Nicla Flacco

• Doctor of Pharmacy
• Universidad Europea de Valencia

Introduction Oral submucous fibrosis (OSMF) is a well‐known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in induc...

Fisiología del Sistema Estomatognático es una asignatura de carácter básico en el plan de estudios del grado en Odontología y es imprescindible para que los estudiantes comprendan, entre otros conceptos, las funciones de los tejidos y músculos orofaciales. Sin embargo, esta asignatura puede resultar compleja y con una alta cantidad de contenidos pa...

Two of the pillars on which university education is based are the integrated curriculum and transdisciplinarity. The first consists of combining and teaching two or more subjects together, while the second refers to interacting and working as a team with professionals from other areas, to have a 360º vision. This work is the result of a collaborati...

Historically, traditional laboratory experiments have been given a central and distinctive role in science education. However, virtual laboratories have received considerable attention over the past several years in different areas of knowledge. The main aim of this study is to analyse the impact of the use of both traditional and virtual laborator...

Background: Biomedical engineering proposes the use of stem cells as a bone rehabilitation treatment in patients with alveolar bone defects. Many authors suggest that this innovative technique could represent the future of bone regeneration in dentistry. The present study systematically reviewed the efficacy of stem cells in bone regeneration in p...

Las prácticas de laboratorio tradicionales juegan un papel protagonista en la enseñanza de las ciencias en todas las áreas y niveles. Sin embargo, en los últimos años la popularidad de los laboratorios virtuales ha aumentado significativamente, debido a que la aplicación de las herramientas TIC en educación permite atender adecuadamente a la divers...

Background and purpose: A NO-mediated desensitization of ?1 -adrenoceptor (AR) vasoconstrictor response has been reported in different vessels. We investigated the involvement of each ?1 -AR subtype and constitutive NOS isoforms and the influence of aging and hypertension in this process. Experimental approach: Wistar and spontaneously hypertens...

This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic treatment with L-NAME (N(G)-nitro...

β-adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β-AR stimulation with isoprenali...

The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved. Contractile responses to noradrenaline (NA) were compared with inositol phosphate accumulation and extracellular signal-regulated kinase (ERK)1/2 phosphorylation...

Background and purpose: To analyse the relative contribution of β1 -, β2 - and β3 -adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing the role of cAMP and/or NO/cGMP signalling pathways. Experimental approach: Rat mesenteric resistance artery (MRA) and aorta were used to analyse the Adrb expression by real-ti...

Among the three alpha(1)-adrenoceptor subtypes (alpha(1A), alpha(1B) and alpha(1D)) a peculiar intracellular localization and poor coupling to membrane signals of cloned alpha(1D)-adrenoceptor have been reported. In addition, the alpha(1L)-adrenoceptor (low affinity for prazosin), a functional phenotype of alpha(1A), has been described. The purpose...

In human and animal hypertension models, increased activity of G-protein-coupled receptor kinase (GRK) 2 determines a generalized decrease of beta-adrenergic vasodilatation. We analyzed the possibility of differential changes in the expression and functionality of alpha(1A), alpha(1B), alpha(1D), beta(1), beta(2), and beta(3)-ARs also being involve...