Nicolas Feltin

Nicolas Feltin
Laboratoire National de Métrologie et d'Essais · DMSI

About

97
Publications
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1,255
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Publications

Publications (97)
Preprint
Background Food-grade titanium dioxide (TiO2), composed of nano- and submicron-sized particles, is used worldwide in various foodstuffs, toothpastes and pharmaceutical tablets as a whitening and opacifying agent. Its use as a food additive (E171 in EU) has raised concerns for human health regarding its systemic availability, tissue accumulation, ge...
Preprint
Background: Edible gold (Au) is commonly used as a food additive (E175 in EU) for confectionery and cake decorations, coatings and in beverages. Food-grade gold is most often composed of thin Au sheets or flakes exhibiting micro- and nanometric dimensions in their thickness. Concerns about the impact of mineral particles used as food additives on h...
Article
Full-text available
In this paper, the accurate determination of the size and size distribution of bipyramidal anatase nanoparticles (NPs) after deposition as single particles on a silicon substrate by correlative Scanning Electron Microscopy (SEM) with Atomic Force Microscopy (AFM) analysis is described as a new measurement procedure for metrological purposes. The kn...
Poster
Full-text available
Titanium dioxide (TiO2) are among the most used nanomaterials in industries but probably the most controversial for human health. In vitro studies have been widely implemented to evaluate the toxicity of TiO2 nanoparticles (NPs). However, physicochemical characterization of NPs in the biological medium prior to in vitro assays are not systematicall...
Article
The market for nano-additive materials has been growing exponentially since 2012, with almost 5040 consumer products containing nanoparticles in 2021. In parallel, the increasing recommendations, definitions and legislations underline the need for traceability of manufactured nanoparticles and for methods able to identify and quantify the “nano” di...
Article
The morphology of amorphous silica NPs in three dimensions (3D) of space is analysed using a single technique: the transmission electron microscope in Scanning Transmission Electron Microscopy with High Angle Annular Dark Field (HAADF-STEM) imaging mode. For this purpose, a method consisting in adjusting the HAADF-STEM signal by a function describi...
Article
Scanning Electron Microscopy (SEM) technique is widely used to characterize nanoparticle (NP) size. The landing energy (LE) of the primary electron beam is considered to be a key parameter related to the ability of electrons to penetrate the sample. However, few studies have been carried out so far on the influence of this parameter on the measurem...
Article
Full-text available
The size characterization of particles present in the form of agglomerates in images measured by scanning electron microscopy (SEM) requires a powerful image segmentation tool in order to properly define the boundaries of each particle. In this work, we propose to use an algorithm from the deep statistical learning community, the Mask-RCNN, coupled...
Article
The nanometric scale reveals unexpected properties of materials, and often completely different from those of the same materials at the micro- or macro-scales. Occupational exposures to engineered nanomaterials (ENMs) concern workers in research laboratories, manufacturing plants or sites of use of ENMs, the number of which remains unknown to date....
Article
In this work we present a comparison exercise between two metrological institutes for size measurement of silica nanoparticles by Asymmetrical Flow Field-Flow Fractionation (AF4) coupled to static light scattering. The work has been performed in the frame of a French inter-laboratory comparison (ILC) exercise organized by the nanoMetrology Club (Cn...
Article
Full-text available
Background: Titanium dioxide (TiO2) is broadly used in common consumer goods, including as a food additive (E171 in Europe) for colouring and opacifying properties. The E171 additive contains TiO2 nanoparticles (NPs), part of them being absorbed in the intestine and accumulated in several systemic organs. Exposure to TiO2-NPs in rodents during pre...
Article
Résumé Le passage de la matière à des dimensions nanométriques fait apparaître des propriétés inattendues et souvent totalement différentes de celles des mêmes matériaux à l’échelle micro- ou macroscopique. Les expositions professionnelles aux nanomatériaux manufacturés (NM) concernent des travailleurs dans les laboratoires de recherche, les usines...
Article
Particle size distribution (PSD) is an important factor determining the efficiency of industrial manufacturing processes for nanomaterials, assuring the reproducibility and safety of the final product. Among the instruments that have been developed to determine size and PSD of nanoparticle dispersions, the easiest to handle are based on indirect me...
Article
Full-text available
An intercomparison campaign on nanoparticle size measurement was organized in the frame of the French nanoMetrology club. The aim of this study is to make an inventory of the metrological capabilities of all measurement techniques in France involved in the “nano” size range, including the SMPS (scanning mobility particle sizer) concerning aerosol m...
Article
Commercial products containing nanomaterials are already a part of our everyday life. The dimensional parameters play an important role for identifying nanoparticles. Various techniques are available for measuring the particles size and shape. However, electron microscopy-based techniques are often considered as the preferred methods for characteri...
Article
Full-text available
Scanning Electron Microscopy (SEM) is considered as a reference technique for the determination of nanoparticle (NP) dimensional properties. Nevertheless, the image analysis is a critical step of SEM measuring process and the initial segmentation phase consisting in determining the contour of each nano-object to be measured must be correctly carrie...
Article
Full-text available
At this time, there is no instrument capable of measuring a nano-object along the three spatial dimensions with a controlled uncertainty. The combination of several instruments is thus necessary to metrologically characterize the dimensional properties of a nano-object. This paper proposes a new approach of hybrid metrology taking advantage of the...
Article
Scanning Electron Microscopy (SEM) technique is widely used for characterizing nanoparticle (NP) size but very few papers deal with NP dimensional metrology. This article reports on the methodology to evaluate the uncertainty budget associated with the measurement of the mean diameter of standard silica NP population by SEM. In this context, the ef...
Article
55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions, Helsinki, FINLAND, SEP 08-11, 2019
Poster
Full-text available
We propose a novel approach of hybrid metrology combining AFM (Atomic Force Microscopy) and SEM (Scanning Electron Microscopy) measurements for measuring the characteristic dimensions of nanoparticles (NP) in 3D with controlled uncertainties. This method takes advantage of the complementary nature of both techniques: SEM gives no quantitative infor...
Poster
Full-text available
Graphene attracts LNE’s interest for more than 10 years as it is today the most promising material to establish a practical traceability for electrical resistance to the quantum Hall effect [1]. Beyond, graphene can have many innovative applications the development of which needs accurate control of the material properties. To support the expected...
Article
Aims: Contrast-induced nephropathy is a commonly encountered problem in clinical practice. The purpose of the study was to design and develop a novel contrast agent, which could be used to prevent contrast-induced nephropathy in the future. Methods: In total, 20-220nm magnetic nanoparticles were conjugated with iodixanol, and their radio-opacity...
Article
Combined influence of oxygenation and salinity on agglomeration and/or aggregation kinetics of silver (Ag) nanomaterials NM-300K was conducted and the relationship between their physico-chemical fate and toxicity towards an estuarine bivalve was established. The results showed that the presence of NaCl under oxygen conditions (8.5 ppm) promoted the...
Article
In order to evaluate the uncertainty budget of the LNE's mAFM, a reference instrument dedicated to the calibration of nanoscale dimensional standards, a numerical model has been developed to evaluate the measurement uncertainty of the metrology loop involved in the XYZ positioning of the tip relative to the sample. The objective of this model is to...
Chapter
The development of the nanometrology, science of the measurement at the nanoscale, aims to tackle the issues related to the reliability, the trueness, and the comparability of measurements on nanomaterials. The structure of the traceability chain for dimensional measurements at the nanoscale causes to divide all the relevant techniques for sizing n...
Article
Full-text available
In the present study, the alkali-activation process potential of the industrial by-product called waste fired clay bricks (Grog) as well as the effects of the addition of another industrial by-product known as granulated blast-furnace slag (S) on the properties of the final products has been studied. Granulated blast-furnace slag has been employed...
Book
Full-text available
https://www.anses.fr/fr/system/files/AP2011SA0088Ra.pdf
Poster
Full-text available
Nanosciences and Nanotechnologies industrial activities raise new questions in terms of production processes and potential risks associated to the use of nanomaterials. The reliability of measurement data appears as a core issue and stresses the importance of developing metrological traceability to common references (most of the time the Internatio...
Presentation
Full-text available
Modeling of a metrological AFM interferometric position measurement system to determine its measurement uncertainty
Article
This article reports on the evaluation of an uncertainty budget associated with the measurement of the mean diameter of a nanoparticle (NP) population by Atomic Force Microscopy. The measurement principle consists in measuring the height of a spherical-like NP population to determine the mean diameter and the size distribution. This method assumes...
Article
We study the room-temperature performance of micro-Hall magnetic sensors based on pseudomorphic InGaAs quantum wells. Active areas of our sensors range from 1 to 80 μm. We focus on the smallest detectable magnetic fields in small sensors and perform a systematic study of noise at room temperature in the frequency range between 1 Hz and 100 kHz. Our...
Article
This article is the first step in the development of a hybrid metrology combining AFM and SEM techniques for measuring the dimensions of a nanoparticle population in 3D space (X,Y,Z). This method exploits the strengths of each technique on the same set of nanoparticles. AFM is used for measuring the nanoparticle height and the measurements along X...
Conference Paper
The commercial products containing nanomaterials are already a part of our everyday life and new products enter the market regularly. But the nanometrology, i.e., science of the measurement at the nanometer scale, is still in its early stages. However, all actors concerned by nanoscience and nanotechnologies in the industrial sector or academic wor...
Article
Full-text available
Créé en 2011 conjointement par le LNE et NanoSciences France-C’Nano, le club nanoMétrologie rassemble les industriels, le secteur académique et les agences gouvernementales afin de partager des problématiques métrologiques dans tous les domaines que recouvrent les nanosciences et les nanotechnologies. Plus de 280 adhérents provenant de près de 140...
Conference Paper
Full-text available
Créé en 2011 conjointement par le LNE et NanoSciences France (réseau C’Nano), le club nanoMétrologie a pour objectif de rassembler industriels, secteur académique et agences gouvernementales au sein d’un véritable réseau afin de partager des problématiques métrologiques dans tous les domaines que recouvrent les nanosciences et les nanotechnologies....
Article
La poursuite du développement des nanotechnologies nécessite de pouvoir disposer de résultats de mesure toujours plus fiables, à la fois pour permettre la mise en place d’un contrôle qualité et pour faciliter l’acceptation par le public de nouveaux produits arrivant sur le marché. La nanométrologie, science des mesurages à l’échelle du nanomètre, a...
Conference Paper
We present an experimental study on the performance of nano-Hall sensors made on the two dimensional electron gaz of a pseudo morphic GaAlAs/GaInAs heterostructures. The active area of the sensor is from sub-micronic scale (down to 500 nm) to 5 microns. Ohmic contacts have micronic size, and a reference sample of 80 micron width has been caracteriz...
Conference Paper
Full-text available
Using combined AFM ( Atomic Force Microscope) and a SEM (Scanning Electron Microscope) makes it possible to accurately measure a nano-object in 3 dimensions. This paper deals with the traceable measurements of the size and the size distribution of a SiO2 spherical shaped nanoparticle population performed by both microscopy techniques. The complemen...
Article
The direct closure of the quantum metrological triangle consists in achieving Ohm's law with the three effects used and investigated in quantum electrical metrology: the Josephson effect (JE), the quantum Hall effect (QHE) and the single-electron tunnelling effect (SET). The aim is to check the consistency of the phenomenological constants KJ, RK a...
Article
Full-text available
LNE is developing a MEtrological ChARacterization of Nanomaterials (CARMEN) platform to offer a complete supply of main parameter measurements characterizing a nano-object (size, shape, polydispersity, agglomeration/aggregation state, surface charges, specific charges. . . ). Other physical properties such local electrical measurements will be able...
Article
Full-text available
Nous présentons les principaux résultats obtenus dans le cadre du projet ANR-TRIMET dont l'objectif était la fermeture du triangle mé-trologique quantique (TMQ) à un niveau d'incertitude relative de 10 −6. L'expérience du TMQ consiste à réaliser une loi d'Ohm en utilisant les trois effets quantiques impliqués en métrologie électrique : l'effet Jose...
Article
Full-text available
We present our experimental set-up and discuss the results obtained with the quantum metrological triangle (QMT) experiment. This experiment consists in realizing Ohm's law with the three effects used and investigated in quantum electrical metrology: the Josephson effect (JE), the quantum Hall effect (QHE) and the single electron tunneling effect (...
Article
We show the first measurements of a silicon electron pump produced in an industrial CMOS facility. Sample fabrication derived from state-of-the-art microelectronics processes results in mass production with high yield, very small sizes and easy operation up to high frequencies as these pump do not suffer from cross-capacitance. Further data with me...
Conference Paper
Full-text available
We present our experimental set-up and discuss the results obtained with the quantum metrological triangle (QMT) experiment. This experiment consists in realizing Ohm's law with the three effects used and investigated in quantum electrical metrology: the Josephson effect (JE), the quantum Hall effect (QHE) and the single electron tunneling effect (...
Article
The elementary charge e is of fundamental importance in physics. The determination of its value, which is closely linked to progress of the measurement techniques, started in the beginning of the twentieth century and is still on-going. Today, in the frame of the CODATA adjustment, the evaluation of the fundamental constant, e, is derived from a co...
Article
Full-text available
The quantum metrological triangle experiment (QMTE) consists in realizing Ohm's law with Josephson (JE), quantum Hall (QHE) and single electron tunneling (SET) effects. The aim is to check the consistency of the link among the phenomenological constants K J, RK and Q X involved in these effects and theoretically expressed with the fundamental const...
Article
The stability of an electron pump composed of three junctions and on-chip chromium resistors at the ends is investigated as a function of applied frequencies on the gate electrodes. For the first time current steps have been obtained with frequencies fSET as high as 100 MHz. Moreover in the complete studied frequency range we show that the nature (...
Article
Full-text available
The combination of a Watt balance, a calculable capacitor, and a single-electron tunneling device forms a triangle that yields a value for the single-electron charge quantum Q S in terms of the SI coulomb. Importantly, this result is independent of the Josephson and quantum Hall effects, and thus avoids the possible confounding corrections from the...
Article
We describe the experimental set-up used at LNE for closing the quantum metrological triangle (QMT) experiment and also testing the quantization of a current generated by a single electron device. Our present device is an R-electron pump composed of 3 tunnel junctions. The influence of the pumping frequency on the noise and on the current stability...