Nicola D'Ascenzo

Nicola D'Ascenzo
Huazhong University of Science and Technology | hust · Department of Biomedical Engineering

Professor

About

331
Publications
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5,800
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Publications

Publications (331)
Article
The immunohistochemical determination of the Ki67 expression is regarded as a reliable method to monitor non small cell lung cancer (NSCLC) proliferation. However, cancer tissues are not uniform and the use of a small tumor sample in biopsy may not be accurate. Although positron emission tomography (PET) represents an alternative to biopsy, by prov...
Article
Full-text available
Plant stress detection is considered one of the most critical areas for the improvement of crop yield in the compelling worldwide scenario, dictated by both the climate change and the geopolitical consequences of the Covid-19 epidemics. A complicated interconnection of biotic and abiotic stressors affect plant growth, including water, salt, tempera...
Article
The RAYCAN Discoverist 180 (RAYCAN D180) is a novel preclinical positron emission tomography (PET) and computed tomography (CT) integrated system for the imaging of small- and medium-sized animals and plants. We measured a system resolution of (2.56±0.04) mm (radial), (2.46±0.05) mm (transverse), and (1.67 ± 0.03) mm (axial) at the center of the fi...
Article
We present a novel silicon photomultiplier based on a shallow junction obtained within a standard 0.35 μm complementary metal oxide semiconductor process. The sensitive structure is equipped with a dedicated optical window as well as an optimized antireflective coating. The device exhibits performances comparable to custom-based commercial technolo...
Article
We propose a new kinetically consistent method for the modelling of magneto gas dynamic processes. The algorithm is consistent with viscous, thermally conducting, resistive flows. Through a computational test we show that it is robust in resolving the physical behaviour of shock structures and instabilities.
Article
Full-text available
Background Parkinson’s Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic pathways significantly correlated with age to develop personalized age-dependent PD blood biomarkers. Results We found 33 metabo...
Article
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Time activity curve (TAC) signal processing in plant positron emission tomography (PET) is a frontier nuclear science technique to bring out the quantitative fluid dynamic (FD) flow parameters of the plant vascular system and generate knowledge on crops and their sustainable management, facing the accelerating global climate change. The sparse spac...
Article
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The mass of the W boson, a mediator of the weak force between elementary particles, is tightly constrained by the symmetries of the standard model of particle physics. The Higgs boson was the last missing component of the model. After observation of the Higgs boson, a measurement of the W boson mass provides a stringent test of the model. We measur...
Article
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Positron Emission Tomography is a non-disruptive and high-sensitive digital imaging technique which allows to measure in-vivo and non invasively the changes of metabolic and transport mechanisms in plants. When it comes to the early assessment of stress-induced alterations of plant functions, plant PET has the potential of a major breakthrough. The...
Article
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Chronic sleep insufficiency is becoming a common issue in the young population nowadays, mostly due to life habits and work stress. Studies in animal models of neurological diseases reported that it would accelerate neurodegeneration progression and exacerbate interstitial metabolic waste accumulation in the brain. In this paper, we study whether c...
Preprint
Full-text available
A study of initial-state gluon radiation (ISR) in hadron collisions is presented using Drell-Yan (DY) events produced in proton-antiproton collisions by the Tevatron collider at a center-of-mass energy of 1.96 TeV. This paper adopts a novel approach which uses the mean value of the Z/$\gamma^*$ transverse momentum $p_T^{DY}$ in DY events as a power...
Preprint
Full-text available
At the Fermilab Tevatron proton-antiproton ($p\bar{p}$) collider, high-mass electron-neutrino ($e\nu$) pairs are produced predominantly in the process $p \bar{p} \rightarrow W(\rightarrow e\nu) + X$. The asymmetry of the electron and positron yield as a function of their pseudorapidity constrain the slope of the ratio of the $u$- to $d$-quark parto...
Article
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Background When Alzheimer’s disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [ $$^{18}$$ 18 F]florbetaben PET biomarkers sensitive to differences between early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (...
Preprint
Full-text available
The Multi-voltage Threshold (MVT) method, which samples the signal by certain reference voltages, has been well developed as being adopted in pre-clinical and clinical digital positron emission tomography(PET) system. To improve its energy measurement performance, we propose a Peak Picking MVT(PP-MVT) Digitizer in this paper. Firstly, a sampled Pea...
Article
Full-text available
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by decreased glucose metabolism and increased neuroinflammation. Hexokinase (HK) is the key enzyme of glucose metabolism and is associated with mitochondria to exert its function. Recent studies have demonstrated that the dissociation of HK from mitochondria is enough to activate...
Article
Full-text available
Background We investigated the image quality of ¹¹C, ⁶⁸Ga, ¹⁸F and ⁸⁹Zr, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed tomography (PET/CT) systems were used in the evaluation, including the Siemens Inveon, RAYCAN X5 and Molecubes β-cube. The evaluation was...
Article
Novel technological solutions for the design of positron emission tomography (PET) systems to be used in the in-beam beam-on monitoring of proton tracks within biological tissues represent the frontier of the instrumentation in proton therapy. We report a novel All-digital PET dual heads prototype based on the Multi Voltage Threshold (MVT) technolo...
Article
Novel design solutions for the functional imaging of patients suffering of motion disorders represent the frontiers of nuclear medicine and neurology. We report the design and simulation of a novel digital helmet-shaped Positron Emission Tomography system with transverse and longitudinal Field Of View of 205 mm and 283.8 mm respectively. We calcula...
Article
Aim: To investigate the relationships between amyloid burden in brain and the age of onset of Alzheimer's disease. Materials and methods: We examined 60 patients with clinical diagnosis of Alzheimer's disease. Of them, 22 were early-onset of Alzheimer's disease and 38 were late-onset of Alzheimer's disease. All of them underwent a brain PET scan...
Article
Novel technological solutions for the design of dedicated brain Positron Emission Tomography systems with improved sensitivity and space resolution represent the frontier of current nuclear medicine techniques in neurology. We report a novel digital brain Positron Emission Tomography system based on the Plug&Imaging sensor technology with transvers...
Article
Full-text available
We report on a search for a spin-zero non–standard model particle in proton-antiproton collisions collected by the Collider Detector at Fermilab at a center-of-mass-energy of 1.96 TeV. This particle, the ϕ boson, is expected to decay into a bottom-antibottom quark pair and to be produced in association with at least one bottom quark. The data sampl...
Preprint
Full-text available
We report on a search for a spin-zero non-standard-model particle in proton-antiproton collisions collected by the Collider Detector at Fermilab at a center-of-mass-energy of 1.96 TeV. This particle, the $\phi$ boson, is expected to decay into a bottom-antibottom quark pair and to be produced in association with at least one bottom quark. The data...
Article
We report on a search for a spin-zero non–standard model particle in proton-antiproton collisions collected by the Collider Detector at Fermilab at a center-of-mass-energy of 1.96 TeV. This particle, the ϕ boson, is expected to decay into a bottom-antibottom quark pair and to be produced in association with at least one bottom quark. The data sampl...
Article
Full-text available
Silicon photomultipliers produced using standard complementary metal oxide semiconductor (CMOS) processes are at the basis of modern applications of sensors for weak photon fluxes. They allow in fact to integrate transistor-based electronic components within sensors and provide intelligent read-out strategies. In this paper, we investigate the scal...
Article
Full-text available
This paper presents a study of the production of a single W boson in association with one or more jets in proton-antiproton collisions at s=1.96 TeV, using the entire data set collected in 2001–2011 by the Collider Detector at Fermilab at the Tevatron, which corresponds to an integrated luminosity of 9.0 fb−1. The W boson is identified through its...
Article
Full-text available
The Collider Detector at Fermilab collected a unique sample of jets originating from bottom-quark fragmentation (b-jets) by selecting online proton-antiproton (pp¯) collisions with a vertex displaced from the pp¯ interaction point, consistent with the decay of a bottom-quark hadron. This data set, collected at a center-of-mass energy of 1.96 TeV, a...
Article
Full-text available
One of the most challenging areas of sensor development for nuclear medicine is the design of proton therapy monitoring systems. Sensors are operated in a high detection rate regime in beam-on conditions. We realized a prototype of a monitoring system for proton therapy based on the technique of positron emission tomography. We used the Plug and Im...
Preprint
Full-text available
This paper presents a study of the production of a single $W$ boson in association with one or more jets in proton-antiproton collisions at $\sqrt{s}=1.96$ TeV, using the entire data set collected in 2001-2011 by the Collider Detector at Fermilab at the Tevatron, which corresponds to an integrated luminosity of $9.0$ fb$^{-1}$. The $W$ boson is ide...
Preprint
Full-text available
The Collider Detector at Fermilab collected a unique sample of jets originating from bottom-quark fragmentation ($b$-jets) by selecting online proton-antiproton ($p\bar{p}$) collisions with a vertex displaced from the $p\bar{p}$ interaction point, consistent with the decay of a bottom-quark hadron. This data set, collected at a center-of-mass energ...
Article
Full-text available
Drell-Yan lepton pairs produced in the process pp¯→ℓ+ℓ−+X through an intermediate γ*/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing p...
Article
Full-text available
A search for the exotic meson X(5568) decaying into the Bs0π± final state is performed using data corresponding to 9.6 fb-1 from pp̄ collisions at s=1960 GeV recorded by the Collider Detector at Fermilab. No evidence for this state is found and an upper limit of 6.7% at the 95% confidence level is set on the fraction of Bs0 produced through the X(5...
Article
An original kinetic model for the molecular velocity distribution function is considered. Based on this model, the equations of ideal magnetogasdynamics (MGD) are derived and an original model for dissipative MGD is obtained. The latter model can be used to construct algorithms easily adaptable to high-performance computer architectures. As an exam...
Article
Full-text available
Modern concepts of single photon or charged particle detection systems are based on geiger mode avalanche devices developed in CMOS technology. The key-problem encountered in the fabrication of these devices in CMOS is the dark rate level. The dark rate and single photon signal are not distinguishable. This sets also the limits of the application o...
Article
Full-text available
The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of s=...
Chapter
CMOS—complementary metal-oxide-semiconductor technology at present time is the most advanced semiconductor technology for the development and production of microelectronic elements. Many signs have long pointed toward CMOS as the preferable sensor technology of the future. In many ways, the bright future for CMOS sensor technology was made official...
Article
Full-text available
A search for the exotic meson X(5568) decaying into the B[subscript s][superscript 0]π[superscript ±] final state is performed using data corresponding to 9.6 fb[superscript -1] from pp[over ¯] collisions at sqrt[s]=1960 GeV recorded by the Collider Detector at Fermilab. No evidence for this state is found and an upper limit of 6.7% at the 95% conf...
Article
Full-text available
A measurement of the inclusive production cross section of isolated prompt photons in proton-antiproton collisions at center-of-mass energy s=1.96 TeV is presented. The results are obtained using the full Run II data sample collected with the Collider Detector at the Fermilab Tevatron, which corresponds to an integrated luminosity of 9.5 fb−1. The...
Article
Full-text available
The possibility to design a silicon photomultiplier (SiPM) using standard complementary metal oxide semiconductor (CMOS) processes represents the frontier of current low photon flux detectors. It allows an integrated development of both sensor and intelligent read-out electronics on the same technology line and enables to create intelligent devices...
Article
Full-text available
We use the 180 nm GLOBALFOUNDRIES (GF) BCDLite CMOS process for the production of a silicon photomultiplier prototype. We study the main characteristics of the developed sensor in comparison with commercial SiPMs obtained in custom technologies and other SiPMs developed with CMOS-compatible processes. We support our discussion with a transient mode...
Article
In this work the equations of ideal magnetogasdynamics are derived based on the introduced local complex Maxwellian distribution function. Using this kinetic model, we obtain the analog of a quasi-dynamic system of equations for magnetogasdynamics, including dissipative processes. The resulting model and the algorithm of its solution have been test...
Article
The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of √s...
Article
Full-text available
The observation of the Y(4140) structure in B±→J/ψϕK± decays produced in p̄ p collisions at s√=1.96 TeV is reported with a statistical significance greater than 5 standard deviations. A fit to the J/ψϕ mass spectrum is performed assuming the presence of a Breit–Wigner resonance. The fit yields a signal of 19±6(stat)±3(syst) resonance events, and re...
Article
Full-text available
The observation of the (Formula presented.) structure in (Formula presented.) decays produced in (Formula presented.) collisions at (Formula presented.) TeV is reported with a statistical significance greater than 5 standard deviations. A fit to the (Formula presented.) mass spectrum is performed assuming the presence of a Breit–Wigner resonance. T...
Data
Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The...
Article
We report on a measurement of the D+-meson production cross section as a function of transverse momentum (pT) in proton-antiproton (pp¯) collisions at 1.96 TeV center-of-mass energy, using the full data set collected by the Collider Detector at Fermilab in Tevatron Run II and corresponding to 10 fb−1 of integrated luminosity. We use D+→K−π+π+ decay...
Article
Full-text available
Challenges in QCD matter physics --The scientific programme of the Compressed Baryonic Matter experiment at FAIR; Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net...
Article
Full-text available
A measurement of the inclusive production cross section of isolated prompt photons in proton-antiproton collisions at center-of-mass energy $\sqrt{s}$=1.96TeV is presented. The results are obtained using the full Run II data sample collected with the Collider Detector at the Fermilab Tevatron, which corresponds to an integrated luminosity of 9.5fb$...
Article
A solution algorithm developed for three-dimensional magnetogasdynamic problems is used to simulate the accretion of interstellar matter onto a massive astronomical object with the formation of collinear jets. A kinetically consistent algorithm is well adapted to the architecture of high-performance computer systems with massive parallelism and has...
Article
Full-text available
We report on a measurement of the $D^{+}$-meson production cross section as a function of transverse momentum ($p_T$) in proton-antiproton ($p\bar{p}$) collisions at 1.96 TeV center-of-mass energy, using the full data set collected by the Collider Detector at Fermilab in Tevatron Run II and corresponding to 10 fb$^{-1}$ of integrated luminosity. We...
Conference Paper
The group of the Huazhong University of Science and Technology developed the technology of the Silicon Photo-multiplier on the basis of standard CMOS technology, produced on the CMOS chinese facility. The performance of the SiPM is presented with detailed analysis, particularly the single photon spectrum.
Article
At the Fermilab Tevatron proton-antiproton (pp) collider, Drell-Yan lepton pairs are produced in the process pp→e+e-+X through an intermediate γ∗/Z boson. The forward-backward asymmetry in the polar-angle distribution of the e- as a function of the e+e - pair mass is used to obtain sin2θefflept, the effective leptonic determination of the electrowe...
Article
We present a measurement of the $WW$ and $WZ$ diboson production cross-sections in a final state consistent with leptonic $W$ boson decay and jets originating from heavy-flavor quarks from either a $W$ or a $Z$ boson decay. This analysis uses the full data set collected with the CDF II detector during Run II of the Tevatron proton-antiproton collid...