Nguyen Trung Kien

• Doctor of Medicine
• Senior Researcher at Can Tho University of Medicine and Pharmacy

The silver nanoparticles–sodium alginate–chitosan (AgNPs–Alg–Chi) nanocomposite film is a compelling material with demonstrated antibacterial efficacy against various pure bacterial strains. However, its potential cytotoxicity at elevated Ag doses warrants investigation. There is a notable dearth of studies assessing its antibacterial effectiveness...

The purpose of this work is to use HPLC/DAD to ascertain the best extraction and cleanup conditions for various forms of vitamin B in powder formula milk. The QuEChERS method’s key variables were optimized using a Box-Behnken design with 3-level 4-variable and Minimum-Run Resolution IV Screening Design. Following the selection of the best experimen...

Response surface methodology was used to estimate the optimum extraction parameters, for which the total phenolic content and total flavonoid content of Avicennia officinalis L. extract were the highest. Based on the 3D surface plots and regression analysis of the independent variables, the optimal conditions for the ultrasound-assisted extraction...

Background: Perindopril is an ACE inhibitor that aids in both blood pressure regulation and homocysteine reduction. Objectives: Our study aimed to evaluate the results of controlling blood pressure and blood homocysteine levels by perindopril in patients with primary hypertension. Materials and methods: A cross-sectional descriptive study with...

Đặt vấn đề: Tìm hiểu nhu cầu cần phục hồi chức năng của người khuyết tật tại cộng đồng là rất quan trọng trong việc giảm tỷ lệ khuyết tật và giúp người khuyết tật nhanh chóng hội nhập với cộng đồng. Mục tiêu: Tìm hiểu nhu cầu phục hồi chức năng của người khuyết tật ở quận Ninh Kiều, thành phố Cần Thơ năm 2011. Phương pháp nghiên cứu: Điều tra cắt n...

Điều tra tỷ lệ khuyết tật đang ngày càng được quan tâm và đã có nhiều đóng góp cho việc cải thiện tình hình cung cấp dịch vụ cho người khuyết tật. Mục tiêu: Xác định tỷ lệ các dạng, nguyên nhân và mức độ khuyết tật của người khuyết tật ở quận Ninh Kiều thành phố Cần Thơ năm 2011. Phương pháp nghiên cứu: Điều tra cắt ngang 13 phường với 348 người kh...

Background: In 2018, GOLD addressed the issues of genotypes associated with risk factors for COPD. The genome-wide association study (GWAS) demonstrated an association between COPD and several genetic variants of single nucleotide polymorphisms (SNPs) of the FAM13A gene with the risk of COPD. Objective: To study the single nucleotide polymorphis...

OBJECTIVE To evaluate a pharmacist-led intervention's effectiveness in reducing drug-related problems (DRPs ( related to prescriptions for pediatric outpatients. METHODS We conducted a randomized controlled trial. We recruited and randomly assigned 31 physicians to control or intervention groups. We collected 775 prescriptions (375 from the contro...

Background: Galectin-3 is a biomarker that has been demonstrated to play a significant role in myocardial fibrosis and remodeling in the pathogenesis of heart failure. Furthermore, spironolactone has the ability to control galectin-3 levels in heart failure patients. Objectives: The aim of our study was to determine the factors associated with t...

Background: Elevated levels of blood total homocysteine is one of the cardiovascular risk factors in hypertensive patients. Objectives: Determine the prevalence of hyperhomocysteinemia and its associated factors in newly diagnosed primary hypertension patients. Materials and methods: A cross-sectional descriptive study on 105 patients with new...

In this study, TiO2 nanowires on TiO2 nanotubes arrays (TNWs/TNAs) and Au-decorated TNWs/TNAs nanostructures are designed and fabricated as a new type of photoanode for photoelectrochemical (PEC) water splitting. The TNWs/TNAs were fabricated on Ti folds by anodization using an aqueous NH4F/ethylene glycol solution, while Au nanoparticles (NPs) and...

The significant drop in estrogen levels during menopause increases the cardiovascular risks, one of which is cerebrovascular atherosclerosis. Research on rheoencephalography (REG) parameters for the early diagnosis of cerebrovascular atherosclerotic lesions is of great interest to scientists because of its ease of implementation, low cost, and non-...

Purpose: To evaluate the characteristics of basal gastric juice in Helicobacter pylori-positive patients before and after Helicobacter pylori eradication therapy. Methods: This was a cross-sectional descriptive study on 150 gastritis patients admitted at the Hospital of Can Tho University of Medicine and Pharmacy. The patients were divided into 2 g...

In Vietnam, Physalis angulata L. has been widely used as a traditional medicine to treat fever, anti-inflammatory, and expectorant. Currently, there have been studies on the content of chemical composition especially physalin with anti-diabetic, anti-inflammatory, antibacterial, prevent cancer. This study developed a reliable and sensitive method t...

Background: Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD), and the relationship between dyslipidemia and renal function in these patients remains controversial. Our objectives were to determine the triglycerides/HDL-cholesterol ratio (TG/HDL-C), evaluate the correlation between TG/HDL-C and the urine albumin/creati...

Abstract: Background: Children are at high risk of drug-related problems, increased risk of treatment failures, and high treatment costs. We aimed to evaluate the effect of pharmacist-led interventions on physicians’ prescribing for pediatric outpatients. Methods: A prospective study with pre- and post-intervention measurement assessment was conduc...

The proportion of geriatric depression recorded in Vietnam was 66.9%. Depression in older people is a risk factor for problems related to dementia, poor quality of life, and suicide. To have a good Vietnamese questionnaire for assessing geriatric depression, we conducted the study to translate and cross-culturally adapt the Geriatric Depression Sca...

Citation: Nguyen, T.V.; Nguyen, K.T.; Nguyen, P.M.; Nguyen, N.M.; Ly, C.L.; Nguyen, T.; Nguyen, M.T.T.; Le, H.M.; Nguyen, X.T.K.; Duong, N.H.P.; et al. Vietnamese

Background: We aimed to translate, cross-culturally adapt, and validate the General Medication Adherence Scale (GMAS) into Vietnamese. Methods: We followed the guidelines of Beaton et al. during the translation and adaptation process. In Stage I, two translators translated the GMAS to Vietnamese. Stage II involved synthesizing the two translatio...

Pneumonia is one of the most common infectious diseases and the fourth leading cause of death globally. According to US statistics in 2019, pneumonia is the most common cause of sepsis and septic shock. In the US, inpatient pneumonia hospitalizations account for the top 10 highest medical costs, totaling $9.5 billion for 960,000 hospital stays. The...

Most of the alkaloids are chiral compounds and are clinically administered as the racemic mixture, even though its enantiomers have been known to exert different pharmacological activity. The determination of the enantiomeric composition of alkaloid-containing plants is subject to severe attention from pharmacological and toxicological points of vi...

ABSTRACT Children are the subject of medical attention because they always need special health care. Compared to adults, children are more vulnerable when undergoing medication. Due to the developmental characteristics of children, with the incomplete development of important parts related to drug pharmacokinetic properties, drug use in children r...

The mangrove plant - Avicennia officinalis L has been widely used for the treatment of various diseases such as anti-inflammatory, anticancer, antioxidant therapy. In this study, we optimize the extraction process using the easily obtainable solvents with different polarities toward obtaining high total phenolic- and flavonoid- contents from Avicen...

Introduction. Nerve stimulation tests are crucial in the early diagnosis and monitoring of neuromuscular disease. The objective of the study was to clinically characterize and validate repetitive nerve stimulation (RNS) testing in patients with the chronic autoimmune neuromuscular disease, myasthenia gravis (MG). Material and methods. Clinical asse...

The effects of calcium and vitamin D supplementation on representative factors of bone health have been separately evaluated in different study populations worldwide, however, no data from solely one study population that comprehensively assess the supplementation outcomes on the skeletal system are available. We aimed to evaluate how calcium and v...

Background Low measured bone mineral density (BMD) in clinical settings is known as an indirect indicator of osteoporosis and fracture risk. Objective To evaluate the mean BMD at the lumbar spine and femoral neck and the correlation between BMD and some associated factors in women aged over 40 years. Methods A prospective cross-sectional research...

Alkaloids are distributed in plant kingdom and play important role in protection, germination as well as plant growth stimulants. Most of them are chiral compounds and are clinically administered as the racemic mixture, even though its enantiomers have been known to exert different pharmacological activity. Liquid chromatography using chiral statio...

Objectives Understanding medical staff’s prescription behaviors helps improve the quality of prescriptions and the rationality of medication use. Although factors affecting the prescribing decisions were discussed in various studies worldwide, limited knowledge of these issues has been reported in Vietnam. This paper aims to examine factors that in...

The increase in the number of multi-drug resistant bacteria causing nosocomial infections at the hospital's intensive care unit (ICU) is a major worldwide problem. This leads to the need for research on clinical characteristics and pathogenic bacteria of hospital-acquired pneumonia (HAP) patients. Our research aimed to describe the clinical charact...

Background: Hypovitaminosis D is arising as a major public health problem causing adverse effects on bone mineral density (BMD), especially on the pediatric skeletal system. Bone turnover markers (BTMs) are used to assess bone health due to their fracture prediction ability. Objectives: We aimed to assess the status of vitamin D and BMD and their...

Objectives To assess the effectiveness of a combined online and face‐to‐face continuing medical education (CME) programme, for improvement in clinical knowledge and skills of family doctors, in comparison with a control group; and to explore the self‐reported satisfaction, competencies and confidence of those in the intervention group. Methods We...

Objectives Well‐designed studies on the impact of a family medicine rotation on medical students are rare, and very few studies include a qualitative component. This study aimed to determine the improvement of medical students’ knowledge, communication skills and attitude towards primary care and explore their perceptions after rotations, in compar...

This study aims to analyze the length polymorphisms in sequence-tagged-site (STS) sY1291 of the Y chromosome in Vietnamese men of infertile couples. All 322 DNA samples were amplified with the sY1291 primer by the quantitative fluorescent polymerase chain reaction (QF-PCR) assay. DNA sequencing technique was employed to evaluate the accuracy of QF-...

Antibiotic residues in aquaculture wastewater are considered as an emerging environmental problem, as they are not efficiently removed in wastewater treatment plants. To address this issue, we fabricated TiO2 nanotube arrays (TNAs), TiO2 nanowires on nanotube arrays (TNWs/TNAs), Au nanoparticle (NP)-decorated-TNAs, and TNWs/TNAs, which were applied...

Atenolol and metoprolol are used in the treatment of angina pectoris, certain arrhythmias, systemic hypertension, and several other cardiovascular disorders. Both compounds are produced commercially in the racemic and enantiomer, even though the S-form is responsible for the desired biological effect. The aim of this study was to development a simp...

A reverse phase UPLC method was developed for simultaneous determination of paracetamol, ibuprofen and its related impurity. The UPLC column was BEH C18 column, (2.1 × 100 mm, 1.7 µm). The mobile phase was composed of an aqueous solution of methanol-triethylamine in gradient mode. The UV detector wavelength was set at UV 230nm for paracetamol and i...

Contributing to find out the distribution of mutations causing beta-Thalassemia in Vietnam, particularly in ethnic minority subjects, we applied the technique ARMSPCR and sequencing in genetic molecule lab of the Ho Chi Minh University of Medicine and Pharmacy. 25 DNA samples from 25 Khmer patients with beta-Thalassemia living in Bac Lieu Province...