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Nicolas Christophorou

Nicolas Christophorou
Institut Curie · Département Biologie cellulaire et biologie du développement

PhD

About

15
Publications
1,711
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530
Citations
Additional affiliations
September 2004 - July 2009
King's College London
Position
  • PhD Student

Publications

Publications (15)
Article
Full-text available
Meiotic crossovers (COs) are important for reshuffling genetic information between homologous chromosomes and they are essential for their correct segregation. COs are unevenly distributed along chromosomes and the underlying mechanisms controlling CO localization are not well understood. We previously showed that meiotic COs are mis-localized in t...
Article
During meiotic prophase I chromosomes undergo dramatic conformational changes that accompany chromosome condensation, pairing and recombination between homologs. These changes include the anchoring of telomeres to the nuclear envelope and their clustering to form a bouquet. In plants, these events have been studied and illustrated in intact meiocyt...
Article
In vertebrates, cranial placodes contribute to all sense organs and sensory ganglia and arsise from a common pool of Six1/Eya2+ progenitors. Here we dissect the events that specify ectodermal cells as placode progenitors using newly identified genes upstream of the Six/Eya complex. We show that two different tissues, the lateral head mesoderm and t...
Article
The orientation of cell division along the long axis of the interphase cell-the century-old Hertwig's rule-has profound roles in tissue proliferation, morphogenesis, architecture and mechanics. In epithelial tissues, the shape of the interphase cell is influenced by cell adhesion, mechanical stress, neighbour topology, and planar polarity pathways....
Article
Full-text available
At the onset of meiosis, each chromosome needs to find its homologue and pair to ensure proper segregation. In Drosophila, pairing occurs during the mitotic cycles preceding meiosis. Here we show that germ cell nuclei undergo marked movements during this developmental window. We demonstrate that microtubules and Dynein are driving nuclear rotations...
Article
Full-text available
Author Summary Meiosis is a special type of cell division occurring in germ cells to produce sexual gametes. Initially, germ cells contain two copies of each chromosome, one from the mother and one from the father, which are called homologs. During meiosis, cells divide twice to produce haploid gametes with only one copy of each chromosome. Each ga...
Article
Full-text available
Few families of signaling factors have been implicated in the control of development. Here, we identify the neuropeptides nociceptin and somatostatin, a neurotransmitter and neuroendocrine hormone, as a class of developmental signals in both chick and zebrafish. We show that signals from the anterior mesendoderm are required for the formation of an...
Data
Full-text available
ClustalW alignment of human, mouse and chicken N-Cadherin En2-DP enhancer sequences. Shaded bases are conserved across all three species, as reflected in the consensus enhancer sequence. The consensus is annotated with putative conserved transcription factor binding sites: those above the consensus are encoded on the sense strand, whereas those bel...
Article
Full-text available
Crucial components of the vertebrate eye, ear and nose develop from discrete patches of surface epithelium, called placodes, which fold into spheroids and undergo complex morphogenesis. Little is known about how the changes in cell and tissue shapes are coordinated with the acquisition of cell fates. Here we explore whether these processes are regu...
Article
Full-text available
In vertebrates, cranial placodes form crucial parts of the sensory nervous system in the head. All cranial placodes arise from a common territory, the preplacodal region, and are identified by the expression of Six1/4 and Eya1/2 genes, which control different aspects of sensory development in invertebrates as well as vertebrates. While So and Eya c...
Article
Full-text available
In the chick embryo, two methods are now used for studying the developmental role of genes by loss-of-function approaches: vector-based shRNA and morpholino oligonucleotides. Both have the advantage that loss-of-function can be conducted in a spatially and temporally controlled way by focal electroporation. Here, we compare these two methods. We fi...

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