Nicolas Baclet

• MD PhD
• Medical Doctor at Lille Catholic University

Background: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. Objective: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older patients. Methods: We conducted a Delphi survey involving French experts on antibiotic stewardship in hospital...

PurposeEnterobacteriaceae (EB) bloodstream infections (BSI) are frequent and serious in older patients. Physicians are faced with the dilemma of prescribing early appropriate empirical antibiotics to limit the risk of death, and sparing broad-spectrum antibiotic prescription. The aim of the study was to assess the rate of appropriate empirical anti...

Context: The use of explicit definitions of potentially inappropriate prescriptions of antibiotics (antibiotic PIPs) might constitute an innovative means to fight against antimicrobial resistance. Explicit definitions of PIPs can reduce the rate of inappropriate prescriptions, but explicit definitions of antibiotic PIPs in geriatric medicine are cu...

In France, around 5% of the general population are taking drug treatments for diabetes mellitus (mainly type 2 diabetes mellitus, T2DM). Although the management of T2DM has become more complex, most of these patients are managed by their general practitioner and not a diabetologist for their antidiabetics treatments; this increases the risk of pote...

Describing the characteristics of COVID-19 patients in the hospital is of importance to assist in the management of hospital capacity in the future. Here, we analyze the trajectories of 1321 patients admitted to hospitals in northern and eastern France. We found that the time from onset to hospitalization decreased with age, from 7.3 days in the 20...

Introduction Les bactériémies à entérobactéries (EB) sont fréquentes chez les sujets âgés. Le choix de l’antibiothérapie probabiliste est souvent difficile. Les modalités de traitement de ces infections (nature et durée de l’antibiothérapie) sont de plus encore mal codifiées dans cette population. L’objectif de cette étude était de décrire les moda...

Introduction Les définitions explicites de prescriptions potentiellement inappropriées (PPI) de médicaments ont déjà montré leur intérêt, particulièrement en gériatrie. L’application de définitions explicites de PPI pour les antibiotiques peut être un nouvel outil complémentaire aux actions menées dans la lutte contre l’antibiorésistance. Cependant...

Le développement des bactéries résistantes aux antibiotiques constitue un problème majeur de santé publique, particulièrement favorisé par l’utilisation inappropriée d’antibiotiques. Plusieurs plans d’action nationaux et internationaux ont donc été élaborés pour réduire les prescriptions inappropriées et améliorer le bon usage des antibiotiques. La...

Electronic health record (EHR) systems were initially developed to improve health care delivery by facilitating the healthcare professionals' access to electronically-stored patient information, but problems are regularly reported in the literature. We present here a preliminary study conducted at a 950-bed university hospital. They have implemente...

Introduction Les infections ostéoarticulaires sur matériel (lOAM) relèvent d’une prise en charge (PEC) pluridisciplinaire spécialisée. Il est essentiel que cette PEC, initiée à l’hôpital, soit sécurisée lors de la sortie d’hospitalisation par la transmission d’une information optimale aux professionnels de ville (suivi thérapeutique, surveillance d...

Context: Potentially inappropriate prescriptions (PIPs) of antibiotics (antibiotic-PIPs) are generally detected by applying implicit definitions based on expert opinion. Explicit definitions are less frequently used, even though this approach would enable the automated detection of antibiotic-PIPs in electronic health records. Here, we systematica...

Introduction Le bon usage des antibiotiques (ATB) est un enjeu de santé publique face au développement des résistances bactériennes. Dans notre établissement, la prescription informatisée nous a permis de construire un outil de suivi des prescriptions d’ATB sous la forme de tableaux de bord. Utile à l’évaluation du bon usage des ATB, cet outil a mi...

BackgroundA cluster of indigenous typhoid fever cases in the greater Lille area, in January 2009, triggered investigations to identify the contamination source and to optimize care for infected individuals.

Context: The hospital-acquired pneumonias are frequent and little studied in medical wards, in particular in geriatrics. Their diagnosis is difficult and these infections entail an overconsumption of antibiotics. Objective: The objective of our study was to assess the interest of the bacteriological data obtained by endotracheal aspiration in the a...

A cluster of indigenous typhoid fever cases in the greater Lille area, in January 2009, triggered investigations to identify the contamination source and to optimize care for infected individuals. A case was defined as a person, living in the greater Lille area of, having presented with symptoms of typhoid fever, from January to March 2009. Sixteen...

A case of Salmonella paratyphi A infection was diagnosed late in a patient treated for febrile pneumonia after his returning from India. This case was remarkable in two aspects: first, it illustrated the reemergence of S.paratyphi A infections in people having traveled to India, with increasing fluoroquinolone resistance, and second the difficulty...

A case of Salmonella paratyphi A infection was diagnosed late in a patient treated for febrile pneumonia after his returning from India. This case was remarkable in two aspects: first, it illustrated the reemergence of S.paratyphi A infections in people having traveled to India, with increasing fluoroquinolone resistance, and second the difficulty...