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Nicola Maffiuletti

Nicola Maffiuletti
Schulthess Clinic, Zürich · Human Performance Lab

PhD

About

304
Publications
203,160
Reads
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14,546
Citations
Citations since 2017
101 Research Items
7860 Citations
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201720182019202020212022202302004006008001,0001,2001,400
201720182019202020212022202302004006008001,0001,2001,400
201720182019202020212022202302004006008001,0001,2001,400
Introduction
I obtained my PhD degree (Sport Science) in 2000 from the University of Burgundy in Dijon (France), where I subsequently worked as an Assistant Professor. Since 2005 I am the Head of the Human Performance Lab at the Schulthess Clinic in Zurich (Switzerland). My current research focuses on different aspects of human neuromuscular function, with the ultimate goal to provide (possibly) useful knowledge to researchers, clinicians and practitioners working in different fields.
Additional affiliations
September 2005 - July 2015
Schulthess Klinik, Zürich
Position
  • Principal Investigator

Publications

Publications (304)
Article
Full-text available
Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via the adipogenic differentiation of fibro-adipogenic progenitors (FAPs). We used single-nuclei and single-cell RNA sequencing to characterize FAP heterogeneity in patients with fatty infiltration. We identified an MME⁺ FAP subpopulation which, based o...
Article
Full-text available
Background Patients with femoroacetabular impingement syndrome (FAIS) show sex-specific differences in hip muscle function, hip morphology, and symptoms. Possible differences in hip muscle characteristics between men and women with FAIS are unknown. Purpose To compare hip muscle cross-sectional area (CSA) and fatty infiltration between men and wom...
Article
Full-text available
Contralateral facilitation, i.e., the increase in contralateral maximal voluntary strength that is observed when neuromuscular electrical stimulation (NMES) is applied to the ipsilateral homonymous muscle, has previously been reported for the knee extensors but the neurophysiological mechanisms remain to be investigated. The aim of this study was t...
Article
Full-text available
Purposes To evaluate peripheral muscle function of the knee extensors during repeated changes of direction in professional soccer players by examining differences between competitive levels, periods of the season and playing positions, and to investigate the relationships between peripheral muscle function and physical activities during matches. M...
Conference Paper
Full-text available
Background Older adults often fail to reach the recommended amount of physical activity to prevent the age-related decline in metabolic, cardiorespiratory, and muscular function. Effective home-based physical training programs could neutralize barriers preventing older adults from being active, and administration/supervision through videoconference...
Article
Full-text available
Submaximal levels of effort are required for the performance of the most common daily tasks. Inaccuracy in modulating motor outputs during submaximal tasks has been reported as indicator of safety during daily activities in subjects with lower limb musculoskeletal disorders. The study is aimed at investigating performance modulation ability during...
Preprint
Purpose The effectiveness of a neuromuscular electrical stimulation (NMES) program has been shown to be proportional to the maximal evocable torque (MET), which is potentially influenced by pulse characteristics such as duration and frequency. The aim of this study was to compare MET between conventional and wide-pulse NMES at two different frequen...
Article
The main aims of this study were to compare the magnitude of inter-limb asymmetry (ILA) and the relation with self-reported knee function between maximal and explosive knee extensor strength outcomes in professional soccer players. Forty-six male soccer players completed different maximal isokinetic and isometric contractions of the knee extensors...
Preprint
Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via the adipogenic differentiation of fibro-adipogenic progenitors (FAPs). We used single-nuclei and single- cell RNA sequencing to characterize FAP heterogeneity in patients with fatty infiltration. We identified an MME ⁺ FAP subpopulation which, based...
Article
Objectives To investigate the mid-term outcomes of exercise therapy in patients with femoroacetabular impingement syndrome (FAIS). Design Follow-up study. Setting Clinical setting. Participants Twenty-six patients with FAIS who completed a 12-week semi-standardized, progressive exercise therapy program. Main outcome measures At a mid-term follo...
Article
Background: older adults often fail to reach the recommended amount of physical activity to prevent the age-related decline in metabolic, cardiorespiratory and muscular function. Effective home-based physical training programs could neutralise barriers preventing older adults from being active, and administration/supervision through videoconferenc...
Article
Full-text available
We compared the effectiveness of a home-based neuromuscular electrical stimulation (NMES) program applied to the quadriceps of the nonoperative side against sham-NMES as a complement to standard rehabilitation on knee extensor neuromuscular function in patients following anterior cruciate ligament (ACL) reconstruction. Twenty-four patients complete...
Conference Paper
Background Lower extremity injury prevention programs are effective in team sport athletes. Objective This study identifies barriers to and facilitators for an injury prevention program in professional male ice hockey teams among players and staff members. Design Cross-sectional survey. Setting Professional male ice hockey teams. Participants E...
Article
Purpose: Neuromuscular electrical stimulation (NMES) is a widely-used technique for diagnostic and therapeutic purposes. Here we developed and tested the reliability of a new NMES-dynamometer system for bedside evaluation of knee extensor muscle function. Materials and methods: Thirty-two healthy participants (16 men, 16 women; 27±5 years) compl...
Article
Full-text available
Deficits in maximal and explosive knee extensor strength, which are usually assessed with unilateral tasks, are substantial in patients with knee osteoarthritis (KOA). The aim of this study was to investigate the clinical relevance of unilateral vs. bilateral tasks for assessing knee extensor strength in patients with KOA. This was achieved primari...
Conference Paper
Full-text available
INTRODUCTION: Sex differences in triathlon performance range around 10-20% of the overall time likely due to physiological, morphological, and hormonal factors (1). To date, studies investigating sex differences showed that women (W) present a higher percentage of type I fibers, a better substrate efficiency, lower VO2max values, and a lower O2-c...
Article
Full-text available
Purpose Spaceflight impairs physical capacity. Here we assessed the protective effect of artificial gravity (AG) on aerobic exercise capacity and muscle function during bed rest, a spaceflight analogue. Methods 24 participants (33 ± 9 years, 175 ± 9 cm, 74 ± 10 kg, 8 women) were randomly allocated to one of three groups: continuous AG (cAG), inter...
Article
Full-text available
Because rate of force development (RFD) is an emerging outcome measure for the assessment of neuromuscular function in unfatigued conditions, and it represents a valid alternative/complement to the classical evaluation of pure maximal strength, this scoping review aimed to map the available evidence regarding RFD as an indicator of neuromuscular fa...
Article
Full-text available
Neuromuscular electrical stimulation (NMES) applied to skeletal muscles is an effective rehabilitation and exercise training modality. However, the relatively low muscle force and rapid muscle fatigue induced by NMES limits the stimulus provided to the neuromuscular system, and subsequent adaptations. We hypothesise that adaptations to NMES will be...
Article
Low-frequency and high-frequency wide-pulse neuromuscular electrical stimulation (NMES) can generate extra-torque (ET) via afferent pathways. Superimposing tendon vibration (TV) to NMES can increase the activation of these afferent pathways and favour ET generation. Knowledge of the characteristics of ET is essential to implement these stimulation...
Article
Objective To appraise the highest evidence on hip morphology as a risk factor for developing hip osteoarthritis (OA). Design We searched for studies evaluating the association between radiological hip morphology parameters and the prevalence, incidence or progression of hip OA (based on different radiographic and clinical criteria) in the MEDLINE,...
Article
Context: Injury prevention programs for the lower extremities are effective in team-sport athletes. Objective: To identify barriers and facilitators among professional ice hockey players and staff members for adhering to an injury prevention program. Design: Cross-sectional survey. Setting and participants: A questionnaire about barriers and...
Article
Background The aim of this cross-sectional comparative study was to investigate potential differences in soleus H-reflex to M-wave ratio between obese and non-obese individuals under different postural constraints. Methods A total of 23 obese individuals and 23 matched non-obese controls took part in the study. The maximal soleus H-reflex to M-wav...
Article
In March 2020, the COVID-19 pandemic forced most activities in Italy, including soccer, to cease. During lockdown, players could only train at home, with limited evidence regarding the effect of this period. Therefore, this study aimed to investigate the effect of COVID-19 lockdown on professional soccer players’ physical performance. Aerobic fitne...
Article
Full-text available
Purpose Neuromuscular electrical stimulation (NMES) has been considered as a promising approach for the early rehabilitation of patients during and/or after intensive care unit (ICU) stay. The overall objective of this study is to evaluate the NMES effectiveness to counteract the post-ICU impairment in physical function of COVID-19 patients. The sp...
Article
Purpose: To compare the effects of different modalities of morning priming exercise on afternoon physical performance with the associated hormonal and psychophysiological responses in young soccer players. Methods: In a randomized counterbalanced crossover design, 12 young soccer players completed 3 different morning conditions on 3 different da...
Article
Full-text available
Objective To summarize available evidence on the association between hip shape as quantified by statistical shape modeling (SSM) and the incidence or progression of hip osteoarthritis. Design We conducted a systematic search of five electronic databases, based on a registered protocol (available: PROSPERO CRD42020145411). Articles presenting origi...
Article
We re-examined the relationship between rate of torque development (RTD) and maximal voluntary contractions (MVC) torque, and investigated some possible neuromuscular determinants of early (≤100 ms) and late (≥200 ms) RTD. Seventeen healthy men performed maximal explosive isometric knee extensions at five joint angles, from which MVC torque, RTD at...
Poster
Full-text available
INTRODUCTION: NMES-induced isometric contractions may arise from the direct activation of motor axons [i.e. efferent pathway; conventional (CONV) NMES] and/or from the recruitment of motoneurons in the spinal cord through the depolarization of sensory axons (i.e. afferent pathway) [1]. This “extra” contraction, the so-called “extra force (EF)” is f...
Article
Full-text available
Background Ice hockey injury patterns in Europe were last evaluated in the 1990s. Purpose The aim of this study was to assess the frequency, type, location, and incidence of traumatic injuries, as well as the prevalence and relative effect of overuse injuries in professional male ice hockey players. Study Design Descriptive epidemiology study. M...
Article
Full-text available
Background: Isometric strength measures and timed up and go (TUG) tests are both recognized as valuable tools for fall prediction in older adults. However, results from direct comparison of these two tests are lacking. We aimed to assess the potential of isometric strength measures and the different modalities of the TUG test to detect individuals...
Article
Full-text available
Despite growing research in the field of inter-limb asymmetries (ILAs), little is known about the variation of ILAs in different populations of athletes. The purpose of this study was to compare ILAs among young basketball, soccer and tennis players. ILAs were assessed in three different types of tests (strength, jumping and change of direction (Co...
Article
Historical, educational, and technical barriers have been reported to limit the use of surface electromyography (sEMG) in clinical neurorehabilitation settings. In an attempt to identify, review, rank, and interpret potential factors that may play a role in this scenario, we gathered information on (1) current use of sEMG and its clinical potential...
Article
Full-text available
Electrical stimulation is widely used in rehabilitation to prevent muscle weakness and to assist the functional recovery of neural deficits. Its application is however limited by the rapid development of muscle fatigue due to the non-physiological motor unit (MU) recruitment. This issue can be mitigated by interleaving muscle belly (mStim) and nerv...
Article
Full-text available
Coaches and athletes in elite sports are constantly seeking to use innovative and advanced training strategies to efficiently improve strength/power performance in already highly-trained individuals. In this regard, high-intensity conditioning contractions have become a popular means to induce acute improvements primarily in muscle contractile prop...
Article
Objective: To determine the influence of neuromuscular electrical stimulation (NMES) pulse waveform and frequency on evoked torque, stimulation efficiency and discomfort at two NMES levels. Design: Repeated measures study. The quadriceps muscle of 24 healthy men was stimulated at submaximal (NMESsub) and maximal (NMESmax) levels using two pulse...
Article
Full-text available
Purpose The purpose of the present study was to investigate the influence of strength outcome (maximal voluntary contraction (MVC) torque vs. rate of torque development (RTD)), motor task (unilateral vs. bilateral) and muscle group (knee extensors vs. flexors) on the magnitude of bilateral deficits and inter-limb asymmetries in a large heterogeneou...
Article
Background Instrumented treadmills are potentially useful tools for the assessment of gait parameters in orthopaedic clinical settings, but their measurement properties remain uncertain. Research question What is the discriminant validity and reproducibility of spatiotemporal and kinetic gait parameters measured by a pressure-instrumented treadmil...
Preprint
Full-text available
During COVID-19 home confinement, athletes are likely exposed to some level of detraining (i.e. the partial or complete loss of training-induced morphological and physiological adaptations), as a consequence of insufficient and/or inappropriate training stimuli. Such changes may result in impaired performance and increased injury risk if, upon rest...
Article
Objective To appraise the highest available evidence provided by randomised controlled trials (RCT) on the effectiveness of hip arthroscopy vs physical therapy in patients with femoroacetabular impingement syndrome (FAIS). Methods Four databases (MEDLINE, EMBASE, Web of Science, Scopus) were systematically searched until 1st October 2019. Eligible...
Article
Full-text available
Background: Muscle quality (i.e., the expression of muscle function per unit of muscle mass) has been proposed as a clinically-relevant measure to detect individuals at risk of functional incapacity. Individuals with obesity might be at an increased risk of having poor muscle quality. Thus, we aimed to analyze the prevalence of poor muscle quality...
Article
Objectives To provide reference values and examine the influence of hip/groin pain on hip adductor and abductor strength in professional male ice hockey players, by using a straightforward 5-min procedure. Design Cross-sectional study. Setting On-field assessment of hip/groin muscle strength with dynamometry, together with the concomitant level o...
Article
Full-text available
Although reverse shoulder arthroplasty (RSA) has shown successful postoperative outcomes, little is known about compensatory activation patterns of remaining shoulder muscles following RSA. The purpose of this experimental case control series was to investigate shoulder muscle strength and neuromuscular activation of deltoid and teres minor muscles...
Article
Objectives: To investigate sex-specific differences in hip muscle strength asymmetries, and associations between hip abductor and flexor strength asymmetries, hip morphology and symptoms in patients with femoroacetabular impingement syndrome (FAIS). Design: Cross-sectional study. Setting: Clinical setting. Participants: Thirty-four patients...
Article
Maximum oxygen consumption (VO2max) is not only an indicator of endurance performance, but also a strong predictor of cardiovascular disease and mortality. This physiological parameter is known to decrease with aging. In turn, physical exercise might attenuate the rate of aging-related decline in VO2max, which in light of the global population agin...
Article
Full-text available
Quadriceps neuromuscular function remains impaired in the short- and long-term following knee arthroscopy for meniscal surgery and/or anterior cruciate ligament (ACL) reconstruction. The aim of this study was to compare quadriceps neuromuscular impairments in patients following meniscal surgery with and without ACL reconstruction. Thirty patients w...
Article
Life expectancy is increasing globally, and the oldest old (≥85 years) are the fastest-growing population segment. Preservation of physical fitness at advanced ages is, therefore , a major medical problem that no drug is likely to target in the foreseeable future. However, some sports achievements by centenarians suggest that, with proper exercise...
Preprint
Background: Falls are a major concern for older adults and their care givers. The Timed Up and Go (TUG) test is extensively used to identify individuals at risk of falling, but less is known about the validity of simple isometric strength measures for this purpose. We aimed to assess the potential of isometric strength measures and the different mo...
Article
We thoroughly appreciate the interest shown by many authors (1) in replying to our previous Viewpoint on eccentric exercise (2). Various important points were raised, and, briefly, we would like to summarize our line of thought. Even if the operational definition/classification can differ from the one we recently suggested (2)-for example based on...
Article
Full-text available
Human spaceflight is associated with a substantial loss of skeletal muscle mass and muscle strength. Neuromuscular electrical stimulation (NMES) evokes involuntary muscle contractions, which have the potential to preserve or restore skeletal muscle mass and neuromuscular function during and/or post spaceflight. This assumption is largely based on e...
Poster
Full-text available
The purpose of this study was to determine the influence of Neuromuscular Electrical Stimulation (NMES) frequency (60 Hz, 80 Hz, 100 Hz) and waveform (symmetrical versus asymmetrical) on knee extensor torque production, stimulation efficiency and discomfort in healthy subkects.
Article
Background Deformities of the femoral head-neck junction are associated with limited hip internal rotation, which may lead to femoroacetabular impingement and consequently to hip osteoarthritis. This study compared inter- and intra-observer reproducibility of 3 different methods to quantify hip internal rotation. Methods 2 investigators assessed h...
Article
Objectives: To investigate the influence of internal and external foot rotation on medial and lateral hamstring electromyographic (EMG) activity during conventional hamstring exercises in patients following anterior cruciate ligament (ACL) reconstruction. Design: Cross-sectional study. Setting: EMG activity of medial and lateral hamstrings was...
Article
Full-text available
Purpose No studies have evaluated the potential benefits of wide-pulse high-frequency (WPHF) neuromuscular electrical stimulation (NMES) despite it being an interesting alternative to conventional NMES. Hence, this study evaluated neuromuscular adaptations induced by 3 weeks of WPHF NMES. Methods Ten young healthy individuals (training group) comp...
Article
Increasing societal awareness for animal welfare can promote changes in legislation. Some of these changes may also affect the person that interacts with the animal in a shared workspace, such as in milking stalls. Swiss milking stalls were designed many years ago, when cows were smaller than they are today. A recent animal-based study indicated th...
Article
Full-text available
Non-surgical treatment of knee osteoarthritis (KOA) is often focused on the motor component of KOA even though there is evidence that sensory dysfunctions play an important role in the impaired control of the affected joint. Excitation of sensory afferents can increase motor function by exploiting the nervous system’s ability to adapt to changing e...
Article
Consensus is lacking regarding optimal neuromuscular electrical stimulation (NMES) parameters for postprandial glycemic control. Therefore, the aim of this study was to determine the NMES frequency inducing the greatest hypoglycemic effect in healthy individuals. The secondary aim was to compare current-related discomfort and muscle soreness betwee...
Article
Full-text available
Aim of this study was to investigate if knee extensor maximal voluntary contraction (MVC) torque and rate of torque development (RTD) deficits are accompanied by neuromuscular activation failure in patients with knee osteoarthritis (KOA). Nineteen patients with unilateral KOA completed gradual MVCs, from which MVC torque, voluntary activation and m...
Article
Purpose: Obesity increases the stresses applied to the foot. Ergonomic rocker sole shoes increase energy expenditure of standing and walking in obese individuals but could potentially alter plantar pressure distribution. The aim of this study was to compare plantar pressure distribution during standing and walking between rocker sole and flat-botto...
Article
Purpose: To examine differences between adult male basketball players of different competitive levels (study 1) and changes over a basketball season (study 2) of knee extensor peripheral muscle function during a multi-stage changes of direction exercise (MCODE). Methods: In study 1, 111 players from 4 different divisions completed the MCODE during...
Article
Objective: Hamstring and patellar tendon autografts are the most frequently-used graft types for anterior cruciate ligament (ACL) reconstruction, with no consensus on their respective effect on thigh muscle strength. The objective of this study was to re-examine isokinetic knee extensor and flexor strength before and after ACL reconstruction with...
Article
Objective To identify which exercise combinations are most effective as part of a lower extremity injury prevention programme for team-sport athletes. Design Umbrella review. Data sources A comprehensive literature search was performed in PubMed, Scopus, Cochrane Library and PEDro databases. Studies published between January 2000 and March 2017 w...
Article
Objective To investigate the responsiveness to exercise therapy of patients with femoroacetabular impingement syndrome (FAIS), and differences in hip function, strength and morphology between responders vs. non‐responders. Methods Patients with FAIS underwent 12 weeks of semi‐standardized and progressive exercise therapy. Good therapy outcome (res...
Article
Background: There are many uncertainties about the advantages and disadvantages of using unicompartmental (UKA) versus total knee arthroplasty (TKA) to treat patients with knee osteoarthritis. It is important to have sufficient early postoperative quadriceps strength for long-term, self-reported and gait-related outcomes after knee arthroplasty, b...
Article
The interaction between the somatosensory and motor systems is important for normal human motor function and learning. Enhancing somatosensory input using somatosensory electrical stimulation (SES) can increase motor performance, but the neuronal mechanisms underlying these effects are largely unknown. With electroencephalography (EEG), we examined...