Neil Koorbanally

Neil Koorbanally
University of KwaZulu-Natal | ukzn · School of Chemistry and Physics

PhD

About

209
Publications
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Publications

Publications (209)
Article
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Background: Apoptosis is a common pathology in malaria and most antimalarial drugs induce apoptosis during chemotherapy. Globimetula braunii is an African mistletoe used for the treatment of malaria but its effect on mitochondria-mediated apoptosis is not known. Methods: Malarial infection was induced by the intraperitoneal injection of NK 65 strai...
Article
The enzymatic modification of phenolic molecules to higher molecular weight compounds is a promising approach for improving biological activity. In the current study, the Trametes pubescens laccase was used to modify isorhamnetin (m/z 315) as a way of improving its antioxidant and antibacterial activities. Using a monophasic system with ethanol as...
Article
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Pro-inflammatory signaling, cell death, and metalloproteinases activation are events in Plasmodium infection. However, it is not known if treatment with mefloquine (MF), and curcumin (CM) supplementation, will modulate these conditions. Malaria was induced in two different studies using susceptible (NK 65, study 1) and resistant (ANKA, study 2) str...
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Markhamia tomentosa crude extract and fractions exhibited potent growth inhibitory effects capable to induce apoptosis in cervical (HeLa) cancer cell line via in vitro model. Presently, interaction of M. tomentosa phytoconstituents with molecular drug targets to exert its anticancer property is evaluated via in silico study. Identified phytoconstit...
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Introduction: Resistant malaria is a fatal disease. Globimetula braunii (African Mistletoe) is traditionally used for malarial treatment but this fact has not been scientifically reported. Methods: Plasmodium berghei (NK65)-infected male Swiss mice (20±2 g) were treated orally and once daily with 100, 200, and 400 mg/kg BW of methanol extract an...
Article
Ethnopharmacological relevance: Raffia palm (Raphia hookeri G. Mann & H. Wendl) wine (RPW) is a natural beverage obtained from the R. hookeri consumed for refreshment and medicinal purposes. For medicinal purposes, it is used singly or as macerating agent for other medicinal plants for the treatment of several diseases. Aim: This study investigates...
Article
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The antidiabetic effect of l-leucine has been attributed to its modulatory effect on glucose uptake and lipid metabolism in muscles. However, there is a dearth on its effect on glucose metabolism in muscles. Thus, the present study investigated the effect of l-leucine – stimulated glucose uptake on glucose metabolism, dysregulated lipid metabolic p...
Article
Antimicrobial resistance and oxidative stress continue to be major challenges globally. The aim of the current study was to enzymatically transform luteolin for the improvement of antioxidant and antimicrobial activities, using the fungal laccase from Trametes pubescens. Laccase-catalysed homocoupling reactions were carried out in a monophasic syst...
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A series of 5,5 0-(phenylmethylene)bis(6-amino-2-thiouracil) derivatives (1-13) were synthesized by the condensation of 6-amino-2-thiouracil and benzaldehyde derivatives under reflux in glacial acetic acid. Nine compounds (3, 5 and 7-13) were novel. Good binding affinity (BE) in the active site of Eg5 was shown by all compounds, which ranged betwee...
Article
This study investigated the therapeutic mechanism of Cola nitida seeds on diabetic cardiomyopathy in hearts of diabetic rats. Type 2 diabetic (T2D) rats were treated with C. nitida infusion at 150 and 300 mg/kg body weight (bw). The rats were sacrificed after 6 weeks of treatment, and their hearts harvested. There was an upsurge in oxidative stress...
Article
A relatively shorter procedure for the synthesis of 3-amino-2-methyl-3H-quinazolin-4-one (4) was developed. The subsequent condensation reaction of 4 with a variety of aldehydes afforded several novel Schiff bases (5a-r) counting its molecular hybridization with the indole, thiophene, and quinoline pharmacophoric units. Full structural elucidation...
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Cardiotoxicity leading to cardiovascular dysfunction and ultimately cardiac failure remains a major global health issue irrespective of race, age and country. Several factors including lipotoxicity, oxidative imbalance, exacerbated angiotensin-converting enzyme (ACE) activity and altered bioenergetics have been implicated in the pathophysiology of...
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The use of medicinal plants in the treatment of malaria is gaining global attention due to their efficacy and cost effectiveness. This study evaluated the bioactivity‑guided antiplasmodial efficacy and immunomodulatory effects of solvent fractions of Diospyros mespiliformis in mice infected with a susceptible strain of Plasmodium berghei (NK 65). T...
Preprint
Objective The effect of Alstonia boonei fractions on glucose homeostasis was investigated via in vitro enzyme inhibition activity, ex vivo glucose uptake assay, and in vivo methods in diabetic rats. Methodology A. boonei fractions were subjected to in vitro α-glucosidase inhibitory assay and then ex vivo glucose uptake activity. The butanol fracti...
Article
A series of quinazolin‐4‐one Schiff bases were synthesized and tested in vitro for their cytotoxicity against two cancerous cell lines (MCF‐7, Caco‐2) and a human embryonic cell line (HEK‐293) including their antibacterial evaluation against two Gram‐positive and four Gram‐negative bacterial strains. Most of the quinazoline‐schiff bases exhibited p...
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The present study investigates the cytotoxic effect of the chemical fractions of Allium cepa (yellow variety) on Human Embryonic Kidney (HEK293) cells. Allium cepa was blended into paste and macerated in distilled water before subjecting to liquid–liquid fractionation, yielding the dichloromethane, ethyl acetate (EtOAc), butanol, and aqueous fracti...
Article
Ammocharis coranica is a bulbous southern African species reported to be used to treat mental illness. Eight Amaryllidaceae alkaloids of the aromatic, lycorine or crinine type were found in the current study, five of which, hippadine, lycorine, caranine, acetylcaranine, and 1-O-acetyl-9-O-demethylpluviine have previously been isolated from this spe...
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The antioxidant and anti-proinflammatory activities of l-leucine were investigated on oxidative testicular injury, ex vivo. In vitro analysis revealed l-leucine to be a potent scavenger of free radicals, while inhibiting acetylcholinesterase activity. Oxidative injury was induced in testicular tissues using FeSO4. Treatment with l-leucine led to de...
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The antidiabetic properties of ferulic acid and its protective role against Fe²⁺‐induced oxidative pancreatic injury were investigated in this study using in vitro and ex vivo models. Induction of oxidative injury in the pancreas was achieved by incubating normal pancreatic tissue with 0.1 mM FeSO4 and treated by co‐incubating with different concen...
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A library of pyrazole–thiazolidinone conjugates was synthesized using a molecular hybridization approach through a Vilsmeier–Haack reaction. The compounds were tested for anti-microbial activity against two Gram-positive bacteria (Staphylococcus aureus and methicillin-resistant Staphylococcus aureus) and four Gram-negative bacteria (Escherichia col...
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The infusion of Chrysophyllum albidum was investigated for its antidiabetic mechanism by studying its ability to promote glucose uptake and utilization as well as its modulatory effect on metabolic activities linked to type 2 diabetes in isolated psoas muscle. Isolated psoas muscle was incubated with different concentrations of the infusion in the...
Article
The antidiabetic potentials of the dichloromethene, ethyl acetate, butanol and aqueous fractions of Bridelia ferruginea leaves were investigated using in vitro, ex vivo and in vivo models. In vitro and ex vivo antidiabetic activities revealed the butanol (BFBF) to be the most active of the fractions, and thus selected for in vivo study. Diabetes wa...
Article
The leaves, stem and root bark of Bridelia ferruginea were sequentially extracted with solvents of increasing polarity to yield the hexane, ethyl acetate, ethanol and aqueous extracts. In vitro analysis revealed the ability of the extracts to scavenge 1,1-diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide (NO) and hydroxyl radical. They also inhibited...
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Caseins are the most abundant milk proteins in mammalian species and are assembled in supra-macromolecular structures called micelles. In this study, the microstructural properties, particle size, and elemental composition of isolated casein from bovine milk and its therapeutic effect on oxidative and cholinergic activities linked to dementia in ox...
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The antioxidant, antidiabetic, and anti-obesogenic potentials of different extracts (dichloromethane, ethyl acetate, ethanol, and aqueous) of the red honeybush (Cyclopia genistoides) tea were investigated in vitro and ex vivo. All extracts exhibited significant scavenging and reducing power activities, with the aqueous and ethyl acetate extracts be...
Article
The present study investigated the effect of raffia palm (Raphia hookeri) wine (RPW) on hyperglycemia-mediated lipid metabolites and pathways, functional chemistry and ultrastructural morphology of cerebellums in type 2 diabetes (T2D). T2D was induced in male Sprague-Dawley rats by feeding with 10% fructose ad libitum for 2 weeks before injecting i...
Article
Objectives: This study was aimed at investigating neuroprotective effect of catechol on redox imbalance, cholinergic dysfunctions, nucleotide hydrolysing enzymes activities, and dysregulated metabolic pathways in iron-mediated oxidative brain injury. Methods: Oxidative injury was induced in brain tissues by incubating with 0.1 mm FeSO4 and treat...
Article
This present study investigated the antioxidative and antidiabetic properties of kolaviron by analysing its inhibitory effect on key metabolic activities linked to T2D, in vitro and ex vivo. Kolaviron significantly inhibited a-glucosidase and a-amylase activities, and intestinal glucose absorption dose-dependently, while promoting muscle glucose up...
Article
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The protective effect of caffeic acid on ferric-induced pancreatic injury was investigated using ex vivo and in silico models. Incubation of pancreatic tissues with Fe²⁺ led to significant depleted levels of glutathione (GSH) and SOD and catalase activities, with concomitant elevated levels of malondialdehyde (MDA) and nitric oxide (NO) and acetylc...
Article
Background: The therapeutic effect of Cola nitida hot infusion against diabetes hepatic injury was investigated in livers of diabetic rats. Cola nitida was infused in boiling water and concentrated. Methods: The concentrated infusion was administered to T2D rats at low and high dose (150 and 300 mg/kg body weight (bw) respectively). The normal gro...
Article
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The therapeutic effect of phenolics on neurodegenerative diseases has been attributed to their potent antioxidant properties. In the present study, the neuroprotective activities of vanillin and vanillic acid were investigated in Fe2+- induced oxidative toxicity in brain tissues by investigating their therapeutic effects on oxidative imbalance, cho...
Article
The comparative phytochemicals, antioxidative and antidiabetic activities of Camellia sinensis (black tea) and Aspalathus linearis (rooibos tea) were studied in vitro and ex vivo. Concentrated infusions of the teas showed significant free radical scavenging activities in vitro. They significantly increased the glutathione level, superoxide dismutas...
Article
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Purpose: To synthesize some pyrimidine derivatives and investigate their radical scavenging activities. Methods: A series of newly pyranopyrimidines derivatives and dithiopyridopyrimidinediones were synthesized by condensation of barbituric acid, malononitrile and different substituted benzaldehydes reacted Results: The potency of radical scavengin...
Article
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The neuroprotective activities of phenolics have been demonstrated in several studies, with their antioxidant properties playing an influential role. In this study, the therapeutic effect of ferulic acid was investigated on oxidative stress, purinergic and cholinergic enzymatic activities, and dysregulated metabolic pathways in oxidative brain inju...
Article
The leaves of Polydora serratuloides, with the synonym Vernonia perrottetii are widely used as purgative agents for gastrointestinal problems, and other members of Vernonieae have been used in African traditional medicine for decades. A new sesquiterpene lactone of the keto-hirsutinolide type, 13-acetoxy-1(4β),5(6)β-diepoxy-8α-(senecioyloxy)−3-oxo-...
Article
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The ability of umbelliferone to stimulate muscle glucose uptake and its effect on glucose and fatty acid metabolism as well as nucleotide hydrolysis and cholinergic activity were investigated in isolated psoas muscles. Incubation of umbelliferone with muscles led to increase glucose uptake, elevated GSH, SOD and catalase activities , as well as dep...
Article
A series of 2‐phenyl‐3‐(2‐(trifluoromethyl)‐1H‐benzoimidazol‐6‐yl)thiazolidin‐4‐one derivatives were synthesized from p‐nitro‐o‐phenylenediamine in a three‐step reaction. Their structures were elucidated by NMR and mass spectral data. The synthesized compounds showed excellent antibacterial activity ranging from 3‐fold, to greater than 100‐fold hig...
Article
Introduction Medicinal plants have long been recognized for their roles in the treatment and management of diabetes and its complications. The antioxidative and antidiabetic properties of Clerodendrum volubile flowers were investigated in vitro and ex vivo. Methods The flowers were sequentially extracted with solvents of increasing polarity (n-hex...
Article
Ethnopharmacological relevance: Buddleja saligna Willd (Loganiaceae), mostly indigenous to South Africa is traditionally used in the treatment cardio-dysfunctional related ailments amongst other diseases. Aims: The cardio-protective effect of B. saligna was investigated in ferric-induced oxidative cardiopathy. Methods: Hearts harvested from he...
Article
A library of novel pyrazole‐imidazo[1,2‐α]pyridine scaffolds was designed and synthesized through a one‐potthree‐component tandem reaction. The structures of synthesized conjugates were confirmed by spectroscopic techniques (NMR, IR and HRMS). In vitro antibacterial evaluation of the twelve synthesized molecules (7a, 8a‐k) against Methicillin‐resis...
Article
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Chloro, fluoro, and nitro derivatives of 7‐amino‐5‐aryl‐6‐cyano‐5H‐pyrano pyrimidin‐2,4‐diones were produced by reacting malononitrile, barbituric acid, and aromatic aldehydes together with a DABCO catalyst in an aqueous one‐pot reaction. This is the first report of these compounds being synthesized with DABCO as a catalyst, which produced the comp...
Article
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Crassocephalum rubens falls under the wild edible, under‐cultivated traditional leafy vegetables (TLV) in Africa; it is used by locals in managing diabetes mellitus among other diseases. This study investigated the in vitro, ex vivo antioxidant and antidiabetic potentials of different extracts of C. rubens. The ameliorative effects of the extracts...
Article
An environmentally friendly Sonogashira cross-coupling reaction is described in this study with high potential for application in a fluidized system. The LaCo0.9Ni0.05Pd0.05O3 perovskite based catalyst provided a high TOF of 900 h-1 via mainly a heterogeneous mechanism in an environmentally friendly azeotrope medium of water and acetonitrile. Nano-...
Article
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Leaves from Flabellaria paniculata Cav (Malpighiaceae) are used in traditional medicine for wound dressing, and to treat ulcers and inflammation in Nigeria. The present study evaluates the gastroprotective activity of the ethyl acetate fraction of the methanolic leaf extract and reports on the chemical constituents from the fraction. The methanolic...
Article
This study investigated the antidiabetic and antioxidant activities of the extracts from three parts of Alstonia boonei. Sequential extraction of leaves, stem and root bark samples was done with the solvents of increasing polarity and these extracts were assayed for total phenolic content and in vitro antioxidant and antidiabetic activities using d...
Article
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Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Hot infusion of V. amygdalina leaves was incubated with rat brain...
Article
Fifteen 2-quinolone thiosemicarbazone derivatives of which eleven were new, were synthesized at room temperature. The key intermediate was the quinolone carbaldehyde, from which thiosemicarbazones were formed by the reaction of thiosemicarbazides with the aldehyde moiety. The structures of the synthesized compounds were elucidated by 1D and 2D-NMR...
Article
The present study was designed to conduct the bioassay-guided isolation of possible bioactive compound(s) responsible for the antidiabetic action of Xylopia aethiopica (Dunal) A. Rich. fruit. The isolation of compound was guided by α-glycosidase and α-amylase inhibitory activities. Molecular docking with Autodock Vina was used to decipher the mode...
Article
The present study was designed to conduct the bioassay-guided isolation of possible bioactive compound(s) responsible for the antidiabetic action of Xylopia aethiopica (Dunal) A. Rich. fruit. The isolation of compound was guided by α-glycosidase and α-amylase inhibitory activities. Molecular docking with Autodock Vina was used to decipher the mode...
Article
Full-text available
Raffia palm wine is a natural drink from the stem of Raffia palm (Raphia hookeri) tree with nutritional and medicinal properties. The effect of fermentation was investigated on its antidiabetic and antioxidative effects in yeast cells and pancreatic tissues, respectively. Both unfermented and fermented palm wine significantly increased glucose upta...
Article
Ethnopharmacological relevance Raffia palm (Raphia hookeri) wine (RPW) is amongst the natural products from plants, utilized singly or in combination with other medicinal plants for the treatment of several ailments including Diabetes Mellitus (DM). However, there is a scientific dearth on its antidiabetic activity. Aim The antidiabetic effect of R...
Article
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A novel series of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles were synthesized via a two-step pathway. In the first step, Ugi-four-component condensation of 2-formylindole, amines, (E)-4-alkoxy-4-oxobut-2-enoic acids, and isocyanides gave the corresponding Ugi-adducts. This adduct underwent intramolecular hydroamination in the presence of K2CO3 in...
Article
Ficus glumosa is reputed for the treatment and management of various health conditions, including diarrhoea, dysentery, oedema, headache, stomach ailments and ulcers. Three phenolic acids (1–3), two coumarins (4 and 5), three flavonoid glycosides (6, 7a, 7b) and five triterpenoids (8–12) were isolated from the aerial parts of F. glumosa. Gastroprot...
Article
The fast decolourization of multi-purpose dye, Brilliant blue (BB-) oxidized by chlorine dioxide was investigated using the stopped flow technique under varied pH conditions by monitoring its oxidation kinetics. The products were identified and reaction mechanism is described, which is confirmed by kinetic simulations. Under [ClO2]0 > [OH-]0 > [BB-...
Article
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Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have the potential to conjugate two asymmetrical groups. This has not been done using other fluorina...
Article
The progression of secondary complications in type 2 diabetes (T2D) has been linked to oxidative stress caused by hyperglycemia. Therefore, the control of hyperglycemia is the main target in the treatment of diabetes. The present study investigated the scavenging and ameliorative potentials of different fractions of Azadirachta indica (A. indica) e...
Article
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In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 diabetes. Plant parts were extracted sequentially with ethyl acetate, ethanol and water. GC-MS analys...
Article
The antioxidative and antidiabetic effects of the aqueous extract of Phaseolus lunatus were investigated in vitro and ex vivo. The seeds were subjected to aqueous extraction, after defatting with n‐hexane. The extract (15, 30, 60, 120, 240 μg/ml) showed significant (p < 0.05) free radical scavenging and enzyme inhibitory activities in vitro. It sig...