Nguyen Thu Anh

Nguyen Thu Anh
The University of Sydney · Faculty of Medicine and Health (Sydney Central Clinical School)

MD, PhD

About

101
Publications
21,997
Reads
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2,134
Citations
Citations since 2016
72 Research Items
1795 Citations
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20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Introduction
Dr Nguyen Thu Anh is an epidemiologist and medical anthropologist, conducting research in the field of infectious diseases. Since June 2013, she is the head of the Woolcock Institute of Medical Research in Viet Nam, and an honorary lecturer at University of Sydney.
Additional affiliations
June 2013 - present
Woolcock Institute of Medical Research
Position
  • Managing Director
January 2012 - April 2013
Medish Comité Nederland-Vietnam
Medish Comité Nederland-Vietnam
Position
  • Deputy Country Representative
October 2008 - December 2011
Chemonics
Position
  • Country Representative/Chief of Party
Education
June 2004 - April 2009
University of Amsterdam
Field of study
  • Medical Anthropology
April 2001 - April 2002
Mahidol University
Field of study
  • Primary Health Care Management
September 1991 - August 1998
Hanoi Medical University
Field of study
  • Epidemiology

Publications

Publications (101)
Article
Full-text available
The infectious spread of COVID-19 has been accompanied by stigma in both global and local contexts, sparking concern about its negative effect on individuals, communities, and public health responses. The changing epidemiological context of the COVID-19 epidemic and evolving public health responses during the first year of the pandemic (2020) in Vi...
Article
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Background and objective Data on the prevalence of anti-tuberculous drug resistance and its association with genetic mutations in Mycobacterium tuberculosis are limited. Our study explores the genomics of tuberculosis in a high Ca Mau, Vietnam. Methods Patients > 15 years in Ca Mau Province, Vietnam, were screened annually for tuberculosis between...
Article
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Background While the safety and efficacy of inhaled budesonide-formoterol, used as-needed for symptoms, has been established for patients with asthma, it has not been trialed in undifferentiated patients with chronic respiratory diseases. We aimed to assess the feasibility of a pragmatic intervention that entails a stepped algorithm using inhaled b...
Article
Full-text available
Stigma and isolation are common in people with tuberculosis (TB). Social isolation contributes to reduced health outcomes and TB treatment adherence. Stigma and the drivers of isolation in people with Drug-Resistant (DR)-TB may include modifiable advice and practices of family and Health Care Workers (HCW). This study aimed to understand the driver...
Article
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Introduction Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem globally. Long, complex treatment regimens coupled with frequent adverse events have resulted in poor treatment adherence and patient outcomes. Smartphone-based mobile health (mHealth) technologies offer national TB programmes an appealing platform to impro...
Article
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Background Limited evidence is available about the combination of multiple smoking cessation modalities in low- and middle-income countries. The study aimed to assess the feasibility of a smoking cessation intervention that integrates follow-up counselling phone calls and scheduled text messages with brief advice from physicians in Vietnam. Method...
Article
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Background This study aimed to evaluate the appropriateness of antibiotic dispensing of private pharmacies in Vietnam. Methods Standardised patient surveys were conducted in randomly selected community pharmacies across 40 districts in Vietnam. Four clinical scenarios were represented by patient actors: (a) an adult requesting treatment for a sibl...
Article
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We evaluated the effects of the coronavirus disease pandemic on diagnosis of and treatment for tuberculosis (TB) in Vietnam. We obtained quarterly notifications for TB and multidrug-resistant/rifampin-resistant (MDR/RR) TB from 2015-2020 and evaluated changes in monthly TB case notifications. We used an interrupted time series to assess the change...
Article
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Over the past 15 years, and despite many difficulties, significant progress has been made to advance child and adolescent tuberculosis (TB) care. Despite increasing availability of safe and effective treatment and prevention options, TB remains a global health priority as a major cause of child and adolescent morbidity and mortality—over one and a...
Article
Full-text available
Background At the early stage of the pandemic, severe COVID-19 was thought to be rare among pregnant women. However, cumulating data showed that gestational state is a risk factor for severe pneumonia, particularly due to the hyperinflammatory state. Recent reports suggested the efficacy of pulse corticosteroids in stopping the cytokine storm in pe...
Article
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Background Improving treatment outcomes for multidrug-resistant tuberculosis (MDR-TB) is a leading priority for global TB control. This retrospective cohort study evaluated the factors associated with treatment success among patients treated for MDR-TB in two provinces in Vietnam. Methods Treatment outcomes were evaluated for adult patients treate...
Article
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Objective We determined the sero-prevalence of severe acute respiratory syndrome – coronavirus – 2 (SARS-CoV-2) antibodies in high-risk communities and quarantine workers in Vietnam. Methods We measured the prevalence of SARS-CoV-2 antibodies in household contacts, close contacts, community members, and migrant workers from two sub-communes in whi...
Article
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Background: Of the estimated 10 million people affected by (TB) each year, one-third are never diagnosed. Delayed case detection within the private healthcare sector has been identified as a particular problem in some settings, leading to considerable morbidity, mortality and community transmission. Using unannounced standardised patient (SP) visi...
Article
Full-text available
Objectives Tuberculosis (TB) stigma contributes to diagnostic delay, disease concealment and reduced wellbeing for affected individuals. Despite several TB stigma scales available; most have not been culturally validated in other settings. This study evaluated the Van Rie TB stigma scale (VTSS) among patients with TB in Vietnam. Methods This study...
Article
Tobacco smoking is a leading cause of premature death. Smoking prevalence in Vietnam ranks among the highest in Southeast Asia. Given the important role of health care workers (HCWs) in promoting and supporting smoking cessation, this project aimed to characterize the prevalence of smoking among HCWs in Vietnam, and their attitudes toward smoking c...
Article
Azole‐resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land‐use types, and determined antifungal susceptibilities of Aspergil...
Article
Full-text available
Introduction Antimicrobial resistance is a global challenge that threatens our ability to prevent and treat common infectious diseases. Vietnam is affected by high rates of antimicrobial resistant infections, driven by the overuse of antibiotics and the Vietnamese government has recognised antimicrobial resistance as a health security priority. Thi...
Article
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Background Chronic obstructive pulmonary disease (COPD) and asthma rank among the leading causes of respiratory morbidity, particularly in low- and middle-income countries. This qualitative study aimed to explore the healthcare pathways of patients with chronic respiratory disease, and factors influencing their ability to access healthcare in Vietn...
Article
Full-text available
As a response to the coronavirus disease 2019 (COVID-19) pandemic, Vietnam enforced strict quarantine, contact tracing and physical distancing policies resulting in one of the lowest numbers of individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) globally. This study aimed to determine the prevalence of SARS-CoV-2...
Article
Full-text available
Nghiên cứu can thiệp về thực trạng chẩn đoán và điều trị lao tiềm ẩn tại hai tỉnh Quảng Nam, Đà Nẵng và kết quả một số giải pháp can thiệp được thực hiện nhằm đánh giá kết quả một số can thiệp y tế công cộng trong việc tăng số người tiếp xúc được sàng lọc, chẩn đoán và điều trị lao tiềm ẩn. Phân tích chuỗi đa bậc quản lý lao tiềm ẩn (cascade) về kế...
Article
BACKGROUND: Drug resistance poses a major barrier to global control of TB - a leading infectious cause of death. Depression and stigma occur commonly among people with TB. However, the relationship between drug-resistant forms of TB, depression and stigma are not well understood.OBJECTIVE: To compare depression, stigma and health-related quality of...
Article
Full-text available
Background Attendance at healthcare facilities provides an opportunity for smoking cessation interventions. However, the smoking behaviours of patients seeking healthcare in Vietnam are not well-understood. We aimed to evaluate behaviours related to smoking among patients presenting to health facilities in Vietnam. Methods We conducted a cross-sec...
Article
Full-text available
The global drive to vaccinate against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) began in December 2020 with countries in Europe, Middle East, and North America leading the roll out of a mass-vaccination program. This systematic review synthesised all available English-language guidelines and research regarding mass-vaccination fo...
Article
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Latent tuberculosis infection affects one quarter of the world’s population, and effective therapies are available. However, scale-up of tuberculosis preventive treatment (TPT) remains limited. We describe strategies to support scale-up of TPT in high-prevalence settings, where the potential benefit for affected individuals is considerable. Patient...
Article
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Background Reaching the UN General Assembly High-Level Meeting on Tuberculosis target of providing tuberculosis preventive treatment to at least 30 million people by 2022, including 4 million children under the age of 5 years and 20 million other household contacts, will require major efforts to strengthen health systems. The aim of this study was...
Article
BACKGROUND: Exposure to people with TB substantially elevates a person’s risk of tuberculous infection and TB disease. Systematic screening of TB contacts enables the early detection and treatment of co-prevalent disease, and the opportunity to prevent future TB disease. However, scale-up of contact investigation in high TB transmission settings re...
Article
Full-text available
Antimicrobial resistance (AMR) is a major global issue and antimicrobial stewardship is central to tackling its emergence. The burden of AMR disproportionately impacts low- and middle-income countries (LMICs), where capacity for surveillance and management of resistant pathogens is least developed. Poorly regulated antibiotic consumption in the com...
Article
Objective Stigma contributes to diagnostic delay, disease concealment and reduced wellbeing for people with multidrug-resistant tuberculosis (MDR-TB) and their communities. Despite the negative effects of stigma, there are no scales to measure stigma in people with MDR-TB. This study aimed to develop and validate a scale to measure stigma in people...
Article
Full-text available
Background: As a response to the coronavirus disease 2019 (COVID-19) pandemic, Vietnam enforced strict quarantine, contact tracing and physical distancing policies. By December 2020, this strategy resulted in one of the lowest numbers of individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) cases globally. This stud...
Article
Full-text available
Objective To estimate the incubation period of Vietnamese confirmed COVID-19 cases. Methods Only confirmed COVID-19 cases who are Vietnamese and locally infected with available data on date of symptom onset and clearly defined window of possible SARS-CoV-2 exposure were included. We used three parametric forms with Hamiltonian Monte Carlo method f...
Article
Full-text available
Since 22nd January 2020, Vietnam has experienced three waves of SARS-CoV-2 infection and 1347 confirmed cases, including 665 community-transmitted cases and 35 deaths [1]. All outbreaks have been effectively contained, with no new community transmission between 3rd September and 30th November 2020 (Fig. 1). In reviewing our experience and lessons l...
Article
Full-text available
Background The aim of the study was to establish syndromic diagnoses in patients presenting with respiratory symptoms to healthcare facilities in Vietnam and to compare the diagnoses with the facility-level clinical diagnoses and treatment decisions. Methods A representative sample of patients, aged ≥ 5 years, presenting with dyspnoea, cough, wheez...
Article
Full-text available
Background The aim of the study was to establish syndromic diagnoses in patients presenting with respiratory symptoms to healthcare facilities in Vietnam and to compare the diagnoses with the facility-level clinical diagnoses and treatment decisions. Methods A representative sample of patients, aged≥5 years, presenting with dyspnoea, cough, wheezi...
Article
Full-text available
The burden of aspergillosis, especially Chronic Pulmonary Aspergillosis, is increasingly recognized, and the increasing presence of azole-resistant environmental Aspergillus fumigatus has been highlighted as a health risk. However, a sizable minority of aspergillosis is caused by Aspergillus flavus, which is assumed to be sensitive to azoles but is...
Article
Full-text available
Background Tuberculosis (TB) continues to account for significant morbidity and mortality annually. Household contacts (HHCs) of persons with TB are a key population for targeting prevention and control interventions. We aimed to identify risk factors associated with developing TB among HHCs. Methods We conducted a nested case-control study among...
Article
Full-text available
SUMMARY OBJECTIVE : To compare two community screening tests for TB: sputum examination using Xpert w MTB/ RIF and chest radiography (CXR). METHOD : Men aged 15 years and women aged .45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide a single sputum specimen that was tested using Xpert. Participants were also invited t...
Conference Paper
Full-text available
Introduction: Vietnam has so far successfully controlled both an initial and a second wave of COVID-19 through a strategy of extensive temperature screening and testing; strict, targeted lockdowns; and an extensive public communication campaign. This study aimed to explore community experiences of, and engagement with, the public health response to...
Preprint
Full-text available
Objective: To estimate the incubation period of Vietnamese confirmed COVID−19 cases. Methods: Only confirmed COVID−19 cases who are Vietnamese and locally infected with available data on date of symptom onset and clearly defined window of possible SARS−CoV−2 exposure were included. We used three parametric forms with Hamiltonian Monte Carlo method...
Preprint
Full-text available
Objectives: Health care system of many countries are facing a surging burden of COVID-19. Although Vietnam has successfully controlled the COVID-19 pandemic to date, there is a sign of initial community transmission. An estimate of possible scenarios to prepare health resources in the future is needed. We used modelling methods to estimate impacts...
Article
Full-text available
Background: The End TB Strategy calls for global scale-up of preventive treatment for latent tuberculosis infection (LTBI), but little information is available about the associated human resource requirements. Our study aimed to quantify the healthcare worker (HCW) time needed to perform the tasks associated with each step along the LTBI cascade o...
Article
Objectives Global tuberculosis (TB) control is restricted by the failure to detect an estimated 3.3 million TB cases annually. In the majority of TB endemic settings, sputum smear microscopy is used to diagnose TB, but this test is insensitive for TB in its early stages. The objective of this study is to establish a concise gene signature that disc...
Article
Full-text available
Introduction Treatment of latent tuberculosis infection (LTBI) plays a substantial role in the prevention of drug-susceptible tuberculosis (TB). However, clinical trials to evaluate the efficacy of preventive therapy for presumed multidrug-resistant (MDR) LTBI are lacking. This trial aims to evaluate the efficacy of the antibiotic levofloxacin in p...
Article
Full-text available
BACKGROUND The World Health Organization has set ambitious targets for the global elimination of tuberculosis. However, these targets will not be achieved at the current rate of progress. METHODS We performed a cluster-randomized, controlled trial in Ca Mau Province, Vietnam, to evaluate the effectiveness of active community-wide screening, as com...
Article
Full-text available
Background: Despite the criticality of adherence to tuberculosis treatment, there is paucity of rigorous experimental research exploring the efficacy of interventions to promote adherence and a greater lack of inquiry addressing the integral role of adherence behaviour. The aim of this formative study was to examine the way in which the Wisepill e...
Article
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Background Pooling sputum specimens is one potential strategy for reducing the cost of using Xpert MTB/RIF, a rapid polymerase chain reaction (PCR)-based test, for the diagnosis of pulmonary tuberculosis. We sought to compare the sensitivity of two alternative method of pooling. Methods Patients referred for assessment for TB, whose initial sputum...
Article
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Background: Active case finding is recommended as an important strategy to control tuberculosis, particularly in low-income and middle-income countries with a high prevalence of the disease. However, the costs and costeffectiveness of active case finding are unclear due to the absence of evidence from randomised trials. We assessed the costs and co...
Article
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Background: Currently in Vietnam contact tracing for multidrug-resistant tuberculosis (MDR-TB) entails passive case finding among symptomatic household contacts who present themselves for diagnosis. Close contacts of MDR-TB cases are therefore not identified adequately. We assessed the added value of active contact tracing within and beyond househ...
Article
Background: Tuberculosis is the leading infectious cause of death. Steep reductions in tuberculosis-related mortality are required to realize the World Health Organization's "End Tuberculosis Strategy." However, accurate mortality estimates are lacking in many countries, particularly following discharge from care. This study aimed to establish the...
Article
Full-text available
Background: Patients completing treatment for tuberculosis (TB) in high-prevalence settings face a risk of developing recurrent disease. This has important consequences for public health, given its association with drug resistance and a poor prognosis. Previous research has implicated individual factors such as smoking, alcohol use, HIV, poor trea...
Article
Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to e...
Article
Full-text available
Setting: The study was conducted in a randomly selected sample of persons aged 15 years living in Ca Mau Province, southern Viet Nam. Objective: To estimate the prevalence of latent tuberculous infection (LTBI) in the general adult population of this province of Viet Nam. The secondary objective was to examine age and sex differences in prevale...
Article
Full-text available
Background Active case finding is a top priority for the global control of tuberculosis, but robust evidence for its effectiveness in high-prevalence settings is lacking. We sought to evaluate the effectiveness of household-contact investigation, as compared with standard, passive measures alone, in Vietnam. Methods We performed a cluster-randomiz...
Article
Full-text available
Background Ensuring patients fully adhere to their treatment is a major challenge for TB control programmes in resource-limited settings. This study was conducted three outpatient tuberculosis clinics in Hanoi, Vietnam. We aimed to evaluate the feasibility of using asynchronous Video Directly Observed Therapy (VDOT) to support treatment adherence...