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19
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503
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Introduction
Additional affiliations
January 2021 - present
January 2016 - December 2020
March 2014 - December 2015
Publications
Publications (19)
Alternaria is a human/animal allergen and plant/animal pathogen. Cereal harvesting emits a large amount of Alternaria spores into the atmosphere. However, estimating the peak spore periods and source areas from large areas is often a challenge because of insufficient observation stations. The purpose of this study was to examine, using remote sensi...
Significance
Coexposure to airborne pollen enhances susceptibility to respiratory viral infections, regardless of the allergy status. We hypothesized this could be also true for SARS-CoV-2 infections. To investigate this, we tested for relationships between SARS-CoV-2 infection rates and pollen concentrations, along with humidity, temperature, popu...
Plant pollen are an important source of antigens that evoke allergic responses. Protein antigens have been the focus of studies aiming to elucidate the mechanisms responsible for allergic reactions to pollen. However, proteins are not the sole active agent present in pollen. It is known that pollen grains contain lipids essential for its reproducti...
Molecular allergology research has provided valuable information on the structure and function of single allergenic molecules. There are several allergens in food and inhalant allergen sources that are able to interact with lipid ligands via different structural features: hydrophobic pockets, hydrophobic cavities, or specialized domains. For only a...
Mast cells (MCs), which are well known for their effector functions in TH2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequ...
Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptidephosphoglycan (LPPG) isolated...
The interaction between tissue-resident mast cells (MCs) and recruited immune cells contributes to tissue immunosurveillance. However, the cells, mechanisms and receptors involved in this cross-talk remain ill-defined. Invariant natural killer T (iNKT) cells are CD1d-restricted innate lymphocytes that recognize glycolipid antigens and have emerged...
Mast cells are important cellular constituents of epithelial-mesenchymal interactions, densely located at sites of microbial entry into the host where they are continuously exposed to products from commensals. In order to avoid excessive activation and the associated pathology, mast cell responses to TLR agonists must be tightly regulated. Here, we...
Amebic liver abscess (ALA), a parasitic disease due to infection with the protozoan Entamoeba histolytica, occurs age and gender dependent with strong preferences for adult males. Using a mouse model for ALA with a similar male bias for the disease, we have investigated the role of female and male sexual hormones and provide evidence for a strong c...
Author Summary
Amoebiasis is a widespread human parasitic disease caused by the intestinal protozoan Entamoeba histolytica. There are two major clinical manifestations of the disease, amebic colitis and amebic liver abscess. Interestingly, only a small proportion of E. histolytica-infected individuals develop invasive disease, whereas the majority...
Inflammation is necessary for survival, but it is also an important cause of human morbidity and mortality, as exemplified by sepsis. During inflammation, cells of the innate immune system are recruited and activated in response to infection, trauma or injury. These cells are activated through receptors, such as Toll-like receptors (TLRs), which re...
To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class II major histocompatibility complex molecules (HLA-DR), and the expression of the splicing variant (svTREM-1) of TREM-1 in septic patients and those subjected to major abdominal surgery.
Using flow cytometry, we examined the surface expression of TREM-1 and...
Projects
Projects (2)
House Dust Mites (HDM) are important inducers of allergic asthma. Chemically, aside from glycoproteins, HDM consist of a large variety of lipids. Lipids can initiate and/or modulate allergic reactions, either on their own or acting as adjuvants for allergens. In addition, several HDM allergens bear hydrophobic domains, thus enabling them to interact with lipids.
In this project we aim to isolate and characterize all lipid species present in Timothy grass (Phleum pratense) pollen that are involved in the development of type 2 immune responses related to allergic inflammation. One branch of the research involves studying the lipid mediators (phytoprostanes), that we believe play a role in the initial phase of sensitization (priming). The second one deals with the glycolipids being a structural part of the pollen grain (e.g. glycoglycerols, ceramides) that are important for the second phase of the sensitization (amplification).
