Neha Gogia

Neha Gogia
Yale University | YU · Department of Genetics

Doctor of Philosophy

About

29
Publications
5,886
Reads
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261
Citations
Citations since 2016
25 Research Items
245 Citations
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20162017201820192020202120220204060
20162017201820192020202120220204060
20162017201820192020202120220204060
Introduction
Presently I am working on understanding the molecular basis of cellular pathology and disease mechanisms in Polyglutamine diseases. Keywords: Neuroscience; Neurobiology; Neural development; Neurological and Neurodegenerative disorders; Neuromuscular and Motor Neuron Diseases.
Additional affiliations
November 2019 - present
Yale University
Position
  • PostDoc Position
Description
  • Cellular Neuroscience, Neurodegeneration and Repair (CNNR) Program
August 2014 - October 2019
University of Dayton
Position
  • PhD Student
August 2014 - August 2019
University of Dayton
Position
  • Graduate Teaching Assistant

Publications

Publications (29)
Article
Full-text available
Spinocerebellar ataxia type 1 (SCA1) is one of nine polyglutamine (polyQ) diseases and is characterized as an adult late-onset, progressive, dominantly inherited genetic disease. SCA1 is caused by an increase in the number of CAG repeats in the ATXN1 gene leading to an expanded polyQ tract in the ATAXIN-1 protein. ATAXIN-1 is broadly expressed thro...
Article
Full-text available
Lectins have always demonstrated their role in bearing insecticidal activity. They are although considered to be toxic for mammals but some studies have reported that the presence of mannose binding region is believed to impart non-toxic nature to lectins against mammals including humans. In the present investigation, the research was conducted to...
Article
Full-text available
Spinal and Bulbar Muscular Atrophy (SBMA) is an X-linked adult-onset progressive neuromuscular disease that affects the spinal and bulbar motor neurons and skeletal muscles. SBMA is caused by expansion of polymorphic CAG trinucleotide repeats in the Androgen Receptor (AR) gene, resulting in expanded glutamine tract in the AR protein. Polyglutamine...
Chapter
The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed.
Chapter
The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed.
Chapter
AMP-activated protein kinase (AMPK) and sirtuins are fuel-sensing enzymes. AMPK is activated upon increased AMP/ATP ratio, and sirtuins activation increases by increased NAD⁺ levels. There are seven isoforms of sirtuin (SIRT1-SIRT7) expressed at different cellular compartments. The most studied sirtuin isoform in the context of aging is SIRT1. SIRT...
Article
Full-text available
Numerous imaging modules are utilized to study changes that occur during cellular processes. Besides qualitative (immunohistochemical) or semiquantitative (Western blot) approaches, direct quantitation method(s) for detecting and analyzing signal intensities for disease(s) biomarkers are lacking. Thus, there is a need to develop method(s) to quanti...
Article
Full-text available
During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas excessive cell death results in neurodegenerative disorders. Many signaling pathways known-to-date hav...
Article
During organogenesis, cell proliferation is followed by the differentiation of specific cell types to form an organ. Any aberration in differentiation can result in developmental defects, which can result in a partial to a near-complete loss of an organ. We employ the Drosophila eye model to understand the genetic and molecular mechanisms involved...
Chapter
Axial patterning, a fundamental process during organogenesis, is required for transition of a single layer organ primordium to a three-dimensional organ in all multi-cellular organisms. Axial patterning involves delineation of antero-posterior (AP), dorsal-ventral (DV), and proximo-distal (PD) axes. Any deviation in this fundamental process of orga...
Article
Full-text available
Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques. These plaques induce oxidative stress and aberrant signaling, which result in the death of neurons and other patho...
Article
Full-text available
Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-conserved protein across different species, which pla...
Article
Full-text available
Brucella abortus S19 is an important tool for controlling bovine brucellosis across the globe. However, vaccination with S19 suffers critical shortcomings such as, presence of residual virulence, induction of abortion and sero-diagnostic interference. In this study, rfbD gene deleted mutant S19 was developed. The mutant strain designated S19ΔR disp...
Article
Full-text available
Cover illustration: The cover image is based on the Original Article Proximal fate marker homothorax marks the lateral extension of stalk‐eyed fly Cyrtodopsis whitei by Amit Singh et al., DOI: 10.1002/dvg.23309.
Article
Full-text available
Alzheimer’s disease (hereafter AD) is a progressive neurodegenerative disorder that affects the central nervous system. There are multiple factors that cause AD, viz., accumulation of extracellular Amyloid-beta 42 plaques, intracellular hyper-phosphorylated Tau tangles, generation of reactive oxygen species due to mitochondrial dysfunction and gene...
Article
Full-text available
The placement of eyes on insect head is an important evolutionary trait. The stalk‐eyed fly, Cyrtodopsis whitei, exhibits a hypercephaly phenotype where compound eyes are located on lateral extension from the head while the antennal segments are placed inwardly on this stalk. This stalk‐eyed phenotype is characteristic of the family Diopsidae in th...
Article
Full-text available
Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, also results from accumulation of amyloid-beta 42 (Aβ42) plaques. These Aβ42 plaques trigger oxidative stress, abnormal signaling, which results in neuronal death by unknown mechanism(s). We misexpress high levels of human Aβ42 in the differentiating retinal neurons of the Dr...
Article
Full-text available
The ability to express a gene of interest in a spatio-temporal manner using Gal4-UAS system has allowed the use of Drosophila model to study various biological phenomenon. During Drosophila eye development, a synchronous wave of differentiation called Morphogenetic furrow (MF) initiates at the posterior margin resulting in differentiation of retina...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing eye imaginal disc. These GMR enhancer lines are carrying CRE sequences of dpp- gene (Table 1). Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing leg imaginal disc. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) leg imaginal disc. None of these lines exhibit GFP reporter ex...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing wing imaginal disc. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) wing imaginal disc. None of these lines exhibit GFP reporter...
Data
Gain-of-function phenotype of reaper (rpr) using dpp-CRM lines exhibits ventral eye loss. (A, B)dpp>rpr, (C,D) GMR18D08>rpr, (E,F) GMR17E04>rpr. Note that dpp>rpr results in highly reduced eye as seen in (A) the eye imaginal disc and (B) the adult eye. (C, D) GMR18D08>rpr results in the reduced (C) eye imaginal disc and (D) the adult eye with prefe...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing haltere imaginal disc. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) haltere imaginal disc. None of these lines exhibit GFP rep...
Data
Study of expression pattern of GMR lines carrying enhancer of dpp using GFP reporter in the developing third instar larval brain. Expression of (A) GMR18B08>GFP, (B) GMR18D08>GFP, (C) GMR19D09>GFP, (D) GMR16G02>GFP, (E) GMR17E04>GFP, (F) GMR17G08>GFP, (G) GMR19B04>GFP, (H) GMR19C03>GFP in (A-H) larval brain. Only GMR18B08 and GMR17E04 exhibits robu...
Article
Full-text available
We have developed an undergraduate laboratory to allow detection and localization of proteins in the compound eye of Drosophila melanogaster, a.k.a fruit fly. This lab was a part of the undergraduate curriculum of the cell biology laboratory course aimed to demonstrate the use of Western Blotting technique to study protein localization in the adult...
Article
Full-text available
Background: The progressive neurodegenerative disorder Alzheimer's disease (AD) manifests as loss of cognitive functions, and finally leads to death of the affected individual. AD may result from accumulation of amyloid plaques. These amyloid plaques comprising of amyloid-beta 42 (Aβ42) polypeptides results from the improper cleavage of amyloid pr...
Article
Full-text available
Brucella abortus S19 is a smooth strain used as live vaccine against bovine brucellosis. Smooth lipopolysaccharide (LPS) is responsible for its residual virulence and serological interference. Rough mutants defective of LPS are more attenuated but confers lower level of protection. We describe a modified B. abortus S19 strain, named as S19Δper, whi...
Article
Full-text available
Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of the genus Leptospira, causing febrile infection characterized by multi-organ failure in humans and animals. Leptospiral Ig-like protein B (LigB) is a surface-expressed antigen that mediates host cell invasion or attachment. In this study, N-terminal conserved region of LigB pro...
Article
Full-text available
Lectins have always demonstrated their role in bearing insecticidal activity. They are although considered to be toxic for mammals but some studies have reported that the presence of mannose binding region is believed to impart non-toxic nature to lectins against mammals including humans. In the present investigation, the research was conducted to...

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