
Nick Edwards- BSc(Hons), PG Dip, MCLIP, FEAPCCT
- Managing Director at Nick Edwards Consulting Ltd
Nick Edwards
- BSc(Hons), PG Dip, MCLIP, FEAPCCT
- Managing Director at Nick Edwards Consulting Ltd
About
79
Publications
29,145
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374
Citations
Introduction
Current institution
Nick Edwards Consulting Ltd
Current position
- Managing Director
Additional affiliations
November 2011 - May 2020
ESMS Global Ltd
Position
- Consultant
Description
- Senior scientist at VPIS, operations, training and research MI support Clinical trials support
Education
September 1978 - June 1979
September 1974 - June 1978
Publications
Publications (79)
Background
Isoxazolines are rarely reported to be associated with neurological adverse events in cats and dogs, but information about the onset and duration of neurological signs is lacking in the summary of product characteristics of these medicines.
Methods
The Veterinary Poisons Information Service and the Dutch Poisons Information Center datab...
Dear Editor,
We read with interest the article on hops toxicosis by Pfaff et al.1
It is extremely useful to have additional cases reported as few are
described in the literature. We published an abstract on 13 cases in
2019 and found a similar fatality rate,2 which is lower than that previously
reported.3 Of the 13 dogs in our report, 76.9% (n = 10...
By reading this book you will learn how to plan for and implement a digital transformation project for the delivery of successful digital services.
This book introduces a new approach to the delivery of new digital services based on addressing critical success factors (CSF) at identified stages of the project implementation and the prioritisation...
5‐fluorouracil (5‐FU) is a topical treatment routinely used to treat actinic keratosis and superficial basal cell carcinomas in humans. As clinicians, we often consent the known adverse effects1 on humans such as erythema, irritation, photosensitivity and prolonged inflammation.
RASPBERRY ketone (4-(4-hydroxyphenyl)-2-butanone) has become popular as a weight loss supplement in humans and is often found in multi-ingredient preparations, particularly with caffeine (usually 30 to 200 mg, but the dosage may not be declared on the label).
Raspberry ketone is structurally similar to other naturally occurring botanical compounds...
A RECENT BBC report highlighted an increase in cases of button battery ingestion and the risks to children (Walsh 2016). Button and disk batteries can cause chemical and electrical burns, which can result in serious tissue injury within a few hours, if they are inserted into the nose or ear or become lodged in the oesophagus. Batteries of many type...
THE Veterinary Medicines Directorate (VMD) reports an increase in cases of monensin toxicity in dogs and a change to the Summary of Product Characteristics (SPC) for Kexxtone 32.4 g continuous-release intraruminal devise for cattle (monensin) ( VR , June 4, 2016, vol 178, p 588).
The Veterinary Poisons Information Service (VPIS) has received three...
Objective: Exposure to ethylene glycol (EG), a common component of antifreeze, is associated with very poor prognosis in cats. Exposure causes renal failure which is reversible with haemodialysis support, both impractical and uncommon in veterinary practice. The objective was to analyse the prevalence and risk factors associated with clinical signs...
The burden of poisoning exposures in Africa is a significant public health concern, yet only ten African countries have poisons information centres. The establishment of poisons centres was subsequently identified as a priority. This article focuses on workshop discussions with international multi-sector stakeholders in Eastern Africa regarding the...
Objective: The toxicity of detergents varies, but they all reduce surface tension and are associated with a risk of respiratory signs from foam aspiration. In humans, detergent exposure is common, but respiratory effects uncommonly reported,1,2 unless large amounts are ingested.3 We examine the prevalence of respiratory signs in cats following expo...
Objective: To determine the clinical signs and outcomes associated with exposure of household pets to oven cleaners. These products typically contain strong alkalis such as sodium or potassium hydroxide which can cause significant tissue injury. Methods: Retrospective analysis of cases of oven cleaner exposure in animals reported to the VPIS. Only...
To establish the common causes of death in cats and dogs with suspected poisoning reported to the VPIS in the UK. Method Objec7ve Results In the UK the most common reported cause of death in cats from poisoning is ethylene glycol but vitamin D and metaldehyde are common in dogs. FataliFes in dogs were equally likely to have resulted from euthanasia...
Bates N, Ellison J, Edwards N. 2015 Palm oil ingestion in dogs [abstract]. Clin Toxicol 53(4):275.
Toxicology is a vast subject. Animals are exposed to numerous drugs, household products, plants, chemicals, pesticides and venomous animals. In addition to the individual toxicity of the various potential poisons, there is also the question of individual response and, more importantly, of species differences in toxicity. This review serves to addre...
Benzalkonium chloride is commonly found in household products. This retrospective study examined 245 cases of feline exposure to benzalkonium chloride-containing products reported to the Veterinary Poisons Information Service (VPIS). A single route of exposure was reported in 188 cats (ingestion 126, skin 58, buccal 4); 57 cats had multiple routes....
Letters TOXICOLOGY Fungal ingestion in companion animals WE read with interest the letter by Irwin and Leech on fatal poisoning with Clitocybe rivulosa (=Clitocybe dealbata) (VR, August 2, 2014, vol 175, pp 122-123). The Veterinary Poisons Information Service (VPIS) regularly receives inquiries about animals that ingest fungi, particularly in the s...
Emetics are used in an effort to reduce absorption of a poison. Apomorphine in dogs and xylazine in cats appear relatively safe and efficacious (they produce vomiting). Emetics are no longer used in the management of poisoning in humans as there is no evidence that the emetic previously used improves the outcome of poisoned patients. There is no ev...
We read with interest the
recent letter1 on exposure of
dogs to liquid laundry detergent
capsules (also known as liquid
tablets, liquid sachets, and liquid
laundry pods). In the United
Kingdom, surveillance of poisoning
in animals is undertaken by
the Veterinary Poisons Information
Service. Information on cases
that are discussed with the service
i...
WE read with interest the letter on the availability of adder antivenom by Alan Sim (VR, June 7, 2014, vol 174, p 586) and share his concerns. Supply of adder antivenom for the treatment of animals is always an issue
but has recently become more acute with the cessation of production of European Adder Antivenom by the Institute of Immunology in Zag...
Background: The African continent is burdened by similar, or more severe, toxicological issues as other continents, yet only a few poisons centres exist to assist in the management of poisoning. In the Eastern Africa (EA) sub-region, there are poisons centres in 2 countries: Kenya and Zimbabwe. The Strategic Approach to International Chemicals Mana...
To the Editor:
We read with interest the study of lipid emulsion in acute glyphosate toxicity by Gil et al. (2013).1 Gil HW, Park JS, Park SH, Hong SY. Effect of intravenous lipid emulsion in patients with acute glyphosate intoxication. Clin Toxicol (Phila) 2013; 51:767–771.
[Taylor & Francis Online], [Web of Science ®], [Google Scholar]
These...
The problems caused by chemicals and toxins in Africa are at least as bad as those on other continents. Yet Africa has very few poisons centres to advise clinicians or the public, to provide training or laboratory services or to lead poisons prevention efforts. The number of poisons centres has not changed in more than three decades. However, the c...
The acronym "ASHT" stands for "Alerting System and Development of a Health Surveillance System for the Deliberate Release of Chemicals by Terrorists". Imagine this scenario: 15 patients with respiratory symptoms following a concert in Rome and 12 patients coughing after lunch in a cafeteria in the Czech Republic; are these events related? Today the...
Objective: The Rapid Alert System for Chemical Threats (RAS-CHEM) will provide a mechanism to facilitate the rapid communication of information concerning chemical health threats, ranging from reports of unusual cases to potential mass exposure incidents. Furthermore, RAS-CHEM will include toxicological profile data for toxic chemicals identified a...
The Rapid Alert System for Chemical Threats (RAS-CHEM) will provide a mechanism to facilitate the rapid communication of information concerning chemical health threats, ranging from reports of unusual cases to potential mass exposure incidents. Furthermore, RAS-CHEM will include toxicological profile data for toxic chemicals identified as potential...
The risk assessment and management of chemical health threats is intrinsically important to ensure the safety and security of EU citizens. Under the current Treaty the response to cross border health threats, including those of chemical origin, should be coordinated at EU level. The Health Security Commit- tee (HSC) was set up in 2001 to ensure coo...
The Rapid Alert System for Chemical Threats (RAS-CHEM) will provide a mechanism to facilitate the rapid communication of information concerning chemical health threats, ranging from reports of unusual cases to potential mass exposure incidents. Furthermore, RAS-CHEM will include toxicological profile data for toxic chemicals identified as potential...
Guy’s and St Thomas’ Poisons Unit (GTPU)
has over 100 enquiries about aconite poisoning
on its case database. There is a large
amount of literature on the subject including
toxicity from the plant itself and herbal
preparations; however, it is a relatively rare
cause of poisoning in the UK.
GTPU was consulted over a fatal case of
intentional aconit...
Surveillance of poisons centre enquiries We agree that an audit of poisons centre enquiry records is important for updating TOXBASE;1 however, case summaries requested from service users are more valuable. Callers often contact a poisons information service before it is possible to determine whether a patient has actually been exposed or has absorb...
Exposure to chemicals may potentially cause immediate acute or chronic effects (often resulting from long-term exposures). The global incidence of poisoning from accidental, occupational or intentional exposure to chemicals is not known, due to inadequate epidemiological data; however, it is estimated that up to half a million deaths are the result...
Background In recent years there has been a change in the perception of unintentional injuries from being the result of random and unavoidable events to being largely preventable accidents. Therefore; developing and implementing effective injury prevention policy is a firm public health concern. A prerequisite to action, however, is to develop a go...
In September 1998, legislation was introduced in the United Kingdom to limit paracetamol pack sizes to 16 tablets of 500 mg at general sales outlets and 32 tablets of 500 mg at pharmacies. The effect of the regulations on severity of paracetamol poisoning is unclear. The aim of this study was to describe trends in the severity of paracetamol poison...
Reports of chemical contamination of food and drink have been dominated by large-scale incidents often associated with the risks of chronic exposure to particular chemicals or additives, e.g., mycotoxins and pesticide residues. This paper is the first serious attempt to collate information on the numerous incidents of acute chemical contamination a...
Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100–200 deaths per year. In 1998, the UK government introduced legislation that reduced the maximum pack size of all non-effervescent tablets and capsules containing aspirin (acet...
National surveillance for chemical incidents is being developed in the UK. It is important to improve the quality of information collected, standardise techniques, and train personnel.
To define the extent to which eight National Poison Information Service specialists in poison information agree on the classification of calls received as "chemical...
Since 1994 the Chemical Incident Response Service (CIRS) contributed to the surveillance of chemical incidents by documenting all chemical incidents that came to its attention within the areas of England which it served. This report contains:
A. a description of the development of data collection at CIRS;
B. feedback on 2002 data from the current C...
To enable consistency of investigation and the establishment of best practice standards, consensus guidelines have been formulated jointly by the UK National Poisons Information Service (NPIS) and the Association of Clinical Biochemists (ACB). The types of laboratory investigation required for poisoned patients were categorized as either (a) essent...
Objective: Sildenafil (Viagra) was introduced in the US and UK in 1998 by Pfizer Ltd as a novel treatment for erectile dysfunction. Until that time the only licensed treatments available for erectile dysfunction were invasive, non-oral medications. State subsidized sildenafil is only available to men with specified clinical conditions. However it c...
Meprobamate is a non-barbiturate hypnotic/tranquillizer, first used clinically in 1955. One preparation (Tenavoid; Edwin Burgess) contains meprobamate and bendrofluazide and is prescribed for pre-menstrual tension.
In adults therapeutic plasma meprobamate concentrations range up to 10 mg/l and unwanted side-effects occur at greater than 40 mg/l. Li...
1 All enquiries received by the London Centre of the National Poisons Information Service [NPIS(L)] relating to household cleaning products were followed up by questionnaire for a 4-month period from November 1978 to February 1979.
2 130 reports (43% of total followed-up) were received.
3 The incidence of misuse of household cleaning products has r...
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Selected References
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