Nico Steckhan

Nico Steckhan
Hasso Plattner Institute · Research Group Digital Health – Connected Healthcare

Doctor of Medicine

About

67
Publications
26,483
Reads
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1,017
Citations
Citations since 2017
58 Research Items
908 Citations
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Introduction
Nico Steckhan is working at the Chair for Connected Healthcare which is part of the Digital Health Center (Hasso Plattner Institute - Faculty of Digital Engineering). He is former member of the department for Clinical Naturopathy (Institute for Social Medicine, Epidemiology and Health Economics, Charité Universitätsmedizin Berlin). Nico does research in Integrative Medicine and Lifestyle Medicine. He is interested in Bioinformatics and Systems thinking.

Publications

Publications (67)
Article
Full-text available
Plant-based diets are associated with numerous health benefits but also bear risks of micronutrient deficiencies if inadequately planned. The risk of nutrient deficiencies can be reliably reduced by supplementation but requires risk-awareness. We distributed a paper-and-pencil questionnaire to n = 902 healthcare professionals attending a congress o...
Article
Full-text available
Background Fasting is beneficial in many diseases, including rheumatoid arthritis (RA), with lasting effects for up to 1 year. However, existing data dates back several decades before the introduction of modern therapeutic modalities. Objective This exploratory RCT compares the effects of a 7-day fast followed by a plant-based diet (PBD) to the ef...
Article
Full-text available
Distress is a growing public health concern. In this three-armed randomized controlled trial, n = 102 adults with elevated stress levels and stress-related symptoms were randomly assigned to (1) "integrative" yoga classes which combined physical exercises, mindfulness training, and ethical/philosophical aspects of traditional yoga; to (2) Iyengar y...
Article
Full-text available
Accurate dietary analysis of energy, nutrient intake, and meal timing in human studies using traditional dietary assessment methods (e.g., food records) is challenging and time-consuming. The widespread use of smartphones, tablets, and nutrition applications (apps) can overcome some of these problems. The objective of this study was to evaluate the...
Article
Full-text available
Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 ± 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet...
Article
Full-text available
Background: Lifestyle interventions, such as fasting, diet, and exercise, are increasingly used as a treatment option for patients with metabolic syndrome (MS). This study assesses the efficacy and safety of fasting followed by lifestyle modification in patients with MS compared to lifestyle modification only. Methods: Single-blind, multicenter,...
Article
Full-text available
Quantifying neurological disorders from voice is a rapidly growing field of research and holds promise for unobtrusive and large-scale disorder monitoring. The data recording setup and data analysis pipelines are both crucial aspects to effectively obtain relevant information from participants. Therefore, we performed a systematic review to provide...
Conference Paper
Full-text available
Background: Fasting has been shown to be beneficial in many diseases, including rheumatoid arthritis (RA). Among other effects, fasting stimulates ketogenic metabolism, induces autophagy, and harbors immunomodulatory functions. Recent studies have highlighted the role of the intestinal microbiota in the still unclear etiology of RA. This could be a...
Article
Aim: Cranberries (Vaccinium macrocarpon) are traditionally used in prevention of urinary tract infections (UTIs). The authors' aim was to evaluate effects of a supplement containing cranberry extract, pumpkin seed extract, vitamin C, and vitamin B2 on recurrent uncomplicated UTIs in women and their intestinal microbiota. Methods: A prospective, unc...
Article
Aim: Study aim was to investigate the effects of therapeutic phlebotomy on ambulatory blood pressure in patients with grade 1 hypertension. Methods: In this randomized-controlled intervention study, patients with unmedicated hypertension grade 1 were randomized into an intervention group (phlebotomy group; 500 mL bloodletting at baseline and after...
Article
Full-text available
Background/objective: Historically, fasting has been practiced not only for medical but also for religious reasons. Bahá'ís follow an annual religious intermittent dry fast of 19 days. We inquired into motivation behind and subjective health impacts of Bahá'í fasting. Methods: A convergent parallel mixed methods design was embedded in a clinical...
Preprint
Full-text available
Background / Objective: Historically, fasting has not only been practiced for medical but also for religious reasons. Bahá’ís follow an annual religious fast of 19 days. We assessed motivation behind and subjective health impacts of Bahá’í fasting. Methods: A convergent parallel mixed methods design was embedded in a clinical single arm observation...
Article
Full-text available
Background: Time-restricted eating is a promising dietary strategy for weight loss, glucose and lipid metabolism improvements, and overall well-being. However, human studies demonstrated contradictory results for the restriction of food intake to the beginning (early TRE, eTRE) or to the end of the day (late TRE, lTRE) suggesting that more carefull...
Article
Full-text available
Aims: To compare the effects of Ayurvedic and conventional nutritional therapy in patients with irritable bowel syndrome (IBS).Methods: Sixty-nine patients with IBS were randomized to Ayurvedic (n = 35) or conventional nutritional therapy according to the recommendations of the German Nutrition Society including the low-FODMAP diet (n = 34). Study...
Article
Full-text available
Background Previous studies have shown beneficial effects of therapeutic fasting and plant-based dietary interventions on disease activity in patients with rheumatoid arthritis (RA) for a duration of up to 1 year. To date, the effects of such interventions on the gut microbiome and on modern diagnostic markers in patients with RA have not been stud...
Article
Full-text available
Background: Religiously motivated Bahá’í fasting (BF) is a form of intermittent dry fasting celebrated by abstaining from food and drinks during daylight hours every year in March for nineteen consecutive days. Aim: To test safety and effects of BF on hydration, metabolism and circadian clock. Methods: Thirty-four healthy Bahá’í volunteers (15 wome...
Article
Psychological studies on religious intermittent dry fasting are scarce. However, a growing number of studies on Ramadan fasting are being produced, although most of them are being limited by their non-longitudinal designs and their focus on secular fasting-induced outcomes. The here-presented longitudinal study is the first that asks whether religi...
Article
Full-text available
We aimed to evaluate the effects of yoga and eurythmy therapy compared to conventional physiotherapy exercises in patients with chronic low back pain. In a three-armed, multicentre, randomized controlled trial, patients with chronic low back pain were treated for 8 weeks in group sessions (75 minutes once per week). Primary outcome was patients’ ph...
Article
Full-text available
Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertens...
Article
Full-text available
Aim To determine the potential anti‐inflammatory effect of a multimodal periodic fasting program on surrogate parameters of periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS). Material and methods A total of 47 patients were recruited hospitalized in an integrative ward for an intensified two‐week multimodal...
Article
Full-text available
Background/objectives A few preliminary studies have documented the safety and feasibility of repeated short-term fasting in patients undergoing chemotherapy. However, there is a lack of data from larger randomized trials on the effects of short-term fasting on quality of life, reduction of side effects during chemotherapy, and a possible reduction...
Article
The state of the art for monitoring hypertension relies on measuring blood pressure (BP) using uncomfortable cuff-based devices. Hence, for increased adherence in monitoring, a better way of measuring BP is needed. That could be achieved through comfortable wearables that contain photoplethysmography (PPG) sensors. There have been several studies s...
Article
Objectives To differentiate the effect of ginger and mustard as warming ingredients from the effect of calmness & attentiveness and thermal warmth in chest compress application. Design & setting In an exploratory, controlled, single-blinded study, we compared the effect of ginger and mustard in healthy adults. Interventions Participants received...
Article
Full-text available
Medically supervised fasting has long tradition and broad acceptance in some European countries. The exact amount to which ketone bodies are produced as well as their possible contribution to beneficial effects in this procedure are open. Open-label observational trial with in-patients undergoing medically supervised fasting with supplementation of...
Preprint
BACKGROUND Background: Prolonged sitting postures have been reported to increase the probability of developing low back pain. Moreover, the majority of employees in the industrial world work ninety percent of their time in a seated position. OBJECTIVE This review focuses on the technologies and algorithms that have been used to classify seating po...
Preprint
Data privacy is a very important issue. Especially in fields like medicine, it is paramount to abide by the existing privacy regulations to preserve patients' anonymity. On the other hand, data is required for research and training machine learning models that could help gain insight into complex correlations or personalised treatments that may oth...
Article
Full-text available
Background: A majority of employees in the industrial world spend most of their work time in a seated position. Monitoring sitting postures can provide insights into underlying causes of occupational discomforts such as low back pain. Objective: This review focuses on the technologies and algorithms used to classify sitting postures on a chair wit...
Article
Full-text available
Background Yoga in school is a beneficial tool to promote the good health and well-being of students by changing the way they react to stress. The positive effects of yoga—taught in schools—on children, youth and young adults have been demonstrated in former studies using mostly subjective psychometric data. Aim The present trial aims to evaluate...
Preprint
Full-text available
Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. We show that in hypertensive metabolic syndrome (MetS) patients (n=35), a 5-day fast followed by a modified DASH diet (Dietary Approach to Stop Hypertension) reduced systolic blood pressure (SBP), antihypertensive medication need, and body-mass index (BMI) at...
Article
Full-text available
Background: Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability. Since pharmacological treatments may have substantial side effects, there is a need for complementary treatment options such as specific dietary approaches. Ketone bodies that are produc...
Preprint
Background: Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability. Since pharmacological treatments may have substantial side effects, there is a need for complementary treatment options such as specific dietary approaches. Ketone bodies that are produce...
Article
Objectives: Distress is an increasing public health problem for adolescents and young adults. We aimed to evaluate potential effects of a 10-week 90-minute once-a-week yoga course. Methods: A non-randomized controlled study with a school sport control group was implemented in two German secondary schools. Primary outcome was stress on the Percei...
Article
Full-text available
This prospective observational trial investigated effects and safety of periodic fasting in subjects with and without type 2 diabetes mellitus (T2DM). The primary end point was set as the change of fatty liver index (FLI) as a surrogate parameter of non-alcoholic fatty liver disease (NAFLD). Six-hundred and ninety-seven subjects (38 with T2DM) were...
Article
Full-text available
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translate...
Poster
Fasting can prolong survival and reduce disease burden in rodent models, and possibly in humans. The relationship between diet, gut microbiota, immune system and host (patho)physiology has only recently been explored, and information is lacking on how periodic fasting affects the gut microbiome in patients with metabolic syndrome (MetS). We show a...
Preprint
Full-text available
Background Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability. Since pharmacological treatments may have substantial side effects, there is a need for complementary treatment options such as specific dietary approaches. Ketone bodies that are produced...
Poster
Full-text available
Hypertension is one of the most prevalent chronic diseases worldwide. Early diagnosis of this condition can prevent the incidence of stroke and also, cardiovascular diseases (CVDs) such as myocardial infarction and heart failure. Lifestyle interventions, such as intermittent fasting (IF), aim to lower blood pressure (BP) levels and increase the hea...
Poster
Hypertension is one of the most prevalent chronic diseases world-wide. Early diagnosis of this condition can prevent the incidenceof stroke and also, cardiovascular diseases (CVDs) such as myocar-dial infarction and heart failure. Lifestyle interventions, such asintermittent fasting (IF), aim to lower blood pressure (BP) levelsand increase the heal...
Article
Background: Leech therapy has been found to be effective in the treatment of a number of chronic musculoskeletal pain syndromes. Leeches are also often used empirically to treat chronic low back pain, but data from clinical trials have been lacking to date. We therefore conducted the first randomized trial of leech therapy for chronic low back pai...
Poster
Periodic fasting may serve as therapeutic strategy for the management of hypertension and metabolic syndrome. We hypothesize that fasting affects the gut microbiome and promotes immune cell homeostasis resulting in lower blood pressure. Patients suffering from metabolic syndrome and hypertension were randomized either to 7-day periodic fasting comb...
Article
Full-text available
PurposeTo analyse the influence of CT-based depth correction in the assessment of split renal function in potential living kidney donors. Methods In 116 consecutive living kidney donors preoperative split renal function was assessed using the CT-based depth correction. Influence on donor side selection and postoperative renal function of the living...
Conference Paper
Full-text available
Background Fasting can improve clinical disease activity in rheumatoid arthritis (RA) [1], but mechanism involved are not clear. Recently, we demonstrated that monocytes in RA express transcriptome patterns of increased myelopoiesis, premature egress from bone marrow and reduced circulation time as indicators of permanent activation of the innate i...
Article
Full-text available
Background This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. Methods In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four...
Conference Paper
Full-text available
Background: High expectations about acupuncture might contribute to larger treatment effects (Prady et al., 2015). However, problems in the assessment are well known: 1) floor or ceiling effects lower variance; 2) expectation measures include general beliefs about complementary medicine; 3) construct validity of expectation measures remains unclear...
Article
Objective: The aim of the study was to evaluate whether intermittent fasting (IF) is an effective preventive measure, and whether it is feasible for healthy volunteers under every day conditions. Methods: A nonrandomized controlled clinical trial on IF was performed with healthy volunteers over a period of 8 wk, and a subsequent 4-mo follow-up....
Article
Objectives Ayurveda claims to be effective in the treatment of psychosomatic disorders by means of lifestyle and nutritional counseling. Design In a randomized controlled study mothers with burnout were randomized into two groups: Ayurvedic nutritional counseling (according to tradition), and conventional nutritional counseling (following the reco...
Article
There is increasing experimental evidence for beneficial effects of calorie restriction and intermittent fasting in type 2 diabetes mellitus (T2DM). In humans, prolonged fasting is established as a health-promoting complementary treatment in Europe and claimed to improve metabolism by a complex hormetic response. We aimed to investigate effects of...
Article
Full-text available
Objective: We developed an integrative day care clinic program for cancer patients focusing on mind-body techniques and health-promoting lifestyle modification (7?h once-per-week group sessions over 12?weeks). Methods: A cohort study design with a waiting group was implemented. Outcome parameters were assessed at the beginning, at the end of the...
Article
Background: Chronic low-grade inflammation has been associated with insulin resistance, diabetes, atherosclerosis, obesity and Metabolic Syndrome (MetS). A pro-inflammatory environment contributes to several metabolic disturbances and possibly the development of MetS. Dietary approaches have defined impact on immune function and putative anti-infla...
Article
We tested the hypothesis that a suggestive placebo intervention can reduce the subjective and neurobiological stress response to psychosocial stress. Fifty-four healthy male subjects with elevated levels of trait anxiety were randomly assigned in a 4:4:1 fashion to receive either no treatment (n = 24), a placebo pill (n = 24), or a herbal drug (n =...
Article
Cardiovascular diseases are the world's leading cause of death. Prevention by nutrition is an easy and effective approach especially by advising foods with nutraceutic properties like high phenolic olive oil (HPOO). The aim of this review was to systematically access and meta-analyse the effects of HPOO on risk factors of the cardiovascular system...
Article
The aim of this systematic review and meta-analysis was to evaluate the quality of evidence and the strength of recommendation for yoga as a therapeutic means in the management of prehypertension and hypertension. MEDLINE/Pubmed, Scopus, CENTRAL, and IndMED were screened through February 2014 for randomized controlled trials (RCTs) on the effects o...
Article
The aim of this review was to systematically assess and meta-analyze the effects of yoga on modifiable biological cardiovascular disease risk factors in the general population and in high-risk disease groups. MEDLINE/PubMed, Scopus, the Cochrane Library, and IndMED were screened through August 2013 for randomized controlled trials (RCTs) on yoga fo...
Article
Seit längerer Zeit wird kontrovers über die Prävention und Behandlung von Brustkrebs mit Phytoöstrogenen diskutiert. Isoflavonhaltige Pflanzen wie z.B. Soja sind besonders reich an diesen östrogenen Wirkstoffen (u.a. Genistein). Als Nahrungsergänzungsmittel in Form von Kapseln sind deren östrogenwirksame Isoflavone hoch dosiert in Apotheken und Ref...

Questions

Question (1)
Question
Hi,
I have thought of one approach:
Leaving out the outcome from different time points and impute only on same timepoints.
But this will yield in 3 timepoints (within subjects) * 5 imputations
into five-teen imputed datasets. And still my grouping variables (between subjects) are not taken into account.
Split also on these would increase my datasets into 30...
Is this correct or what would you suggest ?

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