Nick Johnston

Nick Johnston
Queen's University Belfast | QUB · Queen's University Belfast - School of Natural and Build Environment

PhD

About

10
Publications
704
Reads
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367
Citations
Citations since 2017
1 Research Item
83 Citations
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201720182019202020212022202305101520
201720182019202020212022202305101520
201720182019202020212022202305101520
Additional affiliations
January 2019 - January 2019
Queen's University Belfast
Position
  • Project Manager
July 2008 - May 2009
Queen's University Belfast
Position
  • Research Associate

Publications

Publications (10)
Article
Full-text available
Bovine tuberculosis has been an escalating animal health issue in the UK since the 1980s, even though control policies have been in place for over sixty years. The importance of the genetics of the aetiological agent, Mycobacterium bovis , in the re-emergence of the disease has been largely overlooked. We compared the interaction between bovine mon...
Article
Our understanding of the events that occur in cancer progression has been enhanced by the use of cell lines in vitro. Changes in gene expression, induction of signalling, and cell motility can all be investigated in this setting. However, other aspects of progression can be revealed only in vivo, especially the interactions of tumour cells with hos...
Article
Full-text available
Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive and metastatic by stable transf...
Article
Osteopontin (OPN) is a glycophosphoprotein cytokine that has multiple functions. OPN is expressed and secreted by various cells, and has a role in cell adhesion, chemotaxis, prevention of apoptosis, invasion, migration and anchorage-independent growth of tumor cells. Extensive research has demonstrated the pivotal participation of OPN in the regula...
Article
UCN-01, a Chk1 inhibitor, abrogates S and G(2) arrest and enhances cancer cell killing by DNA-damaging drugs in preclinical models. UCN-01 avidly binds alpha1-acid glycoprotein in plasma; whether sufficient drug concentrations are achieved in human tumors is unknown. A phase I trial tested the hypothesis that UCN-01 abrogates cisplatin-induced cell...
Article
Osteopontin (OPN) is a phosphorylated glycoprotein that binds to a v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive and metastatic by stable transfecti...
Article
Elevated blood ATP and increased red blood cell (RBC) ATP transport is associated with cystic fibrosis (CF). In this report, we demonstrate the presence of the wild-type and the DeltaF508 mutant form of the CF transmembrane conductance regulator protein in RBC membranes and its putative interaction with ecto-apyrase, an ATP hydrolyzing enzyme also...
Article
P-glycoprotein is involved with the removal of drugs, most of them cations, from the plasma membrane and cytoplasm. Pgp is also associated with movement of ATP, an anion, from the cytoplasm to the extracellular space. The central question of this study is whether drug and ATP transport associated with the expression of Pgp are in any way coupled. W...
Article
In addition to the better-known roles of the erythrocyte in the transport of oxygen and carbon dioxide, the concept that the red blood cell is involved in the transport and release of ATP has been evolving (J. Luthje, Blut 59, 367, 1989; G. R. Bergfeld and T. Forrester, Cardiovasc. Res. 26, 40, 1992; M. L. Ellsworth et al., Am. J. Physiol. 269, H21...

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Projects

Project (1)
Project
The overall aim of MISTRAL is to nurture a new generation of researchers who can effectively evaluate the complexity of social acceptance issues facing the deployment of renewable energy infrastructure and propose innovative solutions in a variety of research, government and business contexts.