Nico W Van den Brink

Nico W Van den Brink
Wageningen University & Research | WUR · Sub-Department of Toxicology

PhD

About

202
Publications
34,526
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
4,092
Citations
Citations since 2017
53 Research Items
2350 Citations
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Additional affiliations
February 2014 - December 2021
Wageningen University & Research
Position
  • Professor (Associate)
August 1997 - February 2014
Wageningen University & Research
Position
  • Senior Researcher
June 1997 - February 2014
Alterra Wageningen UR
Position
  • Senior Researcher
Education
August 1991 - June 1997
University of Groningen
Field of study
  • Antarctic ecotoxicology
September 1983 - October 1989
Wageningen University & Research
Field of study
  • Biology, Aquatic ecology

Publications

Publications (202)
Article
We demonstrate that pelagic Antarctic seabirds show significant decreases in concentrations of some persistent organic pollutants. Trends in Adélie penguins and Southern fulmars fit in a general pattern revealed by a broad literature review. Downward trends are also visible in pelagic fish, contrasting sharply with steady or increasing concentratio...
Article
There remains great concern over mercury pollution in the Arctic, though relatively little is known about impacts on biota that inhabit Arctic terrestrial systems. To help address this, the current study was performed with barnacle goslings (Branta leucopsis) from a coal mine-impacted site and a control site near Ny-Ålesund, Spitsbergen (Svalbard)....
Book
Commensal rodents consume and spoil crops and food supplies, cause property damage and can be vectors for disease. Rats have also invaded islands and can pose a serious threat to native wildlife, particularly seabirds. Estimates of rodent damage range into the billions of dollars in developed countries. In southern Asia, rodents are estimated to co...
Article
Full-text available
Toxic trace metals are widespread contaminants that are potentially immunotoxic even at environmentally low exposure levels. They can modulate the immunity to infections, e.g., in wildlife species living in contaminated areas. The diverse immune cell types can be differentially affected by the exposure leading to the modulation of specific protecti...
Article
Full-text available
p>Quantification of the uptake and elimination of nanomaterials (NMs) by organisms is key in assessing the environmental risks of NMs. For this, uptake models for conventional solutes may be used, although no consensus exists on their applicability for NMs. In this critical review therefore, conventional modelling approaches are scrutinised for the...
Article
Antidepressant prescriptions are on a rise worldwide and this increases the concerns for the impacts of these pharmaceuticals on nontarget organisms. Antidepressants are neuroactive compounds that can affect organism’s behavior. Behavior is a sensitive endpoint that may also propagate effects at a population level. Another interesting aspect of ant...
Article
Pharmaceuticals are increasingly released into surface waters and therefore ubiquitous in aquatic systems. While pharmaceuticals are known to influence species interactions, their effect on host-parasite interactions is still underexplored despite potential ecosystem-level consequences. Here, we ask whether diclofenac, a widely used non-steroid ant...
Article
Full-text available
Apex predators are good indicators of environmental pollution since they are relatively long-lived and their high trophic position and spatiotemporal exposure to chemicals provides insights into the persistent, bioaccumulative and toxic (PBT) properties of chemicals. Although monitoring data from apex predators can considerably support chemicals’ m...
Article
Full-text available
Field collected aquatic invertebrates are often used as test organisms in the refinement of the standard Tier 1 risk assessment of various pollutants. This approach can provide insights into the effects of pollutants on the natural environment. However, researchers often pragmatically select test organisms of a specific sex and/or size, which may n...
Article
The fate of engineered nanomaterials in ecosystems is unclear. An aquatic stream mesocosm was explored the fate and bioaccumulation of silver sulfide nanoparticles (Ag2S NPs) compared to silver nitrate (AgNO3). The aims were to determine the total Ag in water, sediment and biota, and to evaluate the bioavailable fractions of silver in the sediment...
Article
Full-text available
A key aspect in the safety testing of metal nanoparticles (NPs) is the measurement of their dissolution and of the true particle uptake in organisms. Here, based on the tendency of Ag-NP to dissolve and Au-NP to be inert in the environment, we exposed the earthworm Eisenia fetida to Au core-Ag shell NPs ([email protected], Ag-NPs with a Au core) an...
Article
Full-text available
p>Little is known about the bioaccumulation potential of manufactured nanomaterials (MNs). For traditional chemicals, the Organisation for Economic Co-operation and Development (OECD) Test Guideline (TG) 305, bioaccumulation in fish is often used. However, for MNs, there are no approved processes to trigger or waive this test, or consider alternati...
Article
Full-text available
Uptake of most metal nanoparticles (NPs) in organisms is assumed to be mainly driven by the bioavailability of the released ions, as has been verified in controlled and short-term exposure tests. However, the changeability of NPs and the dynamic processes which NPs undergo in the soil environment, bring uncertainty regarding their interactions with...
Article
Full-text available
The Wood mouse (Apodemus sylvaticus) is a widespread mammalian species that acts as a reservoir host for multiple infections, including zoonotic diseases. Exposure to immunotoxins, like for instance trace metals, may reduce the ability of the host to mount proper responses to pathogens, potentially increasing the transmission and prevalence of infe...
Article
Full-text available
Mercury (Hg) is a toxic trace metal ubiquitously distributed in the environment. Inorganic mercury (as HgCl2 ) can cause immunotoxicity in birds, but the mechanisms of action are still not fully resolved, especially with respect to responses to viral infections. To investigate the potential immunomodulatory effects of Hg2+ on specific cell types of...
Article
Full-text available
Previous studies have explored effects of imidacloprid and its metabolites on terrestrial species, such as bees, and indicated the importance of some active metabolites. However, the biotransformation of IMI and the toxicity of its metabolites to aquatic arthropods are largely unknown, especially the mechanisms driving species sensitivity differenc...
Article
Full-text available
Stable isotopes are often used to provide an indication of the trophic level (TL) of species. TLs may be derived by using food-web-specific enrichment factors in combination with a representative baseline species. It is challenging to sample stable isotopes for all species, regions and seasons in Arctic ecosystems, e.g. because of practical constra...
Article
Nanotechnology is identified as a key enabling technology due to its potential to contribute to economic growth and societal well-being across industrial sectors. Sustainable nanotechnology requires a scientifically based and proportionate risk governance structure to support innovation, including a robust framework for environmental risk assessmen...
Article
Full-text available
Birds of prey, owls and falcons are widely used as sentinel species in raptor biomonitoring programmes. A major current challenge is to facilitate large-scale biomonitoring by coordinating contaminant monitoring activities and by building capacity across countries. This requires sharing, dissemination and adoption of best practices addressed by the...
Article
Full-text available
The structure of the gut barrier and luminal chemistry in non-mammalian vertebrates and invertebrates has been given little attention with respect to the dietary uptake of engineered nanomaterials (ENMs). This...
Article
Full-text available
The occurrence of persistent organic pollutants (POPs) in the Arctic has been of constant concern, as these chemicals cause reproductive effects and mortality in organisms. The Arctic acts as a chemical sink, which makes this system an interesting case for bioaccumulation studies. However, as conducting empirical studies for all Arctic species and...
Article
Full-text available
Elevated levels of lead have been found in waterfowl, due to human activities. Lead may cause immunomodulatory effects, but the mechanisms are largely unknown, especially upon viral challenges. To characterize avian immunomodulatory hazards of Pb2+, we used chicken macrophage (HD‐11) and B‐lymphocyte (DT40) cell lines, as in vitro models for the in...
Article
Due to unique properties of differently sized and coated silver nanoparticles (AgNPs), they are used in important industrial and biomedical applications. However, their environmental fate in soil ecosystems and potential...
Article
Full-text available
The levels of pollutants in polar regions is gaining progressively more attention from the science community. This is especially so for pollutants that persist in the environment and can reach polar latitudes via a wide range of routes, such as persistent organic pollutants (POPs). In this study samples of Antarctic marine benthic organisms were an...
Article
Population growth in passerine birds is largely driven by fecundity. If fecundity is affected, for instance by hatching failure, populations may decline. We noted high hatching failure of up to 27% per year in relict populations of the Northern wheatear (Oenanthe oenanthe) in The Netherlands, a strongly declining, migratory passerine in Europe. Thi...
Article
Sewage sludge contains Ag2S-NPs causing NP exposure of soil fauna when sludge is applied as soil amendment. Earthworm bioturbation is an important process affecting many soil functions. Bioturbation may be affected by the presence of Ag2S-NPs, but the earthworm activity itself may also influence the displacement of these NPs that otherwise show lit...
Article
Monitoring parameters for the assessment of oil and gas related contaminants and their biological effects need validation before application in the Arctic. For such monitoring purposes, we evaluated the potential use of three biomarkers (acetylcholinesterase, acyl-CoA oxidase and glutathione S-transferase) for application to an Arctic bivalve (Asta...
Article
One of the key components for environmental risk assessment of engineered nanomaterials (ENMs) is data on bioaccumulation potential. Accurately measuring bioaccumulation can be critical for regulatory decision making regarding material...
Article
Full-text available
Increasing oil and gas activities may substantially increase chemical stress to benthic ecosystems in the Arctic, pointing to the necessity to evaluate their environmemtal risks in these systems. Risk assessment procedures for oil related compounds (e.g., polycyclic aromatic hydrocarbons, PAHs) should address differences in exposure between Arctic...
Article
Monitoring parameters for the assessment of oil and gas related contaminants and their biological effects need validation before application in the Arctic. For such monitoring purposes, we evaluated the potential use of three biomarkers (acetylcholinesterase, acyl-CoA oxidase and glutathione S-transferase) for application to an Arctic bivalve (Asta...
Article
Full-text available
Natural populations are persistently exposed to environmental pollution, which may adversely impact animal physiology and behaviour and even compromise survival. Responding appropriately to any stressor ultimately might tip the scales for survival, as mistimed behaviour and inadequate physiological responses may be detrimental. Yet effects of legac...
Article
Carcasses of South Polar Skuas (Catharacta maccormicki) and Kelp gulls (Larus dominicanus) were opportunistically collected around of Rothera Research station (67°35′8″S and 68°7′59″W) during the 2016/2017 austral summer. Samples of their tissues (muscle, liver and subcutaneous fat) were analysed for Persistent Organic Pollutants (POPs). Organochlo...
Article
Full-text available
This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological studies. It appears that results may differ when studying the same chemical in the same species in di...
Article
Full-text available
The soil represents an important environmental compartment that can be regarded as a final sink for metal nanoparticles including silver particles (Ag-NPs). Assessing realistic exposure scenarios, including bioavailability of Ag-NPs...
Article
Currently, risk assessment for oil contamination does not consider behavioral responses of benthos to oil toxicity. Avoidance of oil-contaminated sediment by benthic amphipods, however, may be a highly sensitive endpoint for sub-lethal effects of commonly used distillate fuels. In the present study, the avoidance behavior of temperate freshwater (G...
Chapter
Rodents are known to affect human society globally in various adverse ways, resulting in a widespread demand for their continuous control. Anticoagulant rodenticides (ARs) have been, and currently remain, the cornerstone of rodent control throughout the world. Although alternative control methods exist, they are generally less effective. ARs work b...
Chapter
Full-text available
Both target and non-target small mammals are exposed to rodenticides (AR). A better understanding of the drivers controlling this exposure is critical for the conservation of threatened small mammal species but also because they may represent important pathways of poisoning for birds of prey and carnivore mammals. Here, we consider the spatial comp...
Chapter
Rodents have interacted with people since the beginning of systematic food storage by humans in the early Neolithic era. Such interactions have had adverse outcomes such as threats to human health, spoiling and consumption of food sources, damage to human infrastructure and detrimental effects on indigenous island wildlife (through inadvertent anth...
Article
Rodents are known to affect human society globally in various adverse ways (Chap. 1). Since historic times, they have been vectors for a wide range of human and livestock diseases. Almost all agricultural activity worldwide, both past and present, has been subject to attack and fouling by rodents, which may therefore threaten our ability to feed ou...
Article
Rodents began to associate with humans at least from the early Neolithic era with the beginnings of systematic sequestering of food stores by humans (Cucchi and Vigne 2006; Reperant and Osterhaus 2014). About the year 541, the Justinian plague started amid the central granaries and crowded, unsanitary conditions of the later Roman cities. The resul...
Article
In many areas around the Arctic remains and spoil heaps of old mines can be found, which have been abandoned after their heydays. Runoff from tailings of these abandoned mines can directly contaminate the local environment with elevated concentrations of trace metals. Few studies have investigated the possible negative effects of contaminants on Ar...
Article
In literature, varying and sometimes conflicting effects of physicochemical properties of NPs are reported on their uptake and effects in organisms. To address this, small and medium sized (20 and 50 nm) AgNPs with specified different surface coating/charges were synthesized and used to systematically assess effects of NP-properties on their uptake...
Article
Fullerenes are carbon based nanoparticles that may enter the environment as a consequence of both natural processes and human activities. Although little is known about the presence of these chemicals in the environment, recent studies suggested that soil may act as a sink. The aim of the present work was to investigate the presence of fullerenes i...
Article
Full-text available
Arctic sea routes are opening up for maritime transport due to sea ice retreat leading to increasing human activities in the Arctic and concomitant pressures on the environment. Organotin compounds are used in antifouling paints of large seagoing vessels and are known to leach into the marine environment and accumulate in sediments and biota. As or...
Article
Physicochemical properties of nanoparticles influence their environmental fate and toxicity, and studies investigating this are vital for a holistic approach towards a comprehensive and adequate environmental risk assessment. In this study, we investigated the effects of size, surface coating (charge) of silver nanoparticles (AgNPs) - a most common...
Article
Full-text available
Biomonitoring using birds of prey as sentinel species has been mooted as a way to evaluate the success of European Union directives that are designed to protect people and the environment across Europe from industrial contaminants and pesticides. No such pan-European evaluation currently exists. Coordination of such large scale monitoring would req...
Article
Anticoagulant rodenticides, mainly second-generation forms, or SGARs, dominate the global market for rodent control. Introduced in the 1970s to counter genetic resistance in rodent populations to first-generation compounds such as warfarin, SGARs are extremely toxic and highly effective killers. However, their tendency to persist and accumulate in...
Article
Full-text available
Modeling the environmental fate of nanomaterials (NMs) and their uptake by cells and organisms in the environment is essential to underpin experimental research, develop overarching theories, improve our fundamental understanding of NM exposure and hazard, and thus to enable risk assessment of NMs. Here, we critically review the state-of-the-art of...
Research
Full-text available
Research and Monitoring for and with Raptors in Europe (EURAPMON) is a European Science Foundation (ESF) Research Networking Programme (http://www.eurapmon.net). One objective of EURAPMON is to spread best practice and build capacity in Europe for harmonised monitoring with raptors. From May 31st to June 2nd 2013, representatives from six countries...
Research
Full-text available
There is much information available on the different types of matrices that are useful for contaminant monitoring. However, there are no detailed guides or protocols on appropriate sampling methods for contaminant monitoring schemes. Different studies use different sampling and processing strategies, and different analytical methods, making it hard...
Article
p>Anticoagulant rodenticides, mainly second-generation forms, or SGARs, dominate the global market for rodent control. Introduced in the 1970s to counter genetic resistance in rodent populations to first-generation compounds such as warfarin, SGARs are extremely toxic and highly effective killers. However, their tendency to persist and accumulate i...
Article
Full-text available
Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts. To aid scientific and regulatory discourse on the applicat...
Article
Full-text available
Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from oth...
Article
Environmental context Increasing production and application of engineered nanoparticles has led to an increased potential for their environmental release, raising ecotoxicological concerns. To appropriately characterise the fate, effects and risks of engineered nanoparticles in environmental systems, methods are essential to characterise nanopartic...
Poster
Full-text available
Poster explaining the research project ARCIND - Development of ARCtic biological INDicators for the impact assessment of human activities in the Arctic
Article
Full-text available
Eind jaren 80 van de vorige eeuw was de otter (Lutra lutra) uitgestorven in Nederland. De slechte waterkwaliteit was één van de orrzaken voor het verdwijnen. Om de otter te kunnen herintroduceren in de Biesbosch, een belangrijk oorspronkelijk leefgebied, is onderzoek gedaan naar de kwaliteit van z'n voedsel. Is de vis al schoon genoeg voor deze amb...
Article
De laatste decennia heeft het gebruik van chemische bestrijdingsmid - delen een grote vlucht genomen. Voor bestrijding van knaagdieren worden vooral zogenaamde anticoagulantia-bevattende rodenticiden (hierna aangeduid met ARs) gebruikt. Met name tweede generatie ARs kunnen worden beschouwd als Persistent, Bioaccumulatief en Toxisch (PBT), op basis...
Article
Despite a long history of successful use, routine application of some anticoagulant rodenticides (ARs) may be at a crossroad due to new regulatory guidelines intended to mitigate risk. An adverse outcome pathway for ARs was developed to identify information gaps and endpoints to assess the effectiveness of regulations. This framework describes chem...
Article
The impact of silver nanoparticles (AgNP; at 0, 1.5, 15.4 and 154 mg Ag/kg soil) and silver nitrate (AgNO3 ; 15.4 mg Ag/kg soil) on earthworms, Lumbricus rubellus, was assessed. Four week exposure to the highest AgNP treatment reduced growth and reproduction, compared with the control. AgNO3 exposure also impaired reproduction, but not as much as t...
Article
Full-text available
Interactions within natural soils have often been neglected when assessing fate and bioavailability of engineered nanomaterials (ENM) in soils. This review combines patchwise ENM research using natural soils with the much wider literature on ENM performed in standard tests or on the fate of colloids in soils, and an analysis of the diverse ENM char...