
Nicola GrossheinrichCatholic University of Applied Sciences of North Rhine – Westphalia · Social Sciences
Nicola Grossheinrich
Professor PhD
Clinical Social Work, Developmental and Mental Disorders in Childhood and Adolescence, Attachment Studies
About
48
Publications
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Introduction
Additional affiliations
November 2011 - present
Publications
Publications (48)
Infant carrying may have beneficial effects on the parent‐infant relationship but only limited research has been conducted in this area. Therefore, the main aim of the current study was to investigate whether infant carrying is associated with parental reflective functioning, parental bonding, and parental (emotional) and behavioral responses to in...
Background
Recent studies report that LGBTQ + people have experienced high levels of mental health problems during COVID-19-related social distancing. Given the well-established association between social isolation and mental health, the main aim of the current study was to investigate differences in mental health and (perceived) social isolation a...
Studies using transcranial magnetic stimulation with simultaneous electroencephalography (TMS-EEG) revealed an imbalance between cortical excitation and inhibition (E/I) in the dorsolateral prefrontal cortex (DLPFC) in depression. As adolescence is a developmental period with an increase in depression prevalence and profound neural changes, it is c...
Childhood adversity has been suggested to affect the vulnerability for developmental psychopathology, including both exter-nalizing and internalizing symptoms. This study examines spontaneous attention biases for negative and positive emotional facial expressions as potential intermediate phenotypes. In detail, typically developing boys (6-13 years...
Zusammenfassung
Perspektivklärungsgruppen der stationären Kinder- und Jugendhilfe müssen sowohl eine tragfähige Einschätzung für den weiteren Lebensweg der Kinder und Jugendlichen entwickeln, Krisen bewältigen als auch zum Gelingen der kindlichen Entwicklung beitragen. In dieser Studie wurden Einschätzungen zu gegenwärtigen Voraussetzungen für die...
Background: A deficit in empathy has repeatedly been described in individuals with conduct disorder (CD), and in particular in those with callous unemotional traits. Until now, little is known about the neural basis of empathy in children and adolescents with early onset conduct disorder. The aim of this study was to examine neural responses during...
Background: A noticeable proportion of adolescents with depression do not respond to guideline recommended treatment options. This systematic review and meta-analysis investigated the effectiveness of physical activity interventions as an alternative or complementary treatment for adolescents (12–18 years) with depression. The characteristics of th...
Zusammenfassung
In einer Online-Studie wurden 296 erwachsene Kinder psychisch erkrankter Eltern befragt. Das Anliegen der Studie war es, die Bindungsmuster der interviewten Personen zu erfassen und hiervon ausgehend mögliche Zusammenhänge zwischen berichteten Kindheitserfahrungen und den erwachsenen Bindungsrepräsentationen zu untersuchen. In diese...
Background
Early intervention for children identified as late talkers (LTs) at the age of 24 months is still a controversial issue in research and clinical routine. Previous studies have shown inconsistent results regarding predictors of early lexical deficits on school‐age outcomes of late‐talking toddlers.
Methods
In a five‐wave follow‐up study...
A negative mood-congruent attention bias has been consistently observed, for example, in clinical studies on major depression. This bias is assumed to be dysfunctional in that it supports maintaining a sad mood, whereas a potentially adaptive role has largely been neglected. Previous experiments involving sad mood induction techniques found a negat...
Reduced social motivation is a hallmark of individuals with autism spectrum disorders (ASDs). Although the exact neural mechanisms are unclear, oxytocin has been shown to enhance motivation and attention to social stimuli, suggesting a potential to augment social reinforcement learning as the central mechanism of behavioral interventions in ASD. We...
Background:
Moderate to vigorous endurance and strength-training exercise was suggested as a treatment option for major depression. However, there is little evidence to support this suggestion in adolescent patients. The present study investigates the effects of a whole-body vibration strength-training intervention on symptoms in medication-naïve...
More right-sided frontal brain resting activity has been postulated to be a correlate of major depression in adults. In children and adolescents, more right-sided activity (as indicated by more left-sided alpha activity) seems to be associated with psychosocial risk factors. However, an association of frontal asymmetry and manifest unipolar depress...
To date, little is known about sex differences in the neurophysiological correlates underlying auditory information processing. In the present study, auditory evoked potentials were evoked in typically developing male (n = 15) and female (n = 14) adolescents (13-18 years) during an auditory oddball task. Girls compared to boys displayed lower N100...
Abstract
Background
Major depression (MD) is associated with deficits in selective attention. Previous studies in adults with MD using event-related potentials (ERPs) reported abnormalities in the neurophysiological correlates of auditory selective attention. However, it is yet unclear whether these findings can be generalized to MD in adolescence...
Although attention deficit hyperactivity disorders (ADHD) and autism spectrum disorders (ASD) share certain neurocognitive characteristics, it has been hypothesized to differentiate the two disorders based on their brain’s reward responsiveness to either social or monetary reward. Thus, the present fMRI study investigated neural activation in respo...
Background
Recent studies have proposed the process of emotion regulation as a promising target to study the neurophysiological basis of adolescent depression. Emotion regulation has repeatedly been studied with emotional go/no-go paradigms. To date, no study has examined if the left-frontal hypoactivation associated with depression generalizes to...
The last few years have seen much research on girls with conduct disorder (CD). This article summarizes the gender-specific data regarding prevalence, differences with respect to symptomatology (e.g., subtypes of aggression, callous-unemotional (cu)-traits), and it presents data on the autonomic and neuroendocrine stress system as well as genetic,...
During the last decade, repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has become established as a treatment for various mental diseases. The rational of prefrontal stimulation has been adapted from the mode of action known from rTMS using motor-evoked potentials though little is known about the precise effect of rTMS...
Mean reaction time and mistakes of a GoNogo task after 1 Hz rTMS over different stimulations sites. Means and standard deviations for the immediate (t1: 0–15 min) and delayed (t2: 16–30 min) time frame (N = 18), p values of the ANOVA (stimulation site × time frame).
(DOC)
Until now German language tests have been rarely evaluated for their diagnostic accuracy. The goal of the study was to determine whether frequently used German language instruments are valid measures for identifying developmental language disorders in 3-year-old children.
The language test SETK 3-5 (including the short version SSV) and the parent q...
The present study investigated whether (a) a reduced duration of auditory sensory memory is found in late talking children and (b) whether deficits of sensory memory are linked to persistent difficulties in language acquisition. Former late talkers and children without delayed language development were examined at the age of 4 years and 7 months us...
Psychomotor symptoms related to an impairment of the nigrostriatal dopaminergic system are frequent in major depression (MD). Repetitive transcranial magnetic stimulation (rTMS) has been discussed as a new treatment option for MD. In neurobiological terms, an influence of high-frequency rTMS on dopaminergic neurotransmission has previously been sho...
Because standard repetitive transcranial magnetic stimulation (rTMS) protocols exhibit post-stimulus effects of short duration, novel protocols such as theta burst stimulation (TBS), are promising approaches to enhance the effectiveness of rTMS. However, little is known about the side effect profile of such protocols. Thus, the present study explor...
Background:
Repetitive transcranial magnetic stimulation (rTMS) has been found to exert modest to moderate therapeutic effects in major depression, but mechanism of action and its clinical relevance have not been clarified yet. Previous trials have reported patterns of symptomatology predicting response to rTMS. As most patients also received conc...
Prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to increase striatal dopaminergic activity. Here we investigated dopaminergic neurotransmission using single photon emission computed tomography (SPECT) and [(123)I]IBZM to indirectly assess the change in endogenous striatal dopamine concentration upon rTMS as compared wi...
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a new treatment option for depression. Previous studies were performed with low sample sizes in single centres and reported heterogeneous results.
To investigate the efficacy of rTMS as augmentative treatment in depression.
In a randomised, double-blind, sham-controlled multic...
Given that a considerable portion of depressed patients does not respond to or remit during pharmacotherapy, there is increasing interest in non-pharmacological strategies to treat depressive disorders. Several brain stimulation approaches are currently being investigated as novel therapeutic interventions beside electroconvulsive therapy (ECT), a...
For more than a decade, repetitive transcranial magnetic stimulation (rTMS) has been investigated as therapeutic intervention in mental diseases. Depression was the first psychiatric disorder where rTMS was applied and is still a major application with more than 30 published placebo-controlled trials showing on average a moderate antidepressant eff...
Die Major Depression wird gegenwärtig funktionell-anatomisch als ZNS-Systemerkrankung angesehen und ist durch potenziell reversible
Funktionsänderungen in limbischen und paralimbischen Regelkreisen, v. a. monaminergen Neurotransmittersystemen und spezifischen
molekularen Mediatorsystemen gekennzeichnet (Kap. 30). Trotz der vielfältigen etablierten...
Emotionen sind mit persönlich bedeutsamen Ereignissen verbunden und haben einen großen Einfluss auf unser Handeln. Spezifisch
bezeichnet der Begriff »Emotion« kurzfristige Ereignisse des Fühlens und des damit assoziierten Verhaltens. Emotionen werden
mithilfe der Dimensionen Valenz (Wertigkeit) und Erregung (engl. arousal) charakterisiert. Im weite...
The recent FDA approval of Vagus Nerve Stimulation (VNS) in the long-term treatment of patients with depression has again drawn attention to non-pharmacological biophysical treatment strategies. Regarding these methods there is a need for objective information for both patients and practitioners. Besides VNS, Deep Brain Stimulation (DBS) has long b...
Zusammenfassung
Die kürzlich in den USA erfolgte Zulassung der Vagusnervstimulation (VNS) zur adjuvanten Therapie der Depression hat die Fachdiskussion über die so genannten biophysikalischen Behandlungsverfahren erneut angeregt. Es ist auch von Seiten der Betroffenen mit Fragen zu diesen Methoden und einem vermehrten Informationsbedarf zu rechnen....
In the area of non-pharmacological approaches for the treatment of depression, electroconvulsive therapy (ECT) gains increasing interest, because of its effectiveness in pharmacotherapy-resistant depressions. Beside ECT, new methods of brain stimulation are currently investigated that could theoretically have similar effectiveness as ECT with the a...
Zusammenfassung
Im Bereich nicht-pharmakologischer Ansätze zur Depressionsbehandlung findet die Elektrokrampftherapie (EKT) in den letzten Jahren aufgrund ihrer Wirksamkeit bei pharmakotherapieresistenten Depressionen wieder ein zunehmendes Interesse. Daneben werden gegenwärtig verschiedene neue Hirnstimulationsverfahren als Alternativen untersucht...