Nenad Andjelkov

Västmanland Hospital Västeras · Department of Orthopaedics

Commercially available fibrin is routinely being used as both a matrix in certain cartilage repair techniques and a method for scaffold fixation. Chondrocytes from non-digested particulated cartilage fragments are proposed as a possible source for new cartilage tissue formation in some operative techniques. The goal of this study was to test that c...

Isolated cases of osteoarthritis of the knee represent a major clinical problem. A particular challenge is a case in which both articular surfaces are affected. Such is the case with the isolated form of patellofemoral osteoarthritis. Studies that describe methods for treating such conditions are few, and the results are not too promising. In this...

A critical analysis and review were performed regarding chondrocyte cell-based techniques using cultured chondrocytes. The rationale for use of these methods was analyzed from the level of cultured chondrocyte cell biology to the level of clinical improvement and compared with operative techniques that are not chondrocyte cell-based. No superior re...

Open knee surgery for the treatment of large symptomatic cartilage defects is routinely performed in the inpatient stay, where the patients are hospitalized for several days after surgery. This has implications for both costs for the health system and medical complications such as hospital-related infections. In this article, we describe for the fi...

We investigated the effect of beta-endorphin on the activities of mitogen-activated protein kinases in cultured human articular chondrocytes in order to elucidate its effect on cartilage. Monolayer cultures of chondrocytes obtained from patients undergoing total knee arthroplasty were treated with 60, 600, or 6000 ng/ml beta-endorphin, or 100 ng/ml...

In the present study, we have investigated the presence of pro-opiomelanocortin C-terminal fragment derived-peptides in human articular cartilage and cultured chondrocytes. beta-Lipotropin and beta-endorphin were monitored in different cell cultures and biopsies using different techniques. Biopsies were taken from patients undergoing total knee art...

In order to investigate if beta-endorphins anti-inflammatory effect in cartilage-damaging states is mediated via tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), we examined its influence on these two cytokines in vitro. Human articular chondrocytes were obtained from patients undergoing total knee arthroplasty and stimul...

There is evidence of effects of morphine on cell proliferation and intraarticular morphine produces analgesia and has an anti-inflammatory effect in chronic arthritis. The effects of opioids are mediated through the G-protein-coupled receptors affecting the cAMP pathway. We demonstrated that human osteoarthritic cartilage and cultured chondrocytes...