Nicolás Rosales

• Doctor of Engineering
• PostDoc Position at National University of La Plata

Several closed or hybrid loop controllers for Blood Glucose (BG) regulation, which are also known as Artificial Pancreas (AP) Systems or Automated Insulin Delivery systems (AIDs), are in development worldwide. Most AIDs are designed and evaluated for short-term performance, with a particular emphasis on the post-meal period. However, if controllers...

Background: The first two studies of an artificial pancreas (AP) system carried out in Latin America took place in 2016 (phase 1) and 2017 (phase 2). They evaluated a hybrid algorithm from the University of Virginia (UVA) and the automatic regulation of glucose (ARG) algorithm in an inpatient setting using an AP platform developed by the UVA. The...

En este trabajo se presenta la experiencia argentina en el problema de regulación de los niveles de glucosa en sangre para pacientes con Diabetes Mellitus Tipo 1 (insulino-dependientes), denominado Páncreas Artificial. El grupo de trabajo ha realizado 3 pruebas clínicas, las primeras en Latinoamérica. Las dos primeras fueron concretadas en 2016 y 2...

In recent years, closed-loop controllers for glucose regulation, also called Artificial Pancreas (AP) systems, have become an emblematic problem in the field of automatic control. Several closed-loop systems are in development around the world, such is the case of the Automatic Regulation of Glucose (ARG) algorithm developed in Argentina that has a...

This letter illustrates the potential of a new platform for simultaneous remote monitoring of multiple intensive care unit (ICU) and/or quarantined patients. To our best knowledge, this is the first multicenter, multisensor, multipatient, and potentially multitherapy platform for remote glucose monitoring employed in critically ill COVID patients....

Within the development of closed-loop glucose controllers, one of the major risks is insulin induced hypo-glycemia due to controller overreaction. In this paper, a novel strategy based on sliding mode control is proposed in order to reduce hypoglycemic events in glycemic closed-loop control via the subcutaneous route. This is achieved with the use...

Los pacientes en estado crítico con COVID-19 sufren hiperglucemias sostenidas de difícil manejo. A esto se suma el desafío de minimizar la exposición al contagio.En el presente artículo analizamos la evolución metabólica de dos pacientes pediátricos con COVID-19 admitidos en unidad de cuidados intensivos (UCI) para pacientes COVID-19 del Hospital “...

In this work, a low-order model designed for glucose regulation in T1DM is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intra-patient variations related to daily insulin sensitivity ( ${S_{I}}$ ) changes. To overcome the large inter-subject variability, the mo...

In this paper, an interval simulator that considers different sources of uncertainty to estimate the blood glucose level of type 1 diabetes patients is presented. In particular, this study examines a model that includes the dynamics from the insulin delivery input to the subcutaneous-glucose concentration output, and a model that estimates the insu...

The objective of this work is to present a brief review on the international Artificial Pancreas project. In addition, the local project that led to the first Latin American clinical trials with an Artificial Pancreas will be described. These trials were performed in Buenos Aires during 2016 and 2017. The last trial used an algorithm developed in A...

Background: Emerging therapies such as closed-loop (CL) glucose control, also known as artificial pancreas (AP) systems, have shown significant improvement in type 1 diabetes mellitus (T1DM) management. However, demanding patient intervention is still required, particularly at meal times. To reduce treatment burden, the automatic regulation of glu...

Background and Objective: Although there has been significant progress towards closed-loop type 1 diabetes mellitus (T1DM) treatments, most diabetic patients still treat this metabolic disorder in an open-loop manner, based on insulin pump therapy (basal and bolus insulin infusion). This paper presents a method for automatic insulin bolus shaping b...

Background In this paper we analyze devices for traffic signals (traffic lights) with light-emitting diode (LED) technology. Methods The traditional measurements of luminous intensity were complemented with the luminance analysis of the devices, evaluated for diverse angular fields. Besides, a subjective glare evaluation is presented. In the exp...