Nelo Eidy Zanchi

Federal University of Maranhão | UFMA · Departamento de Educação Física

Purpose The purpose of this study is to evaluate the effect of three different preexercise meals: high-carbohydrate, low-glycemic index (LGI), high-carbohydrate, high-GI (HGI) and low-carbohydrate high fat (LCHO) on substrate oxidation during an incremental cycling test (ICT) in recreationally active adults. Design/methodology/approach This was a...

Betaine supplementation, a dietary practice that possesses potential effects on exercise performance, has undergone extensive study. This study aimed to systematically review and meta-analyse betaine supple-mentation's effects on exercise performance. We searched PubMed, Web of Science, Scopus, and Google Scholar, focusing on studies comparing chro...

To investigate the effects of 8-weeks of full versus split body resistance training (RT) on appetite and energy intake in non-obese untrained men. The participants were pair-matched based on their initial fat mass and then randomly allocated into one of two treatment groups: Full body (FB, n = 20), in which all muscle groups were trained in every s...

Unlabelled: We aimed to compare the effects of beta-alanine on Traditional Resistance Training (TRAD) or Blood Flow Restriction Training (BFR). Methods: 19 subjects were randomly allocated to a Placebo (n = 10) or beta-alanine (n = 9) group. Subjects from both groups were trained unilaterally (unilateral arm curl) for six weeks, and each arm was...

This study aimed to compare the effects of an 8-week creatine (CR) or placebo (PL) supplementation on muscle strength, thickness, endurance, and body composition employing different training paradigms with blood flow restriction (BFR) vs. traditional resistance training (TRAD). Seventeen healthy males were randomized between the PL (n = 9) and CR (...

Objectives: The purpose of this study was to compare the effects of two acute doses of Capsiate (CAP; 6 vs. 12 mg) on upper body resistance exercise performance in trained men. Methods: Using a randomized, crossover and double-blind design, 20 resistance-trained males were supplemented with low-dose CAP (6 mg), high-dose CAP (12 mg) or placebo 4...

As a key mechanism to maintain cellular homeostasis under stress conditions, autophagy/mitophagy is related to the occurrence of metabolic disorders, neurodegenerative diseases, cancer, and other aging-related diseases, but the relevant signal pathways regulating autophagy have not been clarified. Mammalian sterile 20-like kinase 1 (MST1) is a cent...

Background Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflam...

Several studies have indicated a positive effect of exercise (especially resistance exercise) on the mTOR signaling that control muscle protein synthesis and muscle remodeling. However, the relationship between exercise, mTOR activation and leucine-sensing requires further clarification. Two month old Sprague-Dawley rats were subjected to aerobic e...

Lauver, JD, Moran, A, Guilkey, JP, Johnson, KE, Zanchi, NE, and Rotarius, TR. Acute responses to cycling exercise with blood flow restriction during various intensities. J Strength Cond Res 36(12): 3366–3373, 2022—The purpose of this study was to investigate the acute physiological responses during cycling at various intensities with blood flow res...

Introduction: Frailty is a complex syndrome that can is characterized by the loss of physical functional capacity. The effects of multicomponent exercise training on frailty and correlated biomarkers are not yet fully explored in the scientific literature. Objective: Based on the available literature data, our first endpoint in this systematic revi...

Skeletal muscle anabolic resistance (i.e., the decrease in muscle protein synthesis (MPS) in response to anabolic stimuli such as amino acids and exercise) has been identified as a major cause of age-related sarcopenia, to which blunted nutrition-sensing contributes. In recent years, it has been suggested that a leucine sensor may function as a rat...

Background: Ageing is a natural, progressive and irreversible process characterized by morphological, psychological, functional, biochemical and nutritional changes. Physical inactivity (PI) is a factor that contributes to the starting of mass and muscle function decline in the elderly, often related to sarcopenia and physical frailty. Combined to...

Objectives: Performance in running-based sport depends on the ability to perform repetitive high intensity muscle contractions. Previous studies have shown that capsaicin analog (CAP) (i.e. Capsiate) supplementation may improve this performance. The purpose of this study was to investigate the acute effect of CAP supplementation on short (400 m) a...

Lima-Soares, F, Pessoa, KA, Torres Cabido, CE, Lauver, J, Cholewa, J, Rossi, FE, and Zanchi, NE. Determining the arterial occlusion pressure for blood flow restriction: pulse oximeter as a new method compared with a handheld Doppler. J Strength Cond Res XX(X): 000-000, 2020-In laboratorial and clinical settings, the use of Doppler ultrasound equipm...

The frailty syndrome (FS) is characterized by a multifactorial clinical syndrome influenced by environmental and biological factors. The progressive losses of functions that occur in the body and consequently physical function decrease are hallmarks of this negative process (1). Some studies have shown that regular exercise has positive effects on...

Purpose: To screen for candidate hub genes associated with the effects of exercise on melanoma tumor tissues, and to review the potential signaling pathways involved in this process using bioinformatics analysis. Methods: The GSE62628 expression profile was downloaded from Gene Expression Omnibus database. This dataset contains 10 melanoma tumor...

Conrado de Freitas, M, Ricci-Vitor, AL, de Oliveira, JVNS, Quizzini, GH, Vanderlei, LCM, Silva, BSA, Zanchi, NE, Cholewa, JM, Lira, FS, and Rossi, FE. Appetite is suppressed after full-body resistance exercise compared with split-body resistance exercise: the potential influence of lactate and autonomic modulation. J Strength Cond Res XX(X): 000-00...

(1) Background: We investigated the effects of 28 days of beta-alanine (β-alanine) supplementation on the acute interference effect of high-intensity intermittent exercise (HIIE) on lower-body resistance exercise performance, body composition, and strength when combined with a resistance training program. (2) Methods: Twenty-two males were randomiz...

Osteoarthritis is the loss of articular cartilage, which puts increased loading pressure on the subchondral bone. This causes cellular damage to subchondral bone resulting in an inflammatory response to the bone, synovium and remaining articular cartilage resulting in pain associated with movement/load in the affected joint, which leads to disuse a...

The purpose of this study was to investigate the effects of heavy back squat (90% one repetition maximum [1RM]) postactivation potentiation (PAP) on acute resistance exercise performance and force production in recreationally trained men, and to verify the relationship between maximal strength and the PAP response. Ten resistance-trained men random...

It is commonly accepted that adequate carbohydrate availability is necessary for optimal endurance performance. However, for strength- and physique-based athletes, sports nutrition research and recommendations have focused on protein ingestion, with far less attention given to carbohydrate. Varying resistance exercise protocols, such as differences...

Blood flow restriction (BFR) combined with low-intensity strength training has been shown to increase skeletal muscle mass and strength in a variety of populations. BFR results in a robust metabolic stress which is hypothesized to induce muscle growth via increased recruitment of fast-twitch muscle fibers, a greater endocrine response, and/or enhan...

Increased blood flow via vasodilation, metabolite production, and venous pooling contribute to the hyperaemia and cellular swelling experienced during resistance training. These effects have been suggested to play a role in hypertrophic adaptations. Over the past two decades sport supplement products have been marketed to promote exercise hyperaemi...

The positive influence of animal-based proteins supplementation during muscle-damaging exercise has been widely studied. However, the effects of plant-based proteins remain unclear and requires further clarification. This study investigated the protective role of oats protein against exercise induced muscle damage (EIMD), subsequent inflammation, a...

Doxorubicin (DOX) is a chemotherapy agent widely used in clinical practice, and it is very efficient in tumor suppression, but the use of DOX is limited by a strong association with the development of severe muscle atrophy and cardiotoxicity effects. Reversion or neutralization of the muscular atrophy can lead to a better prognosis. Recent studies...

Previous research has demonstrated the positive effects of concurrent/combined aerobic and resistance exercise or leucine supplementation on skeletal muscle protein synthesis (MPS) and hypertrophy in aging organisms. However, the effects...

Metabolic stress is a physiological process that occurs during exercise in response to low energy that leads to metabolite accumulation [lactate, phosphate inorganic (Pi) and ions of hydrogen (H⁺)] in muscle cells. Traditional exercise protocol (i.e., Resistance training) has an important impact on the increase of metabolite accumulation, which inf...

Sarcopenia is defined as the progressive loss of muscle mass with age, and poses a serious threat to the physiological and psychological health of the elderly population with consequential economic and social burdens. Chronic low-grade inflammation plays a central role in the development of sarcopenia such that it alters cellular protein metabolism...

Dietary proteins/essential amino acids (EAAs) are nutrients with anabolic properties that may increase muscle mass or attenuate muscle loss during immobilization and aging via the stimulation of muscle protein synthesis (MPS). An EAA’s anabolic threshold, capable to maximize the stimulation of MPS has been hypothesized, but during certain condition...

Metabolic stress is a physiological process that occurs during exercise in response to low energy that leads to metabolite accumulation [lactate, phosphate inorganic (Pi) and ions of hydrogen (H +)] in muscle cells. Traditional exercise protocol (i.e. , Resistance training) has an important impact on the increase of metabolite accumulation, which i...

Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1® mice were subjected to moderate aerobic...

The purpose of this study was to investigate the influence of short and moderate recovery intervals during heavy strength exercise on performance, inflammatory and metabolic responses in recreational weightlifters. Eight healthy subjects (age= 24.6+/-4.1 years) performed two randomized sequences with different rest intervals: Short = 90% of 1RM and...

The non-steroidal anti-inflammatory drug Diacerein has been shown to reduce markers of inflammation in animal models of type 2 diabetes mellitus; however, the effects of Diacerein on endoplasmic reticulum stress mediated inflammation are unknown. The aim of the current study was to investigate the potential protective role of Diacerein against palm...

The aim of the present study was to evaluate the effect of oral caffeine ingestion during repeated sets of resistance. Fourteen moderately resistance-trained men (20.9±0.36 years and 77.62±2.07 kg of body weight) ingested a dose of caffeine (5 mg.kg-1) or placebo prior to 3 sets of bench press and 3 sets of leg press exercises, respectively. The st...

Alpha-ketoisocaproate (KIC) and Beta hydroxy- beta methylbutyrate (HMB) are metabolites of the amino acid leucine. The first step in HMB metabolism is the reversible transamination of leucine to KIC, which occurs mainly extrahepatically. Following this enzymatic reaction, KIC is converted to HMB by two routes: through the cytosolic enzyme KIC dioxy...

Resistance training is a potent stimulus to increase skeletal muscle mass. The muscle protein accretion process depends on a robust synergistic action between protein intake and overload. The intake of protein after resistance training increases plasma amino acids, which results in the activation of signaling molecules leading to increased muscle p...

Objective: The purpose of this study was to investigate the effects of intensity on rating of perceived exertion (RPE) during multiple sets to volitional failure in bench press exercise. Design and Methods: Thirteen moderately resistance trained men performed 2 experimental sessions in random order: 3 sets to failure in bench press with 1 minute re...

PURPOSE: The increases in rating of perceived exertion (RPE) between sets during moderate- and high-intensity resistance exercises have been attributed to fatigue. Previous studies demonstrated that when total weight lifted is matched, RPE is proportional to resistance exercise intensity. The purpose of this study was to investigate the effects of...

Betaine is a methyl derivative of glycine first isolated from sugar beets. Betaine consumed from food sources and through dietary supplements presents similar bioavailability and is metabolized to di-methylglycine and sarcosine in the liver. The ergogenic and clinical effects of betaine have been investigated with doses ranging from 500 to 9,000 mg...

Caffeine – 1,3,7 trimetilxanthine – is one of the most widely used as a ergogenic aid in sports scenario, with multiple actions on body, either central as peripheral. A great number of studies evaluated the effects of caffeine ingestion on endurance performance, with predominance of aerobic metabolism. However, data in scientific literature about t...

Human muscle hypertrophy brought about by voluntary exercise in laboratorial conditions is the most common way to study resistance exercise training, especially because of its reliability, stimulus control and easy application to resistance training exercise sessions at fitness centers. However, because of the complexity of blood factors and organs...

In general, nutritional sports ergogenics are designed to enhance energy production and/or improve body composition, promoting muscle growth and decreasing body fat. Many nutritional supplements and pharmacological substances have been used during resistance training without knowledge of the effects on human metabolism caused by their chronic admin...

No abstract.

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature on the use of beta-hydroxy-beta-methylbutyrate (HMB) as a nutritional supplement. The ISSN has concluded the following. 1. HMB can be used to enhance recovery by attenuating exercise induced skeletal m...

The purpose of the present study was to determine the effects of short-term supplementation with the free acid form of β-hydroxy-β-methylbutyrate (HMB-FA) on indices of muscle damage, protein breakdown, recovery and hormone status following a high-volume resistance training session in trained athletes. A total of twenty resistance-trained males wer...

Dexamethasone (DEXA) is a potent immunosupressant and anti-inflammatory agent whose main side effects are muscle atrophy and insulin resistance in skeletal muscles. In this context, leucine supplementation may represent a way to limit the DEXA side effects. In this study, we have investigated the effects of a low and a high dose of leucine suppleme...

Branched-chain amino acids (BCAA) (especially leucine) have been shown to activate protein synthesis pathways, decrease proteolysis and increase insulin sensitivity. Furthermore, it appears that leucine can be used as a nutritional therapy to avoid sarcopenia and skeletal muscle atrophy due to immobilization or glucocorticoid treatment. However, it...

We examined the capacity of high-intensity intermittent training (HI-IT) to facilitate the delivery of lipids to enzymes responsible for oxidation, a task performed by the carnitine palmitoyl transferase (CPT) system in the rat gastrocnemius muscle. Male adult Wistar rats (160-250 g) were randomly distributed into 3 groups: sedentary (Sed, N = 5),...

Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the "diseasome of physical inactivity". In contrast, the protective effect of...

Lipid metabolism in the liver is complex and involves the synthesis and secretion of very low density lipoproteins (VLDL), ketone bodies, and high rates of fatty acid oxidation, synthesis, and esterification. Exercise training induces several changes in lipid metabolism in the liver and affects VLDL secretion and fatty acid oxidation. These alterat...

This study aimed to develop an equipment and system of resistance exercise (RE), based on squat-type exercise for rodents, with control of training variables. We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal. With this system, it is not necessary to impose f...

This study aimed to compare the time-course effects of four different intensities of strength exercise (bench press) bouts on the blood lipid profile. Thirty-five Brazilian Army male soldiers were allocated randomly into five groups based at different percentages of one repetition maximum, in previous test (1-RM): 50%-1RM, 75%-1RM, 90%-1RM, 110%-1R...

Branched-chain amino acids (BCAA) supplementation has been considered an interesting nutritional strategy to improve skeletal muscle protein turnover in several conditions. In this context, there is evidence that resistance exercise (RE)-derived biochemical markers of muscle soreness (creatine kinase (CK), aldolase, myoglobin), soreness, and functi...

We aimed to evaluate the effects of resistance exercise (RE) and leucine (LEU) supplementation on dexamethasone (DEXA)-induced muscle atrophy and insulin resistance. Male Wistar rats were randomly divided into DEXA (DEX), DEXA + RE (DEX-RE), DEXA + LEU (DEX-LEU), and DEXA + RE + LEU (DEX-RE-LEU) groups. Each group received DEXA 5 mg · kg(-1) · d(-1...

Abstract The reduction of skeletal muscle loss in pathological states, such as muscle disuse, has considerable effects in terms of rehabilitation and quality of life. Since there is no currently effective and safe treatment available for skeletal muscle atrophy, the search for new alternatives is necessary. Resistance exercise (RE) seems to be an i...

Abstract quality of life. Since there is no currently effective and safe treatment available for skeletal muscle atrophy, the search for new alternatives is necessary. Resistance exercise (RE) seems to be an important tool in the treatment of disuse-induced skeletal muscle atrophy by promoting positive functional (strength and power) and structural...

The purpose of this study was to evaluate the effect of exhaustive exercise on proteins associated with muscle damage and regeneration, including IL-2, IL-4 and MyoD, in extensor digitorum longus (EDL) and soleus muscles and mesenteric (MEAT) and retroperitoneal adipose tissues (RPAT). Rats were killed by decapitation immediately (E0 group, n = 6),...

Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear that these effects may counteract catabolic conditions, as well as enhance skeletal muscle mas...

β-Hydroxy-β-methylbutyrate (HMβ) supplementation is used to treat cancer, sepsis and exercise-induced muscle damage. However, its effects on animal and human health and the consequences of this treatment in other tissues (e.g., fat and liver) have not been examined. The purpose of this study was to evaluate the effects of HMβ supplementation on ske...

Glucocorticoid hormones are important regulators of several physiological processes. Despite having been initially named based on their role in glucose metabolism, glucocorticoids are also fundamental in the regulation of developmental, metabolic, and neurobiological processes, as well as several other biological functions. Due to their involvement...

This study examined the effects of acute supramaximal exercise (approximately 115% VO(2max)) on the blood lipid profile for three different carbohydrate (CHO) storage levels (control, low and high). Six male subjects were randomly divided into three different groups: control, low CHO and high CHO. These groups differed in the diet to which the subj...