Nicolás Mendoza

• University of Granada

Objective To evaluate the efficacy and safety of a non-hormonal vaginal moisturizer in alleviating the clinical symptoms of vulvovaginal atrophy (VVA). Methods This was an observational, single center, open label study in which the investigational product was applied to postmenopausal women (n = 36) with VVA symptoms three times per week for a per...

Bone cell metabolism is strongly regulated by estrogens and therefore the risk of osteoporosis is favored by menopause. Fragility fractures define the outcome to be prevented in osteoporosis. Since age adds to menopause as a risk factor, and menopause occurs at a relatively early age, preventive measures during the early postmenopausal period are d...

Physical activity (PA) is a promoter of health in general. Its benefits include maintaining proper weight, providing stress relief, increasing muscle strength, improving balance and coordination, increasing bone strength, and increasing mental focus. In addition, PA improves the evolution of diseases such as hypertension, diabetes, osteoporosis, an...

Menopause is an opportunity for sexuality to become more intimate and relaxed. Acceptance of physical changes and a previous history of good sexual health positively influence sexual health over the years. At any age, especially in long-term relationships, the quality of the relationship remains the most important factor influencing sexual health a...

Importance Menopause hormone therapy (MHT) effectively alleviates menopausal symptoms. However, it is generally not recommended for breast cancer survivors, although the scientific evidence is scarce. Objective This study aimed to establish eligibility criteria for use of the MHT in breast cancer survivors based on a systematic review and meta-ana...

Objective: to develop eligibility criteria for use in non-gynecological cancer patients. Methods: We searched all the articles published in peer-reviewed journals up to March 2021. We utilized the PICOS standards and the following selection criteria: menopausal women with a history of non-gynecological and non-breast cancer who underwent hormone re...

Background: Sexual dysfunction is a common problem among postmenopausal women. Tibolone is a steroid hormone that is commonly used to alleviate symptoms of menopause, including sexual dysfunction. However, the evidence regarding the effect of tibolone on female sexual function is mixed. Purpose: The aim of this systematic review is to examine the e...

Purpose: The aim of this systematic review is to evaluate the current evidence regarding the effectiveness of platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (VLS). Methods: A comprehensive search was conducted using the Pubmed and Cochrane Library database to identify relevant studies published up to March 2023. The inclusi...

Objective: Our aim was to develop an updated systematic review to delineate the possible role of the Radiofrequency in the treatment of vaginal laxity and sexual health. Methods: We searched the Institute of Scientific Information Web of Knowledge, MEDLINE, PubMed, Scopus, and Cochrane databases for all articles published in peer-reviewed journals...

Objective: to create a set of eligibility criteria for the use of MHT in non-gynecological cancer patients. Methods: We searched all articles published in peer-reviewed journals up to March 2021. The PICOS standards were used and the selection criteria as follows: menopausal women of any age with non-gynecological and non-breast cancer receiving HM...

Objective This article aimed to study the use of menopausal hormone therapy (MHT) among Spanish perimenopausal and postmenopausal women, the presence of menopausal symptoms and the sources of information. Methods The epidemiological study using a survey included Spanish perimenopausal or postmenopausal women aged between 40 and 70 years in August...

Objective To define which ultrasound criteria could replace the classic Rotterdam criteria as the best indicator of the risk of developing endocrine–metabolic changes in women with polycystic ovary syndrome (PCOS). Materials and methods This multicenter cross-sectional study included 200 women with PCOS and one control group of 111 women without P...

This project aims to develop eligibility criteria for menopausal hormone therapy (MHT). The tool should be similar to those already established for contraception A consortium of scientific societies coordinated by the Spanish Menopause Society met to formulate recommendations for the use of MHT by women with medical conditions based on the best ava...

Objective This study aims to investigate if the administration of pentoxifylline during ovarian stimulation have an impact on the quantity and quality of oocytes recovered for in vitro fertilization (IVF), the quality of zygotes and embryos resulting from IVF, the serum estradiol and progesterone concentrations, the endometrial thickness and pregna...

The aim of the study was to evaluate the level of knowledge that women have about menopause and to analyse whether sociodemographic aspects can influence it. For this, a multi-centre observational study was conducted in Spain using a survey including 2500 women between 35 and 75 years. Participants were administered a 10-question questionnaire with...

Subfertility is more than a quality-of-life problem as it has a substantial negative public health impact. Polycystic ovary syndrome (PCOS) is one of the most common causes of subfertility, affecting one out of 10 women in reproductive age. Among PCOS women undergoing assisted reproductive technology, treatment based on myo-inositol and high doses...

Background Relieving vulvar pain caused by atrophy in postmenopausal women is a challenge in our clinical practice. We know more and more about the vulva, its anatomy and physiology and we are realizing that it is different from the vagina. The importance of the vulvar approach in the management of vulvar or vestibular pain (VP) due to atrophy in p...

Background: The signs and symptoms of the genitourinary syndrome of menopause are well established, and there is extensive knowledge with high scientific evidence about the response that vaginal and urinary tissues present to various treatments. However, this does not usually apply to the vulva in general, or any of its structures in particular, si...

A retrospective population-based study aimed to assess the incidence of endometriosis in the general population in Spain and in each of its autonomous communities. The authors used the incidence of diagnosed endometriosis in the minimum basic dataset at discharge in the national hospital discharge registry of Spain. This analysis was carried out wi...

Objective To examine whether adding a second HCG trigger, 12.5 h after the first (36.5 h before ovarian puncture), can facilitate recovery of oocytes in women with a paucifollicular response to ovarian stimulation. Methods A total of 85 women aged 35–42 years, with a paucifollicular response to ovarian stimulation and who had experienced a total f...

Objectives: To determine the predictive and criterion-based validity of the Cervantes-SF scale that measures the impact of menopause on Health-Related Quality of Life. Methods: We recruited a noninstitutionalized sample of peri/postmenopausal women aged 40 to 65 years, who had their last menstrual cycle 12+ months prior to inclusion in the study...

The objective of this project is to create eligibility criteria for the use of menopausal hormone therapy (MHT) similar to those established for contraceptive methods. A consortium of scientific societies coordinated by the Spanish Menopause Society met to formulate recommendations for the use of MHT by patients with medical conditions based on the...

Objective To assess the impact of confinement due to the coronavirus (Covid-19) pandemic on health-related quality of life (HRQoL) and resilience in peri- and postmenopausal women. Material and Methods We used an online questionnaire which was sent between April 30th and May 13th, 2020 to women aged 40–70 years who were peri- or postmenopausal acc...

The objective of this study was to investigate whether the BC tumor biology in women with larger breast volume, in obese women and especially in women with central adiposity at the moment of diagnosis of BC is more aggressive than in those women without these characteristics. 347 pre- and postmenopausal women with a recent diagnosis of BC were anal...

Synopsis The administration of growth hormone during ovarian stimulation in women with RIF and PCOS may improve intracytoplasmic sperm injection outcomes.

Objective To study what women think about menopause treatments and assess their knowledge about them. To analyze adherence to treatment during COVID-19 confinement as a secondary objective. Methods A multi-center cross-sectional observational study was conducted using a survey of 2500 women between January and June 2019. This was administered foll...

Objective To study what women think about menopause treatments and assess their knowledge about them. To analyze adherence to treatment during COVID-19 confinement as a secondary objective. Methods A multi-center cross-sectional observational study was conducted using a survey of 2500 women between January and June 2019. This was administered follo...

Population aging is a global phenomenon that has wide-ranging consequences for the health of individuals, including age-related obesity, muscle loss, and a decline in muscle strength and gait speed. These alterations are associated with disability, functional decline, and mortality in older adults. The objective of this study was to analyze the eff...

COVID-19 is associated with a systemic inflammatory response with activation of coagulation in symptomatic patients. The possibility of coagulopathies in peri- and postmenopausal women taking estrogen therapies makes it necessary to consider antithrombotic strategies, such as the use of low molecular weight heparins (LMWH) at specific prophylactic...

Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified wi...

The aim of this study was to evaluate the effect of two doses of d-chiro-inositol (DCI) in combination with Myo-inositol (MYO) on the oocyte quality (OQ) of women with polycystic ovarian syndrome (PCOS) undergoing intracytoplasmic sperm injection (ICSI). Methods: This was a controlled, randomized, double-blind, parallel group study on 172 oocytes f...

The purpose of this study was to evaluate the effect of two doses of D-chiro-inositol (DCI) in combination with Myo-inositol (MYO) in women with PCOS undergoing ICSI. This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12 weeks. The study group (SG) was administered 550mg of MYO þ 150mg...

Background: Luteal phase deficiency (LPD) was recognized as a potential cause of infertility well before the first attempts at ovarian stimulation and in vitro fertilization (IVF). However, in the subsequent IVF era, the fact that LPD is particularly frequent in the context of ovarian stimulation has driven the attention to LPD almost exclusively t...

Research question: This study aimed to identify women with IVF failure associated with low serum progesterone levels after embryo transfer in HCG-triggered cycles and to evaluate the effects of gonadotrophin-releasing hormone (GnRH) agonist, administered after embryo transfer, on serum progesterone and pregnancy outcomes in these cases. Design:...

The purpose of this study was to evaluate the effect of two doses of D-chiro-inositol (DCI) in combination with Myo-inositol (MYO) in women with PCOS undergoing ICSI. This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12 weeks. The study group (SG) was administered 550 mg of MYO + 150...

Objective: To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain. Study design: Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain. Results: In total, 398 patients with...

The design of optimal courses for obstetric undergraduate teaching is a relevant question. This study evaluates two different designs of simulator-based learning activity on childbirth with regard to respect to the patient, obstetric manoeuvres, interpretation of cardiotocography tracings (CTG) and infection prevention. This randomised experimental...

Background and Objective Administration of growth hormone (GH) during ovarian stimulation has been shown to improve success rates of in vitro fertilization (IVF). GH beneficial effect on oocyte quality is shown in several studies, but GH effect on uterine receptivity is not clear. To assess it, we studied whether GH administration can improve the c...

Sexual health can be defined as a state of physical, emotional, mental and social well-being that is related to sexuality and not merely the absence of disease, dysfunction or infirmity. The sexual health of individuals requires them to have a positive and respectful attitude towards sexuality and sexual relations and the possibility of having sexu...

Objectives To determine whether actively addressing sexuality in a gynaecological consultation with menopausal patients improves the diagnosis of sexual problems. Study design A multi-centre analytical cross-sectional study was conducted at 12 Spanish hospitals. In gynaecological consultations the usual medical histories were taken, except that, i...

Physical activity (PA) is a promoter of health in general. Its benefits include maintaining proper weight, providing stress relief, increasing muscle strength, improving balance and coordination, increasing bone strength, and increasing mental focus. In addition, PA improves the evolution of diseases such as hypertension, diabetes, osteoporosis, an...

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disease that involves menstrual dysfunction and reproductive difficulty, as well as metabolic problems. The aim of this study was to assess the effectiveness of myo-inositol (MYO) and d-chiro-inositol (DCI) on improving oocyte or embryo quality and pregnancy rates for women with PCOS u...

The consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) has shown a great variety of beneficial effects, including cardiovascular, metabolic and inflammatory effects, which make them interesting for the postmenopausal woman. Because LCO3-PUFAs could be effective and safe during this period, a panel of experts from the Spanish...

Sexual health can be defined as a state of physical, emotional, mental and social well-being that is related to sexuality and not merely the absence of disease, dysfunction or infirmity. Achieving sexual health requires the sexual rights of individuals to be recognized and guaranteed. Among these rights are “the right to comprehensive sexual educat...

Background: This study explored multidimensional outcomes that were derived from the adherence to regular exercise among previously sedentary postmenopausal 45-64 years old women who engaged in a ~20-week exercise programme. Methods: A RCT with between-group (intervention and control women) and within-subject measures (baseline, postintervention...

Objectives: This study explored the multidimensional outcomes that resulted from the adherence to regular exercise among previously sedentary postmenopausal women. The exercise was managed through a supervised, multicomponent, adapted approximately 20-week program in a suited health promotion intervention. Methods: A multigroup, mixed-design stu...

Breast cancer is the most common cancer in women. As survival rates are increasing, the long-term health problems of survivors now need attention. Many survivors develop sexual disorders as a consequence of either the side-effects of treatment or induced menopause. A panel of experts from various Spanish scientific societies (Spanish Menopause Soci...

Objective: One of the most common complaints among postmenopausal women is a change in sexual drive. The aim of this study was to assess the current state of sexual health in Spanish postmenopausal women who present at outpatient gynecology clinics. Method: In this multicenter, observational, cross-sectional, questionnaire-based study, a survey...

A uterine intracavital adhesion was detected by non-invasive virtual hysteroscopy and removed by conventional operative hysteroscopy, enabling subsequent embryo implantation.

Objective: To identify women's sociodemographic and variables related to health care with the prescription of hormonal therapy (HT) and phytotherapy (PT) in Spanish postmenopausal women. Method: The survey consisted of a multicenter, observational, cross-sectional, questionnaire-based investigation and was conducted among 3022 postmenopausal wom...

Physical inactivity not only places women's health at risk during menopause, but also increases menopausal problems. Abundant evidence links habitual physical exercise (PE) to a better status on numerous health indicators and better quality of life and to the prevention and treatment of the ailments that typically occur from mid-life onwards. We ca...

Although age is the most important predictor of a woman's reproductive capacity, there is still a risk of pregnancy during the menopause transition as occasional, spontaneous ovulation can occur. Therefore, we are facing a complex dilemma: ageing is accompanied by changes that can increase the risks associated with combined hormonal contraceptive (...

BackgroundDT56a (Femarelle (R)) is a natural medication that contains a variety of phytoestrogens derived from tofu. Treatment with DT56a affects bones, vascular tissues and the nervous system in a manner similar to that of estrogen but DT56a acts as an estrogen antagonist in breast and uterine tissues.AimThe objective of this study was to analyze...

The purpose of our study was to evaluate the effects of six weeks of Pilates regarding functional balance, fear of falling and pain in community living women older than 65 years old with chronic low-back pain. A single blind controlled randomized trial of six weeks of Pilates in addition to physiotherapy treatment (n=50) vs. physiotherapy treatment...

Introduction: The consequences of vulvar disorders in terms of health, sexuality, and quality of life are usually undervalued, with disparities in the conceptual, diagnosis and treatment criteria. Aim: The objective of this guide will be to analyse the factors associated with the diagnosis and treatment of vulvar disorders and to provide recommenda...

While we recognise that the term premature menopause is more accepted by most non-specialist health care providers and by the general population, 'primary ovarian insufficiency' (POI) is currently considered the most apposite term to explain the loss of ovarian function, because it better explains the variability of the clinical picture, does not s...

Introduction: This paper provides a critical review of the data concerning the effects of combined hormonal contraceptives (CHC) for polycystic ovary syndrome (PCOS). The aim is to determine the best treatment option for each PCOS phenotype. Study design: A literature search of the PubMed database was conducted for randomized clinical trials (RC...

ABSTRACT In this review, we analyse the efficacy and safety of DT56a in the treatment of postmenopausal symptoms. Similar to all selective oestrogen receptor modulators (SERMs), DT56a demonstrates dual agonistic and antagonistic effects due to the synergy between its components. DT56a is referred to as a plant-origin SERM (phyto-SERM), and for this...

Denosumab is a new drug developed for the treatment of osteoporosis. Moreover, increasing evidences link denosumab with benefits in cancer, an area of interest for those in charge of the postmenopausal health. Denosumab has shown efficacy in the control of bone loss associated with hypogonadic states created by chemotherapy in breast and other canc...

OBJECTIVE: The purpose of our study was to investigate the relationship between bone mineral density (BMD) and postural stability and the fear of falling in a 50- to 65-year-old postmenopausal population. STUDY DESIGN: A cross-sectional, observational study was conducted on 118 postmenopausal women. According to their BMD values, participants were...

Objective: To assess alcohol abuse as a predictor of risky sexual behavior among adolescents and young adult women, a high-risk population for unintended pregnancies. Subjects: Totally 3163 adolescent and young adult women, 18-29 years, were assessed on sociodemographics, alcohol and drug use and risky sexual behaviors. Interventions: Particip...

Objective To assess whether continuous and extended regimens (CRs/ERs) of combined hormonal contraceptives (CHCs) improve symptoms related to withdrawal bleeding or the hormone-free interval and to compare the efficacy, safety, and cost of CRs/ERs to those of conventional 28-day regimens. Study design A literature search of the PubMed database was...

Sexual health has been defined as “the state of physical, emotional and social wellbeing related to sexuality. However, there are medical, psychological and social reasons that complicate full sexual health that are frequently not attended to sufficiently. The objective of this guide will be to analyze the factors that impact the sexual health of m...

Vaginal health, defined as the vaginal state in which the physiological condition remains stable, being protected from the onset of symptoms and facilitating a satisfying sex life, is one of the most common and less valued concerns in postmenopausal women. Many of the conditions that affect the vagina are related to its trophism and susceptibility...

To assess the current quality of life of menopausal women and determine the effect of treatment.

Although age is the most crucial predictor of a woman's reproductive capacity, it is assumed that there is still a risk of pregnancy in menopause transition, as occasional spontaneous ovulation is possible. Moreover, age alone is not sufficient to contraindicate the use of any contraceptive method, whether hormonal or not. The use of new CHC in wom...

The Quality of Life Questionnaire of the European Foundation for Osteoporosis-31 (QUALEFFO-31) is a reliable and validated questionnaire that assesses quality of life in osteoporotic women. Our objective was to analyze the reliability and validity of the Spanish version of QUALEFFO-31 and its ability to discriminate between women with osteoporosis...

Tibolone is a drug with complex tissue-specific action that exhibits a combination of estrogenic, progestogenic, and slight androgenic activity. Its variable profile explains its clinical effects, depending on the target tissue where it is metabolized, its metabolites' affinity for and potency in hormone receptors, and probable enzymatic activity m...

Perimenopause is an imprecise period in woman over 40 years of age, which comprises the time between the moment that the first changes in the menstrual cycle appear and the year following the definitive cessation of the menses. Besides irregular bleeding, many women also complain of hot flashes and other characteristic symptoms of postmenopause. Mo...

Women's care during perimenopause and postmenopause is taking new paths to help women cope with both somatic manifestations and changes related to psychological and social factors. An updated, systematic review was conducted on non-pharmacological psychosocial interventions with regard to peri- and postmenopause. Several databases complemented with...

Objective: The duration of the fertile period (FP) can be considered a complex parameter that depends on the interaction of multiple factors. In the present study, the role of interaction between genetic variants within estrogen synthesis and signaling pathways in the FP in Spanish women is studied. Material and methods: Nine single nucleotide p...

Objectives: Falls are one of the leading causes of fractures and impaired quality of life in the elderly, and they are related to balance deficit and to fear of falls. The purpose of our study is to evaluate predictors of falls in the 50-65-year-old postmenopausal population. Methods: A prospective cohort study was conducted on 96 postmenopausal...

Introduction A hydatid cyst of the breast is rare and often goes unnoticed by mammography and ultrasound. Preoperative diagnosis may be performed using fine-needle aspiration cytology, which also minimizes the risk of intraoperative rupture. Case presentation We report the case of a 70-year-old Spanish woman who was diagnosed with a hydatid cyst u...