Nguyễn Hoàng Ly

Gachon University | kyungwon · Department of Chemistry

Gold nanoclusters are emerging as new materials for biomedical applications because of promises offered by their ultrasmall size and excellent biocompatibility. Here, the synthesis and optical and biological characterizations of a highly luminescent folate-functionalized Au22 cluster (Au22 -FA) are reported. The Au22 -FA clusters are synthesized by...

Silica-encapsulated gold nanoparticle dimers were self-assembled through a single-insertion process using capillary force and can be utilized as an advanced drug-delivery and sensing platform for organelle-targeting in cancer cells.

We examined the deboronation reaction of 4-mercaptophenylboronic acid (4MPBA) via fructose and glucose on silver surfaces by means of surface-enhanced Raman scattering (SERS) at the excitation wavelengths of 488, 514, and 633 nm. The SERS spectra on silver nanoparticles clearly exhibited specific spectral signatures of thiophenol (TP) peaks, indica...

A facile, selective, and sensitive detection method for the Cu²⁺ ions in environmental and biological solutions has been newly developed by observing the unique CN stretching peaks at ~2108 cm⁻¹ upon the dissociative adsorption of glycine (GLY) in hydrazine buffer on gold nanoparticles (AuNPs). The relative abundance of Cu species on AuNPs was iden...

A unique nanomaterial platform was developed for trace detection and efficient degradation of triclosan (TCS). A facile spectroscopic technique for surface-enhanced Raman scattering (SERS)-supported identification and ultraviolet (UV) degradation of TCS using a SERS template based on silver spherical nanoparticle (AgNP)-modified ZnO multipods (ZnO@...

A potential application of spiky SiO2 nanoparticles (NPs) with tubular and rough surfaces is investigated as superhydrophobic coatings, for their unique transparent, fluorinate‐free, and environmentally friendly properties. This study demonstrates a facile method for the successful fabrication of superhydrophobic coatings and SiO2@polydimethylsilox...

A sensitive and stable substrate plays a vital role in the Raman spectroscopic techniques as an analytical method for detecting pesticides effectively from the environment. Enhancing signals from nanoparticles are low and inconsistent in repeatability since analytes tend to degrade quickly under laser exposure. Herein, a novel substrate of Au@ZIF-6...

Trace amounts of semi-volatile organic compounds (SVOCs) of the two isothiazolinones of 2-methyl-2H-isothiazole-3-one (MIT) and 2-octyl-4-isothiazolin-3-one (OIT) were detected both in the air and on glass surfaces. Equilibria of SVOCs between air and glass were examined by solid phase microextraction-gas chromatography/mass spectrometry (SPME-GC/M...

Manganese oxide-coated nanopipettes were developed to overcome the limitation of photodynamic therapy (PDT) for cancers. Mn3O4–MnO2 core–shell heterostructure manganese oxide-attached nanopipettes catalysed the decomposition of ubiquitous H2O2 inside a tumour into O2, which was converted to reactive oxygen species (ROS). Gold nanoparticles (AuNPs)...

Micro(nano)plastic (MNP) pollutants have not only impacted human health directly, but are also associated with numerous chemical contaminants that increase toxicity in the natural environment. Most recent research about increasing plastic pollutants in natural environments have focused on the toxic effects of MNPs in water, the atmosphere, and soil...

Raman reporter‐based surface‐enhanced Raman scattering (SERS) has been used to investigate the detection of one member of a class of the cationic surfactant quaternary ammonium compounds, alkyl dimethyl benzyl ammonium chloride, also known as benzalkonium chloride (BAC). For this study, SERS was performed using silver nanoparticles (AgNPs). Density...

Many scientists are increasingly interested in on-site detection methods of phenol and its derivatives because these substances have been universally used as a significant raw material in the industrial manufacturing of various chemicals of antimicrobials, anti-inflammatory drugs, antioxidants, and so on. The contamination of phenolic compounds in...

Intracellular Cu(II) in the human body is essential to many physiological functions, and its disruption is connected to several diseases. Synthetic coumarin–lipoic acid (Cou-LA) conjugate-functionalized silver-nanoparticles decorated on nanopipettes (CSNs) were fabricated herein for the determination of intracellular Cu(II) via in situ dual Raman/f...

Facile detection of indoor semi-volatile organic compounds (SVOCs) is a critical issue to raise an increasing concern to current researchers, since their emissions have impacted the health of humans, who spend much of their time indoors after the recent incessant COVID-19 pandemic outbreaks. Plasmonic nanomaterial platforms can utilize an electroma...

This work introduces a facile geometry-controlled method for the fabrication of embossed and engraved polymeric moth-eye-inspired nanostructures in imprinting molds using anodic aluminum oxide (AAO) templates, resulting in a novel anti-reflective transparent coating. The moth-eye nanostructures are prepared directly on the surface of a flexible pol...

Chemical accidents, such as fire, explosion, and leakages, not only cause damage to humans but also have a harmful impact on the environment. In modern industrialization period, researchers have been attracted by the elaboration of novel detection platforms that have been widely adopted for monitoring and the early warning of the risk of hazardous...

The evaporation of the semivolatile organic compound (SVOC) benzothiazole (BZT) from glass surfaces has been estimated by means of surface‐enhanced Raman scattering (SERS) and gas‐phase Fourier‐transform infrared (FTIR) spectroscopy. The FTIR spectrum in the gas cell indicates the presence of BZT in the air. The density functional theory (DFT) of t...

We prepared novel Raman substrates for the sensitive detection of submicron-sized plastic spheres in water. Anisotropic nanostar dimer-embedded nanopore substrates were prepared for the efficient identification of submicron-sized plastic spheres by providing internal hot spots of electromagnetic field enhancements at the tips of nanoparticles. Silv...

We give an updated overview of gold nanomaterials (AuNMs) widely used in bioimaging via various kinds of Raman spectral markers, mainly cancer cells and tumors. Assisted by the plasmonic properties of AuNMs, enhanced Raman spectroscopy in aqueous samples has currently emerged as a versatile analytical technique, widely adopted for the determination...

We report the synthesis and application of a novel probe of the di-2-picolylamine (DPA)-conjugated triarylmethine (TAM) dye which has aimed at detecting Zn²⁺ ions. The 1:2 binding stoichiometry is estimated between Zn²⁺ and DPA-TAM according to Job's plot diagram and density functional theory (DFT) calculations. The increment of Zn²⁺ ion concentrat...

This work presents a surface-enhanced Raman scattering (SERS) and density functional theory (DFT) study of a fipronil adsorbed on colloidal silver nanoparticles (AgNPs). A standard curve was established to quantify fipronil within a range of 0.0001–0.1 ppm (r2 ≥ 0.985), relying on the unique fipronil Raman shift at ~2236 cm−1 adsorbed on AgNPs. DFT...

Multiple sharp‐edged gold nanostars were efficiently assembled on nanopipette tips through electrostatic interactions for use as a potent intracellular hypoxia‐sensing Raman probe. Colloidal stability and surface immobilization were checked using scanning electron microscopy, light scattering, and zeta potential measurements. Site‐specific intracel...

Accurate measurements of intracellular pH are of crucial importance in understanding the cellular activities and in the development of the intracellular drug delivery systems. Here we report a highly sensitive pH probe based on a fluorescein-conjugated Au22 nanocluster. Steady-state photoluminescence (PL) measurements have shown that, when conjugat...

Zidovudine (AZT) adsorbed on colloidal gold nanoparticles (AuNPs) undergoes pH-induced conformational changes according to spectral changes in surface-enhanced Raman scattering (SERS). In acidic pH values conditions, AZT assumes the C(2')-endo conformer, which binds more weakly to AuNPs than under neutral and alkaline conditions. In this study, den...

The nanodiamond (ND) conjugates of gefitinib (GF) and erlotinib (EL) were assembled for in vitro lung cancer treatments. The carboxylate infrared bands along with the negative surface charge of -28.3 (±2.1) mV were found efficient to conjugate the nitrogen-containing quinazoline ring drugs, due to the electrostatic interactions, resulting from the...

We report a facile method for sample preparation and sensitive on-site detection of melamine in powdered infant formula and chocolate using Raman spectroscopy on sharp-edged gold nanostars (AuNSs). The aggregation of AuNSs by sodium chloride (1.2 M) facilitates the more sensitive detection of melamine in comparison with spherical gold nanoparticles...

Zidovudine (AZT) adsorbed on colloidal gold nanoparticles (AuNPs) undergoes pH-induced conformational changes according to spectral changes in surface-enhanced Raman scattering (SERS). In acidic pH values conditions, AZT assumes the C(2')-endo conformer, which binds more weakly to AuNPs than under neutral and alkaline conditions. In this study, den...

For this report, we compared interfacial spectroscopic tools to monitor in situ Fenton reactions of organic dyes on ascorbic acid-reduced gold nanostars (AuNSs). Ultraviolet-visible (UV–vis) absorption and Raman spectroscopic tools were introduced to check the hydroxyl radical destruction of ethyl violet (EV), which contains a triarylmethane group....

We performed a vibrational analysis of a cyclin-dependent kinase inhibitor as an anticancer drug using Raman spectroscopy and quantum mechanical calculations. BMK-Y101, a purine nucleoside analogue cyclin-dependent kinase inhibitor, was found to adsorb on gold nanoparticles as evidenced by ultraviolet–visible absorption spectroscopy. Density functi...

A surface-enhanced Raman scattering (SERS) detection method for environmental copper ions (Cu2+) was developed according to the vibrational spectral change of diethyldithiocarbamate (DDTC) on gold nanoparticles (AuNPs). The ultraviolet-visible (UV-Vis) absorption spectra indicated that DDTC formed a complex with Cu2+, showing a prominent peak at ~4...

Ice nucleation protein (INP) with its functional domain consisting of multiple 48-residue repeat units effectively induces super-cooled water into ice. Circular dichroism and infrared deconvolution analyses on a soluble 240-residue fragment of Pseudomonas syringae InaZ (InaZ240) containing five 48-residue repeat units indicated that it is mostly co...

We report a combined approach that introduces the use of 4-aminobenzo-15-crown-5 (4AB15C5) for the detection of ferric(III) ions by colorimetric, ultraviolet (UV)-visible light absorption, fluorescence, and live-cell imaging techniques along with density functional theory (DFT) calculations. We have found that 4AB15C5 is sensitive and selective for...

We report a combined approach for the detection of Cr(III) after the binding l-methionine (Met) and subsequent treatment with gold nanoparticles (AuNPs) by colorimetric, UV–vis absorption, and surface-enhanced Raman scattering (SERS). Both UV–vis and SERS led to a selective detection of Cr(III) at the submicromolar level. The absorbance values at 6...

After the formation of dithizone with metal ion complexes, a selective Raman detection method for the Zn²⁺ ions in aqueous solutions was developed by observing the intensity change of the ring mode peaks at ∼1585 cm⁻¹ on gold nanoparticles (AuNPs). At high concentrations of Zn²⁺ ions, the conformation of the dithizone complex may have different ori...

We conducted a comparative study of the pH-dependent anchoring behaviors of 3-methyl-2-benzothiazolinone hydrazone (3M2BH) and benzophenone hydrazone (BPH) on gold nanoparticles (AuNPs) by means of interfacial Raman spectroscopy. We found that several bands of 3M2BH in the highly alkaline pH region disappeared as the colloidal conditions became mor...

Tris(hydroxymethyl)aminomethane ethylenediaminetetraacetic acid (Tris-EDTA), upon binding Cr(III) in aqueous solutions at pH 8.0 on silver nanoparticles (AgNPs), was found to provide a sensitive and selective Raman marker band at ~563 cm-1, which can be ascribed to the metal-N band. UV-Vis absorption spectra also supported the aggregation and struc...

We performed density functional theory (DFT) calculations of 4-aminobenzo-15-crown-5 (4AB15C5) in conjugation with 4-mercaptobenzoic acid (4MCB) with the polarizable continuum model (PCM) while considering the aqueous media. After specific binding of the ferric ion onto the 4MCB-4AB15C5 compound, the Raman frequencies and intensities were estimated...

In an effort to develop a spectroscopic mercury ion sensor, the Raman spectral features of di-(2-picolyl)amine (DPA) on gold nanoparticles (AuNPs) were examined in the presence of various ions. The two bands at 1020 and 1060 cm-1 showed different intensities in the presence of Hg2+, whereas the other ions, Pb2+, Ni2+, NH4+, Na+,Mn2+,Mg2+,+, Zn2+, F...

In order to develop optical Hg(II) sensors, the adsorption characteristics of poly-L-lysine (PLL) after the conjugation of various ions on gold nanoparticles (AuNPs) were examined by means of Raman spectroscopy, UV-Vis absorption, and quasi-elastic light scattering (QELS). The intensities of the two bands at 458 and 1115 cm-1 appeared to decrease,...