behavioral features. Hormones seem to play a pivotal role in creating a range of responses to meet environmental and social demands, resulting in better reactions to cope with challenges to survival an...
Article
Full-text available
ResumoOs seres vivos desenvolvem ao longo de sua história evolutiva mecanismos de enfrentamento às condições adversas originadas tanto no ambiente geofísico como no ambiente social. Esta resposta adaptativa é coordenada e envolve diferentes sistemas funcionais, particularmente, os sistemas nervoso, endócrino e imune, e é denominada de resposta ao e...
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Full-text available
Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful event and is associated with a decrease in hippocampa...
Chapter
Full-text available
Major depressive disorder (MDD) is generally classified as a mood disorder with a profound effect on the individual’s behavior and quality of life. According to the World Health Organization, in about 20 years, depression will be the disorder with the most significant repercussions, both socially and economically. Despite the substantial progress i...
Article
Research in stress physiology has demonstrated the benefits of receiving social support during stressful conditions. However, recent data have shown that the efficacy of social support in buffering physiological and behavioral responses to stressor agents depends on species, sex, and relatedness among animals. This study investigated whether differ...
Article
Social non-human primates are potential animal models for studying changes in social dynamics because they build strong emotional bonds inside the group, much as do humans. The common marmoset, a small neotropical primate, is a suitable model because of its low maintenance cost and high reproductive output in captivity associated with the presence...
Article
Full-text available
Some researches demonstrate that the presence of a social partner during a challenging situation modulates the stress response, decreasing its negative effects. In this study common marmoset (Callithrix jacchus) males and females were exposed to a new environment, alone or in companion of a social partner of the same sex and age. When submitted to...

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Projects

Projects (6)
Project
The study aims to evaluate the prospective associations between multiple lifestyle domains and incident mental health problems. A nested case-control study will evaluate the physical health and level of inflammatory biomarkers of those students with mental health problems and paired controls.
Project
This project aims at using different techniques of relevance to neuroscience, such as functional neuroimaging (EEG and fMRI), biochemical, behavioral and scales to investigate the effects of ayahuasca
Project
Elucidate the role of stress in the context of assisted reproduction, by the investigation of how the psychophysiological stress (The salivary cortisol awakening response, anxiety-state, perception of social support and copping style) of patients is related to the success of In vitro fertilization.